Cflar (CASP8 and FADD-like apoptosis regulator) - Rat Genome Database

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Gene: Cflar (CASP8 and FADD-like apoptosis regulator) Rattus norvegicus
Analyze
Symbol: Cflar
Name: CASP8 and FADD-like apoptosis regulator
RGD ID: 620847
Description: Exhibits death receptor binding activity and protease binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Localizes to CD95 death-inducing signaling complex and membrane raft. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator); PARTICIPATES IN FasL mediated signaling pathway; Trail mediated signaling pathway; apoptotic cell death pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Flip; MGC108616
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2960,185,338 - 60,236,173 (+)NCBI
Rnor_6.0 Ensembl965,534,704 - 65,587,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0965,534,608 - 65,586,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0965,342,359 - 65,390,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,309,836 - 57,356,635 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1957,475,312 - 57,481,853 (+)NCBI
Celera957,626,739 - 57,673,502 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Anacardic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (EXP)
arsenous acid  (ISO)
baicalein  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
cafestol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
Deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dimethyl sulfoxide  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxomicin  (ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gingerol  (ISO)
glycochenodeoxycholic acid  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hyperforin  (ISO)
ibrutinib  (ISO)
idelalisib  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
jaceosidin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lonafarnib  (ISO)
LY294002  (ISO)
lysophosphatidylethanolamine  (ISO)
magnesium oxide  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
methotrexate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP,ISO)
Mitotane  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
pemetrexed  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorooctanoic acid  (ISO)
pevonedistat  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
romidepsin  (ISO)
rubimaillin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
succimer  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
Tylophorine  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zerumbone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA)
apoptotic process  (IBA,ISO)
apoptotic signaling pathway  (IEA)
cellular response to dexamethasone stimulus  (IEP)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to nitric oxide  (IMP)
execution phase of apoptosis  (IEA)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cellular response to transforming growth factor beta stimulus  (IMP)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of epithelial cell apoptotic process  (IDA)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IBA,ISO)
negative regulation of hepatocyte apoptotic process  (IMP)
negative regulation of myoblast fusion  (ISO)
negative regulation of necroptotic process  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of extracellular matrix organization  (IMP)
positive regulation of glomerular mesangial cell proliferation  (IMP)
positive regulation of hepatocyte proliferation  (IMP)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
proteolysis  (IEA)
regulation of necroptotic process  (ISO)
regulation of skeletal muscle satellite cell proliferation  (ISO)
response to bacterium  (ISO)
response to hypoxia  (IEP)
response to testosterone  (IDA)
skeletal muscle atrophy  (ISO)
skeletal muscle tissue development  (ISO)
skeletal muscle tissue regeneration  (ISO)
skeletal myofibril assembly  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Benesch M, etal., Leukemia. 2003 Dec;17(12):2460-6.
2. Bhuiyan MS, etal., Cardiovasc Ther. 2008 Spring;26(1):10-23. doi: 10.1111/j.1527-3466.2008.00039.x.
3. Cudrici C, etal., J Immunol. 2006 Mar 1;176(5):3173-80.
4. Davidson SM, etal., J Mol Cell Cardiol. 2003 Nov;35(11):1359-64.
5. Davis AR, etal., J Neurotrauma. 2007 May;24(5):823-34.
6. Dzietko M, etal., Ann Neurol. 2008 Dec;64(6):664-73. doi: 10.1002/ana.21516.
7. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
8. Gao J, etal., PLoS One. 2014 Apr 1;9(4):e93588. doi: 10.1371/journal.pone.0093588. eCollection 2014.
9. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Gilot D, etal., Carcinogenesis. 2005 Dec;26(12):2086-94. Epub 2005 Jul 20.
11. Golan-Gerstl R, etal., Am J Respir Cell Mol Biol. 2012 Sep;47(3):271-9. doi: 10.1165/rcmb.2010-0284RC. Epub 2012 May 10.
