Inha (inhibin subunit alpha) - Rat Genome Database
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Gene: Inha (inhibin subunit alpha) Rattus norvegicus
Analyze
Symbol: Inha
Name: inhibin subunit alpha
RGD ID: 2912
Description: Exhibits inhibin binding activity. Involved in male gonad development; negative regulation of follicle-stimulating hormone secretion; and ovarian follicle development. Localizes to several cellular components, including inhibin A complex; inhibin B complex; and photoreceptor inner segment. Biomarker of Leydig cell tumor. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human INHA (inhibin subunit alpha); INTERACTS WITH (S)-amphetamine; (S)-colchicine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: inhibin alpha; inhibin alpha chain; inhibin alpha subunit; MGC93593
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp34  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0982,700,482 - 82,703,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,700,468 - 82,703,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,469,743 - 82,472,644 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,781,223 - 74,784,124 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1974,928,355 - 74,931,217 (+)NCBI
Celera974,564,342 - 74,567,243 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
(S)-colchicine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
25-hydroxycholesterol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bucladesine  (EXP)
Butylbenzyl phthalate  (EXP)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clozapine  (EXP)
cocaine  (ISO)
dexamethasone  (EXP)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diheptyl phthalate  (EXP)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
flavonoids  (EXP)
fonofos  (ISO)
furan  (EXP)
haloperidol  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (ISO)
methamphetamine  (EXP)
methoxyacetic acid  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
nitrofen  (EXP)
Nonylphenol  (EXP)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (EXP)
phenformin  (EXP)
phenylephrine  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
Ptaquiloside  (ISO)
quercetin  (EXP)
risperidone  (ISO)
rotenone  (EXP)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
titanium dioxide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Ahn JM, etal., Mol Cells. 2004 Aug 31;18(1):79-86.
2. Cobellis L, etal., Eur J Endocrinol. 2001 Dec;145(6):779-84.
3. Feng ZM, etal., Mol Endocrinol 1989 Dec;3(12):1914-25.
4. Florio P, etal., Eur J Endocrinol. 2005 Feb;152(2):277-84.
5. Fujimura H, etal., J Neuroendocrinol. 1999 Mar;11(3):157-63.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GOA data from the GO Consortium
