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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of CCL2 mRNAPMID:29803840
CCL2multiple interactionsEXP 6480464CTDDoxorubicin results in increased expression of and results in increased secretion of CCL2 proteinPMID:12908082 PMID:29959987
CCL2increases expressionISOCcl2 (Mus musculus)6480464CTDDoxorubicin results in increased expression of CCL2 mRNA; Doxorubicin results in increased expression of CCL2 proteinPMID:15033991 PMID:28318631 PMID:32068018 PMID:36227756
CCL2increases expressionISOCcl2 (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of CCL2 mRNA; Doxorubicin results in increased expression of CCL2 proteinPMID:11124598 PMID:18806609 PMID:19915844 PMID:27181935 PMID:32691977
CCL2multiple interactionsISOCcl2 (Mus musculus)6480464CTDNanotubes, Carbon promotes the reaction [Doxorubicin results in increased expression of CCL2 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]PMID:28318631 PMID:32068018
CCL2multiple interactionsISOCcl2 (Rattus norvegicus)6480464CTDAcetylcysteine affects the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; plumbagin inhibits the reaction [Doxorubicin results in increased expression of CCL2 protein]; Razoxane inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]PMID:11124598 PMID:19915844 PMID:27181935 PMID:32691977
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