12. Imanishi T, etal., Am J Pathol. 2000 Jan;156(1):125-37.
13. Imanishi T, etal., Cardiovasc Res. 2000 Oct;48(1):101-10.
14. Jaita G, etal., Horm Metab Res. 2016 Apr;48(4):275-9. doi: 10.1055/s-0035-1565068. Epub 2015 Nov 13.
15. Marques-Fernandez F, etal., Cell Death Dis. 2013 Feb 14;4:e493. doi: 10.1038/cddis.2013.25.
16. McLornan D, etal., Br J Haematol. 2013 Jan;160(2):188-98. doi: 10.1111/bjh.12108. Epub 2012 Nov 20.
17. MGD data from the GO Consortium
18. Moubarak RS, etal., J Neurosci. 2010 Apr 28;30(17):6094-105. doi: 10.1523/JNEUROSCI.0537-10.2010.
19. Nastiuk KL, etal., J Cell Physiol 2003 Aug;196(2):386-93.
20. Nastiuk KL, etal., Mol Cancer Res. 2008 Feb;6(2):231-42. doi: 10.1158/1541-7786.MCR-07-0386.
21. NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Oh HY, etal., Cell Death Differ. 2006 Mar;13(3):512-23.
23. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
24. Pipeline to import KEGG annotations from KEGG into RGD
25. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. RGD automated data pipeline
27. RGD automated import pipeline for gene-chemical interactions
28. Strasser A, etal., Immunity. 2009 Feb 20;30(2):180-92.
29. Wang L, etal., J Immunol. 2008 Mar 1;180(5):3072-80.
30. Wang W, etal., J Biol Chem 2002 Jun 14;277(24):21723-9.
31. Xiao CW, etal., Biol Reprod 2002 Aug;67(2):436-41.
32. Yaniv G, etal., Cardiovasc Res. 2002 Jun;54(3):611-23.
33. Yin J, etal., Zhonghua Nan Ke Xue. 2013 Jul;19(7):588-92.
Additional References at PubMed
PMID:8889548   PMID:9208847   PMID:12477932   PMID:12477972   PMID:12761501   PMID:12947022   PMID:15774698   PMID:16263940   PMID:17658509   PMID:18073330   PMID:18202225   PMID:18566605  
PMID:18726983   PMID:21364645   PMID:21368763   PMID:21737330   PMID:21803845   PMID:21903094   PMID:22089168   PMID:22266862   PMID:22675671   PMID:23012479   PMID:26582200   PMID:28498469  


Genomics

Comparative Map Data
Cflar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2960,185,338 - 60,236,173 (+)NCBI
Rnor_6.0 Ensembl965,534,704 - 65,587,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0965,534,608 - 65,586,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0965,342,359 - 65,390,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,309,836 - 57,356,635 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1957,475,312 - 57,481,853 (+)NCBI
Celera957,626,739 - 57,673,502 (+)NCBICelera
Cytogenetic Map9q31NCBI
CFLAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2201,116,154 - 201,176,687 (+)EnsemblGRCh38hg38GRCh38
GRCh382201,116,164 - 201,176,687 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372201,980,887 - 202,041,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,689,135 - 201,737,260 (+)NCBINCBI36hg18NCBI36
Build 342201,806,395 - 201,854,507NCBI
Celera2195,735,441 - 195,783,644 (+)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2193,832,403 - 193,888,781 (+)NCBIHuRef
CHM1_12201,986,792 - 202,043,389 (+)NCBICHM1_1
Cflar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,750,353 - 58,798,043 (+)NCBIGRCm39mm39
GRCm39 Ensembl158,750,667 - 58,798,043 (+)Ensembl
GRCm38158,711,311 - 58,758,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,711,508 - 58,758,884 (+)EnsemblGRCm38mm10GRCm38
MGSCv37158,770,130 - 58,815,728 (+)NCBIGRCm37mm9NCBIm37
MGSCv36158,657,840 - 58,699,711 (+)NCBImm8
Celera159,232,248 - 59,277,933 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.16NCBI
Cflar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403412,632 - 434,741 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955403415,092 - 442,214 (-)NCBIChiLan1.0ChiLan1.0
CFLAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B206,528,943 - 206,585,848 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,528,943 - 206,577,045 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B88,373,057 - 88,429,959 (+)NCBIMhudiblu_PPA_v0panPan3
CFLAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,268,407 - 10,307,803 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,268,582 - 10,345,095 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3711,153,354 - 11,191,827 (+)NCBI
ROS_Cfam_1.03710,173,456 - 10,212,316 (+)NCBI
UMICH_Zoey_3.13710,154,909 - 10,193,670 (+)NCBI
UNSW_CanFamBas_1.03710,133,242 - 10,172,157 (+)NCBI
UU_Cfam_GSD_1.03710,126,854 - 10,165,741 (+)NCBI
Cflar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,411,636 - 158,453,829 (+)NCBI
