CXCL9 (C-X-C motif chemokine ligand 9) - Rat Genome Database

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Gene: CXCL9 (C-X-C motif chemokine ligand 9) Homo sapiens
Analyze
Symbol: CXCL9
Name: C-X-C motif chemokine ligand 9
RGD ID: 1348195
HGNC Page HGNC
Description: Exhibits CXCR3 chemokine receptor binding activity and chemokine activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; antimicrobial humoral immune response mediated by antimicrobial peptide; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to localize to extracellular space. Biomarker of several diseases, including COVID-19; chronic fatigue syndrome; cystic fibrosis; lung disease (multiple); and severe acute respiratory syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-X-C motif chemokine 9; chemokine (C-X-C motif) ligand 9; CMK; crg-10; gamma-interferon-induced monokine; Humig; MIG; monokine induced by gamma interferon; monokine induced by interferon-gamma; SCYB9; small-inducible cytokine B9
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl476,001,275 - 76,007,509 (-)EnsemblGRCh38hg38GRCh38
GRCh38476,001,275 - 76,007,509 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37476,922,428 - 76,928,662 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,141,647 - 77,147,665 (-)NCBINCBI36hg18NCBI36
Build 34477,279,801 - 77,285,820NCBI
Celera474,223,036 - 74,229,163 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,674,915 - 72,680,933 (-)NCBIHuRef
CHM1_1476,899,060 - 76,905,241 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(-)-demecolcine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
8'-apo-beta,psi-caroten-8'-al  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
aristolochic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
astemizole  (ISO)
barium sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
beta-carotene  (EXP)
bisphenol A  (ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
ceric oxide  (ISO)
chloroquine  (ISO)
cholesterol  (ISO)
choline  (ISO)
chondroitin sulfate  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
divanadium pentaoxide  (EXP)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
flutamide  (ISO)
formaldehyde  (EXP)
fragrance  (EXP)
gadodiamide hydrate  (EXP)
Genipin  (ISO)
glafenine  (ISO)
Imipenem-cilastatin  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
metam  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
monosodium L-glutamate  (ISO)
mycotoxin  (ISO)
N-nitrosodimethylamine  (ISO)
neomycin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pevonedistat  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
protein kinase inhibitor  (EXP)
reactive oxygen species  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
roxarsone  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sterigmatocystin  (ISO)
sulindac  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tofacitinib  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vincristine  (EXP)
zaragozic acid A  (ISO)
zearalenone  (EXP)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Agostini C, etal., Respir Res. 2005 Feb 22;6:20.
