Cxcl10 (chemokine (C-X-C motif) ligand 10) - Rat Genome Database

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Gene: Cxcl10 (chemokine (C-X-C motif) ligand 10) Mus musculus
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Symbol: Cxcl10
Name: chemokine (C-X-C motif) ligand 10
RGD ID: 1550709
MGI Page MGI
Description: Predicted to enable chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Involved in cellular response to interleukin-17. Acts upstream of or within several processes, including defense response to virus; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including alimentary system; axial skeleton; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in hepatitis B; middle cerebral artery infarction; and type 1 diabetes mellitus. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; C7; CRG-; CRG-2; gamma-IP10; gIP-; gIP-10; Ifi; Ifi10; IN; INP10; interferon activated gene 10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; IP; IP-; IP-10; IP10; mob-; mob-1; Scyb1; Scyb10; small inducible cytokine B subfamily (Cys-X-Cys), member 10; small-inducible cytokine B10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,494,497 - 92,496,748 (-)NCBIGRCm39mm39
GRCm39 Ensembl592,494,497 - 92,496,748 (-)Ensembl
GRCm38592,346,638 - 92,348,889 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,346,638 - 92,348,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,775,667 - 92,777,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv36593,421,841 - 93,424,054 (-)NCBImm8
Celera590,490,436 - 90,492,644 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (IEP)
Acute-On-Chronic Liver Failure  (ISO)
adult respiratory distress syndrome  (ISO)
alopecia areata  (ISO)
asthma  (IMP,ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (IEP,IMP)
boutonneuse fever  (IEP)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (IEP)
brain ischemia  (ISO)
bronchiolitis obliterans  (IEP,IMP,ISO)
cardiovascular system disease  (ISO)
Carrington Syndrome  (ISO)
celiac disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (IDA)
Colonic Neoplasms  (ISO)
common cold  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (IEP,IMP)
COVID-19  (ISO)
cryoglobulinemia  (ISO)
Cytomegalovirus Infections  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
encephalitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (IEP,ISO)
fatty liver disease  (ISO)
Foot Ulcer  (ISO)
Graft vs Host Disease  (IEP)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (IDA,ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hypothermia  (ISO)
inhalation anthrax  (IMP)
interstitial cystitis  (ISO)
interstitial lung disease  (ISO)
ischemia  (IEP)
Kabuki Syndrome 1  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (IDA)
Liver Reperfusion Injury  (IMP)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (IEP)
myasthenia gravis  (ISO)
Myocardial Ischemia  (ISO)
myocarditis  (ISO)
non-alcoholic fatty liver disease  (IMP)
non-alcoholic steatohepatitis  (IMP,ISO)
pleurisy  (IEP)
pneumonia  (IEP,IMP)
primary biliary cholangitis  (ISO)
progressive myoclonus epilepsy  (ISO)
proteinuria  (ISO)
pulmonary emphysema  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (IEP,ISO)
respiratory syncytial virus infectious disease  (IMP)
Respiratory Tract Granuloma  (IEP)
severe acute respiratory syndrome  (HEP,IEP,ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
systemic scleroderma  (ISO)
thoracic aortic aneurysm  (ISO)
Thyroid Neoplasms  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IMP,ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)
viral pneumonia  (IEP)
visceral leishmaniasis  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (EXP)
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nitroquinoline N-oxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
acteoside  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alloxanthine  (ISO)
alpha-phellandrene  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (ISO)
amorolfine  (ISO)
amoxicillin  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
arsenous acid  (ISO)
asperentin  (EXP)
atorvastatin calcium  (ISO)
Aurin  (ISO)
bafilomycin A1  (ISO)
bazedoxifene  (EXP)
beclomethasone  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzoates  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
butanal  (ISO)
butenafine  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium phosphate  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP,ISO)
cefaloridine  (ISO)
celastrol  (EXP,ISO)
ceric oxide  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP)
