Casp3 (caspase 3) - Rat Genome Database

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Gene: Casp3 (caspase 3) Rattus norvegicus
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Symbol: Casp3
Name: caspase 3
RGD ID: 2275
Description: Enables several functions, including death receptor binding activity; phospholipase A2 activator activity; and protease binding activity. Involved in several processes, including nervous system development; positive regulation of amyloid-beta formation; and response to anesthetic. Located in cytoplasm and neuronal cell body. Part of death-inducing signaling complex. Used to study artery disease (multiple); brain disease (multiple); and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach cancer. Orthologous to human CASP3 (caspase 3); PARTICIPATES IN apoptotic cell death pathway; intrinsic apoptotic pathway; extrinsic apoptotic pathway; INTERACTS WITH (+)-artemisinin; (+)-catechin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apopain; CASP-3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase-3; CPP-32; CPP32-beta; CPP32beta; cysteine protease CPP32; cysteine protease p32-beta; IRP; Lice; MGC93645; SCA-1; SREBP cleavage activity 1; Yama
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   F344-Tg(NC1-269B17)2Nkg ; F344-Tg(NC1-269B17)3Nkg ; F344-Tg(NC1-269B17)4Nkg ; F344-Tg(NC1-269B17)1Nkg
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,395,539 - 52,413,794 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1652,395,540 - 52,413,732 (-)EnsemblGRCr8
mRatBN7.21645,662,910 - 45,681,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1645,662,910 - 45,684,648 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1651,061,544 - 51,079,742 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01654,429,112 - 54,447,305 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01649,700,916 - 49,719,114 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1652,322,782 - 52,340,975 (-)NCBI
Lyon_Normotensive1653,708,085 - 53,726,278 (-)NCBI
Lyon_Hypertensive1654,146,509 - 54,164,706 (-)NCBI
F344_StmMcwi1650,384,206 - 50,402,399 (-)NCBI
Rnor_6.01648,845,011 - 48,863,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,845,012 - 48,863,204 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01648,560,090 - 48,578,325 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41648,944,226 - 48,962,420 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1643,665,975 - 43,684,168 (-)NCBICelera
RGSC_v3.11648,944,301 - 48,962,495 (-)NCBI
Cytogenetic Map16q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
Acute Liver Failure  (IEP)
Acute Lung Injury  (IEP,ISO)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (IEP)
acute necrotizing pancreatitis  (IEP)
alcohol use disorder  (IEP)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (IEP)
atherosclerosis  (IEP)
bacterial infectious disease  (ISO)
Binge Drinking  (IEP)
Brain Contusion  (IEP)
brain glioma  (IDA)
Brain Hypoxia-Ischemia  (IDA,IEP)
Brain Injuries  (IEP)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
bronchopulmonary dysplasia  (IEP)
Burns  (IEP)
calcinosis  (ISO)
cataract  (IEP)
Cerebral Hemorrhage  (IEP,ISO)
cervical cancer  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
chemical colitis  (ISO)
Chronic Hepatitis  (ISO)
chronic obstructive pulmonary disease  (IEP)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (IEP)
Contrast-Induced Nephropathy  (IDA)
Copper-Overload Cirrhosis  (ISO)
cryptorchidism  (IEP,ISO)
diabetes mellitus  (IEP)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IEP)
diabetic neuropathy  (IEP,ISO)
diabetic retinopathy  (IEP,ISO)
dilated cardiomyopathy  (IEP)
Edema  (ISO)
endometritis  (IEP)
Endotoxemia  (IEP)
esophageal cancer  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Myocarditis  (IEP,ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Mammary Neoplasms  (IDA,IEP)
Experimental Radiation Injuries  (IEP)
Fetal Growth Retardation  (IEP)
gastric ulcer  (IEP)
head and neck squamous cell carcinoma  (ISO)
heart disease  (IEP)
heart valve disease  (ISO)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (IEP)
Huntington's disease  (ISO)
Hypercholesterolemia  (IEP)
hypertension  (IDA,IEP)
hyperthyroidism  (IEP)
hypertrophic cardiomyopathy  (IEP)
Hypoxia  (IEP)
impotence  (IEP)
Insulin Resistance  (IEP)
intermittent claudication  (IDA)
intestinal disease  (IEP)
Intestinal Reperfusion Injury  (IEP)
kidney disease  (IEP)
Kidney Reperfusion Injury  (IEP)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP)
middle cerebral artery infarction  (IDA,IEP)
Mycoplasma Infections  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP,IMP,ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
osteoarthritis  (IEP)
Osteoarthritis, Experimental  (IEP)
Oxygen-Induced Retinopathy  (ISO)
pancreatitis  (IEP)
Parkinson's disease  (ISO)
Parkinsonism  (IDA,IEP,ISO)
Postoperative Cognitive Dysfunction  (IEP)
pre-malignant neoplasm  (IDA)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IDA,IMP,ISO)
retinal detachment  (ISO)
retinal disease  (IEP)
salivary gland disease  (ISO)
sciatic neuropathy  (IEP)
scrapie  (ISO)
Sepsis  (IEP,ISO)
severe acute respiratory syndrome  (ISO)
spermatic cord torsion  (IEP)
Spinal Cord Injuries  (IDA,IEP,IMP,ISO)
status epilepticus  (IEP,ISO)
stomach cancer  (ISO)
stroke  (IEP)
Subarachnoid Hemorrhage  (IDA,ISO)
Testis Reperfusion Injury  (IEP)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (IDA)
transitional cell carcinoma  (ISO)
Transplant Rejection  (IEP)
traumatic brain injury  (IEP)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (IEP)
urinary bladder cancer  (ISO)
Ventricular Remodeling  (ISO)
Viral Myocarditis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (ISO)
(+)-albicanol  (ISO)
(+)-alpha-viniferin  (ISO)
(+)-artemisinin  (EXP,ISO)
(+)-catechin  (EXP,ISO)
(+)-conocarpan  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-sesamin  (EXP,ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-bornyl-caffeate  (EXP)
(-)-citrinin  (EXP,ISO)
(-)-cotinine  (ISO)
(-)-demecolcine  (ISO)
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-gambogic acid  (ISO)
(-)-matairesinol  (ISO)
(-)-noscapine  (ISO)
(-)-selegiline  (ISO)
(-)-voacangine  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (ISO)
(aminomethyl)phosphonic acid  (ISO)
(E)-thiamethoxam  (EXP,ISO)
(E,E)-germacrone  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-carnitine  (EXP,ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-salsolinol  (EXP,ISO)
(R,R)-tramadol  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-AMPA  (EXP)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (EXP,ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-dinitrobenzene  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1,4-naphthoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP,ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP,ISO)
1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol  (ISO)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-hydroxy-1-norresistomycin  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-monopalmitoylglycerol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
10-Hydroxycamptothecin  (ISO)
12-methyltetradecanoic acid  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP,ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2'-deoxycytidine  (ISO)
2'-deoxyguanosine  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP,ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,5-trichlorophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-diaminobutyric acid  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2,4-Dihydroxychalcone  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-dimethylcelecoxib  (ISO)
2,5-hexanedione  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-aminobiphenyl  (ISO)
2-aminoethoxydiphenylborane  (EXP)
2-arachidonoylglycerol  (ISO)
2-cyclopenten-1-one  (ISO)
2-deoxy-D-glucose  (EXP,ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methoxyethanol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-methylcholine  (ISO)
2-nitropropane  (ISO)
2-pyridylethylamine  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP,ISO)
2-trans,6-trans-farnesyl diphosphate  (EXP,ISO)
20-hydroxyecdysone  (ISO)
25-hydroxycholesterol  (EXP,ISO)
28-deoxonimbolide  (ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3',4'-dimethoxyflavone  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-Dichlorobenzidine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzaldehyde  (EXP)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dibromo-4-hydroxybenzonitrile  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-aminobenzamide  (EXP,ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP,ISO)
3-phenoxybenzoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-amino-1,8-naphthalimide  (ISO)
4-aminopyridine  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxyhexenal  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