2. Al Alam D, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):644-50. Epub 2009 Jul 13.
3. Belperio JA, etal., J Immunol. 2002 Jul 15;169(2):1037-49.
4. Blanco-Melo D, etal., Cell. 2020 May 28;181(5):1036-1045.e9. doi: 10.1016/j.cell.2020.04.026. Epub 2020 May 15.
5. Bonville CA, etal., Virology. 2007 Nov 10;368(1):182-90. Epub 2007 Jul 25.
6. Brozyna S, etal., COPD. 2009 Feb;6(1):4-16.
7. Chavez-Bueno S, etal., Virol J. 2005 May 25;2:46.
8. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
9. Chien JY, etal., Respirology. 2006 Nov;11(6):715-22.
10. Costa C, etal., Chest. 2008 Jan;133(1):26-33. Epub 2007 Oct 9.
11. Crawford MA, etal., PLoS Pathog. 2010 Nov 18;6(11):e1001199.
12. Cui A, etal., Respiration. 2010;80(5):372-8. Epub 2009 Oct 6.
13. El Feghaly RE, etal., Pediatr Infect Dis J. 2010 Apr;29(4):e26-31.
14. Eliasson M, etal., Microbes Infect. 2010 Jul;12(7):565-73. Epub 2010 Apr 8.
15. Feferman T, etal., J Immunol. 2005 May 1;174(9):5324-31.
16. Fine JS, etal., Inflammation. 2003 Aug;27(4):161-74.
17. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
18. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
19. GOA_HUMAN data from the GO Consortium
20. Grumelli S, etal., PLoS Med. 2004 Oct;1(1):e8. Epub 2004 Oct 19.
21. Hasan Z, etal., Scand J Immunol. 2009 Mar;69(3):259-67.
22. Hasegawa M, etal., Clin Rheumatol. 2011 Feb;30(2):231-7. Epub 2010 Nov 4.
23. Hildebrandt GC, etal., J Immunol. 2004 Aug 1;173(3):2050-9.
24. Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
25. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
26. Katoh S, etal., Int Arch Allergy Immunol. 2005 Jul;137(3):229-35. Epub 2005 Jun 13.
27. Kelsen SG, etal., Am J Respir Crit Care Med. 2009 May 1;179(9):799-805. Epub 2009 Feb 12.
28. Kishi J, etal., Eur Respir J. 2011 Aug;38(2):415-24. Epub 2011 Jan 27.
29. Landi A, etal., Cytokine. 2016 Feb;78:27-36. doi: 10.1016/j.cyto.2015.11.018. Epub 2015 Nov 28.
30. Medoff BD, etal., J Immunol. 2006 Jun 1;176(11):7087-95.
31. Nance S, etal., Eur J Immunol. 2004 Mar;34(3):677-85.
32. Ng PC, etal., Arch Dis Child. 2005 Apr;90(4):422-3. doi: 10.1136/adc.2004.053660.
33. Nishioka Y, etal., Clin Exp Immunol. 2007 Aug;149(2):317-26. Epub 2007 Jun 5.
34. Pipeline to import KEGG annotations from KEGG into RGD
35. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. Rabquer BJ, etal., Arthritis Res Ther. 2011 Feb 8;13(1):R18.
37. RGD automated import pipeline for gene-chemical interactions
38. Richards TJ, etal., Arthritis Rheum. 2009 Jul;60(7):2183-92.
39. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
40. Tang PC, etal., FASEB J. 2005 Sep;19(11):1528-30. Epub 2005 Jul 12.
41. Thomas MS, etal., J Immunol. 2004 Jul 1;173(1):615-23.
42. Valbuena G, etal., Am J Pathol. 2003 Oct;163(4):1357-69.
43. Wallace KL, etal., Blood. 2009 Jul 16;114(3):667-76. Epub 2009 May 11.
44. Wang CH, etal., Respir Res. 2005 May 11;6:42. doi: 10.1186/1465-9921-6-42.
45. Widney DP, etal., Infect Immun. 2005 Jan;73(1):485-93.
46. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
Additional References at PubMed
PMID:2115167   PMID:2834384   PMID:7595201   PMID:8476424   PMID:8976378   PMID:9660793   PMID:9730616   PMID:10201891   PMID:10201901   PMID:10233762   PMID:10570316   PMID:10903763  
PMID:11110785   PMID:11157474   PMID:11208713   PMID:11390394   PMID:11422029   PMID:11423172   PMID:11449350   PMID:11523044   PMID:12107104   PMID:12162873   PMID:12185171   PMID:12270371  
PMID:12384933   PMID:12477932   PMID:12539042   PMID:12782716   PMID:12847282   PMID:12856973   PMID:12884299   PMID:12946268   PMID:12949249   PMID:14550288   PMID:15081261   PMID:15113590  
PMID:15150261   PMID:15489334   PMID:16200621   PMID:16210647   PMID:16243485   PMID:16344560   PMID:16583210   PMID:17207965   PMID:17255201   PMID:17262710   PMID:17490641   PMID:17703315  
PMID:17703412   PMID:17875534   PMID:17892861   PMID:17975089   PMID:18240029   PMID:18275857   PMID:18292502   PMID:18338951   PMID:18413205   PMID:18415893   PMID:18930766   PMID:19087608  
PMID:19134328   PMID:19157479   PMID:19258635   PMID:19258923   PMID:19274094   PMID:19340290   PMID:19344719   PMID:19410617   PMID:19459809   PMID:19639049   PMID:19800124   PMID:19898927  