chloroethene  (EXP)
chloroquine  (ISO)
chondroitin sulfate  (ISO)
chrysin  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dimethoate  (EXP)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (ISO)
doramapimod  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
eriodictyol  (EXP)
ethanol  (EXP,ISO)
ethionamide  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fluoranthene  (EXP)
fluoxetine  (EXP)
flutamide  (ISO)
folpet  (EXP)
formaldehyde  (ISO)
fragrance  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP,ISO)
gadodiamide hydrate  (ISO)
gemfibrozil  (ISO)
Genipin  (EXP)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
graphene oxide  (EXP)
halothane  (ISO)
heparan sulfate  (ISO)
heparin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hydrazine  (EXP)
hydroxychloroquine  (ISO)
ibuprofen  (ISO)
imiquimod  (ISO)
immunological adjuvant  (EXP,ISO)
indometacin  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (EXP)
isoniazide  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leptomycin B  (ISO)
levonorgestrel  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lucanthone  (ISO)
Luliconazole  (ISO)
luteolin  (EXP)
LY294002  (EXP)
magnesium dihydroxide  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP)
mercury dichloride  (ISO)
metacetamol  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
Muraglitazar  (ISO)
mycotoxin  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naphthalene  (EXP)
naproxen  (ISO)
neoechinulin A  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
oleic acid  (ISO)
ospemifene  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 168393  (ISO)
pentachlorophenol  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
procymidone  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propiconazole  (EXP)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
Pyridostigmine bromide  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
raloxifene  (EXP)
remdesivir  (ISO)
resiquimod  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
rimonabant  (EXP)
ritonavir  (ISO)
roflumilast  (ISO)
rolipram  (ISO)
rotenone  (ISO)
rutin  (ISO)
ruxolitinib  (ISO)
S-nitrosoglutathione  (ISO)
serpentine asbestos  (EXP,ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP,ISO)
sterigmatocystin  (EXP)
succimer  (EXP,ISO)
sumatriptan  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (EXP)
tamoxifen  (EXP)
taurocholic acid  (EXP)
temozolomide  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP,ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
trametinib  (EXP)
trans-piceid  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
tungsten  (EXP)
ursodeoxycholic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
zinc atom  (EXP)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA,ISO)
antiviral innate immune response  (ISO)
cellular response to heat  (ISO)
cellular response to interleukin-17  (IDA)
cellular response to lipopolysaccharide  (IBA,ISO)
cellular response to virus  (ISO)
chemokine-mediated signaling pathway  (IBA,ISO)
chemotaxis  (ISO)
defense response  (IEA)
defense response to virus  (IDA)
endothelial cell activation  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
immune response  (ISO)
inflammatory response  (IBA)
killing of cells of another organism  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of myoblast differentiation  (IMP)
negative regulation of myoblast fusion  (IMP)
neutrophil chemotaxis  (IBA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of leukocyte chemotaxis  (ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of T cell migration  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell population proliferation  (ISO)
regulation of endothelial tube morphogenesis  (ISO)
regulation of T cell chemotaxis  (ISO)
response to auditory stimulus  (ISO)
response to bacterium  (IEP)
response to cold  (ISO)
response to gamma radiation  (ISO)
response to lipopolysaccharide  (ISO)
response to virus  (ISO)
response to vitamin D  (ISO)
T cell chemotaxis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The novel chemokine mob-1: involvement in adult respiratory distress syndrome. Abdullah F, etal., Surgery. 1997 Aug;122(2):303-12.
2. Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. Abu El-Asrar AM, etal., Eur Cytokine Netw. 2006 Sep;17(3):155-65.
3. Involvement of the IP-10 chemokine in sarcoid granulomatous reactions. Agostini C, etal., J Immunol. 1998 Dec 1;161(11):6413-20.
4. CXCR3/CXCL10 interactions in the development of hypersensitivity pneumonitis. Agostini C, etal., Respir Res. 2005 Feb 22;6:20.
