Gene: Inha (inhibin subunit alpha) Rattus norvegicus
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Symbol:
Inha
Name:
inhibin subunit alpha
Description:
Exhibits inhibin binding activity. Involved in male gonad development; negative regulation of follicle-stimulating hormone secretion; and ovarian follicle development. Localizes to several cellular components, including the inhibin A complex; inhibin B complex; and photoreceptor inner segment. Biomarker of Leydig cell tumor. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human INHA (inhibin subunit alpha); INTERACTS WITH (S)-amphetamine; (S)-colchicine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
inhibin alpha; inhibin alpha chain; inhibin alpha subunit; MGC93593
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
INHA (inhibin subunit alpha) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Inha (inhibin alpha) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Inha (inhibin subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
INHA (inhibin subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
INHA (inhibin subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Inha (inhibin subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
INHA (inhibin subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Inha (inhibin alpha)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
INHA (inhibin subunit alpha)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
inha (inhibin subunit alpha)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Is Marker For:
QTLs:
Bp34
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 9 82,700,482 - 82,703,383 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 82,700,468 - 82,703,400 (+) Ensembl Rnor_5.0 9 82,469,743 - 82,472,644 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 74,781,223 - 74,784,124 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 9 74,928,355 - 74,931,217 (+) NCBI Celera 9 74,564,342 - 74,567,243 (+) NCBI Celera Cytogenetic Map 9 q33 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Neurodevelopmental Disorders ISO RGD:736727 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 polydactyly ISO RGD:736727 8554872 ClinVar Annotator: match by term: Polydactyly ClinVar
Imported Annotations - CTD
Familial Testotoxicosis ISO RGD:736727 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16684832 Spontaneous Abortions ISO RGD:736727 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18539642
(S)-amphetamine increases expression EXP 6480464 Dextroamphetamine results in increased expression of INHA mRNA CTD PMID:16715494 (S)-colchicine decreases expression EXP 6480464 Colchicine results in decreased expression of INHA mRNA CTD PMID:20624997 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactions EXP 6480464 2 more ... CTD PMID:19414516 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of INHA mRNA CTD PMID:12655037 , PMID:15834898 17beta-estradiol decreases expression ISO RGD:10808 6480464 Estradiol results in decreased expression of INHA mRNA CTD PMID:17255206 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of INHA protein CTD PMID:17532555 17beta-estradiol decreases abundance EXP 6480464 INHA protein results in decreased abundance of Estradiol CTD PMID:18992787 17beta-estradiol decreases expression ISO RGD:736727 6480464 Estradiol results in decreased expression of INHA mRNA CTD PMID:23373633 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of INHA mRNA CTD PMID:15644576 25-hydroxycholesterol increases expression EXP 6480464 25-hydroxycholesterol results in increased expression of INHA mRNA, 25-hydroxycholesterol results in increased expression of INHA protein CTD PMID:19464342 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of INHA mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of INHA mRNA CTD PMID:30779732 atrazine increases expression ISO RGD:736727 6480464 Atrazine results in increased expression of INHA mRNA CTD PMID:18461179 atrazine increases expression EXP 6480464 Atrazine results in increased expression of INHA mRNA CTD PMID:23200735 atrazine multiple interactions EXP 6480464 [Atrazine co-treated with Bucladesine] results in increased expression of INHA mRNA more ... CTD PMID:21693180 , PMID:23200735 atrazine multiple interactions ISO RGD:736727 6480464 NR5A1 protein promotes the reaction [Atrazine results in