4-nitro-m-cresol  (ISO)
4-nitroaniline  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-tert-Octylphenol  (ISO)
4-Vinylcyclohexene  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-aminolevulinic acid  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (EXP,ISO)
5-formyltetrahydrofolic acid  (ISO)
5-Geranyloxy-7-methoxycoumarin  (ISO)
5-Hydroxycapric acid  (EXP,ISO)
5-hydroxymethylfurfural  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxypsoralen  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-decylubiquinone  (EXP)
6-formylpterin  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7,8-dihydroxycoumarin  (ISO)
7-ketocholesterol  (EXP,ISO)
7-O-(beta-D-glucosyl)isovitexin  (EXP)
7alpha-hydroxycholesterol  (ISO)
7H-xanthine  (EXP,ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
8-OH-DPAT  (ISO)
9'-cis-neoxanthin  (ISO)
9,10-anthraquinone  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
9-hydroxycanthin-6-one  (ISO)
9-Methoxycamptothecin  (ISO)
9H-xanthine  (EXP,ISO)
[6]-Shogaol  (ISO)
AB-Fubinaca  (ISO)
abamectin  (EXP,ISO)
Abemaciclib  (ISO)
abexinostat  (ISO)
ABT-737  (ISO)
acadesine  (EXP,ISO)
acetaldehyde  (ISO)
acetamiprid  (EXP)
acetazolamide  (ISO)
acetic acid  (EXP)
acetochlor  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP,ISO)
aclacinomycin A  (ISO)
aconitine  (EXP,ISO)
acridines  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (EXP,ISO)
adenosine  (EXP,ISO)
Aeroplysinin 1  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
aflatoxin M1  (ISO)
afzelechin  (EXP)
agathisflavone  (EXP)
agomelatine  (EXP)
AH23848  (ISO)
AICA ribonucleotide  (EXP,ISO)
ajmalicine  (ISO)
Alamandine  (EXP)
alantolactone  (ISO)
alborixin  (ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (EXP)
aldicarb  (EXP)
aldosterone  (EXP)
aldrithiol  (EXP)
alendronic acid  (EXP,ISO)
alginic acid  (ISO)
aliskiren  (EXP)
all-trans-acitretin  (ISO)
all-trans-neoxanthin  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allethrin  (EXP,ISO)
allopurinol  (EXP)
alloxan  (EXP)
Allyl chloride  (EXP)
allyl isothiocyanate  (ISO)
Aloe emodin  (ISO)
alogliptin  (EXP)
Aloperine  (EXP)
aloxistatin  (EXP,ISO)
alpha-amanitin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-ergocryptine  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-santonin  (EXP)
alpha-Solamarine  (ISO)
alpidem  (ISO)
Alpinetin  (ISO)
alpinumisoflavone  (ISO)
alprazolam  (ISO)
alsterpaullone  (EXP)
alternariol  (ISO)
aluminium atom  (EXP,ISO)
aluminium oxide  (EXP,ISO)
aluminium(0)  (EXP,ISO)
alvocidib  (EXP,ISO)
amarogentin  (ISO)
ambrisentan  (ISO)
amentoflavone  (EXP,ISO)
amidotrizoic acid  (EXP,ISO)
amifostine  (ISO)
amiloride  (EXP,ISO)
amino acid  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (EXP,ISO)
amitriptyline  (EXP)
amitrole  (EXP,ISO)
amlexanox  (ISO)
amlodipine  (EXP,ISO)
ammonia  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amosite asbestos  (ISO)
amoxicillin  (ISO)
amphetamine  (EXP,ISO)
amphotericin B  (ISO)
anandamide  (ISO)
andrographolide  (EXP,ISO)
Anemoside B4  (ISO)
anethole  (EXP)
anilines  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene  (ISO)
antimony trichloride  (EXP,ISO)
antimony(0)  (EXP,ISO)
ANTIMYCIN  (ISO)
antimycin A  (EXP,ISO)
Antrocin  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
apremilast  (EXP)
aprepitant  (ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arecoline  (EXP,ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (EXP,ISO)
arjunolic acid  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsanilic acid  (EXP)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
Arsenobetaine  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
ARV-825  (ISO)
asiatic acid  (EXP,ISO)
Asimicin  (ISO)
aspartame  (EXP,ISO)
Aspidin  (ISO)
astaxanthin  (EXP,ISO)
astilbin  (ISO)
astragaloside IV  (EXP,ISO)
atenolol  (ISO)
Atipamezole  (EXP)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atractylenolide I  (ISO)
Atractylenolide III  (ISO)
Atranorin  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
aucubin  (ISO)
Augmentin  (EXP)
auranofin  (EXP,ISO)
aurantio-obtusin  (ISO)
aureusidin  (ISO)
Auriculasin  (ISO)
azadirachtin A  (ISO)
azadiradione  (ISO)
Azaspiracid  (ISO)
azathioprine  (EXP)
azithromycin  (EXP,ISO)
Azoxymethane  (EXP,ISO)
azoxystrobin  (ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
BAPTA  (ISO)
bathocuproine disulfonic acid  (EXP)
Bay-K-8644  (ISO)
bazedoxifene  (ISO)
beauvericin  (EXP,ISO)
belinostat  (ISO)
bellidifolin  (ISO)
benidipine  (EXP)
benzalkonium chloride  (ISO)
benzamide  (ISO)
benzbromarone  (EXP)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (EXP,ISO)
benzoates  (ISO)
benzophenanthridine  (ISO)
benzyl isothiocyanate  (ISO)
beraprost  (ISO)
Berbamine  (ISO)
berberine  (EXP,ISO)
Berberrubine  (ISO)
Bergenin  (ISO)
beta-amyrin  (EXP)
beta-carboline  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
beta-Elemonic acid  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-ionone  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-patchoulene  (EXP)
Beta-Solamarine  (ISO)
beta-tocopherol  (EXP,ISO)
betaxolol  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bicuculline  (ISO)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (EXP,ISO)
biliverdin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisoprolol  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bleomycin A5  (ISO)
boric acid  (ISO)
boron atom  (ISO)
borrelidin  (ISO)
bortezomib  (ISO)
bosentan  (EXP)
BQ 123  (EXP)
brassinin  (ISO)
brassinolide  (ISO)
brazilin  (ISO)
brefeldin A  (ISO)
brilliant green  (ISO)
bromodichloromethane  (ISO)
bromuconazole  (EXP)
brucine  (ISO)
Brusatol  (EXP,ISO)
bucladesine  (ISO)
budesonide  (ISO)
bufalin  (ISO)
Bufotalin  (ISO)
bupivacaine  (EXP,ISO)
buprofezin  (ISO)
bupropion  (ISO)
buserelin  (ISO)
buspirone  (EXP)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butachlor  (ISO)
butan-1-ol  (EXP)
butane-2,3-dione  (ISO)
butein  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP,ISO)
C60 fullerene  (ISO)
cabazitaxel  (ISO)
Cacalol  (ISO)
cadmium acetate  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cadmium telluride  (ISO)
cafestol  (ISO)
caffeine  (EXP,ISO)
cajanol  (ISO)
Calcimycin  (EXP,ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium carbonate  (ISO)
calcium dichloride  (EXP)
calcium oxalate  (ISO)
calcium(0)  (EXP,ISO)
calmidazolium  (ISO)
Calpeptin  (EXP,ISO)
calycosin  (EXP)
calycosin-7-O-beta-D-glucoside  (ISO)
camphene  (EXP)
camptothecin  (EXP,ISO)
canagliflozin  (ISO)
candesartan  (EXP)
cannabidiol  (EXP,ISO)
cantharidic acid  (ISO)
cantharidin  (EXP,ISO)
capillarisin  (ISO)
capivasertib  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captan  (ISO)
captopril  (EXP,ISO)
carbachol  (EXP,ISO)
carbamate ester  (ISO)
carbamazepine  (EXP,ISO)
carbaryl  (EXP)
carbendazim  (EXP,ISO)
CARBENOXOLONE  (EXP,ISO)
carbidopa  (ISO)
carbimazole  (EXP)
carbofuran  (EXP,ISO)
carbon atom  (ISO)
carbon disulfide  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP,ISO)
carboxy-PTIO  (ISO)
Cardamonin  (ISO)
carfilzomib  (EXP,ISO)
carmustine  (EXP,ISO)
carnosic acid  (EXP,ISO)
carnosine  (EXP,ISO)
Carnosol  (ISO)
carvacrol  (EXP,ISO)
carvedilol  (EXP,ISO)
casticin  (EXP,ISO)
catalpol  (ISO)
catechol  (ISO)
CB-5083  (ISO)
CCCP  (EXP,ISO)
CDN1163  (ISO)
CDP-choline  (ISO)
CEDRELONE  (ISO)
cefalotin  (ISO)
celastrol  (EXP,ISO)
celecoxib  (EXP,ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
cerivastatin  (ISO)
cerulenin  (ISO)
ceruletide  (EXP)
cetrorelix  (EXP,ISO)
cetylpyridinium  (ISO)
CGP 52608  (ISO)
chalcone  (ISO)
chalcones  (ISO)
chelerythrine  (EXP,ISO)
chenodeoxycholic acid  (ISO)
Chikusetsusaponin-IVa  (ISO)
CHIR 99021  (ISO)
chitosan  (EXP,ISO)
chlorambucil  (ISO)
chloramphenicol  (ISO)
chlorfenapyr  (EXP)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
Chloroacetonitrile  (ISO)
chlorogenic acid  (EXP,ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chondroitin sulfate  (ISO)
chromium atom  (EXP,ISO)
chromium trioxide  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (EXP,ISO)
chromone  (ISO)
chrysazin  (ISO)
chrysene  (ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (EXP)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cilnidipine  (EXP,ISO)
cilostazol  (EXP,ISO)
cimetidine  (EXP,ISO)
cinchocaine  (EXP)
Cinobufotalin  (ISO)
ciprofloxacin  (EXP,ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP,ISO)
citric acid  (ISO)
cladribine  (ISO)
clavulone II  (ISO)
Clivoline  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
clofarabine  (ISO)
clofibrate  (EXP)
clomipramine  (ISO)
clonidine  (EXP,ISO)
clonidine (amino form)  (EXP,ISO)
clonidine (imino form)  (EXP,ISO)
clorgyline  (ISO)
clotrimazole  (ISO)
cloxacillin  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (EXP)
cocaine  (EXP,ISO)
codeinone  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
colistin  (EXP,ISO)
columbianadin  (EXP)