5. High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. Antonelli A, etal., Am J Gastroenterol. 2008 Oct;103(10):2488-94. doi: 10.1111/j.1572-0241.2008.02040.x. Epub 2008 Sep 4.
6. Serum Th1 (CXCL10) and Th2 (CCL2) chemokine levels in children with newly diagnosed Type 1 diabetes: a longitudinal study. Antonelli A, etal., Diabet Med. 2008 Nov;25(11):1349-53.
7. Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. Belperio JA, etal., J Immunol. 2002 Jul 15;169(2):1037-49.
8. Diminished inflammatory responses to natural pneumovirus infection among older mice. Bonville CA, etal., Virology. 2007 Nov 10;368(1):182-90. Epub 2007 Jul 25.
9. Early high expression of IP-10 in F344 rats resistant to Sendai virus-induced airway injury. Cai X and Castleman WL, Am J Physiol Lung Cell Mol Physiol. 2003 Dec;285(6):L1263-9. Epub 2003 Aug 8.
10. Granzyme-b mediated cell death in the spinal cord-injured rat model. Chaitanya GV, etal., Neuropathology. 2008 Dec 24.
11. The role of interferon-γ inducible protein-10 in a mouse model of acute liver injury post induced pluripotent stem cells transplantation. Chan CC, etal., PLoS One. 2012;7(12):e50577. doi: 10.1371/journal.pone.0050577. Epub 2012 Dec 5.
12. SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation. Chang YS, etal., Int J Mol Sci. 2020 Apr 30;21(9). pii: ijms21093179. doi: 10.3390/ijms21093179.
13. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
14. Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Chien JY, etal., Respirology. 2006 Nov;11(6):715-22.
15. CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Costa C, etal., Chest. 2008 Jan;133(1):26-33. Epub 2007 Oct 9.
16. Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection. Crawford MA, etal., PLoS Pathog. 2010 Nov 18;6(11):e1001199.
17. Angiogenic and angiostatic chemokines in idiopathic pulmonary fibrosis and granulomatous lung disease. Cui A, etal., Respiration. 2010;80(5):372-8. Epub 2009 Oct 6.
18. Regulatory polymorphisms in the promoter of CXCL10 gene and disease progression in male hepatitis B virus carriers. Deng G, etal., Gastroenterology. 2008 Mar;134(3):716-26. doi: 10.1053/j.gastro.2007.12.044. Epub 2008 Jan 1.
19. IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. Dufour JH, etal., J Immunol 2002 Apr 1;168(7):3195-204.
20. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. Feferman T, etal., J Immunol. 2005 May 1;174(9):5324-31.
21. Suppression of experimental autoimmune myasthenia gravis by inhibiting the signaling between IFN-gamma inducible protein 10 (IP-10) and its receptor CXCR3. Feferman T, etal., J Neuroimmunol. 2009 Apr 30;209(1-2):87-95. Epub 2009 Feb 20.
22. Impairment of leukocyte trafficking in a murine pleuritis model by IL-4 and IL-10. Fine JS, etal., Inflammation. 2003 Aug;27(4):161-74.
23. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
24. Hypothermia-enhanced splenic cytokine gene expression is independent of the sympathetic nervous system. Ganta CK, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R558-65.
25. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
26. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. Grumelli S, etal., PLoS Med. 2004 Oct;1(1):e8. Epub 2004 Oct 19.
27. IFN-inducible protein-10 plays a pivotal role in maintaining slit-diaphragm function by regulating podocyte cell-cycle balance. Han GD, etal., J Am Soc Nephrol. 2006 Feb;17(2):442-53. Epub 2005 Dec 28.
28. Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis. Hasegawa M, etal., Clin Rheumatol. 2011 Feb;30(2):231-7. Epub 2010 Nov 4.
