Ccl7 (C-C motif chemokine ligand 7) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ccl7 (C-C motif chemokine ligand 7) Rattus norvegicus
Analyze
Symbol: Ccl7
Name: C-C motif chemokine ligand 7
RGD ID: 1359152
Description: Predicted to enable CCR1 chemokine receptor binding activity; CCR2 chemokine receptor binding activity; and chemokine activity. Involved in cellular response to ethanol and response to gamma radiation. Predicted to be active in extracellular space. Used to study glomerulonephritis. Biomarker of bronchiolitis obliterans; interstitial nephritis; nephrosis; and silicosis. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human CCL7 (C-C motif chemokine ligand 7); PARTICIPATES IN chemokine mediated signaling pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C motif chemokine 7; chemokine (C-C motif) ligand 7; chemotactic protein-3; MCP-3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; small-inducible cytokine A7
RGD Orthologs
Human
Mouse
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,514,095 - 67,515,945 (+)NCBIGRCr8
mRatBN7.21067,016,446 - 67,018,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,016,446 - 67,018,303 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,637,651 - 71,639,501 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,143,000 - 71,144,850 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,604,125 - 66,605,975 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,423,083 - 69,424,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,423,086 - 69,424,979 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,058,109 - 69,059,959 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,267,281 - 70,269,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11070,280,903 - 70,282,754 (+)NCBI
Celera1065,963,980 - 65,965,830 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-acetyldeoxynivalenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
AB-Fubinaca  (EXP)
abexinostat  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
apocynin  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
asperentin  (ISO)
astemizole  (EXP)
atrazine  (ISO)
barium sulfate  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
Calcimycin  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbofuran  (EXP)
carbon nanotube  (EXP,ISO)
ceric oxide  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
cisplatin  (EXP)
cobalt atom  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (ISO)
dichromium trioxide  (ISO)
diethyl malate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
Fusarenone X  (ISO)
gadodiamide hydrate  (EXP)
gentamycin  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
iodixanol  (ISO)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
MeIQx  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
Muraglitazar  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pioglitazone  (ISO)
piperidines  (ISO)
polymyxin B2  (ISO)
potassium dichromate  (ISO)
procyanidin B3  (ISO)
propanal  (ISO)
quartz  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (EXP)
troglitazone  (EXP)
valproic acid  (ISO)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Chemokines in the limbal form of vernal keratoconjunctivitis. Abu El-Asrar AM, etal., Br J Ophthalmol. 2000 Dec;84(12):1360-6.
2. Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis. Adarichev VA, etal., Autoimmunity. 2006 Dec;39(8):663-73.
3. Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population. Batra J, etal., J Allergy Clin Immunol. 2011 Mar 8.
4. IL-1beta disrupts postnatal lung morphogenesis in the mouse. Bry K, etal., Am J Respir Cell Mol Biol. 2007 Jan;36(1):32-42. Epub 2006 Aug 3.
5. Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia. Choi ES, etal., Am J Respir Crit Care Med. 2004 Sep 1;170(5):508-15. Epub 2004 Jun 10.
6. Monocyte chemotactic protein-3: possible involvement in apical periodontitis chemotaxis. Dezerega A, etal., Int Endod J. 2010 Oct;43(10):902-8. doi: 10.1111/j.1365-2591.2010.01764.x. Epub 2010 Jul 15.
7. Chemokine monocyte chemoattractant protein-3 in progressive periodontal lesions in patients with chronic periodontitis. Dezerega A, etal., J Periodontol. 2010 Feb;81(2):267-76.
8. Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic asthma. Dharajiya N, etal., PLoS One. 2009 Dec 21;4(12):e8172.