PMID:19929857   PMID:20038462   PMID:20137825   PMID:20237496   PMID:20299237   PMID:20456109   PMID:20485444   PMID:20503287   PMID:20626297   PMID:20628624   PMID:20810571   PMID:20838432  
PMID:20942936   PMID:21167783   PMID:21179030   PMID:21314817   PMID:21470996   PMID:21475065   PMID:21601475   PMID:21645215   PMID:21812928   PMID:21873635   PMID:21962843   PMID:21988832  
PMID:22037980   PMID:22333315   PMID:22367045   PMID:22401175   PMID:22467521   PMID:22580676   PMID:22586042   PMID:22689822   PMID:22766105   PMID:22889476   PMID:22905138   PMID:23012327  
PMID:23150742   PMID:23179902   PMID:23352833   PMID:23383108   PMID:23417848   PMID:23502337   PMID:23527708   PMID:23535064   PMID:23600831   PMID:23769451   PMID:23902475   PMID:23968332  
PMID:23975214   PMID:24063316   PMID:24084359   PMID:24124595   PMID:24278236   PMID:24351073   PMID:24363401   PMID:24438589   PMID:24600982   PMID:24614402   PMID:24742347   PMID:25115612  
PMID:25151370   PMID:25398650   PMID:25416956   PMID:25422100   PMID:25528189   PMID:25559603   PMID:25702175   PMID:25713416   PMID:25890876   PMID:25950774   PMID:25972108   PMID:26268659  
PMID:26344576   PMID:26506526   PMID:26545124   PMID:26564003   PMID:26694099   PMID:26828996   PMID:26898419   PMID:26910919   PMID:26999330   PMID:27490802   PMID:27503909   PMID:27617644  
PMID:27863059   PMID:28100872   PMID:28375674   PMID:28381538   PMID:28450066   PMID:28637080   PMID:28793883   PMID:29286143   PMID:29795405   PMID:29901197   PMID:30130730   PMID:30359318  
PMID:30619292   PMID:30813187   PMID:30952065   PMID:31173051   PMID:31173052   PMID:31344361   PMID:31515488   PMID:31636098   PMID:31696911   PMID:31696912   PMID:31696913   PMID:31699671  
PMID:31750736   PMID:31799781   PMID:31836011   PMID:31929430   PMID:31964786   PMID:32060845   PMID:32296183   PMID:32607510   PMID:33841438  


Genomics

Comparative Map Data
CXCL9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl476,001,275 - 76,007,509 (-)EnsemblGRCh38hg38GRCh38
GRCh38476,001,275 - 76,007,509 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37476,922,428 - 76,928,662 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,141,647 - 77,147,665 (-)NCBINCBI36hg18NCBI36
Build 34477,279,801 - 77,285,820NCBI
Celera474,223,036 - 74,229,163 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,674,915 - 72,680,933 (-)NCBIHuRef
CHM1_1476,899,060 - 76,905,241 (-)NCBICHM1_1
Cxcl9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,469,190 - 92,475,938 (-)NCBIGRCm39mm39
GRCm39 Ensembl592,469,206 - 92,475,938 (-)Ensembl
GRCm38592,321,331 - 92,328,079 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,321,347 - 92,328,079 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,750,357 - 92,757,105 (-)NCBIGRCm37mm9NCBIm37
MGSCv36593,398,190 - 93,403,317 (-)NCBImm8
Celera590,465,046 - 90,472,120 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.51NCBI
Cxcl9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21415,722,868 - 15,727,779 (+)NCBI
Rnor_6.0 Ensembl1417,228,856 - 17,234,712 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01417,228,832 - 17,233,743 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01417,144,966 - 17,150,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,284,085 - 17,288,996 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11417,284,135 - 17,289,652 (+)NCBI
Celera1415,117,313 - 15,122,212 (+)NCBICelera
Cytogenetic Map14p22NCBI
Cxcl9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955433724,515 - 732,192 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955433724,566 - 731,945 (-)NCBIChiLan1.0ChiLan1.0
CXCL9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1454,036,343 - 54,042,502 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,036,342 - 54,042,502 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0448,198,478 - 48,204,658 (+)NCBIMhudiblu_PPA_v0panPan3
Cxcl9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,466,180 - 11,472,856 (+)NCBI
SpeTri2.0NW_00493667633,580 - 40,323 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,663,495 - 71,670,271 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,665,541 - 71,670,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,801,515 - 75,806,212 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL9
