GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | increases cleavage | EXP | | 6480464 | CTD | Metformin results in increased cleavage of CASP3 protein | PMID:35199402 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 mRNA]; Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of CASP3 protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Metformin inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Metformin inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA] | PMID:26818447 PMID:27551045 PMID:28106847 PMID:30144576 PMID:34801538 PMID:35414346 PMID:36800006 | Casp3 | decreases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Metformin results in decreased activity of CASP3 protein | PMID:15531508 | Casp3 | increases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Metformin results in increased activity of CASP3 protein | PMID:21388661 | Casp3 | increases cleavage | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Metformin results in increased cleavage of CASP3 protein | PMID:35350904 | Casp3 | increases expression | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Metformin results in increased expression of CASP3 mRNA | PMID:29117515 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]] | PMID:29095437 PMID:36800006 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | [epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA; Cisplatin promotes the reaction [Metformin results in increased activity of CASP3 protein]; Metformin inhibits the reaction [Sunitinib results in increased cleavage of CASP3 protein]; plantamajoside promotes the reaction [Metformin results in increased cleavage of CASP3 protein]; Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of CASP3 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA] | PMID:21388661 PMID:21906609 PMID:29117515 PMID:35350904 | | ||||||||||||||||||||||
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