increased expression of INHA mRNA] CTD PMID:18461179 benzo[a]pyrene increases mutagenesis ISO RGD:736727 6480464 Benzo(a)pyrene results in increased mutagenesis of INHA gene CTD PMID:25435355 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of INHA mRNA CTD PMID:26472102 bis(2-ethylhexyl) phthalate increases expression ISO RGD:736727 6480464 Diethylhexyl Phthalate results in increased expression of INHA mRNA CTD PMID:31163220 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of INHA mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:736727 6480464 bisphenol A affects the expression of INHA mRNA CTD PMID:30903817 bucladesine decreases expression EXP 6480464 Bucladesine results in decreased expression of INHA mRNA CTD PMID:21693180 bucladesine multiple interactions EXP 6480464 [Atrazine co-treated with Bucladesine] results in increased expression of INHA mRNA more ... CTD PMID:21693180 , PMID:23200735 Butylbenzyl phthalate decreases expression EXP 6480464 butylbenzyl phthalate results in decreased expression of INHA mRNA CTD PMID:26472102 chlorpyrifos increases expression ISO RGD:10808 6480464 Chlorpyrifos results in increased expression of INHA mRNA CTD PMID:20350560 clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of INHA mRNA CTD PMID:16715494 cocaine decreases expression ISO RGD:736727 6480464 Cocaine results in decreased expression of INHA mRNA CTD PMID:18000554 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of INHA mRNA CTD PMID:14618091 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of INHA mRNA CTD PMID:14618091 Di-n-hexyl phthalate decreases expression EXP 6480464 di-n-hexyl phthalate results in decreased expression of INHA mRNA CTD PMID:22112501 dibutyl phthalate increases expression ISO RGD:736727 6480464 Dibutyl Phthalate results in increased expression of INHA mRNA CTD PMID:18214805 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of INHA mRNA, Dibutyl Phthalate results in decreased expression of INHA protein CTD PMID:17379624 more ... dichloroacetic acid decreases expression ISO RGD:10808 6480464 Dichloroacetic Acid results in decreased expression of INHA mRNA CTD PMID:28962523 diethyl phthalate increases expression EXP 6480464 diethyl phthalate results in increased expression of INHA mRNA CTD PMID:26472102 diethylstilbestrol multiple interactions EXP 6480464 Diethylstilbestrol promotes the reaction [FSHB protein results in increased expression of INHA mRNA] CTD PMID:15878960 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of INHA protein CTD PMID:9361775 diheptyl phthalate decreases expression EXP 6480464 diheptyl phthalate results in decreased expression of INHA mRNA CTD PMID:22112501 dipentyl phthalate multiple interactions EXP 6480464 [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INHA mRNA CTD PMID:25055962 dipentyl phthalate decreases expression EXP 6480464 di-n-pentyl phthalate results in decreased expression of INHA mRNA CTD PMID:25055962 , PMID:26472102 disodium selenite multiple interactions ISO RGD:10808 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of INHA mRNA CTD PMID:23274088 doxorubicin affects expression ISO RGD:736727 6480464 Doxorubicin affects the expression of INHA mRNA CTD PMID:29803840 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of INHA mRNA CTD PMID:29391264 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of INHA mRNA CTD PMID:18035473 fonofos increases methylation ISO RGD:736727 6480464 Fonofos results in increased methylation of INHA promoter CTD PMID:22847954 furan increases expression EXP 6480464 furan results in increased expression of INHA mRNA CTD PMID:20562052 , PMID:22079235 haloperidol decreases expression EXP 6480464 Haloperidol results in decreased expression of INHA mRNA CTD PMID:16715494 lead(0) affects expression ISO RGD:736727 6480464 Lead affects the expression of INHA mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:736727 6480464 Lead affects the expression of INHA mRNA CTD PMID:28903495 levonorgestrel multiple interactions ISO RGD:736727 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of INHA mRNA CTD PMID:19074003 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of INHA mRNA CTD PMID:19149911 methamphetamine multiple interactions EXP 6480464 Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of INHA mRNA] CTD PMID:19149911 methoxyacetic acid increases