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Gene: Casp3 (caspase 3) Rattus norvegicus
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Symbol: Casp3
Name: caspase 3
Description: Exhibits several functions, including death receptor binding activity; phospholipase A2 activator activity; and protease binding activity. Involved in several processes, including luteolysis; nervous system development; and positive regulation of amyloid-beta formation. Localizes to several cellular components, including the cytosol; death-inducing signaling complex; and membrane raft. Used to study artery disease (multiple); brain disease (multiple); and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); eye disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP3 (caspase 3); PARTICIPATES IN intrinsic apoptotic pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-artemisinin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: apopain; CASP-3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase-3; CPP-32; CPP32-beta; CPP32beta; cysteine protease CPP32; cysteine protease p32-beta; IRP; Lice; MGC93645; SCA-1; SREBP cleavage activity 1; Yama
Orthologs:
Homo sapiens (human) : CASP3 (caspase 3)  HGNC  Alliance
Mus musculus (house mouse) : Casp3 (caspase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp3 (caspase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP3 (caspase 3)
Canis lupus familiaris (dog) : CASP3 (caspase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp3 (caspase 3)
Sus scrofa (pig) : CASP3 (caspase 3)
more info ...
Is Marker For: Strains:   F344-Tg(NC1-269B17)1Nkg   F344-Tg(NC1-269B17)2Nkg   F344-Tg(NC1-269B17)3Nkg   F344-Tg(NC1-269B17)4Nkg  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01648,845,011 - 48,863,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01648,560,090 - 48,578,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41648,944,226 - 48,962,420 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11648,944,301 - 48,962,495 (-)NCBI
Celera1643,665,975 - 43,684,168 (-)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model