GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CCL2 | decreases expression | EXP | | 6480464 | CTD | resveratrol results in decreased expression of CCL2 mRNA | PMID:21371465 PMID:21756928 PMID:21967610 PMID:22748497 PMID:23782265 PMID:24584901 | CCL2 | decreases secretion | EXP | | 6480464 | CTD | resveratrol results in decreased secretion of CCL2 protein | PMID:21967610 PMID:23661232 | CCL2 | multiple interactions | EXP | | 6480464 | CTD | [Resveratrol affects the localization of RELA protein] inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; [Resveratrol affects the localization of RELA protein] inhibits the reaction [Glucose results in increased expression of CCL2 protein]; garcinol promotes the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; garcinol promotes the reaction [Resveratrol results in decreased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of CCL2 mRNA]; Pertussis Toxin inhibits the reaction [Resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]]; Pertussis Toxin inhibits the reaction [Resveratrol inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]]; Resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of CCL2 protein]; Resveratrol inhibits the reaction [CCL2 protein affects the localization of Calcium]; Resveratrol inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of CCL2 protein]; Resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [PD168393 results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]] | PMID:16212921 PMID:17191021 PMID:20531350 PMID:21371465 PMID:21652769 PMID:21756928 PMID:21967610 PMID:22414048 PMID:22748497 PMID:23981542 PMID:24145091 PMID:24436987 PMID:24513509 PMID:24584901 PMID:24707119 PMID:24895526 | CCL2 | decreases expression | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | resveratrol analog results in decreased expression of CCL2 mRNA; resveratrol results in decreased expression of CCL2 protein | PMID:15652768 PMID:17872969 | CCL2 | decreases expression | ISO | Ccl2 (Rattus norvegicus) | 6480464 | CTD | resveratrol results in decreased expression of CCL2 mRNA; resveratrol results in decreased expression of CCL2 protein | PMID:20050970 PMID:20709957 PMID:23428596 PMID:24012391 PMID:24436987 | CCL2 | decreases secretion | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | resveratrol results in decreased secretion of CCL2 protein | PMID:23514766 | CCL2 | decreases secretion | ISO | Ccl2 (Rattus norvegicus) | 6480464 | CTD | resveratrol results in decreased secretion of CCL2 protein | PMID:20050970 | CCL2 | multiple interactions | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | [Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL2 mRNA; Resveratrol inhibits the reaction [Arginine results in increased secretion of CCL2 protein]; Resveratrol inhibits the reaction [Calcium Chloride results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Calcium Chloride results in increased phosphorylation of CCL2 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; Resveratrol inhibits the reaction [stearic acid results in increased expression of CCL2 mRNA] | PMID:16806235 PMID:17374693 PMID:19279313 PMID:19293636 PMID:20712904 PMID:21530968 PMID:22118570 PMID:34423886 | CCL2 | multiple interactions | ISO | Ccl2 (Rattus norvegicus) | 6480464 | CTD | resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 protein]; resveratrol inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein]; resveratrol inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA]; resveratrol inhibits the reaction [Streptozocin results in increased expression of CCL2 protein] | PMID:15734790 PMID:24513509 PMID:25025298 PMID:25108154 PMID:25833014 | | ||||||||||||||||||||||
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