Inha (inhibin subunit alpha) - Rat Genome Database

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Gene: Inha (inhibin subunit alpha) Rattus norvegicus
Analyze
Symbol: Inha
Name: inhibin subunit alpha
RGD ID: 2912
Description: Enables inhibin binding activity. Involved in male gonad development; negative regulation of follicle-stimulating hormone secretion; and ovarian follicle development. Located in several cellular components, including neuronal cell body; photoreceptor inner segment; and photoreceptor outer segment. Part of inhibin A complex and inhibin B complex. Biomarker of Leydig cell tumor. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human INHA (inhibin subunit alpha); INTERACTS WITH (S)-amphetamine; (S)-colchicine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inhibin alpha; inhibin alpha chain; inhibin alpha subunit; MGC93593
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp34  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2976,994,465 - 76,997,366 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl976,993,589 - 76,997,248 (+)Ensembl
Rnor_6.0982,700,482 - 82,703,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,700,468 - 82,703,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,469,743 - 82,472,644 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,781,223 - 74,784,124 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1974,928,355 - 74,931,217 (+)NCBI
Celera974,564,342 - 74,567,243 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
(S)-colchicine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
25-hydroxycholesterol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bucladesine  (EXP)
Butylbenzyl phthalate  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP)
clozapine  (EXP)
cocaine  (ISO)
DDE  (EXP)
dexamethasone  (EXP)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
flavonoids  (EXP)
fonofos  (ISO)
furan  (EXP)
gentamycin  (EXP)
ginsenoside Rg1  (ISO)
haloperidol  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (ISO)
methamphetamine  (EXP)
methoxyacetic acid  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
nitrofen  (EXP)
Nonylphenol  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
phenformin  (EXP)
phenylephrine  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
Ptaquiloside  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
risperidone  (ISO)
rotenone  (EXP)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
titanium dioxide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Changes in the reproductive functions of mice due to injection of a plasmid expressing an inhibin alpha-subunit into muscle: a transient transgenic model. Ahn JM, etal., Mol Cells. 2004 Aug 31;18(1):79-86.
2. Gonadal malignant germ cell tumors express immunoreactive inhibin/activin subunits. Cobellis L, etal., Eur J Endocrinol. 2001 Dec;145(6):779-84.
3. Analysis of the 5'-flanking regions of rat inhibin alpha- and beta-B-subunit genes suggests two different regulatory mechanisms. Feng ZM, etal., Mol Endocrinol 1989 Dec;3(12):1914-25.
4. Inhibin alpha-subunit and the inhibin coreceptor betaglycan are downregulated in endometrial carcinoma. Florio P, etal., Eur J Endocrinol. 2005 Feb;152(2):277-84.
5. Immunological localization and ontogenetic development of inhibin alpha subunit in rat brain. Fujimura H, etal., J Neuroendocrinol. 1999 Mar;11(3):157-63.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Development and evaluation of a novel DNA vaccine expressing inhibin alpha (1-32) fragment for improving the fertility in rats and sheep. Han L, etal., Anim Reprod Sci. 2007 Dec 31;.
9. Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. Herath CB, etal., J Androl. 2001 Sep-Oct;22(5):838-46.
10. Cytokine modulation of inhibin secretion in cultured rat granulosa cells. Imai M, etal., J Endocrinol. 1996 Dec;151(3):449-57.
11. Testicular and serum levels of inhibin and expression of inhibin subunit mRNAs are differentially affected by hemicastration in rats of various ages. Klaij IA, etal., J Endocrinol. 1994 Apr;141(1):143-51.
12. Effects of inhibin on rat gonadal differentiation and development in vitro. Koike S and Noumura T, Zoolog Sci. 1996 Jun;13(3):385-92.
13. A role of inhibin as a tumor suppressor in Sertoli cells: down-regulation upon aging and repression by a viral oncogene. Lopez P, etal., Oncogene. 1999 Dec 2;18(51):7303-9.
14. Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. Matzuk MM, etal., Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8817-21.
15. Ovarian sertoli-leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid sertoli-leydig cell tumors). McCluggage WG and Young RH, Am J Surg Pathol. 2007 Apr;31(4):592-7.
16. Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer. Mellor SL, etal., J Clin Endocrinol Metab. 1998 Mar;83(3):969-75.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Inhibin/activin subunits (inhibin-alpha, -betaA and -betaB) are differentially expressed in human breast cancer and their metastasis. Mylonas I, etal., Oncol Rep. 2005 Jan;13(1):81-8.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Regulation of the alpha inhibin gene by cyclic adenosine 3',5'-monophosphate after transfection into rat granulosa cells. Pei L, etal., Mol Endocrinol 1991 Apr;5(4):521-34.
21. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. Purdue MP, etal., Cancer Res. 2008 Apr 15;68(8):3043-8.
22. Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Immunoneutralization of endogenous inhibin modifies hormone secretion and ovulation rate in the rat. Rivier C and Vale W, Endocrinology. 1989 Jul;125(1):152-7.
26. Inhibin forms in serum from postmenopausal women with ovarian cancers. Robertson DM, etal., Clin Endocrinol (Oxf). 1999 Mar;50(3):381-6.