concanamycin A  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
coptisine  (ISO)
cordycepin  (EXP,ISO)
corilagin  (EXP,ISO)
corosolic acid  (EXP,ISO)
corticosterone  (EXP)
cortisol  (EXP,ISO)
cortisone  (EXP)
coumarin  (ISO)
coumestrol  (EXP,ISO)
creatine  (EXP)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP,ISO)
crotonaldehyde  (EXP)
Cryptotanshinone  (ISO)
crystal violet  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (ISO)
cucurbitacin E  (EXP,ISO)
cucurbitacin I  (ISO)
cudraflavone B  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cyclizine  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyprodinil  (ISO)
cyproheptadine  (EXP)
cytarabine  (EXP,ISO)
cytochalasin B  (ISO)
D-aspartic acid  (EXP)
D-glucitol  (EXP,ISO)
D-gluconic acid  (ISO)
D-glucosamine  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
D-penicillamine  (EXP,ISO)
D-ribofuranose  (EXP)
dacarbazine  (ISO)
dactolisib  (ISO)
daidzein  (EXP,ISO)
dantrolene  (EXP,ISO)
dapagliflozin  (EXP)
dapoxetine  (EXP)
DAPT  (EXP)
daunorubicin  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deferasirox  (ISO)
deferiprone  (ISO)
deguelin  (ISO)
dehydrocostus lactone  (ISO)
delphinidin  (ISO)
delta-hexachlorocyclohexane  (ISO)
delta-tocopherol  (EXP)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
Dendrobine  (ISO)
deoxycholic acid  (EXP,ISO)
deoxynivalenol  (EXP,ISO)
Deoxyschizandrin  (ISO)
Deoxyshikonin  (ISO)
desferrioxamine B  (EXP,ISO)
desipramine  (EXP,ISO)
desloratadine  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (EXP,ISO)
dexmedetomidine  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diacetylmonoxime  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
diazoxide  (EXP)
dibenz[a,h]anthracene  (EXP)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibromoacetic acid  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloroacetyl chloride  (ISO)
dichloromethane  (ISO)
dichlorvos  (EXP,ISO)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
Didecyldimethylammonium  (ISO)
dideuterium oxide  (ISO)
Didymin  (ISO)
dieckol  (ISO)
dieldrin  (EXP,ISO)
diepoxybutane  (ISO)
diethanolamine  (EXP,ISO)
diethyl fumarate  (ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethyl sulfate  (ISO)
diethyldithiocarbamic acid  (EXP,ISO)
diethylstilbestrol  (ISO)
difenoconazole  (EXP)
digitoxin  (ISO)
dihydroactinidiolide  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydrogen  (ISO)
dihydrolipoic acid  (ISO)
dihydrosanguinarine  (ISO)
dihydroxyacetone  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
diminazene diaceturate  (ISO)
dinaciclib  (ISO)
dioscin  (EXP,ISO)
diosgenin  (EXP,ISO)
diosmetin  (EXP)
diosmin  (EXP,ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diprotium  (ISO)
diprotium oxide  (EXP)
dipyridamole  (ISO)
diquat  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP,ISO)
dithionite(2-)  (EXP,ISO)
divanadium pentaoxide  (EXP)
dizocilpine maleate  (EXP,ISO)
docebenone  (ISO)
dodecanoic acid  (ISO)
Dodecyl gallate  (ISO)
domoic acid  (ISO)
donepezil hydrochloride  (EXP,ISO)
dopamine  (EXP,ISO)
dopaminechrome (enol form)  (EXP)
doramapimod  (ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
drimenol  (ISO)
dronedarone  (ISO)
duvoglustat  (EXP)
ebselen  (EXP,ISO)
Echimidine  (ISO)
echinacoside  (ISO)
Echinocystic acid  (ISO)
edaravone  (EXP,ISO)
efavirenz  (EXP,ISO)
EHT 1864  (ISO)
elaidic acid  (EXP)
elamipretide  (EXP)
elemental boron  (ISO)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
ellipticine  (ISO)
emamectin benzoate  (ISO)
embelin  (EXP,ISO)
emetine  (ISO)
emodin  (EXP,ISO)
empagliflozin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
enniatin  (EXP)
entacapone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
epalrestat  (EXP,ISO)
epothilone A  (ISO)
epoxomicin  (ISO)
equol  (ISO)
erastin  (ISO)
erdosteine  (EXP,ISO)
ergocristine  (ISO)
ergosine  (ISO)
ergosterol peroxide  (ISO)
ergotamine  (ISO)
ergothioneine  (EXP)
eritoran  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
escitalopram  (EXP)
esculetin  (ISO)
esketamine  (ISO)
estragole  (EXP)
estrone  (ISO)
etacrynic acid  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
Ethyl icosapentate  (EXP,ISO)
ethylbenzene  (EXP)
ethylene glycol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etodolac  (ISO)
etomidate  (ISO)
etoposide  (EXP,ISO)
eugenol  (EXP,ISO)
EUK-134  (ISO)
eumelanin  (ISO)
euscaphic acid  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP,ISO)
fangchinoline  (ISO)
farnesol  (EXP,ISO)
farnesyl diphosphate  (EXP,ISO)
farrerol  (ISO)
fasudil  (EXP)
favipiravir  (EXP)
febuxostat  (EXP)
fenbendazole  (ISO)
fenetylline  (EXP)
fenitrothion  (EXP)
fenofibrate  (EXP,ISO)
fenpropathrin  (EXP)
fenpyroximate  (ISO)
fenthion  (EXP)
fenvalerate  (EXP,ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
ferrosoferric oxide  (ISO)
ferrostatin-1  (EXP,ISO)
ferrous oxide  (ISO)
ferruginol  (ISO)
ferulic acid  (EXP)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
fipronil  (EXP,ISO)
fisetin  (EXP,ISO)
flavanone  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
flavone  (ISO)
flavones  (ISO)
flavonoids  (ISO)
flavonols  (ISO)
flecainide  (ISO)
fluazinam  (ISO)
flubendazole  (ISO)
flucloxacillin  (ISO)
fludioxonil  (ISO)
flufenamic acid  (ISO)
flunitrazepam  (ISO)
fluorometholone  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
flutriafol  (EXP)
fluvastatin  (EXP,ISO)
fluvoxamine  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
formononetin  (EXP,ISO)
Forsythiaside  (ISO)
fostriecin  (ISO)
fraxetin  (ISO)
friedelin  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furazolidone  (ISO)
furosemide  (EXP)
Fusaric acid  (EXP)
gadolinium atom  (EXP,ISO)
gadolinium trichloride  (ISO)
galactose  (EXP,ISO)
galangin  (EXP,ISO)
galanthamine  (EXP)
galanthamine Trifluoroacetic acid  (EXP)
Galbanic acid  (ISO)
gallic acid  (EXP,ISO)
gallium atom  (ISO)
gallium nitrate  (ISO)
gamma-aminobutyric acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (EXP,ISO)
Ganoderic acid A  (ISO)
Ganoderic acid T  (ISO)
Garcinol  (ISO)
gardenin B  (ISO)
Gastrodin  (EXP,ISO)
gedunin  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
geneticin  (ISO)
Genipin  (ISO)
Geniposide  (EXP,ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP,ISO)
genkwanin  (ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
geranylgeraniol  (ISO)
gibberellin A3  (EXP)
gingerol  (EXP,ISO)
ginkgetin  (ISO)
Ginkgoic acid  (ISO)
ginkgolide B  (EXP,ISO)
Ginkgolide C  (EXP)
ginsenoside Rb1  (ISO)
ginsenoside Rd  (EXP)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (EXP)
Ginsenoside Rg5  (ISO)
glabridin  (ISO)
gliclazide  (EXP,ISO)
glimepiride  (ISO)
gliotoxin  (EXP,ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutinol  (ISO)
glyburide  (EXP,ISO)
glycerol  (EXP)
glycidol  (EXP)
glycine betaine  (EXP)
glycochenodeoxycholic acid  (EXP,ISO)
glycodeoxycholic acid  (EXP)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glycyrrhizinic acid  (EXP,ISO)
glyoxylic acid  (ISO)
glyphosate  (EXP,ISO)
Goe 6976  (EXP)
gold atom  (EXP,ISO)
gold(0)  (EXP,ISO)
gossypetin  (ISO)
gossypin  (ISO)
gossypol  (EXP,ISO)
graphite  (ISO)
Grifolin  (ISO)
griseofulvin  (ISO)
GSK690693  (ISO)
guaiazulene  (ISO)
guanidines  (ISO)
guanosine  (EXP)
guggulsterone  (ISO)
GW 1929  (ISO)
GW 3965  (EXP)
GW 6471  (ISO)
Gyrophoric acid  (ISO)
haloperidol  (EXP)
harmalol  (ISO)
harman  (ISO)
Harpagoside  (ISO)
helenalin  (ISO)
Heliotrine  (ISO)
hemin  (EXP,ISO)
heparin  (EXP,ISO)
herbacetin  (EXP)
herbicide  (ISO)
heroin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexaflumuron  (EXP)
hexane  (EXP)
hinokiflavone  (ISO)
histamine  (EXP)
homocysteine  (EXP,ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
HT-2 toxin  (ISO)
hyaluronic acid  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP,ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
hydroxytyrosol  (EXP,ISO)
hydroxyurea  (ISO)
hymexazol  (EXP)
hyperforin  (EXP,ISO)
hypoxanthine  (ISO)
ibuprofen  (EXP)
icariin  (EXP,ISO)
icariside II  (ISO)
icosanoid  (EXP)
idarubicin  (ISO)
idelalisib  (ISO)
ifosfamide  (EXP)
Ilimaquinone  (ISO)
imidacloprid  (EXP)
imipramine  (ISO)
imiquimod  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
indoxacarb  (EXP)
indoxyl sulfate  (EXP)
inositol  (ISO)
Inostamycin  (ISO)
insulin  (EXP)
inulin  (ISO)
inuviscolide  (ISO)
iodoacetic acid  (EXP)
iohexol  (EXP,ISO)
ionomycin  (ISO)
Ioversol  (EXP)
ipratropium  (EXP)
iprodione  (EXP)
irbesartan  (EXP,ISO)
irigenin  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
iron(III) nitrilotriacetate  (EXP)
isatin  (ISO)
isoalantolactone  (ISO)
Isoangustone A  (ISO)
isocarbophos  (EXP)
isoconazole  (ISO)
isoflavones  (EXP)
isoflurane  (EXP,ISO)
Isoliensinine  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
jaceosidin  (ISO)
JBIR-99  (ISO)
juglone  (ISO)
Jujuboside A  (ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
kainic acid  (EXP,ISO)
kenpaullone  (ISO)
ketamine  (EXP,ISO)