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,507,121 - 24,513,830 (-)NCBI
Cxcl9
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475714,995,649 - 15,009,771 (+)NCBI

Position Markers
CXCL9_560.2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,922,477 - 76,923,263UniSTSGRCh37
Build 36477,141,501 - 77,142,287RGDNCBI36
Celera474,222,890 - 74,223,676RGD
HuRef472,674,769 - 72,675,555UniSTS
STS-X72755  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,922,972 - 76,923,114UniSTSGRCh37
Build 36477,141,996 - 77,142,138RGDNCBI36
Celera474,223,385 - 74,223,527RGD
Cytogenetic Map4q21UniSTS
HuRef472,675,264 - 72,675,406UniSTS
GeneMap99-GB4 RH Map4436.59UniSTS
NCBI RH Map4903.2UniSTS
D4S3297  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,922,692 - 76,922,841UniSTSGRCh37
Build 36477,141,716 - 77,141,865RGDNCBI36
Celera474,223,105 - 74,223,254RGD
Cytogenetic Map4q21UniSTS
HuRef472,674,984 - 72,675,133UniSTS
SHGC-50181  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,922,692 - 76,922,855UniSTSGRCh37
Build 36477,141,716 - 77,141,879RGDNCBI36
Celera474,223,105 - 74,223,268RGD
Cytogenetic Map4q21UniSTS
HuRef472,674,984 - 72,675,147UniSTS
TNG Radiation Hybrid Map443981.0UniSTS
D4S3315  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,923,323 - 76,923,523UniSTSGRCh37
Build 36477,142,347 - 77,142,547RGDNCBI36
Celera474,223,736 - 74,223,936RGD
Cytogenetic Map4q21UniSTS
HuRef472,675,615 - 72,675,815UniSTS
SHGC-60006  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,923,323 - 76,923,503UniSTSGRCh37
Build 36477,142,347 - 77,142,527RGDNCBI36
Celera474,223,736 - 74,223,916RGD
Cytogenetic Map4q21UniSTS
HuRef472,675,615 - 72,675,795UniSTS
TNG Radiation Hybrid Map443985.0UniSTS
SHGC-12003  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,924,438 - 76,924,680UniSTSGRCh37
Build 36477,143,462 - 77,143,704RGDNCBI36
Celera474,224,851 - 74,225,093RGD
Cytogenetic Map4q21UniSTS
HuRef472,676,730 - 72,676,972UniSTS
Stanford-G3 RH Map44274.0UniSTS
GeneMap99-G3 RH Map44258.0UniSTS
G33390  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,924,358 - 76,924,680UniSTSGRCh37
Build 36477,143,382 - 77,143,704RGDNCBI36
Celera474,224,771 - 74,225,093RGD
Cytogenetic Map4q21UniSTS
HuRef472,676,650 - 72,676,972UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:923
Count of miRNA genes:648
Interacting mature miRNAs:713
Transcripts:ENST00000264888
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1 1 27 1 1 1 1 1
Medium 166 147 333 120 193 113 269 22 52 109 145 538 7 174 101
Low 1143 1613 988 384 631 248 2322 835 859 209 863 821 137 886 1577 3 2
Below cutoff 1007 1080 365 99 682 79 1484 1240 2321 49 314 46 27 141 1068

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000264888   ⟹   ENSP00000354901
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl476,001,275 - 76,007,509 (-)Ensembl
RefSeq Acc Id: NM_002416   ⟹   NP_002407
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38476,001,275 - 76,007,509 (-)NCBI
GRCh37476,922,623 - 76,928,641 (-)ENTREZGENE
Build 36477,141,647 - 77,147,665 (-)NCBI Archive
HuRef472,674,915 - 72,680,933 (-)ENTREZGENE
CHM1_1476,899,060 - 76,905,241 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002407   ⟸   NM_002416
- Peptide Label: precursor
- UniProtKB: Q07325 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000354901   ⟸   ENST00000264888

Promoters
RGD ID:6867764
Promoter ID:EPDNEW_H7047
Type:multiple initiation site
Name:CXCL9_1
Description:C-X-C motif chemokine ligand 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38476,007,509 - 76,007,569EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q21.1-21.23(chr4:75453111-84094295)x1 copy number loss See cases [RCV000050786] Chr4:75453111..84094295 [GRCh38]
Chr4:76378321..85015448 [GRCh37]
Chr4:76597345..85234472 [NCBI36]
Chr4:4q21.1-21.23
pathogenic
GRCh38/hg38 4q21.1(chr4:75729757-76160423)x1 copy number loss See cases [RCV000051054] Chr4:75729757..76160423 [GRCh38]
Chr4:76654941..77081576 [GRCh37]
Chr4:76873965..77300600 [NCBI36]
Chr4:4q21.1
uncertain significance
GRCh38/hg38 4q13.3-21.21(chr4:71128874-78099088)x3 copy number gain See cases [RCV000051774] Chr4:71128874..78099088 [GRCh38]
Chr4:71994591..79020242 [GRCh37]
Chr4:72213455..79239266 [NCBI36]
Chr4:4q13.3-21.21