29. A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies. Hassan AO, etal., Cell. 2020 Jun 10. pii: S0092-8674(20)30742-X. doi: 10.1016/j.cell.2020.06.011.
30. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. Hildebrandt GC, etal., J Immunol. 2004 Aug 1;173(3):2050-9.
31. Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice. Hu Z, etal., Theranostics. 2017 May 2;7(7):1942-1952. doi: 10.7150/thno.16236. eCollection 2017.
32. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
33. An interferon-gamma-related cytokine storm in SARS patients. Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
34. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
35. The complement system plays a critical role in the development of experimental autoimmune anterior uveitis. Jha P, etal., Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1030-8.
36. Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome. Jiang Y, etal., Am J Respir Crit Care Med. 2005 Apr 15;171(8):850-7. doi: 10.1164/rccm.200407-857OC. Epub 2005 Jan 18.
37. Accumulation of CXCR3-expressing eosinophils and increased concentration of its ligands (IP10 and Mig) in bronchoalveolar lavage fluid of patients with chronic eosinophilic pneumonia. Katoh S, etal., Int Arch Allergy Immunol. 2005 Jul;137(3):229-35. Epub 2005 Jun 13.
38. CXCR3 chemokine receptor-plasma IP10 interaction in patients with coronary artery disease. Kawamura A, etal., Circ J. 2003 Oct;67(10):851-4.
39. Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3. Kelsen SG, etal., Am J Respir Crit Care Med. 2009 May 1;179(9):799-805. Epub 2009 Feb 12.
40. Circulating BAFF and CXCL10 levels predict response to pegylated interferon in patients with HBeAg-positive chronic hepatitis B. Khlaiphuengsin A, etal., Asian Pac J Allergy Immunol. 2019 Jan 13. doi: 10.12932/AP-050718-0365.
41. Forced Expression of CXCL10 Prevents Liver Metastasis of Colon Carcinoma Cells by the Recruitment of Natural Killer Cells. Kikuchi N, etal., Biol Pharm Bull. 2019 Jan 1;42(1):57-65. doi: 10.1248/bpb.b18-00538. Epub 2018 Nov 1.
42. Urine IP-10 as a biomarker of therapeutic response in patients with active pulmonary tuberculosis. Kim SY, etal., BMC Infect Dis. 2018 May 29;18(1):240. doi: 10.1186/s12879-018-3144-3.
43. Blockade of Th1 chemokine receptors ameliorates pulmonary granulomatosis in mice. Kishi J, etal., Eur Respir J. 2011 Aug;38(2):415-24. Epub 2011 Jan 27.
44. Decreased T-bet expression and changes in chemokine levels in adults with asthma. Ko FW, etal., Clin Exp Immunol. 2007 Mar;147(3):526-32.
45. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
46. Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration. Koniaris LG, etal., J Immunol. 2001 Jul 1;167(1):399-406. doi: 10.4049/jimmunol.167.1.399.
47. Minocycline modulates chemokine receptors but not interleukin-10 mRNA expression in hypoxic-ischemic neonatal rat brain. Kremlev SG, etal., J Neurosci Res. 2007 Aug 15;85(11):2450-9.
48. Induction of interferon-gamma-inducible protein 10 by SARS-CoV infection, interferon alfacon 1 and interferon inducer in human bronchial epithelial Calu-3 cells and BALB/c mice. Kumaki Y, etal., Antivir Chem Chemother. 2010 Mar 9;20(4):169-77. doi: 10.3851/IMP1477.
49. HIV infection is associated with higher levels of monocyte chemoattractant protein-1 and eotaxin among people with recent hepatitis C virus infection. Lamoury FM, etal., BMC Infect Dis. 2016 Jun 1;16:241. doi: 10.1186/s12879-016-1567-2.
50. Circulating CXCL10 in cirrhotic portal hypertension might reflect systemic inflammation and predict ACLF and mortality. Lehmann JM, etal., Liver Int. 2018 May;38(5):875-884. doi: 10.1111/liv.13610. Epub 2017 Nov 6.
51. CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation. Li CX, etal., J Hepatol. 2016 Nov;65(5):944-952. doi: 10.1016/j.jhep.2016.05.032. Epub 2016 May 28.
52. Identification of chemokine CXCL10 in tumor microenvironment by antibody array as a prognostic marker in hepatocellular carcinoma. Li L, etal., Neoplasma. 2017;64(5):778-786. doi: 10.4149/neo_2017_517.
53. Clinical and pathological investigation of severe COVID-19 patients. Li S, etal., JCI Insight. 2020 May 19. pii: 138070. doi: 10.1172/jci.insight.138070.
54. CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. Lindell DM, etal., Eur J Immunol. 2008 Aug;38(8):2168-79.
55. Expression of the CXC chemokine receptor 3 and its ligands in ischemia-reperfusion injury of liver in rats. Liu Z, etal., Transplant Proc. 2008 Jun;40(5):1300-2.
56. Aberrant expression of CC and CXC chemokines and their receptors in patients with asthma. Lun SW, etal., J Clin Immunol. 2006 Mar;26(2):145-52. Epub 2006 Apr 7.
57. Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway. Ma Q, etal., Pharmacol Res. 2020 Apr 30;158:104850. doi: 10.1016/j.phrs.2020.104850.
58. The chemokine binding protein M3 prevents diabetes induced by multiple low doses of streptozotocin. Martin AP, etal., J Immunol. 2007 Apr 1;178(7):4623-31.
59. C protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy. Matsumoto Y, etal., J Immunol. 2004 Sep 1;173(5):3535-41.
60. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. Medoff BD, etal., J Immunol. 2002 May 15;168(10):5278-86.
61. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. Medoff BD, etal., J Immunol. 2006 Jun 1;176(11):7087-95.
62. Alterations of Serum IP-10 and TARC in Patients with Early Acute Rejection after Liver Transplantation. Meng X, etal., Cell Physiol Biochem. 2017;41(3):1063-1071. doi: 10.1159/000464114. Epub 2017 Feb 27.
63. MGDs mouse GO annotations MGD data from the GO Consortium
64. Chemokine production during hypersensitivity pneumonitis. Nance S, etal., Eur J Immunol. 2004 Mar;34(3):677-85.
65. Chemokine response in children with SARS. Ng PC, etal., Arch Dis Child. 2005 Apr;90(4):422-3. doi: 10.1136/adc.2004.053660.
66. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. Niewczas MA, etal., Clin J Am Soc Nephrol. 2009 Jan;4(1):62-70. Epub 2008 Dec 10.
67. CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. Nishioka Y, etal., Clin Exp Immunol. 2007 Aug;149(2):317-26. Epub 2007 Jun 5.
68. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
69. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Rabquer BJ, etal., Arthritis Res Ther. 2011 Feb 8;13(1):R18.
70. Serum IP-10 levels and increased DPPIV activity are linked to circulating CXCR3+ T cells in cholestatic HCV patients. Rau M, etal., PLoS One. 2018 Dec 3;13(12):e0208225. doi: 10.1371/journal.pone.0208225. eCollection 2018.
71. Mouse MP Annotation Import Pipeline RGD automated import pipeline
72. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
73. Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development. Rhode A, etal., J Immunol. 2005 Sep 15;175(6):3516-24.
74. Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease. Richards TJ, etal., Arthritis Rheum. 2009 Jul;60(7):2183-92.
75. Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection. Riva A, etal., Hepatology. 2014 Aug;60(2):487-96. doi: 10.1002/hep.27139. Epub 2014 May 19.
76. Changes in helper lymphocyte chemokine receptor expression and elevation of IP-10 during acute respiratory syncytial virus infection in infants. Roe MF, etal., Pediatr Allergy Immunol. 2011 Mar;22(2):229-34. doi: 10.1111/j.1399-3038.2010.01032.x.