8. Han L, etal., Anim Reprod Sci. 2007 Dec 31;.
9. Herath CB, etal., J Androl. 2001 Sep-Oct;22(5):838-46.
10. Imai M, etal., J Endocrinol. 1996 Dec;151(3):449-57.
11. Klaij IA, etal., J Endocrinol. 1994 Apr;141(1):143-51.
12. Koike S and Noumura T, Zoolog Sci. 1996 Jun;13(3):385-92.
13. Lopez P, etal., Oncogene. 1999 Dec 2;18(51):7303-9.
14. Matzuk MM, etal., Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8817-21.
15. McCluggage WG and Young RH, Am J Surg Pathol. 2007 Apr;31(4):592-7.
16. Mellor SL, etal., J Clin Endocrinol Metab. 1998 Mar;83(3):969-75.
17. MGD data from the GO Consortium
18. Mylonas I, etal., Oncol Rep. 2005 Jan;13(1):81-8.
19. NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Pei L, etal., Mol Endocrinol 1991 Apr;5(4):521-34.
21. Purdue MP, etal., Cancer Res. 2008 Apr 15;68(8):3043-8.
22. Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
23. RGD automated data pipeline
24. RGD automated import pipeline for gene-chemical interactions
25. Rivier C and Vale W, Endocrinology. 1989 Jul;125(1):152-7.
26. Robertson DM, etal., Clin Endocrinol (Oxf). 1999 Mar;50(3):381-6.
27. Schmitt JF, etal., Mol Endocrinol. 2002 Feb;16(2):213-20.
28. Suescun MO, etal., J Endocrinol. 2001 Jul;170(1):113-20.
29. Woodruff TK, etal., Mol Endocrinol 1987 Aug;1(8):561-8.
30. Worbs S, etal., Oncol Rep. 2007 Jan;17(1):97-104.
31. Yeh J and Kim B, Reprod Sci. 2007 Jan;14(1):10-9.
32. Ying SY, etal., Life Sci. 1995;57(1):45-52.
33. Yu WH, etal., Life Sci. 1994;55(2):93-102.
Additional References at PubMed
PMID:1310063   PMID:2484214   PMID:2829170   PMID:7890768   PMID:9032295   PMID:10746731   PMID:12477932   PMID:12732619   PMID:15070852   PMID:15489334   PMID:15650079   PMID:16269517  
PMID:16770574   PMID:19372236   PMID:19464342   PMID:22249524   PMID:23767829  


Genomics

Comparative Map Data
Inha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0982,700,482 - 82,703,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,700,468 - 82,703,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,469,743 - 82,472,644 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,781,223 - 74,784,124 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1974,928,355 - 74,931,217 (+)NCBI
Celera974,564,342 - 74,567,243 (+)NCBICelera
Cytogenetic Map9q33NCBI
INHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2219,569,162 - 219,575,711 (+)EnsemblGRCh38hg38GRCh38
GRCh382219,572,310 - 219,575,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372220,436,954 - 220,440,435 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,145,198 - 220,148,671 (+)NCBINCBI36hg18NCBI36
Build 342220,262,458 - 220,265,932NCBI
Celera2214,206,917 - 214,210,389 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2212,289,982 - 212,293,463 (+)NCBIHuRef
CHM1_12220,442,773 - 220,446,254 (+)NCBICHM1_1
Inha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,483,721 - 75,487,010 (+)NCBIGRCm39mm39
GRCm38175,507,077 - 75,510,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,507,077 - 75,510,366 (+)EnsemblGRCm38mm10GRCm38
MGSCv37175,503,652 - 75,506,929 (+)NCBIGRCm37mm9NCBIm37
MGSCv36175,390,225 - 75,393,502 (+)NCBImm8
Celera175,996,369 - 75,999,645 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map139.16NCBI
Inha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545313,902,277 - 13,905,008 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545313,902,443 - 13,905,008 (-)NCBIChiLan1.0ChiLan1.0
INHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B225,419,747 - 225,423,386 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,419,176 - 225,423,386 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B106,828,948 - 106,832,993 (+)NCBIMhudiblu_PPA_v0panPan3
INHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3726,080,510 - 26,083,391 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13726,080,465 - 26,083,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Inha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365691,949,747 - 1,954,179 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,580,801 - 121,586,010 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,581,847 - 121,586,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,507,304 - 134,511,349 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap15q2.5NCBI
INHA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl10105,467,963 - 105,471,688 (+)Ensembl
ChlSab1.110105,467,575 - 105,471,388 (+)NCBI
Inha
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248235,487,930 - 5,491,447 (-)NCBI

Position Markers
D9Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0982,700,141 - 82,700,263NCBIRnor6.0
Rnor_5.0982,469,402 - 82,469,524UniSTSRnor5.0
RGSC_v3.4974,780,881 - 74,781,004RGDRGSC3.4
RGSC_v3.4974,780,882 - 74,781,004UniSTSRGSC3.4
RGSC_v3.1974,927,989 - 74,928,112RGD
Celera974,564,001 - 74,564,123UniSTS
Cytogenetic Map9q33UniSTS
RH 3.4 Map9757.3UniSTS
RH 3.4 Map9757.3RGD
RH136772  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0982,703,196 - 82,703,320NCBIRnor6.0
Rnor_5.0982,472,457 - 82,472,581UniSTSRnor5.0
RGSC_v3.4974,783,937 - 74,784,061UniSTSRGSC3.4
Celera974,567,056 - 74,567,180UniSTS
Cytogenetic Map9q33UniSTS
RH 3.4 Map9744.1UniSTS
UniSTS:143587  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0982,702,445 - 82,702,889NCBIRnor6.0
Rnor_5.0982,471,706 - 82,472,150UniSTSRnor5.0
RGSC_v3.4974,783,186 - 74,783,630UniSTSRGSC3.4
