Exhibits chemokine activity. Involved in several processes, including ERK1 and ERK2 cascade; leukocyte chemotaxis; and response to interleukin-13. Localizes to extracellular space. Used to study allergic rhinitis; asthma; pleurisy; and pneumonia. Biomarker of several diseases, including allergic conjunctivitis; asthma; pneumonia; prostatitis; and rhinitis. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; hyperglycemia; and multiple sclerosis. Orthologous to several human genes including CCL11 (C-C motif chemokine ligand 11); PARTICIPATES IN interleukin-4 signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA], Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA]
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL11 mRNA, Tetrachlorodibenzodioxin inhibits the reaction [Dextran Sulfate results in increased secretion of CCL11 protein]
CCL11 protein promotes the reaction [Bleomycin results in increased expression of CCL2 mRNA], CCL11 protein promotes the reaction [Bleomycin results in increased expression of TGFB1 mRNA]
[Dietary Fats co-treated with Choline deficiency] results in increased expression of CCL11 protein, PANX1 gene mutant form inhibits the reaction [[Dietary Fats co-treated with Choline deficiency] results in increased expression of CCL11 protein]
[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CCL11 mRNA, Tetrachlorodibenzodioxin inhibits the reaction [Dextran Sulfate results in increased secretion of CCL11 protein]
fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA], fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein]
CCL11 protein promotes the reaction [Calcimycin affects the abundance of and affects the chemical synthesis of Reactive Oxygen Species], IL5 protein promotes the reaction [CCL11 protein promotes the reaction [Calcimycin affects the abundance of and affects the chemical synthesis of Reactive Oxygen Species]]
Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein], Synephrine inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Gene-Chemical Interaction Annotations