77. Characterization of cytomegalovirus disease in solid organ transplant recipients by markers of inflammation in plasma. Rollag H, etal., PLoS One. 2013 Apr 8;8(4):e60767. doi: 10.1371/journal.pone.0060767. Print 2013.
78. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Schulthess FT, etal., Cell Metab. 2009 Feb;9(2):125-39.
79. CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice. Shigihara T, etal., J Immunol. 2005 Dec 15;175(12):8401-8.
80. Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary inflammation of MRL/lpr mice. Shiozawa F, etal., Arthritis Res Ther. 2004;6(1):R78-R86. Epub 2003 Nov 19.
81. Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokine. Smith JB and Herschman HR, J Biol Chem 1995 Jul 14;270(28):16756-65.
82. Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection. Spurrell JC, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Jul;289(1):L85-95. Epub 2005 Mar 11.
83. Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats. Steinmetz OM, etal., Am J Physiol Renal Physiol. 2007 Feb;292(2):F876-87. Epub 2006 Oct 24.
84. CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demyelination. Stiles LN, etal., Autoimmunity. 2009 Sep;42(6):484-91. doi: 10.1080/08916930902810708.
85. Invariant NKT cells are essential for the regulation of hepatic CXCL10 gene expression during Leishmania donovani infection. Svensson M, etal., Infect Immun. 2005 Nov;73(11):7541-7. doi: 10.1128/IAI.73.11.7541-7547.2005.
86. Serum inducible protein-10 chemokine as a biomarker for clearance of HCV with and without treatment in Egyptian patients. Tabll A, etal., Hum Antibodies. 2019;27(4):265-273. doi: 10.3233/HAB-190381.
87. Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
88. Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms. Tang PC, etal., FASEB J. 2005 Sep;19(11):1528-30. Epub 2005 Jul 12.
89. Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. Valbuena G, etal., Am J Pathol. 2003 Oct;163(4):1357-69.
90. Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan. Villapol S, etal., Am J Pathol. 2015 Oct;185(10):2641-52. doi: 10.1016/j.ajpath.2015.06.016.
91. NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines. Wallace KL, etal., Blood. 2009 Jul 16;114(3):667-76. Epub 2009 May 11.
92. Expression of CXC chemokine IP-10 in patients with chronic hepatitis B. Wang J, etal., Hepatobiliary Pancreat Dis Int. 2008 Feb;7(1):45-50.
93. Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke. Wang X, etal., Mol Pharmacol 2000 Jun;57(6):1190-8.
94. Predictive Value of Serum IFN-γ inducible Protein-10 and IFN-γ/IL-4 Ratio for Liver Fibrosis Progression in CHB Patients. Wang Y, etal., Sci Rep. 2017 Jan 9;7:40404. doi: 10.1038/srep40404.
95. Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids. Ward SE, etal., Antivir Ther. 2005;10(2):263-75.
96. Immune mediators in patients with acute diabetic foot syndrome. Weigelt C, etal., Diabetes Care. 2009 Jun 9.
97. CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung. Widney DP, etal., Infect Immun. 2005 Jan;73(1):485-93.
98. Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy. Wong CK, etal., Clin Exp Immunol. 2007 Jul;149(1):123-31. Epub 2007 Apr 11.
99. [The possible mechanism of lung injury induced by severe acute respiratory syndrome coronavirus spike glycoprotein]. Yang XY, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Sep;29(9):587-90.
100. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
101. Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2. Yao Z, etal., Aging (Albany NY). 2020 May 2;12(9):7639-7651. doi: 10.18632/aging.103101. Epub 2020 May 2.
102. Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Yoshida H, etal., Nat Immunol 2005 Jan;6(1):49-56. Epub 2004 Nov 28.
103. Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia. Zeng X, etal., Infect Immun. 2005 Dec;73(12):8226-36.
