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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2decreases expressionEXP 6480464CTDCadmium results in decreased expression of CCL2 mRNAPMID:31646340
CCL2multiple interactionsEXP 6480464CTD[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of CCL2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of CCL2 mRNA; Fulvestrant inhibits the reaction [Cadmium results in decreased expression of CCL2 mRNA]PMID:21481475 PMID:31646340 PMID:35301059
CCL2affects expressionISOCcl2 (Rattus norvegicus)6480464CTDCadmium affects the expression of CCL2 mRNAPMID:36278208
CCL2increases expressionISOCcl2 (Rattus norvegicus)6480464CTDCadmium results in increased expression of CCL2 proteinPMID:25343288
CCL2multiple interactionsISOCcl2 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCL2 protein; [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of CCL2 mRNAPMID:31904401 PMID:33359024
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