27. Hypermethylation of the inhibin alpha-subunit gene in prostate carcinoma. Schmitt JF, etal., Mol Endocrinol. 2002 Feb;16(2):213-20.
28. Correlation between inhibin secretion and damage of seminiferous tubules in a model of experimental autoimmune orchitis. Suescun MO, etal., J Endocrinol. 2001 Jul;170(1):113-20.
29. Rat inhibin: molecular cloning of alpha- and beta-subunit complementary deoxyribonucleic acids and expression in the ovary. Woodruff TK, etal., Mol Endocrinol 1987 Aug;1(8):561-8.
30. Expression of the inhibin/activin subunits (-alpha, -betaA and -betaB) in normal and carcinogenic endometrial tissue: possible immunohistochemical differentiation markers. Worbs S, etal., Oncol Rep. 2007 Jan;17(1):97-104.
31. Increasing blunting of inhibin responses to dynamic ovarian challenge is associated with reproductive aging in the rat. Yeh J and Kim B, Reprod Sci. 2007 Jan;14(1):10-9.
32. Expression and localization of inhibin alpha-subunit in rat retinal photoreceptor cells. Ying SY, etal., Life Sci. 1995;57(1):45-52.
33. Effects of alpha-inhibin-92 fragments and alpha-inhibin-92 antiserum on the control of follicle-stimulating hormone release in male rats. Yu WH, etal., Life Sci. 1994;55(2):93-102.
Additional References at PubMed
PMID:1310063   PMID:2484214   PMID:2829170   PMID:7890768   PMID:9032295   PMID:10746731   PMID:12477932   PMID:12732619   PMID:15070852   PMID:15489334   PMID:15650079   PMID:16269517  
PMID:16770574   PMID:19372236   PMID:19464342   PMID:22249524   PMID:23767829  


Genomics

Comparative Map Data
Inha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2976,994,465 - 76,997,366 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl976,993,589 - 76,997,248 (+)Ensembl
Rnor_6.0982,700,482 - 82,703,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,700,468 - 82,703,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,469,743 - 82,472,644 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,781,223 - 74,784,124 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1974,928,355 - 74,931,217 (+)NCBI
Celera974,564,342 - 74,567,243 (+)NCBICelera
Cytogenetic Map9q33NCBI
INHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,572,310 - 219,575,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2219,569,162 - 219,575,711 (+)EnsemblGRCh38hg38GRCh38
GRCh372220,437,032 - 220,440,433 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,145,198 - 220,148,671 (+)NCBINCBI36hg18NCBI36
Build 342220,262,458 - 220,265,932NCBI
Celera2214,206,917 - 214,210,389 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2212,289,982 - 212,293,463 (+)NCBIHuRef
CHM1_12220,442,773 - 220,446,254 (+)NCBICHM1_1
T2T-CHM13v2.02220,057,015 - 220,060,416 (+)NCBI
Inha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,483,721 - 75,487,010 (+)NCBIGRCm39mm39
GRCm39 Ensembl175,483,721 - 75,487,010 (+)Ensembl
GRCm38175,507,077 - 75,510,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,507,077 - 75,510,366 (+)EnsemblGRCm38mm10GRCm38
MGSCv37175,503,652 - 75,506,929 (+)NCBIGRCm37mm9NCBIm37
MGSCv36175,390,225 - 75,393,502 (+)NCBImm8
Celera175,996,369 - 75,999,645 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map139.16NCBI
Inha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545313,902,277 - 13,905,008 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545313,902,443 - 13,905,008 (-)NCBIChiLan1.0ChiLan1.0
INHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B225,419,747 - 225,423,386 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,419,176 - 225,423,386 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B106,828,948 - 106,832,993 (+)NCBIMhudiblu_PPA_v0panPan3
INHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13726,080,465 - 26,083,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3726,080,510 - 26,083,391 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,905,885 - 26,908,990 (+)NCBI
ROS_Cfam_1.03726,095,548 - 26,098,652 (+)NCBI
ROS_Cfam_1.0 Ensembl3726,095,593 - 26,098,473 (+)Ensembl
UMICH_Zoey_3.13725,999,522 - 26,002,625 (+)NCBI
UNSW_CanFamBas_1.03725,935,517 - 25,938,622 (+)NCBI
UU_Cfam_GSD_1.03725,956,124 - 25,959,282 (+)NCBI
Inha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,606,985 - 175,611,402 (+)NCBI
SpeTri2.0NW_0049365691,949,747 - 1,954,179 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,580,801 - 121,586,010 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,581,847 - 121,586,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,507,304 - 134,511,349 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap15q2.5NCBI
INHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,467,575 - 105,471,388 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,467,963 - 105,471,688 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604093,930,128 - 93,933,947 (-)NCBIVero_WHO_p1.0
Inha
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,487,278 - 5,491,635 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248235,487,930 - 5,491,447 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D9Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,994,123 - 76,994,246 (+)MAPPERmRatBN7.2