ketoconazole  (ISO)
KN-93  (EXP,ISO)
KT 5720  (EXP,ISO)
KT 5823  (ISO)
Kukoamine B  (ISO)
kurarinol  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cystathionine  (ISO)
L-dehydroascorbic acid  (ISO)
L-ethionine  (EXP)
L-gamma-glutamyl-L-cysteine  (EXP,ISO)
L-glutamic acid  (EXP,ISO)
L-leucine  (ISO)
L-methionine  (EXP,ISO)
L-mimosine  (ISO)
lactacystin  (EXP,ISO)
lactucin  (ISO)
lactulose  (EXP)
lamivudine  (EXP)
lanreotide  (EXP)
lansoprazole  (EXP,ISO)
lanthanum trichloride  (EXP)
lapatinib  (ISO)
latrunculin A  (ISO)
LDN-193189  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (EXP,ISO)
Leonurine  (EXP,ISO)
letrozole  (EXP)
leuprolide  (ISO)
levetiracetam  (EXP)
levocabastine  (ISO)
levofloxacin  (ISO)
levomilnacipran  (EXP)
LGK974  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
licoricidin  (ISO)
lidocaine  (EXP,ISO)
Liensinine  (ISO)
limonin  (ISO)
linagliptin  (ISO)
linalool  (ISO)
linderalactone  (ISO)
linsidomine  (EXP,ISO)
linuron  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
liraglutide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium carbonate  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (ISO)
litreol  (ISO)
LM-1685  (ISO)
Lobetyolin  (ISO)
loganin  (ISO)
lonafarnib  (ISO)
Longikaurin A  (ISO)
lonidamine  (ISO)
loratadine  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
lupeol  (EXP,ISO)
Lupiwighteone  (ISO)
luteolin  (EXP,ISO)
Luteolin 7-methyl ether  (EXP)
luteolin 7-O-beta-D-glucoside  (ISO)
LY 379268  (EXP)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
lysophosphatidylcholine  (ISO)
lysophosphatidylethanolamine  (ISO)
m-xylene  (ISO)
maculosin  (ISO)
madecassoside  (ISO)
Maduramicin  (EXP,ISO)
magnesium dichloride  (EXP,ISO)
magnesium oxide  (ISO)
Magnolol  (ISO)
malathion  (EXP,ISO)
malic acid  (ISO)
malonic acid  (EXP)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manumycin A  (ISO)
Maprotiline  (ISO)
masoprocol  (EXP,ISO)
MC1568  (EXP,ISO)
mebendazole  (ISO)
mechlorethamine  (ISO)
meglumine amidotrizoate  (EXP,ISO)
MeIQx  (ISO)
melamine  (ISO)
Melarsoprol  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (EXP,ISO)
melphalan  (ISO)
memantine  (EXP,ISO)
menadione  (EXP,ISO)
menaquinone  (ISO)
mephedrone  (ISO)
mercaptopurine  (EXP)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (EXP)
Metaflumizone  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methapyrilene  (EXP)
methimazole  (EXP,ISO)
methomyl  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl beta-cyclodextrin  (ISO)
methyl caffeate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP,ISO)
methylcobalamin  (ISO)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (EXP)
Methylone  (EXP)
methylparaben  (ISO)
methylphenidate  (EXP,ISO)
methylseleninic acid  (ISO)
methyltestosterone  (EXP)
metipranolol  (EXP,ISO)
metiram  (ISO)
metoclopramide  (ISO)
metoprolol  (ISO)
mevalonic acid  (EXP,ISO)
mevinphos  (EXP)
micafungin  (EXP,ISO)
miconazole  (ISO)
microcystin-LR  (EXP,ISO)
midostaurin  (ISO)
mifepristone  (EXP,ISO)
Miltirone  (ISO)
minocycline  (EXP,ISO)
mirabegron  (EXP)
mirtazapine  (EXP,ISO)
misoprostol  (EXP)
mitomycin C  (ISO)
Mitoquinone  (EXP,ISO)
Mitotane  (EXP,ISO)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
MK 571  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
ML324  (ISO)
molibresib  (ISO)
molybdenum atom  (ISO)
momelotinib  (ISO)
monensin A  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
montelukast  (EXP,ISO)
morin  (EXP,ISO)
morphine  (EXP,ISO)
morphinone  (ISO)
Morroniside  (EXP,ISO)
morusin  (ISO)
motexafin gadolinium  (ISO)
Muconic dialdehyde  (ISO)
muscimol  (ISO)
mycophenolic acid  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
myricitrin  (ISO)
myriocin  (ISO)
myristicin  (ISO)
Myrtucommulone A  (ISO)
myxothiazol  (ISO)
N(5)-ethyl-L-glutamine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (EXP,ISO)
N,N-dimethylsphingosine  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP,ISO)
N-(3-oxododecanoyl)homoserine lactone  (ISO)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (ISO)
N-(p-amylcinnamoyl)anthranilic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetyl-L-tryptophan  (ISO)
N-acetylsphingosine  (ISO)
N-acylsphinganine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-phosphocreatine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nafcillin  (ISO)
naloxone  (ISO)
Nandrolone decanoate  (EXP)
naphthalene  (ISO)
naringin  (EXP,ISO)
navitoclax  (ISO)
NCX-4040  (ISO)
nectandrin B  (ISO)
nefazodone  (EXP,ISO)
Neferine  (EXP,ISO)
nelfinavir  (ISO)
neoastilbin  (ISO)
neocuproine  (EXP,ISO)
neohesperidin dihydrochalcone  (ISO)
Neoisoliquiritin  (ISO)
neomycin  (ISO)
Neosolaniol  (ISO)
nerolidol  (ISO)
nevadensin  (ISO)
nevirapine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel ferrite  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP,ISO)
nicorandil  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (EXP,ISO)
Niflumic acid  (ISO)
nifuroxazide  (EXP)
nigericin  (ISO)
nilotinib  (EXP,ISO)
nimesulide  (EXP,ISO)
nimetazepam  (ISO)
nimodipine  (EXP,ISO)
nimustine  (ISO)
Nitidine  (ISO)
nitrazepam  (ISO)
nitric oxide  (EXP,ISO)
nitrofen  (ISO)
nitroglycerin  (ISO)
nitroprusside  (EXP,ISO)
nitroxyl  (ISO)
Nivalenol  (ISO)
NMS-873  (ISO)
nobiletin  (EXP,ISO)
nocodazole  (ISO)
Nonylphenol  (EXP,ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
nortriptyline  (ISO)
norwogonin  (EXP)
notoginsenoside R1  (EXP,ISO)
NS-398  (EXP,ISO)
NSC 23766  (ISO)
Nutlin-3  (ISO)
O-acetyl-L-carnitine  (EXP)
O-methyleugenol  (EXP,ISO)
Obacunone  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP,ISO)
Octachlorostyrene  (ISO)
octadecanoic acid  (EXP)
octhilinone  (ISO)
octreotide  (ISO)
octyl gallate  (ISO)
okadaic acid  (EXP,ISO)
olaparib  (ISO)
oleamide  (ISO)
oleandrigenin  (ISO)
oleandrin  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
olesoxime  (ISO)
oleuropein  (ISO)
oligopeptide  (EXP,ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (EXP)
oltipraz  (ISO)
omacetaxine mepesuccinate  (ISO)
omeprazole  (EXP,ISO)
omipalisib  (ISO)
Ondansetron  (EXP,ISO)
organoselenium compound  (ISO)
oridonin  (EXP,ISO)
orlistat  (EXP,ISO)
oroxylin A  (ISO)
Ortho-topolin riboside  (ISO)
osimertinib  (ISO)
osthole  (EXP,ISO)
ouabain  (EXP,ISO)
oxalic acid  (ISO)
oxaliplatin  (EXP,ISO)
oxcarbazepine  (EXP)
oxfendazole  (EXP)
oxidopamine  (EXP,ISO)
oxirane  (ISO)
oxybenzone  (EXP)
oxybuprocaine  (ISO)
ozone  (EXP,ISO)
P(1),P(4)-bis(5'-adenosyl) tetraphosphate  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (EXP,ISO)
pacritinib  (ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP,ISO)
palbociclib  (ISO)
pamidronate  (ISO)
panaxydol  (EXP)
Panaxynol  (EXP)
Pancratistatin  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (EXP)
paroxetine  (ISO)
Parthenin  (ISO)
parthenolide  (EXP)
patulin  (ISO)
PCB138  (ISO)
PD 168393  (ISO)
pefloxacin  (ISO)
pendimethalin  (EXP)
Pendulone  (ISO)
pentachlorophenol  (EXP,ISO)
pentetic acid  (ISO)
pentetrazol  (EXP)
Pentoxifylline  (EXP,ISO)
pepstatin A  (EXP,ISO)
perchlorate  (EXP)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perifosine  (ISO)
permethrin  (EXP)
peroxynitrous acid  (EXP,ISO)
petunidin chloride  (EXP)
pevonedistat  (ISO)
pexidartinib  (ISO)
PF-4708671  (EXP)
PHA-665752  (ISO)
phenanthrene  (ISO)
phencyclidine  (EXP)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phentolamine  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
phenylmethanesulfonyl fluoride  (ISO)
PhIP  (EXP,ISO)
phloretin  (ISO)
phloroglucinol  (ISO)
phorate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phosphoramide mustard  (EXP)
phylloquinone  (ISO)
Physalin A  (ISO)
phytol  (ISO)
Phytolaccoside E  (ISO)
phytosphingosine  (ISO)
piclamilast  (EXP)
picolinic acid  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
Pinacidil  (EXP)
pinostrobin  (EXP,ISO)
pioglitazone  (EXP,ISO)
piperazine  (ISO)
piperidine  (ISO)
piperine  (ISO)
piperonyl butoxide  (EXP)
pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
PK-11195  (ISO)
Plantamajoside  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (ISO)
plumbagin  (EXP,ISO)
pluronic P-123  (EXP)
podophyllotoxin  (ISO)
polaprezinc  (EXP)
Poloxamer  (EXP)
poly(ethylene)  (ISO)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (ISO)
Polygodial  (ISO)
polymyxin B2  (ISO)
pomalidomide  (ISO)
ponasterone A  (EXP)
ponatinib  (ISO)
Ponicidin  (ISO)
porphyrins  (ISO)
potassium atom  (EXP)
potassium bromate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
Pramanicin  (ISO)
pramipexole  (EXP)
Pranoprofen  (ISO)
pravastatin  (EXP,ISO)
prednisolone  (EXP)
pregabalin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
proanthocyanidin  (ISO)
procaine  (ISO)
procyanidin B1  (ISO)
procyanidin B2  (EXP,ISO)
procymidone  (ISO)
prodigiosin  (EXP,ISO)
profenofos  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propacetamol  (ISO)
propafenone  (ISO)
propan-2-ol  (EXP)
propiconazole  (EXP)
propionic acid  (EXP)
