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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2decreases expressionEXP 6480464CTDSimvastatin results in decreased expression of CCL2 mRNA; Simvastatin results in decreased expression of CCL2 proteinPMID:12117737 PMID:15184351 PMID:16781696 PMID:19225232
CCL2decreases response to substanceEXP 6480464CTDSimvastatin results in decreased susceptibility to CCL2 proteinPMID:15781755
CCL2multiple interactionsEXP 6480464CTD[Simvastatin co-treated with Ramipril] results in decreased expression of CCL2 protein; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL2 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL2 protein]; Simvastatin results in decreased expression of and results in decreased secretion of CCL2 proteinPMID:12117737 PMID:15184351 PMID:15824212 PMID:16321392 PMID:16443229 PMID:19225232 PMID:21268089
CCL2affects expressionISOCcl2 (Mus musculus)6480464CTDSimvastatin affects the expression of CCL2 mRNAPMID:12818400
CCL2decreases expressionISOCcl2 (Mus musculus)6480464CTDSimvastatin results in decreased expression of CCL2 mRNAPMID:19262002
CCL2decreases expressionISOCcl2 (Rattus norvegicus)6480464CTDSimvastatin results in decreased expression of CCL2 mRNA; Simvastatin results in decreased expression of CCL2 proteinPMID:15855201 PMID:16414398 PMID:17449418 PMID:18309148 PMID:22305382
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