Gene: Mdh1b (malate dehydrogenase 1B) Rattus norvegicus
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Symbol:
Mdh1b
Name:
malate dehydrogenase 1B
Description:
Predicted to have L-malate dehydrogenase activity. Predicted to be involved in NADH metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Orthologous to human MDH1B (malate dehydrogenase 1B); INTERACTS WITH bisphenol A; furan; vinclozolin.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC316444; malate dehydrogenase 1B, NAD (soluble); putative malate dehydrogenase 1B
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
MDH1B (malate dehydrogenase 1B) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Mdh1b (malate dehydrogenase 1B, NAD (soluble)) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Mdh1b (malate dehydrogenase 1B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
MDH1B (malate dehydrogenase 1B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
MDH1B (malate dehydrogenase 1B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Mdh1b (malate dehydrogenase 1B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
MDH1B (malate dehydrogenase 1B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
MDH1B (malate dehydrogenase 1B)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Mdh1b (malate dehydrogenase 1B, NAD (soluble))
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
mdh1b (malate dehydrogenase 1B, NAD (soluble))
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 9 70,403,612 - 70,450,204 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 70,404,093 - 70,450,170 (-) Ensembl Rnor_5.0 9 72,123,041 - 72,169,621 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 62,368,173 - 62,418,212 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 9 62,555,822 - 62,565,152 (-) NCBI Celera 9 62,531,570 - 62,578,420 (-) NCBI Celera Cytogenetic Map 9 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol multiple interactions ISO RGD:1550831 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDH1B mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550831 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDH1B mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550831 6480464 Tetrachlorodibenzodioxin affects the expression of MDH1B mRNA CTD PMID:26377647 aflatoxin B1 increases expression ISO RGD:1550831 6480464 Aflatoxin B1 results in increased expression of MDH1B mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression ISO RGD:1550831 6480464 Benzo(a)pyrene results in decreased expression of MDH1B mRNA CTD PMID:22228805 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of MDH1B mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:1550831 6480464 bisphenol F results in increased expression of MDH1B mRNA CTD PMID:30951980 butanal decreases expression ISO RGD:1317321 6480464 butyraldehyde results in decreased expression of MDH1B mRNA CTD PMID:26079696 carbon nanotube decreases expression ISO RGD:1550831 6480464 Nanotubes, Carbon analog results in decreased expression of MDH1B mRNA, Nanotubes, Carbon results in decreased expression of MDH1B mRNA CTD PMID:25554681 chloroprene increases expression ISO RGD:1550831 6480464 Chloroprene results in increased expression of MDH1B mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:1550831 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MDH1B mRNA CTD PMID:20938992 cisplatin multiple interactions ISO RGD:1317321 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of MDH1B mRNA CTD PMID:27392435 folic acid multiple interactions ISO RGD:1550831 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MDH1B mRNA CTD PMID:20938992 furan increases expression EXP 6480464 furan results in increased expression of MDH1B mRNA CTD PMID:25539665 gold atom multiple interactions ISO RGD:1317321 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of MDH1B mRNA CTD PMID:28433809 gold(0) multiple interactions ISO RGD:1317321 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of MDH1B mRNA CTD PMID:28433809 L-methionine multiple interactions ISO RGD:1550831 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MDH1B mRNA CTD PMID:20938992 methylmercury chloride decreases expression ISO RGD:1317321 6480464 methylmercuric chloride results in decreased expression of MDH1B mRNA CTD PMID:28001369 pirinixic acid multiple interactions ISO RGD:1550831 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MDH1B mRNA CTD PMID:19710929 potassium dichromate increases expression ISO RGD:1550831 6480464 Potassium Dichromate results in increased expression of MDH1B mRNA CTD PMID:23608068 sodium arsenite decreases expression ISO RGD:1317321 6480464 sodium arsenite results in decreased expression of MDH1B mRNA CTD PMID:25879800 titanium