propofol  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin D2  (EXP,ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (EXP,ISO)
prostaglandin J2  (EXP,ISO)
protein kinase inhibitor  (EXP,ISO)
Protolichesterinic acid  (ISO)
protoporphyrin  (EXP,ISO)
protosappanin A  (EXP)
pseudolaric acid B  (ISO)
psoralen  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
Pulsatilla saponin D  (ISO)
punicalagin  (EXP,ISO)
purine-6-thiol  (EXP)
purmorphamine  (EXP)
puromycin  (ISO)
putrescine  (EXP)
pyrazinecarboxamide  (EXP,ISO)
pyrene  (EXP,ISO)
pyrethrins  (EXP,ISO)
pyridaben  (EXP)
Pyridostigmine bromide  (ISO)
pyridoxine  (EXP)
pyrimethamine  (ISO)
pyrimethanil  (ISO)
pyriproxyfen  (ISO)
pyrithione  (ISO)
pyrogallol  (ISO)
pyrroles  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrroloquinoline quinone  (EXP,ISO)
pyruvic acid  (EXP)
pyrvinium  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP,ISO)
quercetin 3-O-beta-D-glucopyranoside  (EXP,ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quercitrin  (EXP,ISO)
quinacrine  (ISO)
quinoline  (ISO)
quinolines  (ISO)
quinolinic acid  (EXP)
quizartinib  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
rac-lactic acid  (ISO)
radicicol  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP,ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
regorafenib  (ISO)
remdesivir  (ISO)
remifentanil  (EXP)
Repaglinide  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
RGFP966  (ISO)
Rhein  (ISO)
Rhynchophylline  (EXP)
ribavirin  (ISO)
riboflavin  (ISO)
ricolinostat  (ISO)
rifampicin  (EXP,ISO)
Riluzole  (ISO)
rimonabant  (ISO)
Risedronate sodium  (EXP)
risperidone  (ISO)
ritonavir  (ISO)
rivastigmine  (EXP)
Ro 31-8220  (EXP,ISO)
Ro 61-8048  (ISO)
robinin  (EXP)
roflumilast  (EXP,ISO)
rolipram  (EXP)
romidepsin  (ISO)
ropinirole  (ISO)
rosmarinic acid  (EXP,ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
royal jelly  (EXP,ISO)
rubimaillin  (ISO)
rubitecan  (ISO)
rucaparib  (ISO)
Rutecarpine  (ISO)
ruthenium atom  (ISO)
ruthenium red  (ISO)
rutin  (EXP,ISO)
ryanodine  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (EXP,ISO)
S-adenosyl-L-methionine  (EXP,ISO)
S-allylcysteine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-methylglutathione  (ISO)
S-nitroso-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP,ISO)
S-nitrosoglutathione  (ISO)
S63845  (ISO)
saccharin  (EXP)
safrole  (ISO)
Salidroside  (EXP,ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (EXP)
Sanggenon C  (EXP,ISO)
sanguinarine  (ISO)
sapanisertib  (ISO)
sappanchalcone  (ISO)
sarpogrelate  (ISO)
Satratoxin H  (EXP)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 415286  (EXP)
SB 431542  (EXP,ISO)
SB-239063  (ISO)
SCH 23390  (ISO)
Schizandrin  (EXP)
sclareol  (ISO)
scoparone  (ISO)
scopolamine  (EXP,ISO)
scopoletin  (EXP,ISO)
scullcapflavone II  (ISO)
scutellarin  (EXP,ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenic acid  (ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
selumetinib  (ISO)
semaglutide  (EXP,ISO)
semilicoisoflavone B  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sepantronium  (ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
sertraline  (ISO)
Sesamol  (EXP,ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP,ISO)
Shikonin  (EXP,ISO)
sibutramine  (ISO)
sildenafil citrate  (EXP,ISO)
silibinin  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (EXP,ISO)
sirtinol  (EXP,ISO)
SKF 38393  (ISO)
SKF-96365 hydrochloride  (EXP)
SM-164  (ISO)
SNX-2112  (ISO)
sodium acetate trihydrate  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP)
sodium benzoate  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium cholate  (ISO)
sodium chromate  (ISO)
sodium cyanate  (ISO)
sodium dichromate  (EXP,ISO)
sodium disulfite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (EXP,ISO)
sodium hydrogensulfite  (EXP)
sodium hydroxide  (EXP)
sodium iodide  (EXP)
sodium nitrite  (EXP)
sodium propionate  (ISO)
Sodium salicylate  (EXP,ISO)
sodium sulfite  (EXP)
sodium thiosulfate pentahydrate  (EXP)
solanesol  (ISO)
solasodine  (ISO)
Soman  (EXP)
Sophoricoside  (ISO)
sorafenib  (EXP,ISO)
sotorasib  (ISO)
SP2509  (ISO)
spermidine  (ISO)
spermine  (EXP,ISO)
spironolactone  (EXP,ISO)
Spiroquinazoline  (ISO)
Spiruchostatin A  (ISO)
spiruchostatin B  (ISO)
splitomicin  (ISO)
squalene  (EXP)
Squamocin  (ISO)
SR 144528  (ISO)
starch  (ISO)
staurosporine  (EXP,ISO)
stavudine  (ISO)
sterigmatocystin  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
strychnine  (EXP)
styrene oxide  (EXP,ISO)
succimer  (EXP)
sucrose  (ISO)
sufentanil  (ISO)
Suillin  (ISO)
sulfadimethoxine  (EXP)
sulfaphenazole  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sulpiride  (ISO)
sumatriptan  (EXP)
sunitinib  (EXP,ISO)
suramin  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
swainsonine  (EXP)
Swertiamarin  (ISO)
syringaldehyde  (ISO)
syringic acid  (EXP,ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (EXP)
taiwanin C  (ISO)
talazoparib  (ISO)
Talc  (ISO)
tamarixetin  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP,ISO)
tangeretin  (EXP,ISO)
tannic acid  (EXP)
Tanshinone I  (EXP,ISO)
tapentadol  (ISO)
taraxasterol  (ISO)
tartrazine  (EXP)
Tartrolon D  (ISO)
taurine  (EXP)
taurocholic acid  (EXP)
taurodeoxycholic acid  (ISO)
taurolithocholic acid sulfate  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
Tautomycin  (ISO)
tazarotene  (ISO)
tebuconazole  (EXP)
tectorigenin  (EXP)
tellurium atom  (EXP)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
TEMPO  (EXP,ISO)
Temsirolimus  (EXP,ISO)
tenofovir disoproxil fumarate  (EXP)
teprenone  (ISO)
terbutaline  (ISO)
Terfenadine  (EXP,ISO)
teroxirone  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
tetracaine  (EXP)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachlorocatechol  (ISO)
tetrachloroethene  (ISO)
tetrachlorohydroquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrahydrocurcumin  (ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
tetrazolium violet  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (EXP,ISO)
theaflavin  (EXP)
Theaflavin 3,3'-digallate  (EXP,ISO)
theophylline  (ISO)
thiabendazole  (EXP)
thiamethoxam  (EXP,ISO)
thiamine(1+) chloride  (EXP)
thiazoles  (ISO)
thimerosal  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiopental  (ISO)
thioridazine  (ISO)
thiosalicylic acid  (EXP)
Thiotepa  (ISO)
thiourea  (EXP,ISO)
Thrombin  (EXP)
thymidine  (ISO)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (EXP,ISO)
ticlopidine  (ISO)
tigecycline  (EXP)
tilmicosin  (EXP)
tipifarnib  (ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topiramate  (EXP)
topotecan  (ISO)
torin 1  (ISO)
Tormentic acid  (ISO)
Torularhodin  (ISO)
torulene  (ISO)
tramadol  (EXP,ISO)
trametinib  (ISO)
tranexamic acid  (ISO)
trans-anethole  (EXP)
trans-caffeic acid  (EXP,ISO)
trans-chalcone  (ISO)
trans-cinnamic acid  (EXP)
tranylcypromine  (EXP)
trenbolone  (EXP)
triacetin  (ISO)
triacsin C  (ISO)
triadimefon  (ISO)
triazoles  (ISO)
tributyl phosphate  (EXP)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (ISO)
tricetin  (ISO)
trichlorfon  (ISO)
trichloroacetic acid  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triciribine  (ISO)
triclosan  (ISO)
trifluoperazine  (EXP,ISO)
trifluridine  (ISO)
trilostane  (EXP)
trimellitic anhydride  (ISO)
trimethylamine N-oxide  (ISO)
trimethylarsine oxide  (EXP)
trimethylenediamine  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
triptorelin  (EXP)
tris(picolinato)chromium  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tropisetron  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (EXP,ISO)
tyrphostin B42  (ISO)
U-73122  (ISO)
ubiquinones  (EXP,ISO)
umbelliferone  (EXP,ISO)
uranium atom  (EXP)
uridine  (ISO)
Urolithin A  (EXP,ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (EXP,ISO)
usnic acid  (ISO)
valinomycin  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
Valtratum  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
vandetanib  (ISO)
vanillic acid  (EXP)
vanillin  (EXP)
Vasicinone  (ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
venlafaxine hydrochloride  (EXP)
venom  (ISO)
verapamil  (EXP,ISO)
Vernodalin  (ISO)
Vernodalol  (ISO)
Vicanicin  (ISO)
vincaleukoblastine  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vinorelbine  (ISO)
Vinpocetine  (EXP)
vinyl carbamate  (ISO)
violacein  (ISO)
vismodegib  (ISO)
vitamin D  (ISO)
vitamin E  (EXP,ISO)
vitexin  (ISO)
vorinostat  (EXP,ISO)
vosaroxin  (ISO)
VX nerve agent  (EXP,ISO)
warfarin  (EXP,ISO)
water  (EXP)
wedelolactone  (EXP,ISO)
WIN 55212-2  (ISO)
withaferin A  (EXP,ISO)
wogonin  (EXP,ISO)
wortmannin  (EXP,ISO)
WP1066  (ISO)
xanthohumol  (EXP,ISO)
Xanthorrhizol  (ISO)
XAV939  (ISO)
XMU-MP-1  (ISO)
xylitol  (ISO)
Y-27632  (EXP,ISO)
yttrium chloride  (EXP)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc acetate  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc molecular entity  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zineb  (ISO)
