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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:8198
Term: trans-piceid
Definition: A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue.
Chemical ID: MESH:C058229
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2decreases expressionEXP 6480464CTDpolydatin results in decreased expression of CCL2 mRNAPMID:21756928 PMID:21967610
CCL2decreases secretionEXP 6480464CTDpolydatin results in decreased secretion of CCL2 proteinPMID:21967610
CCL2multiple interactionsEXP 6480464CTDpolydatin inhibits the reaction [leptomycin B results in increased secretion of CCL2 protein]; polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; polydatin inhibits the reaction [PD168393 results in increased expression of CCL2 mRNA]PMID:21756928 PMID:21967610
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