pathogenic
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3
pathogenic
GRCh38/hg38 4q13.2-21.23(chr4:67869564-85517308)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|See cases [RCV000053294] Chr4:67869564..85517308 [GRCh38]
Chr4:68735282..86438461 [GRCh37]
Chr4:68417877..86657485 [NCBI36]
Chr4:4q13.2-21.23
pathogenic
GRCh38/hg38 4q13.3-21.22(chr4:71079179-81802208)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|See cases [RCV000053295] Chr4:71079179..81802208 [GRCh38]
Chr4:71944896..82723361 [GRCh37]
Chr4:72163760..82942385 [NCBI36]
Chr4:4q13.3-21.22
pathogenic
GRCh38/hg38 4q13.3-22.1(chr4:74031395-90421127)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|See cases [RCV000053296] Chr4:74031395..90421127 [GRCh38]
Chr4:74897112..91342278 [GRCh37]
Chr4:75115976..91561301 [NCBI36]
Chr4:4q13.3-22.1
pathogenic
GRCh38/hg38 4q13.3-21.3(chr4:72262258-86002147)x3 copy number gain See cases [RCV000138312] Chr4:72262258..86002147 [GRCh38]
Chr4:73127975..86923300 [GRCh37]
Chr4:73346839..87142324 [NCBI36]
Chr4:4q13.3-21.3
pathogenic
GRCh38/hg38 4q21.1-21.21(chr4:75801143-79005805)x3 copy number gain See cases [RCV000141486] Chr4:75801143..79005805 [GRCh38]
Chr4:76722296..79926959 [GRCh37]
Chr4:76941320..80145983 [NCBI36]
Chr4:4q21.1-21.21
pathogenic
GRCh38/hg38 4q13.2-22.3(chr4:68686088-95294456)x3 copy number gain See cases [RCV000143458] Chr4:68686088..95294456 [GRCh38]
Chr4:69551806..96215607 [GRCh37]
Chr4:69234401..96434630 [NCBI36]
Chr4:4q13.2-22.3
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q13.3-21.1(chr4:74890695-77318961)x1 copy number loss not provided [RCV000682421] Chr4:74890695..77318961 [GRCh37]
Chr4:4q13.3-21.1
uncertain significance
GRCh37/hg19 4q13.3-21.1(chr4:75353931-77183033)x1 copy number loss not provided [RCV000682422] Chr4:75353931..77183033 [GRCh37]
Chr4:4q13.3-21.1
uncertain significance
GRCh37/hg19 4q21.1(chr4:76770579-76998151)x3 copy number gain not provided [RCV000682423] Chr4:76770579..76998151 [GRCh37]
Chr4:4q21.1
likely benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_002416.3(CXCL9):c.375A>G (p.Thr125=) single nucleotide variant not provided [RCV000886789] Chr4:76003601 [GRCh38]
Chr4:76924754 [GRCh37]
Chr4:4q21.1
benign
GRCh37/hg19 4q13.2-21.21(chr4:68950363-79738598)x1 copy number loss not provided [RCV001005553] Chr4:68950363..79738598 [GRCh37]
Chr4:4q13.2-21.21
pathogenic
GRCh37/hg19 4q13.3-21.23(chr4:72680879-86426232)x1 copy number loss not provided [RCV001005556] Chr4:72680879..86426232 [GRCh37]
Chr4:4q13.3-21.23
pathogenic
GRCh37/hg19 4q13.3-21.1(chr4:71561780-78304341)x1 copy number loss not provided [RCV000846231] Chr4:71561780..78304341 [GRCh37]
Chr4:4q13.3-21.1
pathogenic
GRCh37/hg19 4q13.2-21.22(chr4:68242784-82991431)x3 copy number gain not provided [RCV000845944] Chr4:68242784..82991431 [GRCh37]
Chr4:4q13.2-21.22
pathogenic
NM_002416.3(CXCL9):c.119C>G (p.Thr40Ser) single nucleotide variant not provided [RCV000913344] Chr4:76006220 [GRCh38]
Chr4:76927373 [GRCh37]
Chr4:4q21.1
likely benign
GRCh37/hg19 4q21.1(chr4:76714825-76978984)x3 copy number gain not provided [RCV001259273] Chr4:76714825..76978984 [GRCh37]
Chr4:4q21.1
uncertain significance
GRCh37/hg19 4q13.3-21.3(chr4:71412409-87920784)x1 copy number loss See cases [RCV001263040] Chr4:71412409..87920784 [GRCh37]
Chr4:4q13.3-21.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7098 AgrOrtholog
COSMIC CXCL9 COSMIC
Ensembl Genes ENSG00000138755 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000354901 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000264888 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000138755 GTEx
HGNC ID HGNC:7098 ENTREZGENE
Human Proteome Map CXCL9 Human Proteome Map
InterPro Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:4283 UniProtKB/Swiss-Prot
NCBI Gene 4283 ENTREZGENE
OMIM 601704 OMIM
PANTHER PTHR10179 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35495 PharmGKB
PRINTS SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CXCL9_HUMAN UniProtKB/Swiss-Prot
  L8E8X0_HUMAN UniProtKB/TrEMBL
  Q07325 ENTREZGENE
UniProt Secondary Q503B4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CXCL9  C-X-C motif chemokine ligand 9  CXCL9  chemokine (C-X-C motif) ligand 9  Symbol and/or name change 5135510 APPROVED