Ccl11 (C-C motif chemokine ligand 11) - Rat Genome Database

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Gene: Ccl11 (C-C motif chemokine ligand 11) Rattus norvegicus
Symbol: Ccl11
Name: C-C motif chemokine ligand 11
RGD ID: 3644
Description: Enables chemokine activity. Involved in several processes, including ERK1 and ERK2 cascade; leukocyte chemotaxis; and response to interleukin-13. Located in extracellular space. Used to study allergic rhinitis; asthma; pleurisy; and pneumonia. Biomarker of several diseases, including allergic conjunctivitis; pneumonia; prostatitis; rhinitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; and hyperglycemia. Orthologous to human CCL11 (C-C motif chemokine ligand 11); PARTICIPATES IN interleukin-4 signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
Previously known as: C-C motif chemokine 11; chemokine (C-C motif) ligand 11; eosinophil chemotactic protein; eotaxin; Scya11; small inducible cytokine A11; small inducible cytokine subfamily A11; small-inducible cytokine A11
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Candidate Gene For: Eae18b Eau9
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21067,028,328 - 67,032,929 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,028,328 - 67,032,926 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,649,521 - 71,654,122 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,154,872 - 71,159,475 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,615,995 - 66,620,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,434,965 - 69,439,566 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,434,941 - 69,439,575 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,069,783 - 69,074,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,279,161 - 70,283,762 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11070,292,783 - 70,297,384 (+)NCBI
Celera1065,975,844 - 65,980,445 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-D  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chlorophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
9,10-phenanthroquinone  (ISO)
actinomycin D  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apocynin  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
Bardoxolone methyl  (ISO)
barium sulfate  (EXP)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
budesonide  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
catechol  (ISO)
ceric oxide  (EXP,ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clopidogrel  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (ISO)
diethylstilbestrol  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
emamectin benzoate  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
Fexofenadine hydrochloride  (ISO)
flutamide  (ISO)
fluticasone  (ISO)
fumaric acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
graphene oxide  (ISO)
heparin  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
ionomycin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
mercury dichloride  (ISO)
metam  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (EXP)
MK 571  (ISO)
mycotoxin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrogen dioxide  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalic anhydride  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salmeterol xinafoate  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
synephrine  (ISO)
syringin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (EXP)
zileuton  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Cytokine production increases and cytokine clearance decreases in mice with bilateral nephrectomy. Andres-Hernando A, etal., Nephrol Dial Transplant. 2012 Dec;27(12):4339-47. doi: 10.1093/ndt/gfs256. Epub 2012 Jul 9.
2. Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis. Bocchino V, etal., Allergy. 2002 Jan;57(1):17-22.
3. Eotaxin and capping protein in experimental vasculopathy. Chen J, etal., Am J Pathol. 1998 Jul;153(1):81-90.
4. The acute effect of clamped hyperglycemia on the urinary excretion of inflammatory cytokines/chemokines in uncomplicated type 1 diabetes: a pilot study. Cherney DZ, etal., Diabetes Care. 2011 Jan;34(1):177-80. doi: 10.2337/dc10-1219. Epub 2010 Sep 14.
5. The effect of aliskiren on urinary cytokine/chemokine responses to clamped hyperglycaemia in type 1 diabetes. Cherney DZ, etal., Diabetologia. 2013 Jul 28.
6. Intrinsic expression of Th2 cytokines in urothelium of congenital ureteropelvic junction obstruction. Chiou YY, etal., Kidney Int. 2005 Feb;67(2):638-46.
7. Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. Chiu BC, etal., Am J Respir Cell Mol Biol. 2003 Jul;29(1):106-16. Epub 2003 Jan 10.
8. Eosinophil and T cell markers predict functional decline in COPD patients. D'Armiento JM, etal., Respir Res. 2009 Nov 19;10:113.
9. Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis. Emad A and Emad Y, J Clin Immunol. 2007 Nov;27(6):605-12. Epub 2007 Jul 10.
10. Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice. Firoved AM, etal., Am J Pathol. 2005 Nov;167(5):1309-20.
11. T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice. Forbes E, etal., Gastroenterology. 2004 Jul;127(1):105-18.
12. A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Fulkerson PC, etal., Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16418-23. Epub 2006 Oct 23.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Eotaxin expression in Sephadex-induced lung injury in rats. Guo RF, etal., Am J Pathol. 1999 Dec;155(6):2001-8.
16. Regulatory effects of eotaxin on acute lung inflammatory injury. Guo RF, etal., J Immunol. 2001 Apr 15;166(8):5208-18.
17. mRNA differential display analysis of nephrotic kidney glomeruli. Haltia A, etal., Exp Nephrol. 1999 Jan-Feb;7(1):52-8.
18. Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate. Harris MT, etal., Prostate. 2000 Jun 15;44(1):19-25.
19. Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat. Hessner MJ, etal., J Immunol 2004 Dec 1;173(11):6993-7002.
20. Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Huaux F, etal., Am J Pathol. 2005 Dec;167(6):1485-96.
21. Quantitative expression levels of regulated on activation, normal T cell expressed and secreted and eotaxin transcripts in toluene diisocyanate-induced allergic rats. Im GJ, etal., Acta Otolaryngol. 2005 Apr;125(4):370-7.
22. Cloning of rat eotaxin: ozone inhalation increases mRNA and protein expression in lungs of brown Norway rats. Ishi Y, etal., Am J Physiol 1998 Jan;274(1 Pt 1):L171-6.
23. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. Jahnsen FL, etal., J Immunol. 1999 Aug 1;163(3):1545-51.
24. A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. Katoh S, etal., J Clin Invest. 2003 May;111(10):1563-70.
25. Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis. Kim HH, etal., J Korean Med Sci. 2007 Feb;22(1):37-42.
26. Platelet-activating factor drives eotaxin production in an allergic pleurisy in mice. Klein A, etal., Br J Pharmacol. 2002 Mar;135(5):1213-8.
27. HIV infection is associated with higher levels of monocyte chemoattractant protein-1 and eotaxin among people with recent hepatitis C virus infection. Lamoury FM, etal., BMC Infect Dis. 2016 Jun 1;16:241. doi: 10.1186/s12879-016-1567-2.
28. VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration. Larbi KY, etal., Blood. 2000 Nov 15;96(10):3601-9.
29. The migration of T cells in response to influenza virus is altered in neonatal mice. Lines JL, etal., J Immunol. 2010 Sep 1;185(5):2980-8. Epub 2010 Jul 23.
30. [The roles of interleukin-5 and eotaxin in signal transmission between lung and bone marrow of rat asthmatic models] Liu CT, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Aug;29(8):558-62.
31. Multiplex bead analysis of urinary cytokines of type 2 diabetic patients with normo- and microalbuminuria. Liu J, etal., J Immunoassay Immunochem. 2010 Oct;31(4):279-89.
32. Zinc suppressed the airway inflammation in asthmatic rats: effects of zinc on generation of eotaxin, MCP-1, IL-8, IL-4, and IFN-gamma. Lu H, etal., Biol Trace Elem Res. 2012 Dec;150(1-3):314-21. doi: 10.1007/s12011-012-9493-7. Epub 2012 Aug 30.
33. Immune profile and Epstein-Barr virus infection in acute interstitial nephritis: an immunohistochemical study in 78 patients. Mansur A, etal., Nephron Clin Pract. 2011;119(4):c293-300. doi: 10.1159/000329671. Epub 2011 Sep 21.
34. Biomarker analysis of Morquio syndrome: identification of disease state and drug responsive markers. Martell L, etal., Orphanet J Rare Dis. 2011 Dec 16;6:84. doi: 10.1186/1750-1172-6-84.
35. Differential cytokine mRNA expression in Dermatophagoides farinae allergen-sensitized and respiratory syncytial virus-infected mice. Matsuse H, etal., Microbes Infect. 2000 Jun;2(7):753-9.
36. Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection. Matthews SP, etal., J Virol. 2005 Feb;79(4):2050-7.
37. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
38. Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema. Miller M, etal., J Allergy Clin Immunol. 2007 Nov;120(5):1118-25.
39. Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients. Min JW, etal., Chest. 2005 Nov;128(5):3127-32.
40. Production of granulomatous inflammation in lungs of rat pups and adults by Sephadex beads. Miyake M, etal., Pediatr Res. 2004 Aug;56(2):205-11. Epub 2004 Jun 4.
41. Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages. Nagarkar DR, etal., J Immunol. 2010 Aug 15;185(4):2525-35. Epub 2010 Jul 19.
42. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
43. Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. Ockinger J, etal., Genes Immun. 2010 Mar;11(2):142-54. Epub 2009 Oct 29.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. Comparison of the cytokine and chemokine dynamics of the early inflammatory response in models of burn injury and infection. Orman MA, etal., Cytokine. 2011 Sep;55(3):362-71. doi: 10.1016/j.cyto.2011.05.010. Epub 2011 Jun 8.
46. Mast-cell activation augments the late phase reaction in experimental immune-mediated blepharoconjunctivitis. Ozaki A, etal., Graefes Arch Clin Exp Ophthalmol. 2003 May;241(5):394-402. Epub 2003 Apr 4.
47. Influence of murine Toxocara canis infection on plasma and bronchoalveolar lavage fluid eosinophil numbers and its correlation with cytokine levels. Pecinali NR, etal., Vet Parasitol. 2005 Nov 25;134(1-2):121-30. Epub 2005 Sep 15.