zingerone  (EXP,ISO)
zingiberene  (EXP)
ziram  (ISO)
zofenopril  (EXP)
zoledronic acid  (ISO)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
anterior neural tube closure  (ISO)
apoptotic process  (IBA,IEA,ISO)
axonal fasciculation  (IEA,IMP)
B cell homeostasis  (ISO)
cell fate commitment  (ISO)
cellular response to staurosporine  (IEA,ISO)
DNA damage response  (ISO)
erythrocyte differentiation  (IBA,IEA,ISO)
execution phase of apoptosis  (IBA,IEA,ISO)
glial cell apoptotic process  (IEP,ISO)
heart development  (ISO)
hippocampus development  (IEP)
intracellular signal transduction  (IMP)
intrinsic apoptotic signaling pathway  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to osmotic stress  (IEA,ISO)
keratinocyte differentiation  (IBA,ISO)
learning or memory  (IMP)
leukocyte apoptotic process  (IEP)
luteolysis  (IEP)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of cytokine production  (IEA,ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (IBA,IEP)
neurotrophin TRK receptor signaling pathway  (ISO)
positive regulation of amyloid-beta formation  (IDA,IEA,ISO)
positive regulation of apoptotic DNA fragmentation  (ISO)
positive regulation of apoptotic process  (IEA,IMP,ISO)
positive regulation of neuron apoptotic process  (IBA,IMP)
positive regulation of pyroptotic inflammatory response  (IEA,ISO)
protein catabolic process  (IDA,IEA,ISO)
protein maturation  (IEA,ISO)
protein processing  (IEA,ISO)
proteolysis  (IBA,IDA,IEA,ISO)
pyroptotic inflammatory response  (IEA,ISO)
regulation of neuron apoptotic process  (IEP)
regulation of protein localization  (IEA,ISO)
regulation of protein stability  (IDA,IEA,ISO)
regulation of synaptic vesicle cycle  (IEA,ISO)
response to amino acid  (IEP)
response to anesthetic  (IEP)
response to auditory stimulus  (ISO)
response to cobalt ion  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to glucocorticoid  (IEP)
response to glucose  (IDA)
response to hydrogen peroxide  (IDA)
response to hypoxia  (IEP)
response to insulin-like growth factor stimulus  (IEP)
response to ionizing radiation  (IEA)
response to lipopolysaccharide  (IEP)
response to metal ion  (IEP)
response to nicotine  (IEP)
response to UV  (ISO)
response to wounding  (ISO)
response to X-ray  (IEP)
response to xenobiotic stimulus  (IEP)
sensory perception of sound  (ISO)
striated muscle cell differentiation  (IEP)
swimming behavior  (IEP)
synapse pruning  (IEA,ISO,ISS)
T cell homeostasis  (ISO)

Cellular Component
caspase complex  (ISO)
cytoplasm  (IBA,IDA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
death-inducing signaling complex  (IBA,IDA)
glutamatergic synapse  (IEA,ISO)
neuronal cell body  (IDA)
nucleus  (IEA,ISO)
postsynaptic density  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration. Abdul-Muneer PM, etal., Brain Behav Immun. 2017 Jan;59:190-199. doi: 10.1016/j.bbi.2016.09.002. Epub 2016 Sep 7.
2. Therapeutic efficacy of Ac-DMQD-CHO, a caspase 3 inhibitor, for rat spinal cord injury. Akdemir O, etal., J Clin Neurosci. 2008 Jun;15(6):672-8. Epub 2008 Apr 2.
3. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Al-Mashat HA, etal., Diabetes. 2006 Feb;55(2):487-95.
4. Neutrophil gelatinase-associated lipocalin (NGAL) may play a protective role against rats ischemia/reperfusion renal injury via inhibiting tubular epithelial cell apoptosis. An S, etal., Ren Fail. 2013;35(1):143-9. doi: 10.3109/0886022X.2012.741877. Epub 2012 Nov 15.
5. Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. Atkin JD, etal., J Biol Chem. 2006 Oct 6;281(40):30152-65. Epub 2006 Jul 17.
6. Repetitive transcranial magnetic stimulation for treatment of lactacystin-induced Parkinsonian rat model. Ba M, etal., Oncotarget. 2017 Apr 20;8(31):50921-50929. doi: 10.18632/oncotarget.17285. eCollection 2017 Aug 1.
7. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
8. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
9. Inhibition of HtrA2/Omi ameliorates heart dysfunction following ischemia/reperfusion injury in rat heart in vivo. Bhuiyan MS and Fukunaga K, Eur J Pharmacol. 2007 Feb 28;557(2-3):168-77. Epub 2006 Nov 14.
10. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Bishayee A, etal., Int J Cancer. 2013 Sep 1;133(5):1054-63. doi: 10.1002/ijc.28108. Epub 2013 Mar 29.
11. Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Bishayee A, etal., Nutr Cancer. 2016;68(1):120-30. doi: 10.1080/01635581.2016.1115094. Epub 2015 Dec 23.
12. Peripheral proteasome and caspase activity in Parkinson disease and Alzheimer disease. Blandini F, etal., Neurology. 2006 Feb 28;66(4):529-34. doi: 10.1212/01.wnl.0000198511.09968.b3.
13. Hypothyroidism minimizes the effects of acute hepatic failure caused by endoplasmic reticulum stress and redox environment alterations in rats. Blas-Valdivia V, etal., Acta Histochem. 2015 Oct;117(8):811-9. doi: 10.1016/j.acthis.2015.07.003. Epub 2015 Jul 31.
14. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Cai J, etal., Neurosci Lett. 2008 Aug 22;441(2):167-72. Epub 2008 May 24.
15. Vasoactive intestinal peptide inhibits TNF-alpha-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands. Calafat M, etal., Arthritis Res Ther. 2009;11(2):R53. Epub 2009 Apr 8.
16. Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis. Canon JR, etal., Clin Exp Metastasis. 2008;25(2):119-29. Epub 2007 Dec 5.
17. Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells. Capano M, etal., Biochem J 2002 Apr 1;363(Pt 1):29-36.
18. Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. Cayli S, etal., J Mol Histol. 2016 Feb;47(1):91-100. doi: 10.1007/s10735-016-9652-9. Epub 2016 Jan 11.
19. Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats. Chandirasegaran G, etal., Biomed Pharmacother. 2017 Nov;95:175-185. doi: 10.1016/j.biopha.2017.08.040. Epub 2017 Sep 12.
20. 4'-O-ß-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. Chang CZ and Wu SC, World Neurosurg. 2016 May;89:474-88. doi: 10.1016/j.wneu.2016.01.061. Epub 2016 Feb 8.
21. A purine antimetabolite attenuates toll-like receptor-2, -4, and subarachnoid hemorrhage-induced brain apoptosis. Chang CZ, etal., J Surg Res. 2015 Dec;199(2):676-87. doi: 10.1016/j.jss.2015.06.011. Epub 2015 Jun 12.
22. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Chen M, etal., Nat Med. 2000 Jul;6(7):797-801.
23. Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis. Cheng CF, etal., Apoptosis. 2008 May 16;.
24. Schizandrin protects primary cultures of rat cortical cells from glutamate-induced excitotoxicity. Cheng HY, etal., J Pharmacol Sci. 2008 May;107(1):21-31.
25. Caspase-3 mediated neuronal death after traumatic brain injury in rats. Clark RS, etal., J Neurochem. 2000 Feb;74(2):740-53. doi: 10.1046/j.1471-4159.2000.740740.x.
26. Anti-tumor effect of endostatin mediated by retroviral gene transfer in mice bearing renal cell carcinoma. Coutinho EL, etal., FASEB J. 2007 Oct;21(12):3153-61. Epub 2007 May 18.
27. Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis. Das A, etal., J Neurosci Res. 2008 Oct;86(13):2992-3001.
28. FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury. Davis AR, etal., J Neurotrauma. 2007 May;24(5):823-34.
29. Caspase-3 activity, response to chemotherapy and clinical outcome in patients with colon cancer. de Oca J, etal., Int J Colorectal Dis. 2008 Jan;23(1):21-7. Epub 2007 Sep 4.
30. Critical role for death-receptor mediated apoptotic signaling in viral myocarditis. DeBiasi RL, etal., J Card Fail. 2010 Nov;16(11):901-10. doi: 10.1016/j.cardfail.2010.05.030.
31. Protective effect of novel substituted nicotine hydrazide analogues against hypoxic brain injury in neonatal rats via inhibition of caspase. Deng CB, etal., Bioorg Med Chem Lett. 2016 Jul 1;26(13):3195-3201. doi: 10.1016/j.bmcl.2016.04.031. Epub 2016 Apr 13.
32. [Effects of BNP preconditioning on myocardial cell apoptosis and expressions of bcl-2 and Bax during myocardial ischemia-reperfusion injury in rats]. Deng YJ, etal., Zhonghua Yi Xue Za Zhi. 2010 Dec 28;90(48):3431-4.
33. Changes in ocular aquaporin-4 (AQP4) expression following retinal injury. Dibas A, etal., Mol Vis. 2008 Sep 25;14:1770-83.
34. [Study of L-NAME treatment on experimental autoimmune myocarditis]. Ding GL, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Mar;29(2):119-23.
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169. Insulin-like growth factor-1 improves postoperative cognitive dysfunction following splenectomy in aged rats. Wang B, etal., Exp Ther Med. 2021 Mar;21(3):215. doi: 10.3892/etm.2021.9647. Epub 2021 Jan 15.
170. Critical role of regulator of calcineurin 1 in spinal cord injury. Wang G, etal., J Physiol Biochem. 2016 Dec;72(4):605-613. doi: 10.1007/s13105-016-0499-z. Epub 2016 Jun 23.
171. Demethylation of miR-9-3 and miR-193a genes suppresses proliferation and promotes apoptosis in non-small cell lung cancer cell lines. Wang J, etal., Cell Physiol Biochem. 2013;32(6):1707-19. doi: 10.1159/000356605. Epub 2013 Dec 13.
172. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. Wang J, etal., J Biol Chem. 2004 May 7;279(19):19948-54. Epub 2004 Mar 5.
173. Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathways. Wang LY, etal., Mol Med Rep. 2016 Oct;14(4):3403-12. doi: 10.3892/mmr.2016.5586. Epub 2016 Aug 4.
174. [Time-dependent expression of caspase-3 during contused skeletal muscle wound healing in rats] Wang Q, etal., Fa Yi Xue Za Zhi. 2008 Feb;24(1):5-7, 11.
175. miR-140-5p Attenuates Neuroinflammation and Brain Injury in Rats Following Intracerebral Hemorrhage by Targeting TLR4. Wang S, etal., Inflammation. 2019 Oct;42(5):1869-1877. doi: 10.1007/s10753-019-01049-3.
176. Melittin ameliorates CVB3-induced myocarditis via activation of the HDAC2-mediated GSK-3ß/Nrf2/ARE signaling pathway. Wang T, etal., Biochem Biophys Res Commun. 2016 Nov 4;480(1):126-131. doi: 10.1016/j.bbrc.2016.09.135. Epub 2016 Sep 28.
177. 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action. Wang W, etal., Br J Cancer. 2008 Feb 26;98(4):792-802. Epub 2008 Feb 5.
178. LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of Retinal Endothelial Cells in Retinopathy of Prematurity via MiR-145-5p. Wang Y, etal., Front Med (Lausanne). 2022 Apr 4;9:803214. doi: 10.3389/fmed.2022.803214. eCollection 2022.
179. Death Receptor 6 and Caspase-6 Regulate Prion Peptide-Induced Axonal Degeneration in Rat Spinal Neurons. Wang Y, etal., J Mol Neurosci. 2015 Aug;56(4):966-976. doi: 10.1007/s12031-015-0562-1. Epub 2015 Apr 22.
180. BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway. Wang YB, etal., Mol Med Rep. 2018 Nov;18(5):4259-4270. doi: 10.3892/mmr.2018.9453. Epub 2018 Sep 4.
181. Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx. Wei Y, etal., Cell Physiol Biochem. 2018;46(2):687-698. doi: 10.1159/000488725. Epub 2018 Mar 29.
182. Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. Wei Y, etal., Mol Med Rep. 2018 Jan;17(1):1493-1498. doi: 10.3892/mmr.2017.8036. Epub 2017 Nov 13.
183. Testicular developmental impairment caused by flutamide-induced and DEHP-induced cryptorchid rat models is mediated by excessive apoptosis and deficient autophagy. Wei Y, etal., Toxicol Mech Methods. 2018 Sep;28(7):507-519. doi: 10.1080/15376516.2018.1459994. Epub 2018 Jun 5.
184. Evaluation of apoptotic pathways in dorsal root ganglion neurons following peripheral nerve injury. Wiberg R, etal., Neuroreport. 2018 Jun 13;29(9):779-785. doi: 10.1097/WNR.0000000000001031.
185. The protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with SAP. Xiping Z, etal., Mediators Inflamm. 2007;2007:19469.
186. Protecting effects of dexamethasone on thymus of rats with severe acute pancreatitis. Xiping Z, etal., Mediators Inflamm. 2007;2007:72361.
187. XZ-1 regulates cell apoptosis of gastric epithelial dysplasia via NF-¿B/p53/Ki67 signaling pathway. Xu B, etal., Biosci Rep. 2018 Jun 12;38(3). pii: BSR20171529. doi: 10.1042/BSR20171529. Print 2018 Jun 29.
188. Glutamate-induced losses of oligodendrocytes and neurons and activation of caspase-3 in the rat spinal cord. Xu GY, etal., Neuroscience. 2008 Mar 7;.
189. Bajijiasu Ameliorates ß-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. Xu TT, etal., Cell Physiol Biochem. 2018;46(1):107-117. doi: 10.1159/000488414. Epub 2018 Mar 20.
190. Neuroprotective Effects of Loganin on MPTP-Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies. Xu YD, etal., J Cell Biochem. 2017 Oct;118(10):3495-3510. doi: 10.1002/jcb.26010. Epub 2017 May 16.
191. Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis. Yacobi K, etal., Endocrinology. 2007 Apr;148(4):1717-26. Epub 2007 Jan 11.
192. Potential neuroprotective effect of gamma-glutamylcysteine ethyl ester on rat brain against kainic acid-induced excitotoxicity. Yalcin A, etal., Free Radic Res. 2010 May;44(5):513-21. doi: 10.3109/10715761003645964.
193. Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs. Yan X, etal., J Ethnopharmacol. 2018 May 8;227:105-112. doi: 10.1016/j.jep.2018.05.006.
194. Activation of caspase-12 at early stage contributes to cardiomyocyte apoptosis in trauma-induced secondary cardiac injury. Yan Z, etal., Sheng Li Xue Bao. 2017 Aug 25;69(4):367-377.
195. Effects of Lignans from Schisandra chinensis Rattan Stems against Aß1-42-Induced Memory Impairment in Rats and Neurotoxicity in Primary Neuronal Cells. Yang BY, etal., Molecules. 2018 Apr 10;23(4). pii: molecules23040870. doi: 10.3390/molecules23040870.
196. Protection effect of survivin protein overexpression on acute myocardial infarction in rats. Yang M, etal., Int J Clin Exp Med. 2015 Aug 15;8(8):12995-3000. eCollection 2015.
197. Tumor necrosis factor-a mediates JNK activation response to intestinal ischemia-reperfusion injury. Yang Q, etal., World J Gastroenterol. 2013 Aug 14;19(30):4925-34. doi: 10.3748/wjg.v19.i30.4925.
198. MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1. Yang S, etal., J Cell Biochem. 2019 Mar;120(3):3813-3821. doi: 10.1002/jcb.27663. Epub 2018 Sep 27.
199. Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents. Yang X-, etal., J Mol Neurosci. 2017 Mar;61(3):368-378. doi: 10.1007/s12031-016-0866-9. Epub 2016 Dec 6.
200. Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats. Yang Y, etal., Reprod Sci. 2015 May;22(5):572-84. doi: 10.1177/1933719114553445. Epub 2014 Oct 20.
201. Protective effect of curcumin on chemotherapy-induced intestinal dysfunction. Yao Q, etal., Int J Clin Exp Pathol. 2013 Oct 15;6(11):2342-9. eCollection 2013.
202. Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer. Ye Y, etal., Tumour Biol. 2016 Mar;37(3):3185-95. doi: 10.1007/s13277-015-4100-0. Epub 2015 Oct 2.
203. Time course of apoptosis induced by photodynamic therapy with PsD007 in LT12 acute myeloid leukemia cells. Yin H, etal., Lasers Med Sci. 2016 Jul;31(5):817-24. doi: 10.1007/s10103-016-1887-x. Epub 2016 Feb 9.
204. Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1alpha and p53 pathways. Yin R, etal., Respir Physiol Neurobiol. 2016 Jan;220:81-7. doi: 10.1016/j.resp.2015.09.011. Epub 2015 Sep 30.
205. The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia. Yip KK, etal., Neuroscience. 2011 Sep 8;190:301-6. doi: 10.1016/j.neuroscience.2011.06.022. Epub 2011 Jun 17.
206. Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation. Yoo KC, etal., Int J Nanomedicine. 2012;7:1203-14. doi: 10.2147/IJN.S28647. Epub 2012 Mar 5.
207. Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer. Yu X, etal., J Exp Clin Cancer Res. 2020 Apr 10;39(1):62. doi: 10.1186/s13046-020-01566-2.
208. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
209. Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage: an experimental and immunohistochemical study. Yumusak N, etal., Nucl Med Commun. 2018 Feb;39(2):131-139. doi: 10.1097/MNM.0000000000000788.
210. Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. Zeng C, etal., PLoS One. 2018 Mar 14;13(3):e0193845. doi: 10.1371/journal.pone.0193845. eCollection 2018.
211. Inhibiting caspase-3 activity blocks beta-catenin degradation after focal ischemia in rat. Zhang H, etal., Neuroreport. 2008 May 28;19(8):821-4.
212. Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways. Zhang HB, etal., Brain Inj. 2017;31(3):406-415. doi: 10.1080/02699052.2016.1225984. Epub 2017 Jan 31.
213. H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation. Zhang X, etal., Cell Physiol Biochem. 2017;43(4):1311-1324. doi: 10.1159/000481843. Epub 2017 Oct 9.
214. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. Zhang X, etal., J Biol Chem 2003 Jan 10;278(2):1248-58.
215. Astragalus mongholicus (Fisch.) Bge Improves Peripheral Treg Cell Immunity Imbalance in the Children With Viral Myocarditis by Reducing the Levels of miR-146b and miR-155. Zhang Z, etal., Front Pediatr. 2018 Jun 21;6:139. doi: 10.3389/fped.2018.00139. eCollection 2018.
216. Amyloid oligomers in diabetic and nondiabetic human pancreas. Zhao HL, etal., Transl Res. 2009 Jan;153(1):24-32. Epub 2008 Nov 19.
217. Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. Zhong C, etal., Oncotarget. 2017 Apr 10;8(33):54187-54198. doi: 10.18632/oncotarget.17018. eCollection 2017 Aug 15.