SpeTri2.0NW_004936726381,888 - 425,565 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFLAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,781,615 - 104,844,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,780,744 - 104,835,631 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,105,245 - 116,184,924 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFLAR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11086,768,252 - 86,819,963 (+)NCBI
ChlSab1.1 Ensembl1086,782,240 - 86,816,652 (+)Ensembl
Cflar
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462488976,760 - 108,619 (-)NCBI

Position Markers
RH133639  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0965,584,344 - 65,584,534NCBIRnor6.0
Rnor_5.0965,391,116 - 65,391,306UniSTSRnor5.0
RGSC_v3.4957,358,533 - 57,358,723UniSTSRGSC3.4
Celera957,675,400 - 57,675,590UniSTS
RH 3.4 Map9478.27UniSTS
Cytogenetic Map9q31UniSTS
RH133684  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0965,586,979 - 65,587,189NCBIRnor6.0
Rnor_5.0965,393,751 - 65,393,961UniSTSRnor5.0
RGSC_v3.4957,361,168 - 57,361,378UniSTSRGSC3.4
Celera957,678,035 - 57,678,245UniSTS
RH 3.4 Map9495.69UniSTS
Cytogenetic Map9q31UniSTS
BE112005  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0965,536,860 - 65,537,036NCBIRnor6.0
Rnor_5.0965,344,604 - 65,344,780UniSTSRnor5.0
RGSC_v3.4957,311,992 - 57,312,168UniSTSRGSC3.4
Celera957,628,901 - 57,629,077UniSTS
RH 3.4 Map9494.79UniSTS
Cytogenetic Map9q31UniSTS
AI169244  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0965,560,511 - 65,560,660NCBIRnor6.0
Rnor_5.0965,367,286 - 65,367,435UniSTSRnor5.0
RGSC_v3.4957,369,365 - 57,369,515UniSTSRGSC3.4
RGSC_v3.4957,334,701 - 57,334,850UniSTSRGSC3.4
Celera957,651,574 - 57,651,723UniSTS
RH 3.4 Map9494.8UniSTS
Cytogenetic Map9q31UniSTS
AA946075  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0965,545,276 - 65,545,502NCBIRnor6.0
Rnor_5.0965,353,020 - 65,353,246UniSTSRnor5.0
RGSC_v3.4957,320,408 - 57,320,634UniSTSRGSC3.4
Celera957,637,317 - 57,637,543UniSTS
RH 3.4 Map9514.5UniSTS
Cytogenetic Map9q31UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92488509969885099Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92569234292741406Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92569237370692373Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92748603666757620Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92748615588333183Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92907507983686404Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)929075079122095297Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)929466970107878528Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93238513377385133Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93764235182642351Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93764235182642351Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)94126103490024806Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94126103498606834Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)941261034102531865Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94657976991579769Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94657976991579769Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94695242783686153Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94724896594124663Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95417754299177542Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95488504176677636Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)96081029882732466Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)961186278106186278Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)96173092382890620Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)96173092382890620Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)96173092382890620Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)963270073107878387Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000016730
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 12 31 15 19 15 8 9 19 29 24 11 8
Low 31 26 26 26 2 55 6 17
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_057138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF244366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM388207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF108550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000016730   ⟹   ENSRNOP00000016730
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl965,534,704 - 65,587,251 (+)Ensembl
RefSeq Acc Id: NM_001033864   ⟹   NP_001029036
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,376 - 60,236,173 (+)NCBI
Rnor_6.0965,534,704 - 65,582,446 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
RGSC_v3.4957,309,836 - 57,356,635 (+)RGD
Celera957,626,739 - 57,673,502 (+)RGD
Sequence:
RefSeq Acc Id: NM_057138   ⟹   NP_476479