9. Chemokine expression by small sputum macrophages in COPD. Frankenberger M, etal., Mol Med. 2011;17(7-8):762-70. doi: 10.2119/molmed.2010.00202. Epub 2011 Feb 9.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation. Gu N, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L290-6. Epub 2009 Dec 4.
13. CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. Huber J, etal., J Clin Endocrinol Metab. 2008 Aug;93(8):3215-21. Epub 2008 May 20.
14. Fibrogenic and redox-related but not proinflammatory genes are upregulated in Lewis rat model of chronic silicosis. Langley RJ, etal., J Toxicol Environ Health A. 2011;74(19):1261-79.
15. Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Luesink M, etal., Blood. 2009 Dec 24;114(27):5512-21. Epub 2009 Oct 14.
16. Single-dose gamma-irradiation induces up-regulation of chemokine gene expression and recruitment of granulocytes into the portal area but not into other regions of rat hepatic tissue. Malik IA, etal., Am J Pathol. 2010 Apr;176(4):1801-15. Epub 2010 Feb 25.
17. MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization study. McManus C, etal., J Neuroimmunol. 1998 Jun 1;86(1):20-9.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. Morgan DL, etal., Toxicol Pathol. 2012 Apr;40(3):448-65. Epub 2012 Jan 3.
20. Gelatinase B, PECAM-1 and MCP-3 gene polymorphisms in Belgian multiple sclerosis. Nelissen I, etal., J Neurol Sci. 2002 Aug 15;200(1-2):43-8.
21. Effective methylprednisolone dose in experimental crescentic glomerulonephritis. Ou ZL, etal., Am J Kidney Dis. 2001 Feb;37(2):411-7.
22. Gene expression of CC chemokines in experimental acute tubulointerstitial nephritis. Ou ZL, etal., J Lab Clin Med. 1999 Jan;133(1):41-7.
23. Transient and sequential expression of chemokine mRNA in glomeruli in puromycin aminonucleoside nephrosis. Ou ZL, etal., Nephron. 2000 Jul;85(3):254-7.
24. Elevated expression of platelet-derived chemokines in patients with antiphospholipid syndrome. Patsouras MD, etal., J Autoimmun. 2015 Dec;65:30-7. doi: 10.1016/j.jaut.2015.08.001. Epub 2015 Aug 15.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Biomarkers of acute respiratory allergen exposure: screening for sensitization potential. Pucheu-Haston CM, etal., Toxicol Appl Pharmacol. 2010 Apr 15;244(2):144-55. Epub 2010 Jan 4.
27. Dual mechanisms for ethanol-induced inhibition of monocyte chemotactic protein-3 mRNA expression in activated glial cells. Ren L and Syapin PJ, J Pharmacol Exp Ther. 2002 Oct;303(1):265-72.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Study of plasma protein C and inflammatory pathways: biomarkers for dimethylnitrosamine-induced liver fibrosis in rats. Saha JK, etal., Eur J Pharmacol. 2007 Dec 1;575(1-3):158-67. Epub 2007 Aug 2.
31. Role of monocyte chemotactic protein-3 and -4 in children with virus exacerbation of asthma. Santiago J, etal., Eur Respir J. 2008 Nov;32(5):1243-9. Epub 2008 Jun 25.
32. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
33. The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis - a mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide. Steger-Hartmann T, etal., Exp Toxicol Pathol. 2009 Nov;61(6):537-52. Epub 2009 Jan 7.
34. Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis. Uguccioni M, etal., Am J Pathol. 1999 Aug;155(2):331-6.
35. Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma. Walsh ER, etal., J Exp Med. 2008 Jun 9;205(6):1285-92. Epub 2008 May 19.
36. Molecular cloning and expression of the rat monocyte chemotactic protein-3 gene: a possible role in stroke. Wang X, etal., Brain Res Mol Brain Res 1999 Aug 25;71(2):304-12.
37. Reduced degradation of the chemokine MCP-3 by matrix metalloproteinase-2 exacerbates myocardial inflammation in experimental viral cardiomyopathy. Westermann D, etal., Circulation. 2011 Nov 8;124(19):2082-93. Epub 2011 Oct 10.
38. Monocyte chemotactic protein expression in allergy and non-allergy-associated chronic sinusitis. Wright ED, etal., J Otolaryngol. 1998 Oct;27(5):281-7.
39. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
40. Activation of microglia and chemokines in light-induced retinal degeneration. Zhang C, etal., Mol Vis. 2005 Oct 27;11:887-95.
41. Complementary DNA microarray analysis of chemokines and their receptors in allergic rhinitis. Zhang RX, etal., J Investig Allergol Clin Immunol. 2007;17(5):329-36.
Additional References at PubMed
PMID:7545673   PMID:8662823   PMID:10072545   PMID:10660125   PMID:18420193   PMID:22417871   PMID:22960654   PMID:23374966   PMID:27295026   PMID:37021908  