Additional References at PubMed
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Genomics

Comparative Map Data
Casp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,395,539 - 52,413,794 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1652,395,540 - 52,413,732 (-)EnsemblGRCr8
mRatBN7.21645,662,910 - 45,681,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1645,662,910 - 45,684,648 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1651,061,544 - 51,079,742 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01654,429,112 - 54,447,305 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01649,700,916 - 49,719,114 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1652,322,782 - 52,340,975 (-)NCBI
Lyon_Normotensive1653,708,085 - 53,726,278 (-)NCBI
Lyon_Hypertensive1654,146,509 - 54,164,706 (-)NCBI
F344_StmMcwi1650,384,206 - 50,402,399 (-)NCBI
Rnor_6.01648,845,011 - 48,863,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,845,012 - 48,863,204 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01648,560,090 - 48,578,325 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41648,944,226 - 48,962,420 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1643,665,975 - 43,684,168 (-)NCBICelera
RGSC_v3.11648,944,301 - 48,962,495 (-)NCBI
Cytogenetic Map16q11NCBI
CASP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384184,627,696 - 184,649,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4184,627,695 - 184,650,418 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh374185,548,850 - 185,570,601 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364185,785,844 - 185,807,623 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344185,923,999 - 185,945,750NCBI
Celera4182,877,510 - 182,899,293 (-)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4181,303,305 - 181,324,956 (-)NCBIHuRef
CHM1_14185,525,377 - 185,547,156 (-)NCBICHM1_1
T2T-CHM13v2.04187,971,378 - 187,993,131 (-)NCBIT2T-CHM13v2.0
Casp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39847,070,326 - 47,092,733 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl847,070,326 - 47,092,731 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38846,617,291 - 46,639,698 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl846,617,291 - 46,639,689 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37847,702,803 - 47,724,071 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36848,116,266 - 48,137,534 (+)NCBIMGSCv36mm8
Celera849,300,031 - 49,321,270 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.39NCBI
Casp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540324,315,727 - 24,324,732 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495540324,315,712 - 24,326,271 (+)NCBIChiLan1.0ChiLan1.0
CASP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23182,351,669 - 182,373,528 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14182,713,461 - 182,735,319 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04176,793,190 - 176,815,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14189,018,422 - 189,040,217 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4189,018,422 - 189,040,185 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
CASP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11645,920,074 - 45,940,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1645,920,071 - 45,940,505 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1646,413,238 - 46,434,538 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01648,136,012 - 48,157,278 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1648,135,662 - 48,157,268 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11646,101,180 - 46,122,422 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01646,715,535 - 46,736,806 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01646,848,704 - 46,870,015 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Casp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11433,923,415 - 33,946,405 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_02440494333,516,817 - 33,538,924 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365544,571,109 - 4,593,740 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365544,571,072 - 4,593,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1545,742,751 - 45,764,213 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.11545,744,320 - 45,753,252 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21552,291,074 - 52,299,625 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap17135,262,478 - 135,283,702 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666037110,841,187 - 110,862,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.17130,589,592 - 130,610,845 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7130,591,166 - 130,610,899 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Casp3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11341,290,923 - 41,309,762 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Casp3
96 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:139
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000014095
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164975766656898388Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat

Markers in Region
RH133488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21645,663,076 - 45,663,267 (+)MAPPERmRatBN7.2
Rnor_6.01648,845,178 - 48,845,368NCBIRnor6.0
Rnor_5.01648,560,257 - 48,560,447UniSTSRnor5.0
RGSC_v3.41648,944,393 - 48,944,583UniSTSRGSC3.4
Celera1643,666,142 - 43,666,332UniSTS
Cytogenetic Map16q11UniSTS
PMC148819P9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21645,664,509 - 45,664,701 (+)MAPPERmRatBN7.2
Rnor_6.01648,846,611 - 48,846,802NCBIRnor6.0
Rnor_5.01648,561,690 - 48,561,881UniSTSRnor5.0
RGSC_v3.41648,945,826 - 48,946,017UniSTSRGSC3.4
Celera1643,667,575 - 43,667,766UniSTS
Cytogenetic Map16q11UniSTS
Casp3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1643,669,226 - 43,670,099UniSTS
Celera533,605,508 - 33,605,721UniSTS
Cytogenetic Map1q12UniSTS
Cytogenetic Map16q11UniSTS


Related Rat Strains
The following Strains have been annotated to Casp3
F344-Tg(NC1-269B17)1Nkg     F344-Tg(NC1-269B17)2Nkg     F344-Tg(NC1-269B17)3Nkg     F344-Tg(NC1-269B17)4Nkg    


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
276 156 729 1588 4032 1010 1726 133 873 489 855 156 5380 2587 448 3945 38 1387 736 908 160 158

Sequence


Ensembl Acc Id: ENSRNOT00000014095   ⟹   ENSRNOP00000014096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1652,395,540 - 52,413,732 (-)Ensembl
mRatBN7.2 Ensembl1645,662,910 - 45,684,648 (-)Ensembl
Rnor_6.0 Ensembl1648,845,012 - 48,863,204 (-)Ensembl
RefSeq Acc Id: NM_012922   ⟹   NP_037054
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,395,539 - 52,413,732 (-)NCBI
mRatBN7.21645,662,910 - 45,681,103 (-)NCBI
Dahl_SR_JrHsd1652,322,782 - 52,340,975 (-)NCBI
Lyon_Normotensive1653,708,085 - 53,726,278 (-)NCBI
Lyon_Hypertensive1654,146,509 - 54,164,706 (-)NCBI
F344_StmMcwi1650,384,206 - 50,402,399 (-)NCBI
Rnor_6.01648,845,011 - 48,863,204 (-)NCBI
Rnor_5.01648,560,090 - 48,578,325 (-)NCBI
RGSC_v3.41648,944,226 - 48,962,420 (-)RGD
Celera1643,665,975 - 43,684,168 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253130   ⟹   XP_006253192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,395,539 - 52,413,794 (-)NCBI
mRatBN7.21645,662,910 - 45,681,171 (-)NCBI
Rnor_6.01648,845,011 - 48,863,249 (-)NCBI
Rnor_5.01648,560,090 - 48,578,325 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094205   ⟹   XP_038950133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,397,355 - 52,413,794 (-)NCBI
mRatBN7.21645,664,730 - 45,681,165 (-)NCBI
RefSeq Acc Id: NP_037054   ⟸   NM_012922
- UniProtKB: P97699 (UniProtKB/Swiss-Prot),   P70543 (UniProtKB/Swiss-Prot),   Q62993 (UniProtKB/Swiss-Prot),   P55213 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253192   ⟸   XM_006253130
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000014096   ⟸   ENSRNOT00000014095
RefSeq Acc Id: XP_038950133   ⟸   XM_039094205
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55213-F1-model_v2 AlphaFold P55213 1-277 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700095
Promoter ID:EPDNEW_R10619
Type:initiation region
Name:Casp3_1
Description:caspase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01648,863,191 - 48,863,251EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2275 AgrOrtholog
BioCyc Gene G2FUF-11360 BioCyc
Ensembl Genes ENSRNOG00000010475 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055011427 UniProtKB/Swiss-Prot
  ENSRNOG00060007399 UniProtKB/Swiss-Prot
  ENSRNOG00065015182 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014095 ENTREZGENE
  ENSRNOT00000014095.7 UniProtKB/Swiss-Prot
  ENSRNOT00055019386 UniProtKB/Swiss-Prot
  ENSRNOT00060012174 UniProtKB/Swiss-Prot
  ENSRNOT00065025146 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1460 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7104685 IMAGE-MGC_LOAD
InterPro Caspase-like_dom_sf UniProtKB/Swiss-Prot
  Caspase_cys_AS UniProtKB/Swiss-Prot
  Caspase_his_AS UniProtKB/Swiss-Prot
  Pept_C14 UniProtKB/Swiss-Prot
  Pept_C14_caspase UniProtKB/Swiss-Prot
  Pept_C14_p10 UniProtKB/Swiss-Prot
  Pept_C14_p20 UniProtKB/Swiss-Prot
  Pept_C14A UniProtKB/Swiss-Prot
KEGG Report rno:25402 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93645 IMAGE-MGC_LOAD
NCBI Gene 25402 ENTREZGENE
PANTHER CASPASE-3 UniProtKB/Swiss-Prot
  PTHR10454 UniProtKB/Swiss-Prot
Pfam Peptidase_C14 UniProtKB/Swiss-Prot
PharmGKB CASP3 RGD
PhenoGen Casp3 PhenoGen
PRINTS IL1BCENZYME UniProtKB/Swiss-Prot
PROSITE CASPASE_CYS UniProtKB/Swiss-Prot
  CASPASE_HIS UniProtKB/Swiss-Prot
  CASPASE_P10 UniProtKB/Swiss-Prot
  CASPASE_P20 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010475 RatGTEx
  ENSRNOG00055011427 RatGTEx
  ENSRNOG00060007399 RatGTEx
  ENSRNOG00065015182 RatGTEx
SMART CASc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52129 UniProtKB/Swiss-Prot
UniProt CASP3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70543 ENTREZGENE
  P97699 ENTREZGENE
  Q62993 ENTREZGENE
UniProt Secondary P70543 UniProtKB/Swiss-Prot
  P97699 UniProtKB/Swiss-Prot
  Q62993 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-05 Casp3  caspase 3  Casp3  caspase 3, apoptosis related cysteine protease  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Casp3  caspase 3, apoptosis related cysteine protease      Name updated 1299863 APPROVED
2002-11-06 Casp3  caspase 3    Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease)  Name updated 625702 APPROVED
2002-06-10 Casp3  Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease plays a major role in brain injury leading to hypoxia-ischemia in developing brain 625571
gene_drugs after neonatal hypoxia-ischemia activity is reversibly inhibited by M826, resulting in neuroprotection 625571
gene_drugs activity blocked by z-DEVD-fmk 628545
gene_drugs M826 (ICV injection of 30nmol) is a selective reversible inhibitor of the caspase activity after neonatal hypoxia-ischemia, it cleaves all the substrates resulting in neuroprotection 628545
gene_function cysteine-aspartic acid protease (caspase) 628545
gene_process responsible for delayed-neuronal cell death 625571
gene_process brings about calpain activation involved in excitotoxic/necrotic cell death 625571
gene_process brings about calpain activation involved in excitotoxic/necrotic cell death 628545
gene_process active in later stages of apoptosis; cleaves and activates caspases 6,7 and 9 628545
gene_process plays a role in neural protection 634699
gene_process plays a role in carbon monoxide inhibition of apoptosis 634700
gene_product member of the caspase family 625571
gene_regulation activated by cholecystokinin (CCK) in pancreatic acinar cells 625521
gene_regulation activated during Tnf alpha mediated cell death in vascular smooth muscle cells 628545
gene_regulation protein kinase C phosphorylation decreases ability to bind to epsilon protein kinase C 69798