104. Intrahepatic and Peripheral CXCL10 Expression in Hepatitis C Virus-Infected Patients Treated With Telaprevir, Pegylated Interferon, and Ribavirin. Zeremski M, etal., J Infect Dis. 2015 Jun 1;211(11):1795-9. doi: 10.1093/infdis/jiu807. Epub 2014 Dec 15.
105. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Zhai Y, etal., Hepatology. 2008 Jan;47(1):207-14. doi: 10.1002/hep.21986.
106. CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis. Zhang X, etal., J Hepatol. 2014 Dec;61(6):1365-75. doi: 10.1016/j.jhep.2014.07.006. Epub 2014 Jul 15.
107. C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis. Zhang X, etal., Theranostics. 2017 Jul 8;7(11):2822-2836. doi: 10.7150/thno.19068. eCollection 2017.
Additional References at PubMed
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Genomics

Comparative Map Data
Cxcl10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,494,497 - 92,496,748 (-)NCBIGRCm39mm39
GRCm39 Ensembl592,494,497 - 92,496,748 (-)Ensembl
GRCm38592,346,638 - 92,348,889 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,346,638 - 92,348,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,775,667 - 92,777,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv36593,421,841 - 93,424,054 (-)NCBImm8
Celera590,490,436 - 90,492,644 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.57NCBI
CXCL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38476,021,118 - 76,023,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)EnsemblGRCh38hg38GRCh38
GRCh37476,942,271 - 76,944,650 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,161,295 - 77,163,674 (-)NCBINCBI36hg18NCBI36
Build 34477,299,451 - 77,301,829NCBI
Celera474,243,028 - 74,245,407 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,694,720 - 72,697,139 (-)NCBIHuRef
CHM1_1476,918,847 - 76,921,265 (-)NCBICHM1_1
T2T-CHM13v2.0479,361,779 - 79,364,158 (-)NCBI
Cxcl10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21415,704,772 - 15,706,969 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1415,704,758 - 15,706,975 (+)Ensembl
Rnor_6.01417,210,733 - 17,212,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,126,865 - 17,129,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,265,986 - 17,268,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11417,265,985 - 17,268,183 (+)NCBI
Celera1415,099,217 - 15,101,414 (+)NCBICelera
RH 3.4 Map14182.09RGD
Cytogenetic Map14p22NCBI
Cxcl10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955433748,284 - 750,927 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955433748,392 - 750,890 (-)NCBIChiLan1.0ChiLan1.0
CXCL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1454,020,204 - 54,022,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,020,204 - 54,022,606 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0448,182,355 - 48,184,733 (+)NCBIMhudiblu_PPA_v0panPan3
CXCL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132598,406 - 599,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32597,987 - 599,979 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,282,571 - 41,284,090 (+)NCBI
ROS_Cfam_1.032623,230 - 624,745 (-)NCBI
ROS_Cfam_1.0 Ensembl32622,462 - 624,803 (-)Ensembl
UMICH_Zoey_3.132622,982 - 624,501 (-)NCBI
UNSW_CanFamBas_1.032577,290 - 578,808 (-)NCBI
UU_Cfam_GSD_1.03239,590,894 - 39,592,413 (+)NCBI
Cxcl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,442,665 - 11,446,615 (+)NCBI
SpeTri2.0NW_00493667660,869 - 63,028 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,693,339 - 71,695,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,693,641 - 71,695,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,829,909 - 75,831,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2875,881,457 - 75,882,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,526,657 - 24,529,193 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl724,526,680 - 24,529,130 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660372,868,983 - 2,871,422 (-)NCBIVero_WHO_p1.0
Cxcl10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475714,989,084 - 14,991,910 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475714,989,241 - 14,991,650 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AI661308  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38592,346,900 - 92,347,014UniSTSGRCm38
MGSCv37592,775,926 - 92,776,040UniSTSGRCm37
Celera590,490,696 - 90,490,810UniSTS
Cytogenetic Map5E2UniSTS
cM Map553.0UniSTS
cM Map552.0UniSTS
Whitehead/MRC_RH51115.14UniSTS
M86829  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38592,347,070 - 92,347,256UniSTSGRCm38
MGSCv37592,776,096 - 92,776,282UniSTSGRCm37
Celera590,490,867 - 90,491,053UniSTS
Cytogenetic Map5E2UniSTS
cM Map553.0UniSTS
cM Map552.0UniSTS
Whitehead_YAC5 UniSTS
Cxcl10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5E2UniSTS
cM Map553.0UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:516
Count of miRNA genes:395
Interacting mature miRNAs:440
Transcripts:ENSMUST00000038816, ENSMUST00000118006, ENSMUST00000138169
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF227743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY165450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M86829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M86830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000038816   ⟹   ENSMUSP00000047646
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl592,494,497 - 92,496,741 (-)Ensembl
GRCm38.p6 Ensembl592,346,638 - 92,348,882 (-)Ensembl
RefSeq Acc Id: ENSMUST00000118006   ⟹   ENSMUSP00000114134
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl592,494,664 - 92,496,748 (-)Ensembl
GRCm38.p6 Ensembl592,346,805 - 92,348,889 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138169
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl592,495,860 - 92,496,741 (-)Ensembl
GRCm38.p6 Ensembl592,348,001 - 92,348,882 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201176
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl592,494,497 - 92,496,726 (-)Ensembl
GRCm38.p6 Ensembl592,346,638 - 92,348,867 (-)Ensembl
RefSeq Acc Id: NM_021274   ⟹   NP_067249
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39592,494,497 - 92,496,748 (-)NCBI
GRCm38592,346,638 - 92,348,889 (-)ENTREZGENE
MGSCv37592,775,667 - 92,777,880 (-)RGD
Celera590,490,433 - 90,492,679 (-)ENTREZGENE
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067249   ⟸   NM_021274
- Peptide Label: precursor
- UniProtKB: P17515 (UniProtKB/Swiss-Prot),   Q548V9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000114134   ⟸   ENSMUST00000118006
RefSeq Acc Id: ENSMUSP00000047646   ⟸   ENSMUST00000038816
Protein Domains
SCY

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17515-F1-model_v2 AlphaFold P17515 1-98 view protein structure

Promoters
RGD ID:6887174
Promoter ID:EPDNEW_M7038
Type:multiple initiation site
Name:Cxcl10_1
Description:Mus musculus chemokine (C-X-C motif) ligand 10 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38592,348,879 - 92,348,939EPDNEW
RGD ID:6849173
Promoter ID:MM_XEF:5515
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:NM_001010949,   NM_001032892,   NM_001114940
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36592,776,941 - 92,777,441 (-)MPROMDB
RGD ID:6838311
Promoter ID:MM_KWN:42891
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000071189,   OTTMUST00000071191,   UC008YDA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36592,777,516 - 92,778,016 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1352450 AgrOrtholog
Ensembl Genes ENSMUSG00000034855 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000047646 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114134.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000038816 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000118006.3 UniProtKB/TrEMBL
InterPro Chemokine_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1352450 ENTREZGENE
NCBI Gene 15945 ENTREZGENE
PANTHER PTHR10179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cxcl10 PhenoGen
PRINTS SMALLCYTKCXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CXL10_MOUSE UniProtKB/Swiss-Prot
  D3YW23_MOUSE UniProtKB/TrEMBL
  P17515 ENTREZGENE
  Q3U6X5_MOUSE UniProtKB/TrEMBL
  Q3UAS6_MOUSE UniProtKB/TrEMBL
  Q3UCV1_MOUSE UniProtKB/TrEMBL
  Q3UK71_MOUSE UniProtKB/TrEMBL
  Q548V9 ENTREZGENE, UniProtKB/TrEMBL