Genomics

Comparative Map Data
Ccl7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,514,095 - 67,515,945 (+)NCBIGRCr8
mRatBN7.21067,016,446 - 67,018,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,016,446 - 67,018,303 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,637,651 - 71,639,501 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,143,000 - 71,144,850 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,604,125 - 66,605,975 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,423,083 - 69,424,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,423,086 - 69,424,979 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,058,109 - 69,059,959 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,267,281 - 70,269,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11070,280,903 - 70,282,754 (+)NCBI
Celera1065,963,980 - 65,965,830 (+)NCBICelera
Cytogenetic Map10q26NCBI
CCL7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,270,221 - 34,272,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,270,221 - 34,272,242 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,597,240 - 32,599,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,621,353 - 29,623,369 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,621,352 - 29,623,368NCBI
Celera1729,507,053 - 29,509,069 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,782,528 - 28,784,554 (+)NCBIHuRef
CHM1_11732,661,096 - 32,663,122 (+)NCBICHM1_1
T2T-CHM13v2.01735,216,497 - 35,218,518 (+)NCBIT2T-CHM13v2.0
Ccl7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,936,538 - 81,938,351 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,936,538 - 81,938,351 (+)EnsemblGRCm39 Ensembl
GRCm381182,045,712 - 82,047,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,045,712 - 82,047,525 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,859,214 - 81,861,027 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,861,909 - 81,863,720 (+)NCBIMGSCv36mm8
Celera1191,659,161 - 91,660,974 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1149.83NCBI
CCL7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,994,638 - 38,996,103 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,993,911 - 39,010,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,217,925 - 38,219,390 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,808,818 - 39,810,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,808,231 - 39,824,636 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1938,595,171 - 38,596,636 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,875,478 - 38,879,658 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,963,214 - 38,964,679 (-)NCBIUU_Cfam_GSD_1.0
CCL7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,777,795 - 27,780,413 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660752,239,664 - 2,241,876 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccl7
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:51
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000000256
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944767750281Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944767750281Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)106631944767750281Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944767750281Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944767750281Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944768164786Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944768164786Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944768164786Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944768164786Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)106697895567750281Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat

Markers in Region
RH133164  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,017,975 - 67,018,193 (+)MAPPERmRatBN7.2
Rnor_6.01069,424,613 - 69,424,830NCBIRnor6.0
Rnor_5.01069,059,639 - 69,059,856UniSTSRnor5.0
RGSC_v3.41070,268,811 - 70,269,028UniSTSRGSC3.4
Celera1065,965,510 - 65,965,727UniSTS
Cytogenetic Map10q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1
Low 2 33 14 1 19 1 8 11 34 29 37 10 8
Below cutoff 8 26 23 23 32 6 3

Sequence


RefSeq Acc Id: ENSRNOT00000000256   ⟹   ENSRNOP00000000256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,016,446 - 67,018,303 (+)Ensembl
Rnor_6.0 Ensembl1069,423,086 - 69,424,979 (+)Ensembl
RefSeq Acc Id: NM_001007612   ⟹   NP_001007613
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81067,514,095 - 67,515,945 (+)NCBI
mRatBN7.21067,016,446 - 67,018,296 (+)NCBI
Rnor_6.01069,423,083 - 69,424,933 (+)NCBI
Rnor_5.01069,058,109 - 69,059,959 (+)NCBI
RGSC_v3.41070,267,281 - 70,269,131 (+)RGD
Celera1065,963,980 - 65,965,830 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001007613 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF24172 (Get FASTA)   NCBI Sequence Viewer  
  EDM05438 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000256
  ENSRNOP00000000256.2
  ENSRNOP00055036174
  ENSRNOP00060027363
  ENSRNOP00065026377
GenBank Protein Q9QXY8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007613   ⟸   NM_001007612
- Peptide Label: precursor
- UniProtKB: Q9QXY8 (UniProtKB/Swiss-Prot),   A6HHD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000256   ⟸   ENSRNOT00000000256
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QXY8-F1-model_v2 AlphaFold Q9QXY8 1-97 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697508
Promoter ID:EPDNEW_R8033
Type:single initiation site
Name:Ccl7_1
Description:C-C motif chemokine ligand 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01069,423,081 - 69,423,141EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359152 AgrOrtholog
BioCyc Gene G2FUF-23934 BioCyc
Ensembl Genes ENSRNOG00000000239 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055025633 UniProtKB/Swiss-Prot
  ENSRNOG00060019349 UniProtKB/Swiss-Prot
  ENSRNOG00065019603 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000256 ENTREZGENE
  ENSRNOT00000000256.5 UniProtKB/Swiss-Prot
  ENSRNOT00055044216 UniProtKB/Swiss-Prot
  ENSRNOT00060033438 UniProtKB/Swiss-Prot
  ENSRNOT00065033005 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287561 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 287561 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccl7 PhenoGen
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000239 RatGTEx
  ENSRNOG00055025633 RatGTEx
  ENSRNOG00060019349 RatGTEx
  ENSRNOG00065019603 RatGTEx
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Interleukin 8-like chemokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HHD3 ENTREZGENE, UniProtKB/TrEMBL
  CCL7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ccl7  C-C motif chemokine ligand 7  Ccl7  chemokine (C-C motif) ligand 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ccl7  chemokine (C-C motif) ligand 7      Symbol and Name updated 1559027 APPROVED
2005-07-29 Ccl7  chemokine (C-C motif) ligand 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation upregulated in brain after ischemic injury; contributes to the recruitment of inflammatory cells to the ischemic tissue 1359749