Celera974,566,305 - 74,566,749UniSTS
Cytogenetic Map9q33UniSTS
ECD17211  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0982,699,055 - 82,699,463NCBIRnor6.0
Rnor_5.0982,468,316 - 82,468,724UniSTSRnor5.0
RGSC_v3.4974,779,796 - 74,780,204UniSTSRGSC3.4
Celera974,562,915 - 74,563,323UniSTS
Cytogenetic Map9q33UniSTS
REN53413  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0982,698,775 - 82,699,047NCBIRnor6.0
Rnor_5.0982,468,036 - 82,468,308UniSTSRnor5.0
RGSC_v3.4974,779,516 - 74,779,788UniSTSRGSC3.4
Celera974,562,635 - 74,562,907UniSTS
Cytogenetic Map9q33UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92569234292741406Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92748615588333183Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92907507983686404Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)929075079122095297Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)929466970107878528Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)94126103490024806Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94126103498606834Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)941261034102531865Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94657976991579769Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94657976991579769Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94695242783686153Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94724896594124663Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95417754299177542Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)96081029882732466Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)961186278106186278Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)96173092382890620Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)96173092382890620Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)96173092382890620Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)963270073107878387Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)966757444112943287Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96745166499920892Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96745166499920892Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)970241351115241351Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)970942881115942881Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)981411073119983851Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:31
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000027227
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 26 2 47 8 32
Low 3 17 35 21 17 21 8 11 27 27 7 11 8
Below cutoff 18 18 2 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027227   ⟹   ENSRNOP00000027227
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl982,700,468 - 82,703,400 (+)Ensembl
RefSeq Acc Id: NM_012590   ⟹   NP_036722
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0982,700,482 - 82,703,383 (+)NCBI
Rnor_5.0982,469,743 - 82,472,644 (+)NCBI
RGSC_v3.4974,781,223 - 74,784,124 (+)RGD
Celera974,564,342 - 74,567,243 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036722 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41437 (Get FASTA)   NCBI Sequence Viewer  
  AAH83564 (Get FASTA)   NCBI Sequence Viewer  
  EDL75453 (Get FASTA)   NCBI Sequence Viewer  
  P17490 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036722   ⟸   NM_012590
- Peptide Label: precursor
- UniProtKB: P17490 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027227   ⟸   ENSRNOT00000027227

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696783
Promoter ID:EPDNEW_R7308
Type:initiation region
Name:Inha_1
Description:inhibin alpha subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0982,700,485 - 82,700,545EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 82472270 82472271 C A snv SR/JrHsd (MCW), SR/JrHsd (KNAW), LN/MavRrrc (KNAW), LL/MavRrrc (KNAW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 82703009 82703010 C A snv SR/JrHsd (MCW), SR/JrHsd (RGD), LL/MavRrrc (RGD), LN/MavRrrc (RGD)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 74783750 74783751 C A snv SR/JrHsd (MCW), SR/JrHsd (ICL), LN/MavRrrc (ICL), LL/MavRrrc (ICL)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2912 AgrOrtholog
Ensembl Genes ENSRNOG00000020097 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000027227 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027227 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112717 IMAGE-MGC_LOAD
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Inhibin_asu UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:24504 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93593 IMAGE-MGC_LOAD
NCBI Gene 24504 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot
  PTHR11848:SF117 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
PhenoGen Inha PhenoGen
PIRSF Inhibin_alpha_subunit UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniGene Rn.8831 ENTREZGENE
UniProt INHA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Inha  inhibin subunit alpha  Inha  inhibin alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-01 Inha  inhibin alpha subunit  Inha  inhibin alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Inha  Inhibin, alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in granulosa cells of the developing follicles 61638
gene_regulation expression stimulated by FSH in the ovary 729330