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,376 - 60,210,470 (+)NCBI
Rnor_6.0965,534,704 - 65,560,687 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
RGSC_v3.4957,309,836 - 57,356,635 (+)RGD
Celera957,626,739 - 57,651,750 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244946   ⟹   XP_006245008
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0965,534,767 - 65,586,395 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244947   ⟹   XP_006245009
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0965,535,651 - 65,586,395 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244948   ⟹   XP_006245010
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,193,179 - 60,236,173 (+)NCBI
Rnor_6.0965,542,478 - 65,586,395 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244949   ⟹   XP_006245011
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,371 - 60,236,173 (+)NCBI
Rnor_6.0965,534,608 - 65,586,395 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244950   ⟹   XP_006245012
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0965,554,239 - 65,586,395 (+)NCBI
Rnor_5.0965,342,359 - 65,390,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596249   ⟹   XP_017451738
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0965,554,173 - 65,586,395 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082957   ⟹   XP_038938885
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,338 - 60,236,173 (+)NCBI
RefSeq Acc Id: XM_039082958   ⟹   XP_038938886
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,524 - 60,236,173 (+)NCBI
RefSeq Acc Id: XM_039082959   ⟹   XP_038938887
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,186,151 - 60,236,173 (+)NCBI
RefSeq Acc Id: XM_039082961   ⟹   XP_038938889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,338 - 60,236,173 (+)NCBI
RefSeq Acc Id: XM_039082962   ⟹   XP_038938890
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,185,338 - 60,236,173 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001029036   ⟸   NM_001033864
- Peptide Label: isoform 1
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_476479   ⟸   NM_057138
- Peptide Label: isoform 2
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL),   Q99MZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245011   ⟸   XM_006244949
- Peptide Label: isoform X1
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245008   ⟸   XM_006244946
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006245009   ⟸   XM_006244947
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006245010   ⟸   XM_006244948
- Peptide Label: isoform X1
- UniProtKB: C0H5Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245012   ⟸   XM_006244950
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017451738   ⟸   XM_017596249
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000016730   ⟸   ENSRNOT00000016730
RefSeq Acc Id: XP_038938889   ⟸   XM_039082961
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038938890   ⟸   XM_039082962
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938885   ⟸   XM_039082957
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038938886   ⟸   XM_039082958
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038938887   ⟸   XM_039082959
- Peptide Label: isoform X1
Protein Domains
CASPASE_P20   DED

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696693
Promoter ID:EPDNEW_R7217
Type:initiation region
Name:Cflar_1
Description:CASP8 and FADD-like apoptosis regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0965,534,623 - 65,534,683EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620847 AgrOrtholog
Ensembl Genes ENSRNOG00000012473 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016730 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016730 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7376876 IMAGE-MGC_LOAD
InterPro Caspase-like_dom UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_ICE_p20 UniProtKB/TrEMBL
  Pept_C14_p45_core UniProtKB/TrEMBL
KEGG Report rno:117279 UniProtKB/TrEMBL
MGC_CLONE MGC:108616 IMAGE-MGC_LOAD
NCBI Gene 117279 ENTREZGENE
PANTHER PTHR10454 UniProtKB/TrEMBL
Pfam DED UniProtKB/TrEMBL
PhenoGen Cflar PhenoGen
PROSITE CASPASE_P20 UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt C0H5Y5 ENTREZGENE, UniProtKB/TrEMBL
  Q99MZ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cflar  CASP8 and FADD-like apoptosis regulator      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cflar  CASP8 and FADD-like apoptosis regulator      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is induced by TNF alpha 632418