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Adipose tissue expression of IL-18 and HIV-associated lipodystrophy.

Authors: Lindegaard, B  Hansen, AB  Pilegaard, H  Keller, P  Gerstoft, J  Pedersen, BK 
Citation: Lindegaard B, etal., AIDS. 2004 Sep 24;18(14):1956-8.
Pubmed: (View Article at PubMed) PMID:15353983

IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.

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RGD Object Information
RGD ID: 8655934
Created: 2014-05-23
Species: All species
Last Modified: 2014-05-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.