48. Invariant natural killer T cell agonist modulates experimental focal and segmental glomerulosclerosis. Pereira RL, etal., PLoS One. 2012;7(3):e32454. doi: 10.1371/journal.pone.0032454. Epub 2012 Mar 12.
49. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
50. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
51. GOA pipeline RGD automated data pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Comprehensive gene review and curation RGD comprehensive gene curation
55. Long-term exacerbation by interleukin 13 of IgE-mediated eosinophilia in rats. Rossi MI, et al., Int Immunopharmacol. 2005 Aug;5(9):1353-64. Epub 2005 Mar 19.
56. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. Rothenberg ME, etal., J Exp Med. 1997 Feb 17;185(4):785-90.
57. Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. Rothenberg ME, etal., Proc Natl Acad Sci U S A 1995 Sep 12;92(19):8960-4.
58. Nasal lavage fluid concentrations of eotaxin-1 (CCL11) in naturally occurring allergic rhinitis: relationship to disease activity, nasal luminal eosinophil influx, and plasma protein exudation. Salib RJ, etal., Clin Exp Allergy. 2005 Aug;35(8):995-1002.
59. Human eotaxin induces alpha 4 and beta 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4. Sanz MJ, etal., J Immunol. 1998 Apr 1;160(7):3569-76.
60. Modulation of eotaxin formation and eosinophil migration by selective inhibitors of phosphodiesterase type 4 isoenzyme. Silva PM, etal., Br J Pharmacol. 2001 Sep;134(2):283-94.
61. Innate and adaptive mediators in cystic fibrosis and allergic fungal rhinosinusitis. Skinner ML, etal., Am J Rhinol. 2007 Sep-Oct;21(5):538-41.
62. Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation. Su YC, etal., J Immunol. 2008 Feb 15;180(4):2600-7.
63. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
64. Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model. Tirgan N, etal., Exp Diabetes Res. 2012;2012:349320. doi: 10.1155/2012/349320. Epub 2012 Sep 20.
65. Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis. Umezawa M, etal., Cytokine. 2008 Aug;43(2):105-9. Epub 2008 Jul 1.
66. The polymorphisms of Eotaxin 1 and CCR3 genes influence on serum IgE, Eotaxin levels and mild asthmatic children in Taiwan. Wang TN, etal., Allergy. 2007 Oct;62(10):1125-30.
67. Conserved structure and tissue expression of rat eotaxin. Williams CM, etal., Immunogenetics 1998;47(2):178-80.
68. Influenza A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia. Wohlleben G, etal., J Immunol. 2003 May 1;170(9):4601-11.
69. Eotaxin induces migration of RBL-2H3 mast cells via a Rac-ERK-dependent pathway. Woo CH, etal., Biochem Biophys Res Commun. 2002 Nov 1;298(3):392-7.
70. Effects of cryptoporus polysaccharide on rat allergic rhinitis associated with inhibiting eotaxin mRNA expression. Xie QM, etal., J Ethnopharmacol. 2006 Oct 11;107(3):424-30. Epub 2006 Apr 18.
71. Effect of Tong Qiao drops on the expression of eotaxin, IL-13 in the nasal mucosa of rats with allergic rhinitis. Xu YY, etal., J Chin Med Assoc. 2012 Oct;75(10):524-9. doi: 10.1016/j.jcma.2012.07.003. Epub 2012 Oct 2.
72. Eotaxin-1, -2, and -3 immunoreactivity and protein concentration in the nasal polyps of eosinophilic chronic rhinosinusitis patients. Yao T, etal., Laryngoscope. 2009 Jun;119(6):1053-9.
73. Functional consequences of inhibiting exocytosis of Weibel-Palade bodies in acute renal ischemia. Yasuda K, etal., Am J Physiol Renal Physiol. 2012 Mar 15;302(6):F713-21. doi: 10.1152/ajprenal.00541.2011. Epub 2011 Dec 7.
74. Eotaxin-1 in exhaled breath condensate of stable and unstable asthma patients. Zietkowski Z, etal., Respir Res. 2010 Aug 12;11:110.
75. Eotaxin/CCL11 levels correlate with myocardial fibrosis and mast cell density in native and transplanted rat hearts. Zweifel M, etal., Transplant Proc. 2010 Sep;42(7):2763-6.