dioxide decreases expression ISO RGD:1550831 6480464 titanium dioxide results in decreased expression of MDH1B mRNA CTD PMID:23131501 more ... titanium dioxide affects expression ISO RGD:1550831 6480464 titanium dioxide affects the expression of MDH1B mRNA CTD PMID:23557971 valproic acid increases expression ISO RGD:1317321 6480464 Valproic Acid results in increased expression of MDH1B mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:1317321 6480464 Valproic Acid affects the expression of MDH1B mRNA CTD PMID:25979313 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of MDH1B mRNA CTD PMID:23555832 vorinostat increases expression ISO RGD:1317321 6480464 vorinostat results in increased expression of MDH1B mRNA CTD PMID:27188386
Gene Ontology Annotations
10054125 Srcrt7 Stress Responsive Cort QTL 7 3.33 0.0011 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 9 1055222 93442944 Rat 70186 Niddm26 Non-insulin dependent diabetes mellitus QTL 26 3.87 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 9 25692342 92741406 Rat 631643 Bp120 Blood pressure QTL 120 3 0.004 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 25692373 70692373 Rat 7207814 Bmd91 Bone mineral density QTL 91 3.5 femur size trait (VT:1000369) femoral neck cross-sectional area (CMO:0001697) 9 27486155 88333183 Rat 70218 Cm28 Cardiac mass QTL 28 8.3 0.0001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 9 29075079 83686404 Rat 724544 Uae9 Urinary albumin excretion QTL 9 4.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 9 29075079 122095297 Rat 731164 Uae25 Urinary albumin excretion QTL 25 3.5 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 29466970 107878528 Rat 1641894 Alcrsp12 Alcohol response QTL 12 response to alcohol trait (VT:0010489) brain neurotensin receptor 1 density (CMO:0002068) 9 32385133 77385133 Rat 7411571 Bw138 Body weight QTL 138 14.3 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 9 37642351 82642351 Rat 7411656 Foco26 Food consumption QTL 26 9.8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 9 37642351 82642351 Rat 1598834 Memor11 Memory QTL 11 2.5 exploratory behavior trait (VT:0010471) average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674) 9 41261034 90024806 Rat 8662828 Vetf6 Vascular elastic tissue fragility QTL 6 3.9 artery integrity trait (VT:0010639) patent ductus arteriosus score (CMO:0002566) 9 41261034 98606834 Rat 2290450 Scl57 Serum cholesterol level QTL 57 4.15 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 9 41261034 102531865 Rat 6903941 Pur31 Proteinuria QTL 31 0.036 total urine protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 9 46579769 91579769 Rat 11353949 Bp393 Blood pressure QTL 393 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 46579769 91579769 Rat 61352 Bp34 Blood pressure QTL 34 5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 46952427 83686153 Rat 10058949 Gmadr5 Adrenal mass QTL 5 2 0.014 adrenal gland mass (VT:0010420) both adrenal glands wet weight to body weight ratio (CMO:0002411) 9 47248965 94124663 Rat 631656 Bp108 Blood pressure QTL 108 5.97 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 54177542 99177542 Rat 1598849 Memor17 Memory QTL 17 2.2 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) 9 54885041 76677636 Rat 2303170 Bp332 Blood pressure QTL 332 3.73 0.027 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9 60810298 82732466 Rat 1578760 Cm53 Cardiac mass QTL 53 3.3 0.0001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 9 61186278 106186278 Rat 2303180 Bp333 Blood pressure QTL 333 0.001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 61730923 82890620 Rat 2303180 Bp333 Blood pressure QTL 333 0.001 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 9 61730923 82890620 Rat 2303180 Bp333 Blood pressure QTL 333 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9 61730923 82890620 Rat 724515 Uae16 Urinary albumin excretion QTL 16 8 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 63270073 107878387 Rat 1578659 Tspe1 Trichinella spiralis expulsion QTL 1 4.8 parasite quantity (VT:0010441) logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024) 9 66757444 71010122 Rat 1300134 Bp185 Blood pressure QTL 185 3.73 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9 66757444 112943287 Rat 1581580 Uae34 Urinary albumin excretion QTL 34 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 67451664 99920892 Rat 1578757 Pur6 Proteinuria QTL 6 3.3 0.005 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 9 67451664 99920892 Rat
Predicted Target Of
Count of predictions: 32 Count of miRNA genes: 31 Interacting mature miRNAs: 32 Transcripts: ENSRNOT00000017207 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
