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Gene: Cflar (CASP8 and FADD-like apoptosis regulator) Rattus norvegicus
Symbol: Cflar
Name: CASP8 and FADD-like apoptosis regulator
Description: Exhibits death receptor binding activity and protease binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Localizes to CD95 death-inducing signaling complex and membrane raft. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator); PARTICIPATES IN FasL mediated signaling pathway; Trail mediated signaling pathway; apoptotic cell death pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Flip; MGC108616
Homo sapiens (human) : CFLAR (CASP8 and FADD like apoptosis regulator)  HGNC  Alliance
Mus musculus (house mouse) : Cflar (CASP8 and FADD-like apoptosis regulator)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cflar (CASP8 and FADD like apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CFLAR (CASP8 and FADD like apoptosis regulator)
Canis lupus familiaris (dog) : CFLAR (CASP8 and FADD like apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cflar (CASP8 and FADD like apoptosis regulator)
Sus scrofa (pig) : CFLAR (CASP8 and FADD like apoptosis regulator)
Chlorocebus sabaeus (African green monkey) : CFLAR (CASP8 and FADD like apoptosis regulator)
Heterocephalus glaber (naked mole-rat) : Cflar (CASP8 and FADD like apoptosis regulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0965,534,608 - 65,586,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,534,704 - 65,587,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,342,359 - 65,390,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,309,836 - 57,356,635 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1957,475,312 - 57,481,853 (+)NCBI
Celera957,626,739 - 57,673,502 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cflar
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620847
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.