Rnor_6.0982,700,141 - 82,700,263NCBIRnor6.0
Rnor_5.0982,469,402 - 82,469,524UniSTSRnor5.0
RGSC_v3.4974,780,881 - 74,781,004RGDRGSC3.4
RGSC_v3.4974,780,882 - 74,781,004UniSTSRGSC3.4
RGSC_v3.1974,927,989 - 74,928,112RGD
Celera974,564,001 - 74,564,123UniSTS
RH 3.4 Map9757.3UniSTS
RH 3.4 Map9757.3RGD
Cytogenetic Map9q33UniSTS
RH136772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,997,178 - 76,997,303 (+)MAPPERmRatBN7.2
Rnor_6.0982,703,196 - 82,703,320NCBIRnor6.0
Rnor_5.0982,472,457 - 82,472,581UniSTSRnor5.0
RGSC_v3.4974,783,937 - 74,784,061UniSTSRGSC3.4
Celera974,567,056 - 74,567,180UniSTS
RH 3.4 Map9744.1UniSTS
Cytogenetic Map9q33UniSTS
UniSTS:143587  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,996,427 - 76,996,872 (+)MAPPERmRatBN7.2
Rnor_6.0982,702,445 - 82,702,889NCBIRnor6.0
Rnor_5.0982,471,706 - 82,472,150UniSTSRnor5.0
RGSC_v3.4974,783,186 - 74,783,630UniSTSRGSC3.4
Celera974,566,305 - 74,566,749UniSTS
Cytogenetic Map9q33UniSTS
ECD17211  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,993,037 - 76,993,446 (+)MAPPERmRatBN7.2
Rnor_6.0982,699,055 - 82,699,463NCBIRnor6.0
Rnor_5.0982,468,316 - 82,468,724UniSTSRnor5.0
RGSC_v3.4974,779,796 - 74,780,204UniSTSRGSC3.4
Celera974,562,915 - 74,563,323UniSTS
Cytogenetic Map9q33UniSTS
REN53413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,992,757 - 76,993,030 (+)MAPPERmRatBN7.2
Rnor_6.0982,698,775 - 82,699,047NCBIRnor6.0
Rnor_5.0982,468,036 - 82,468,308UniSTSRnor5.0
RGSC_v3.4974,779,516 - 74,779,788UniSTSRGSC3.4
Celera974,562,635 - 74,562,907UniSTS
Cytogenetic Map9q33UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:31
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000027227
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 26 2 47 8 32
Low 3 17 35 21 17 21 8 11 27 27 7 11 8
Below cutoff 18 18 2 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027227   ⟹   ENSRNOP00000027227
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,993,589 - 76,997,248 (+)Ensembl
Rnor_6.0 Ensembl982,700,468 - 82,703,400 (+)Ensembl
RefSeq Acc Id: NM_012590   ⟹   NP_036722
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2976,994,465 - 76,997,366 (+)NCBI
Rnor_6.0982,700,482 - 82,703,383 (+)NCBI
Rnor_5.0982,469,743 - 82,472,644 (+)NCBI
RGSC_v3.4974,781,223 - 74,784,124 (+)RGD
Celera974,564,342 - 74,567,243 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036722 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41437 (Get FASTA)   NCBI Sequence Viewer  
  AAH83564 (Get FASTA)   NCBI Sequence Viewer  
  EDL75453 (Get FASTA)   NCBI Sequence Viewer  
  P17490 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036722   ⟸   NM_012590
- Peptide Label: precursor
- UniProtKB: P17490 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027227   ⟸   ENSRNOT00000027227

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17490-F1-model_v2 AlphaFold P17490 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696783
Promoter ID:EPDNEW_R7308
Type:initiation region
Name:Inha_1
Description:inhibin alpha subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0982,700,485 - 82,700,545EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 82703009 82703010 C A snv SR/JrHsd (MCW), LN/MavRrrc (RGD), LL/MavRrrc (RGD), SR/JrHsd (2020), LL/MavRrrcAek (2020), LN/MavRrrcAek (2020), SR/JrHsd (RGD)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 82472270 82472271 C A snv SR/JrHsd (MCW), SR/JrHsd (KNAW), LN/MavRrrc (KNAW), LL/MavRrrc (KNAW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 74783750 74783751 C A snv SR/JrHsd (MCW), SR/JrHsd (ICL), LN/MavRrrc (ICL), LL/MavRrrc (ICL)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 76996992 76996993 C A snv LL/MavRrrcAek (2020), SR/JrHsd (2020), LN/MavRrrcAek (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2912 AgrOrtholog
BioCyc Gene G2FUF-27059 BioCyc
Ensembl Genes ENSRNOG00000020097 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000027227 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027227 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112717 IMAGE-MGC_LOAD
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Inhibin_asu UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:24504 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93593 IMAGE-MGC_LOAD
NCBI Gene 24504 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot
  PTHR11848:SF117 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
PhenoGen Inha PhenoGen
PIRSF Inhibin_alpha_subunit UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt INHA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Inha  inhibin subunit alpha  Inha  inhibin alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-01 Inha  inhibin alpha subunit  Inha  inhibin alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Inha  Inhibin, alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in granulosa cells of the developing follicles 61638
gene_regulation expression stimulated by FSH in the ovary 729330