Additional References at PubMed
PMID:9712872   PMID:10072545   PMID:10804170   PMID:11425309   PMID:12949249   PMID:16722399   PMID:16838745   PMID:19525930   PMID:19631640   PMID:20041150   PMID:20359111   PMID:21886162  
PMID:22387551   PMID:22815714   PMID:23272499   PMID:24646746   PMID:28279120   PMID:34830041  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21067,028,328 - 67,032,929 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,028,328 - 67,032,926 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,649,521 - 71,654,122 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,154,872 - 71,159,475 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,615,995 - 66,620,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,434,965 - 69,439,566 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,434,941 - 69,439,575 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,069,783 - 69,074,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,279,161 - 70,283,762 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11070,292,783 - 70,297,384 (+)NCBI
Celera1065,975,844 - 65,980,445 (+)NCBICelera
Cytogenetic Map10q26NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381734,285,742 - 34,288,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,285,742 - 34,288,334 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,612,761 - 32,615,353 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,636,800 - 29,639,312 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,636,799 - 29,639,312NCBI
Celera1729,522,500 - 29,525,011 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,797,991 - 28,800,502 (+)NCBIHuRef
CHM1_11732,676,549 - 32,679,061 (+)NCBICHM1_1
T2T-CHM13v2.01735,232,017 - 35,234,610 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391181,948,658 - 81,953,781 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,948,649 - 81,953,781 (+)EnsemblGRCm39 Ensembl
GRCm381182,057,832 - 82,062,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,057,823 - 82,062,955 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,871,334 - 81,876,457 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,874,117 - 81,879,148 (+)NCBIMGSCv36mm8
Celera1191,671,281 - 91,676,404 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1149.84NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440560237,957,463 - 37,971,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538847,464 - 848,907 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936538835,859 - 837,710 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936538835,436 - 848,907 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1240,779,173 - 40,782,893 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,779,906 - 40,782,862 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,424,321 - 42,427,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11627,792,699 - 27,796,437 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1627,794,033 - 27,796,460 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660752,223,450 - 2,226,274 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Ccl11
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:263
Count of miRNA genes:176
Interacting mature miRNAs:207
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944767750281Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944767750281Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)106631944767750281Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944767750281Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944767750281Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944768164786Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944768164786Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944768164786Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944768164786Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)106697895567750281Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,031,763 - 67,031,865 (+)MAPPERmRatBN7.2
Rnor_6.01069,438,401 - 69,438,502NCBIRnor6.0
Rnor_5.01069,073,219 - 69,073,320UniSTSRnor5.0
RGSC_v3.41070,282,597 - 70,282,698UniSTSRGSC3.4
Celera1065,979,280 - 65,979,381UniSTS
Cytogenetic Map10q26UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 2 2 6 3
Low 6 16 2 14 2 7 10 1 1 26 8 7
Below cutoff 29 25 25 3 25 1 1 21 21 7 1


RefSeq Acc Id: ENSRNOT00000009756   ⟹   ENSRNOP00000009756
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,028,328 - 67,032,926 (+)Ensembl
Rnor_6.0 Ensembl1069,434,941 - 69,439,575 (+)Ensembl
RefSeq Acc Id: NM_019205   ⟹   NP_062078
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,028,328 - 67,032,929 (+)NCBI
Rnor_6.01069,434,965 - 69,439,566 (+)NCBI
Rnor_5.01069,069,783 - 69,074,384 (+)NCBI
RGSC_v3.41070,279,161 - 70,283,762 (+)RGD
Celera1065,975,844 - 65,980,445 (+)RGD
Protein Sequences
Protein RefSeqs NP_062078 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB65775 (Get FASTA)   NCBI Sequence Viewer  
  CAA69645 (Get FASTA)   NCBI Sequence Viewer  
  EDM05439 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009756
GenBank Protein P97545 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062078   ⟸   NM_019205
- Peptide Label: precursor
- UniProtKB: O08780 (UniProtKB/Swiss-Prot),   P97545 (UniProtKB/Swiss-Prot),   A6HHD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009756   ⟸   ENSRNOT00000009756
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97545-F1-model_v2 AlphaFold P97545 1-97 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697509
Promoter ID:EPDNEW_R8034
Type:single initiation site
Description:C-C motif chemokine ligand 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01069,434,954 - 69,435,014EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3644 AgrOrtholog
BioCyc Gene G2FUF-23933 BioCyc
Ensembl Genes ENSRNOG00000007335 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009756 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29397 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccl11 PhenoGen
RatGTEx ENSRNOG00000007335 RatGTEx
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Interleukin 8-like chemokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC212586
  CCL11_RAT UniProtKB/Swiss-Prot
UniProt Secondary O08780 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ccl11  C-C motif chemokine ligand 11  Ccl11  chemokine (C-C motif) ligand 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ccl11  chemokine (C-C motif) ligand 11  Scya11  small inducible cytokine subfamily A11  Symbol and Name updated 1299863 APPROVED
2002-06-10 Scya11  small inducible cytokine subfamily A11      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference