Cflar (CASP8 and FADD-like apoptosis regulator) - Rat Genome Database

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Gene: Cflar (CASP8 and FADD-like apoptosis regulator) Rattus norvegicus
Analyze
Symbol: Cflar
Name: CASP8 and FADD-like apoptosis regulator
RGD ID: 620847
Description: Enables death receptor binding activity and protease binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in membrane raft. Part of CD95 death-inducing signaling complex. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator); PARTICIPATES IN FasL mediated signaling pathway; Trail mediated signaling pathway; apoptotic cell death pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Flip; MGC108616
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2960,185,338 - 60,236,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,185,452 - 60,237,034 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx968,680,901 - 68,731,637 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0973,796,857 - 73,847,595 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0972,115,115 - 72,165,854 (+)NCBIRnor_WKY
Rnor_6.0965,534,608 - 65,586,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,534,704 - 65,587,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,342,359 - 65,390,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,309,836 - 57,356,635 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1957,475,312 - 57,481,853 (+)NCBI
Celera957,626,739 - 57,673,502 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alvocidib  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP,ISO)
arsenous acid  (ISO)
baicalein  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
cafestol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
Cardanol  (ISO)
celecoxib  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dimethyl sulfoxide  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
epoxomicin  (ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
Glutathione ethyl ester  (ISO)
glycochenodeoxycholic acid  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hyperforin  (ISO)
ibrutinib  (ISO)
idelalisib  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
jaceosidin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lonafarnib  (ISO)
LY294002  (ISO)
lysophosphatidylethanolamine  (ISO)
magnesium oxide  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
methotrexate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP,ISO)
Mitotane  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
pemetrexed  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorooctanoic acid  (ISO)
pevonedistat  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
romidepsin  (ISO)
rubimaillin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
succimer  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
Tylophorine  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zerumbone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
apoptotic process  (ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to nitric oxide  (IMP)
erythrocyte differentiation  (IBA)
keratinocyte differentiation  (IBA)
necroptotic process  (ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cellular response to transforming growth factor beta stimulus  (IMP)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of epithelial cell apoptotic process  (IDA)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of hepatocyte apoptotic process  (IMP)
negative regulation of myoblast fusion  (ISO)
negative regulation of necroptotic process  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
neuron differentiation  (IBA)
positive regulation of apoptotic process  (IBA)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of extracellular matrix organization  (IMP)
positive regulation of glomerular mesangial cell proliferation  (IMP)
positive regulation of hepatocyte proliferation  (IMP)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
proteolysis  (IEA)
regulation of necroptotic process  (ISO)
regulation of skeletal muscle satellite cell proliferation  (ISO)
response to bacterium  (ISO)
response to hypoxia  (IEP)
response to testosterone  (IDA)
skeletal muscle atrophy  (ISO)
skeletal muscle tissue development  (ISO)
skeletal muscle tissue regeneration  (ISO)
skeletal myofibril assembly  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of FLIP(Long) and FLIP(Short) in bone marrow mononuclear and CD34+ cells in patients with myelodysplastic syndrome: correlation with apoptosis. Benesch M, etal., Leukemia. 2003 Dec;17(12):2460-6.
2. Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein. Bhuiyan MS, etal., Cardiovasc Ther. 2008 Spring;26(1):10-23. doi: 10.1111/j.1527-3466.2008.00039.x.
3. C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. Cudrici C, etal., J Immunol. 2006 Mar 1;176(5):3173-80.
4. FLIP protects cardiomyocytes from apoptosis induced by simulated ischemia/reoxygenation, as demonstrated by short hairpin-induced (shRNA) silencing of FLIP mRNA. Davidson SM, etal., J Mol Cell Cardiol. 2003 Nov;35(11):1359-64.
5. FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury. Davis AR, etal., J Neurotrauma. 2007 May;24(5):823-34.
6. A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury. Dzietko M, etal., Ann Neurol. 2008 Dec;64(6):664-73. doi: 10.1002/ana.21516.
7. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
8. Emodin suppresses hyperglycemia-induced proliferation and fibronectin expression in mesangial cells via inhibiting cFLIP. Gao J, etal., PLoS One. 2014 Apr 1;9(4):e93588. doi: 10.1371/journal.pone.0093588. eCollection 2014.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. A role for caspase-8 and c-FLIPL in proliferation and cell-cycle progression of primary hepatocytes. Gilot D, etal., Carcinogenesis. 2005 Dec;26(12):2086-94. Epub 2005 Jul 20.
11. Cellular FLICE-like inhibitory protein deviates myofibroblast fas-induced apoptosis toward proliferation during lung fibrosis. Golan-Gerstl R, etal., Am J Respir Cell Mol Biol. 2012 Sep;47(3):271-9. doi: 10.1165/rcmb.2010-0284RC. Epub 2012 May 10.
12. Expression of cellular FLICE-inhibitory protein in human coronary arteries and in a rat vascular injury model. Imanishi T, etal., Am J Pathol. 2000 Jan;156(1):125-37.
13. Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues. Imanishi T, etal., Cardiovasc Res. 2000 Oct;48(1):101-10.
14. Estradiol Upregulates c-FLIPlong Expression in Anterior Pituitary Cells. Jaita G, etal., Horm Metab Res. 2016 Apr;48(4):275-9. doi: 10.1055/s-0035-1565068. Epub 2015 Nov 13.
15. TNFalpha induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathway. Marques-Fernandez F, etal., Cell Death Dis. 2013 Feb 14;4:e493. doi: 10.1038/cddis.2013.25.
16. Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia. McLornan D, etal., Br J Haematol. 2013 Jan;160(2):188-98. doi: 10.1111/bjh.12108. Epub 2012 Nov 20.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins. Moubarak RS, etal., J Neurosci. 2010 Apr 28;30(17):6094-105. doi: 10.1523/JNEUROSCI.0537-10.2010.
19. Androgen regulation of FLICE-like inhibitory protein gene expression in the rat prostate. Nastiuk KL, etal., J Cell Physiol 2003 Aug;196(2):386-93.
20. FLICE-like inhibitory protein blocks transforming growth factor beta 1-induced caspase activation and apoptosis in prostate epithelial cells. Nastiuk KL, etal., Mol Cancer Res. 2008 Feb;6(2):231-42. doi: 10.1158/1541-7786.MCR-07-0386.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Dexamethasone protects primary cultured hepatocytes from death receptor-mediated apoptosis by upregulation of cFLIP. Oh HY, etal., Cell Death Differ. 2006 Mar;13(3):512-23.
23. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. The many roles of FAS receptor signaling in the immune system. Strasser A, etal., Immunity. 2009 Feb 20;30(2):180-92.
29. The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation. Wang L, etal., J Immunol. 2008 Mar 1;180(5):3072-80.
30. Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis. Wang W, etal., J Biol Chem 2002 Jun 14;277(24):21723-9.
31. Nuclear factor kappaB-mediated induction of Flice-like inhibitory protein prevents tumor necrosis factor alpha-induced apoptosis in rat granulosa cells. Xiao CW, etal., Biol Reprod 2002 Aug;67(2):436-41.
32. Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis induced by activation of the Fas (CD95/Apo-1) receptor: Fas activation and apoptosis in hypoxic myocytes. Yaniv G, etal., Cardiovasc Res. 2002 Jun;54(3):611-23.
33. [Hypobaric hypoxia increases the expression of death receptor 5 and inhibits that of FLICE-like inhibitory protein in the rat testis]. Yin J, etal., Zhonghua Nan Ke Xue. 2013 Jul;19(7):588-92.
Additional References at PubMed
PMID:8889548   PMID:9208847   PMID:12477932   PMID:12477972   PMID:12761501   PMID:12947022   PMID:15774698   PMID:16263940   PMID:17658509   PMID:18073330   PMID:18202225   PMID:18566605  
PMID:18726983   PMID:21364645   PMID:21368763   PMID:21737330   PMID:21803845   PMID:21903094   PMID:22089168   PMID:22266862   PMID:22675671   PMID:23012479   PMID:26582200   PMID:28498469  


Genomics

Comparative Map Data
Cflar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2960,185,338 - 60,236,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,185,452 - 60,237,034 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx968,680,901 - 68,731,637 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0973,796,857 - 73,847,595 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0972,115,115 - 72,165,854 (+)NCBIRnor_WKY
Rnor_6.0965,534,608 - 65,586,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,534,704 - 65,587,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,342,359 - 65,390,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,309,836 - 57,356,635 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1957,475,312 - 57,481,853 (+)NCBI
Celera957,626,739 - 57,673,502 (+)NCBICelera
Cytogenetic Map9q31NCBI
CFLAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382201,116,164 - 201,176,687 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2201,116,154 - 201,176,687 (+)EnsemblGRCh38hg38GRCh38
GRCh372201,980,887 - 202,041,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,689,135 - 201,737,260 (+)NCBINCBI36Build 36hg18NCBI36
Build 342201,806,395 - 201,854,507NCBI
Celera2195,735,441 - 195,783,644 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2193,832,403 - 193,888,781 (+)NCBIHuRef
CHM1_12201,986,842 - 202,043,389 (+)NCBICHM1_1
T2T-CHM13v2.02201,599,606 - 201,660,139 (+)NCBIT2T-CHM13v2.0
Cflar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,750,353 - 58,798,043 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,750,667 - 58,798,043 (+)EnsemblGRCm39 Ensembl
GRCm38158,711,311 - 58,758,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,711,508 - 58,758,884 (+)EnsemblGRCm38mm10GRCm38
MGSCv37158,770,130 - 58,815,728 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36158,657,840 - 58,699,711 (+)NCBIMGSCv36mm8
Celera159,232,248 - 59,277,933 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.16NCBI
Cflar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403412,632 - 434,741 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955403415,092 - 442,214 (-)NCBIChiLan1.0ChiLan1.0
CFLAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B206,528,943 - 206,585,848 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,528,943 - 206,577,045 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B88,373,057 - 88,429,959 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CFLAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,268,407 - 10,307,803 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,268,582 - 10,345,095 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3711,153,354 - 11,191,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03710,173,456 - 10,212,316 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3710,173,527 - 10,222,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13710,154,909 - 10,193,670 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03710,133,242 - 10,172,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03710,126,854 - 10,165,741 (+)NCBIUU_Cfam_GSD_1.0
Cflar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,411,636 - 158,453,829 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936726381,835 - 423,311 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936726381,888 - 425,565 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFLAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,781,616 - 104,835,630 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,780,744 - 104,835,631 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,105,245 - 116,184,924 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFLAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11086,768,252 - 86,819,963 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1086,782,240 - 86,816,652 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040112,604,271 - 112,651,003 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cflar
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462488975,396 - 100,989 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462488976,760 - 108,619 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cflar
233 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000016730
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat

Markers in Region
RH133639  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,234,126 - 60,234,317 (+)MAPPERmRatBN7.2
Rnor_6.0965,584,344 - 65,584,534NCBIRnor6.0
Rnor_5.0965,391,116 - 65,391,306UniSTSRnor5.0
RGSC_v3.4957,358,533 - 57,358,723UniSTSRGSC3.4
Celera957,675,400 - 57,675,590UniSTS
RH 3.4 Map9478.27UniSTS
Cytogenetic Map9q31UniSTS
RH133684  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,236,761 - 60,236,972 (+)MAPPERmRatBN7.2
Rnor_6.0965,586,979 - 65,587,189NCBIRnor6.0
Rnor_5.0965,393,751 - 65,393,961UniSTSRnor5.0
RGSC_v3.4957,361,168 - 57,361,378UniSTSRGSC3.4
Celera957,678,035 - 57,678,245UniSTS
RH 3.4 Map9495.69UniSTS
Cytogenetic Map9q31UniSTS
BE112005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,187,607 - 60,187,784 (+)MAPPERmRatBN7.2
Rnor_6.0965,536,860 - 65,537,036NCBIRnor6.0
Rnor_5.0965,344,604 - 65,344,780UniSTSRnor5.0
RGSC_v3.4957,311,992 - 57,312,168UniSTSRGSC3.4
Celera957,628,901 - 57,629,077UniSTS
RH 3.4 Map9494.79UniSTS
Cytogenetic Map9q31UniSTS
AI169244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,210,293 - 60,210,443 (+)MAPPERmRatBN7.2
Rnor_6.0965,560,511 - 65,560,660NCBIRnor6.0
Rnor_5.0965,367,286 - 65,367,435UniSTSRnor5.0
RGSC_v3.4957,369,365 - 57,369,515UniSTSRGSC3.4
RGSC_v3.4957,334,701 - 57,334,850UniSTSRGSC3.4
Celera957,651,574 - 57,651,723UniSTS
RH 3.4 Map9494.8UniSTS
Cytogenetic Map9q31UniSTS
AA946075  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,196,024 - 60,196,251 (+)MAPPERmRatBN7.2
Rnor_6.0965,545,276 - 65,545,502NCBIRnor6.0
Rnor_5.0965,353,020 - 65,353,246UniSTSRnor5.0
RGSC_v3.4957,320,408 - 57,320,634UniSTSRGSC3.4
Celera957,637,317 - 57,637,543UniSTS
RH 3.4 Map9514.5UniSTS
Cytogenetic Map9q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 12 31 15 19 15 8 9 19 29 24 11 8
Low 31 26 26 26 2 55 6 17
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_057138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF244366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM388207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF108550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000016730   ⟹   ENSRNOP00000016730
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl960,185,452 - 60,237,034 (+)Ensembl
Rnor_6.0 Ensembl965,534,704 - 65,587,251 (+)Ensembl
RefSeq Acc Id: NM_001033864   ⟹   NP_001029036
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,376 - 60,236,173 (+)NCBI
Rnor_6.0965,534,704 - 65,582,446 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
RGSC_v3.4957,309,836 - 57,356,635 (+)RGD
Celera957,626,739 - 57,673,502 (+)RGD
Sequence:
RefSeq Acc Id: NM_057138   ⟹   NP_476479
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,376 - 60,210,470 (+)NCBI
Rnor_6.0965,534,704 - 65,560,687 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
RGSC_v3.4957,309,836 - 57,356,635 (+)RGD
Celera957,626,739 - 57,651,750 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244948   ⟹   XP_006245010
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,193,179 - 60,236,173 (+)NCBI
Rnor_6.0965,542,478 - 65,586,395 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244949   ⟹   XP_006245011
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,371 - 60,236,173 (+)NCBI
Rnor_6.0965,534,608 - 65,586,395 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082957   ⟹   XP_038938885
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,338 - 60,236,173 (+)NCBI
RefSeq Acc Id: XM_039082958   ⟹   XP_038938886
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,524 - 60,236,173 (+)NCBI
RefSeq Acc Id: XM_039082959   ⟹   XP_038938887
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,186,151 - 60,236,173 (+)NCBI
RefSeq Acc Id: XM_039082961   ⟹   XP_038938889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,338 - 60,236,173 (+)NCBI
RefSeq Acc Id: XM_039082962   ⟹   XP_038938890
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,338 - 60,236,173 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001029036   ⟸   NM_001033864
- Peptide Label: isoform 1
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_476479   ⟸   NM_057138
- Peptide Label: isoform 2
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL),   Q99MZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245011   ⟸   XM_006244949
- Peptide Label: isoform X1
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245010   ⟸   XM_006244948
- Peptide Label: isoform X1
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016730   ⟸   ENSRNOT00000016730
RefSeq Acc Id: XP_038938889   ⟸   XM_039082961
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038938890   ⟸   XM_039082962
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938885   ⟸   XM_039082957
- Peptide Label: isoform X1
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938886   ⟸   XM_039082958
- Peptide Label: isoform X1
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938887   ⟸   XM_039082959
- Peptide Label: isoform X1
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL)
Protein Domains
Caspase family p20   DED

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-C0H5Y5-F1-model_v2 AlphaFold C0H5Y5 1-480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696693
Promoter ID:EPDNEW_R7217
Type:initiation region
Name:Cflar_1
Description:CASP8 and FADD-like apoptosis regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0965,534,623 - 65,534,683EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620847 AgrOrtholog
BioCyc Gene G2FUF-27442 BioCyc
Ensembl Genes ENSRNOG00000012473 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016730 ENTREZGENE
  ENSRNOP00000016730.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016730 ENTREZGENE
  ENSRNOT00000016730.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7376876 IMAGE-MGC_LOAD
InterPro Caspase-like_dom UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_ICE_p20 UniProtKB/TrEMBL
  Pept_C14_p45_core UniProtKB/TrEMBL
KEGG Report rno:117279 UniProtKB/TrEMBL
MGC_CLONE MGC:108616 IMAGE-MGC_LOAD
NCBI Gene 117279 ENTREZGENE
PANTHER CASP8 AND FADD-LIKE APOPTOSIS REGULATOR A-RELATED UniProtKB/TrEMBL
  DED DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam DED UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PhenoGen Cflar PhenoGen
PROSITE CASPASE_P20 UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt C0H5Y5 ENTREZGENE, UniProtKB/TrEMBL
  Q99MZ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cflar  CASP8 and FADD-like apoptosis regulator      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cflar  CASP8 and FADD-like apoptosis regulator      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is induced by TNF alpha 632418