secretion EXP 6480464 methoxyacetic acid results in increased secretion of INHA protein CTD PMID:1898883 mono(2-ethylhexyl) phthalate decreases expression EXP 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of INHA mRNA CTD PMID:22087261 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of INHA mRNA CTD PMID:26720608 Nonylphenol increases expression EXP 6480464 nonylphenol results in increased expression of INHA mRNA CTD PMID:27832966 paracetamol decreases expression ISO RGD:736727 6480464 Acetaminophen results in decreased expression of INHA mRNA CTD PMID:22230336 parathion increases methylation ISO RGD:736727 6480464 Parathion results in increased methylation of INHA promoter CTD PMID:22847954 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of INHA mRNA CTD PMID:18158353 pirinixic acid increases expression ISO RGD:10808 6480464 pirinixic acid results in increased expression of INHA mRNA CTD PMID:20813756 progesterone multiple interactions ISO RGD:736727 6480464 INHA mutant form inhibits the reaction [FSHB protein results in increased secretion of Progesterone], INHA mutant form inhibits the reaction [GDF9 protein inhibits the reaction [INHBA protein inhibits the reaction [FSHB protein results in increased secretion of Progesterone]]] CTD PMID:20660033 progesterone increases expression ISO RGD:10808 6480464 Progesterone results in increased expression of INHA mRNA CTD PMID:22285243 progesterone decreases abundance EXP 6480464 INHA protein results in decreased abundance of Progesterone CTD PMID:18992787 Ptaquiloside multiple interactions ISO RGD:10808 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of INHA mRNA CTD PMID:23274088 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of INHA mRNA], Quercetin inhibits the reaction [Atrazine results in increased expression of INHA mRNA] CTD PMID:23200735 risperidone multiple interactions ISO RGD:736727 6480464 Risperidone results in increased expression of [INHA protein binds to INHBB protein] CTD PMID:18838228 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of INHA mRNA CTD PMID:28374803 simvastatin multiple interactions EXP 6480464 [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INHA mRNA CTD PMID:25055962 sodium arsenite decreases expression ISO RGD:736727 6480464 sodium arsenite results in decreased expression of INHA mRNA CTD PMID:29301061 sodium fluoride increases expression ISO RGD:10808 6480464 Sodium Fluoride results in increased expression of INHA protein CTD PMID:28918527 terbufos increases methylation ISO RGD:736727 6480464 terbufos results in increased methylation of INHA promoter CTD PMID:22847954 testosterone multiple interactions ISO RGD:736727 6480464 [FSHB protein co-treated with Testosterone] results in increased expression of INHA mRNA CTD PMID:18535249 testosterone undecanoate multiple interactions ISO RGD:736727 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of INHA mRNA CTD PMID:19074003 testosterone undecanoate decreases expression ISO RGD:736727 6480464 testosterone undecanoate results in decreased expression of INHA mRNA CTD PMID:19074003 titanium dioxide decreases expression ISO RGD:10808 6480464 titanium dioxide results in decreased expression of INHA mRNA, titanium dioxide results in decreased expression of INHA protein CTD PMID:23565150 troglitazone decreases expression ISO RGD:736727 6480464 troglitazone results in decreased expression of INHA mRNA CTD PMID:19140230 urethane multiple interactions ISO RGD:10808 6480464 [Urethane co-treated with Freund's Adjuvant] results in increased expression of INHA mRNA CTD PMID:12400877 urethane decreases expression ISO RGD:736727 6480464 Urethane results in decreased expression of INHA mRNA CTD PMID:28818685 urethane increases expression ISO RGD:10808 6480464 Urethane results in increased expression of INHA mRNA CTD PMID:12400877 valproic acid increases methylation ISO RGD:736727 6480464 Valproic Acid results in increased methylation of INHA gene CTD PMID:29154799 valproic acid multiple interactions EXP 6480464 Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of INHA mRNA] CTD PMID:19149911 vincaleukoblastine decreases expression EXP 6480464 Vinblastine results in decreased expression of INHA mRNA CTD PMID:20624997 vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of INHA mRNA CTD PMID:20624997
Gene-Chemical Interaction Annotations
