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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2increases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNAPMID:22262711 PMID:28351761 PMID:30768972 PMID:35618242
CCL2increases secretionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of CCL2 proteinPMID:30768972
CCL2multiple interactionsEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL2 mRNA]; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]PMID:22262711 PMID:30768972
CCL2decreases expressionISOCcl2 (Rattus norvegicus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CCL2 mRNAPMID:23196670
CCL2increases expressionISOCcl2 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 proteinPMID:19265715 PMID:24378064 PMID:28163111 PMID:37080397
CCL2increases expressionISOCcl2 (Rattus norvegicus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNAPMID:19692669 PMID:20959002
CCL2increases secretionISOCcl2 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of CCL2 proteinPMID:27663891
CCL2multiple interactionsISOCcl2 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CCL2 mRNA]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of CCL2 protein; CAV1 affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; CAV1 affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein]; Sunphenon inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]PMID:19265715 PMID:24378064 PMID:28973532
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