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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2decreases expressionISOCcl2 (Mus musculus)6480464CTDBleomycin results in decreased expression of CCL2 mRNAPMID:29720568
CCL2increases expressionISOCcl2 (Mus musculus)6480464CTDBleomycin results in increased expression of CCL2 mRNA; Bleomycin results in increased expression of CCL2 proteinPMID:15541506 PMID:16314464 PMID:17177178 PMID:19147827 PMID:26209236 PMID:26520185 PMID:26526764 PMID:30033591 PMID:32828905
CCL2increases expressionISOCcl2 (Rattus norvegicus)6480464CTDBleomycin results in increased expression of CCL2 proteinPMID:35112775
CCL2multiple interactionsISOCcl2 (Mus musculus)6480464CTDCalcitriol inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; CCL11 protein promotes the reaction [Bleomycin results in increased expression of CCL2 mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of CCL2 mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; Rosiglitazone inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]; SPL-334 inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]PMID:15541506 PMID:16314464 PMID:17177178 PMID:19147827 PMID:26209236 PMID:26520185 PMID:26526764 PMID:30033591
CCL2multiple interactionsISOCcl2 (Rattus norvegicus)6480464CTD[Bleomycin co-treated with Tobacco Smoke Pollution] results in increased expression of CCL2 proteinPMID:33516805
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