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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:68554
Term: deferiprone
Definition: A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.
Chemical ID: MESH:C044919
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2multiple interactionsEXP 6480464CTDdeferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]PMID:14576080
CCL2multiple interactionsISOCcl2 (Rattus norvegicus)6480464CTDdeferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]PMID:25813056
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