Enables chemokine activity. Involved in several processes, including ERK1 and ERK2 cascade; leukocyte chemotaxis; and response to interleukin-13. Located in extracellular space. Used to study allergic rhinitis; asthma; pleurisy; and pneumonia. Biomarker of several diseases, including allergic conjunctivitis; pneumonia; prostatitis; rhinitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; and hyperglycemia. Orthologous to human CCL11 (C-C motif chemokine ligand 11); PARTICIPATES IN interleukin-4 signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA] and Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA]
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL11 mRNA and Tetrachlorodibenzodioxin inhibits the reaction [Dextran Sulfate results in increased secretion of CCL11 protein]
CCL11 protein promotes the reaction [Bleomycin results in increased expression of CCL2 mRNA] and CCL11 protein promotes the reaction [Bleomycin results in increased expression of TGFB1 mRNA]
[Dietary Fats co-treated with Choline deficiency] results in increased expression of CCL11 protein and PANX1 gene mutant form inhibits the reaction [[Dietary Fats co-treated with Choline deficiency] results in increased expression of CCL11 protein]
ferric oxide results in increased expression of and results in increased secretion of CCL11 protein and RAG1 promotes the reaction [ferric oxide analog results in increased expression of CCL11 protein]
fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] and fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein]
CCL11 protein promotes the reaction [Calcimycin affects the abundance of and affects the chemical synthesis of Reactive Oxygen Species] and IL5 protein promotes the reaction [CCL11 protein promotes the reaction [Calcimycin affects the abundance of and affects the chemical synthesis of Reactive Oxygen Species]]
Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein] and Synephrine inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA]
The acute effect of clamped hyperglycemia on the urinary excretion of inflammatory cytokines/chemokines in uncomplicated type 1 diabetes: a pilot study.
Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis.
Quantitative expression levels of regulated on activation, normal T cell expressed and secreted and eotaxin transcripts in toluene diisocyanate-induced allergic rats.
Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia.
Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis.
VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration.
Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema.
Nasal lavage fluid concentrations of eotaxin-1 (CCL11) in naturally occurring allergic rhinitis: relationship to disease activity, nasal luminal eosinophil influx, and plasma protein exudation.
Human eotaxin induces alpha 4 and beta 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4.
