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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:27827
Term: paraoxon
Definition: An aryl dialkyl phosphate where both the alkyl groups are ethyl and the aryl group is 4-nitrophenyl.
Chemical ID: MESH:D010261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDParaoxon results in increased activity of CASP3 proteinPMID:17561261
Casp3increases expressionEXP 6480464CTDParaoxon results in increased expression of CASP3 mRNA; Paraoxon results in increased expression of CASP3 proteinPMID:31493121
Casp3multiple interactionsEXP 6480464CTDRo 31-8220 inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]PMID:17561261
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDParaoxon results in increased activity of CASP3 proteinPMID:11032765
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDbenzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP3 protein]; Egtazic Acid inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein]; Heparin inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased activity of and results in increased cleavage of CASP3 protein]; Paraoxon results in increased activity of and results in increased cleavage of CASP3 protein; Paraoxon results in increased cleavage of and results in increased activity of CASP3 protein; Paraoxon results in increased expression of and affects the activity of CASP3 protein; Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein]PMID:12831782 PMID:26998625 PMID:29027213
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDCyclosporine inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]PMID:11032765
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