GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IL18 | affects response to substance | EXP | | 6480464 | CTD | IL18 gene SNP affects the susceptibility to Ethanol | PMID:24349532 | IL18 | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of IL18 mRNA; Ethanol results in increased expression of IL18 protein | PMID:28964808 PMID:34474091 | IL18 | multiple interactions | EXP | | 6480464 | CTD | [Ethanol co-treated with Folic Acid] results in increased expression of IL18 mRNA; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 protein; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA]; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of IL18 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL18 protein]] | PMID:23378141 PMID:28964808 PMID:34474091 | IL18 | affects expression | ISO | Il18 (Mus musculus) | 6480464 | CTD | Ethanol affects the expression of IL18 mRNA | PMID:30319688 | IL18 | increases expression | ISO | Il18 (Rattus norvegicus) | 6480464 | CTD | Ethanol results in increased expression of IL18 mRNA | PMID:34547370 | IL18 | increases expression | ISO | Il18 (Mus musculus) | 6480464 | CTD | Ethanol results in increased expression of IL18 mRNA | PMID:28964808 | IL18 | multiple interactions | ISO | Il18 (Mus musculus) | 6480464 | CTD | [ethylene dichloride co-treated with Ethanol] results in increased expression of IL18 protein; acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]; allyl sulfide inhibits the reaction [[ethylene dichloride co-treated with Ethanol] results in increased expression of IL18 protein] | PMID:28964808 PMID:37150348 | | ||||||||||||||||||||||
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