GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | increases activity | EXP | | 6480464 | CTD | Copper deficiency results in increased activity of CASP3 protein | PMID:22362149 | Casp3 | increases expression | EXP | | 6480464 | CTD | Copper results in increased expression of CASP3 mRNA; Copper results in increased expression of CASP3 protein | PMID:22465980 PMID:30556269 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | [Copper binds to neocuproine] which results in increased activity of CASP3 protein; [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased activity of CASP3 protein; [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP3 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP3 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP3 protein; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA; [pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP3 protein]; bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of CASP3 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA]; Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA]; MAPK1 protein affects the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased activity of CASP3 protein] | PMID:10941151 PMID:18056745 PMID:22085843 PMID:22276220 PMID:34577062 | Casp3 | increases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Copper results in increased activity of CASP3 protein | PMID:25542178 | Casp3 | increases cleavage | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Copper analog results in increased cleavage of CASP3 protein | PMID:21319953 PMID:22000994 | Casp3 | increases expression | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Copper results in increased expression of CASP3 protein | PMID:16246896 PMID:16962711 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | [Copper co-treated with Cholesterol] results in increased activity of CASP3 protein; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 protein; [Disulfiram binds to Copper] which results in increased activity of CASP3 protein; Copper analog results in increased expression of and results in increased cleavage of CASP3 protein | PMID:17134702 PMID:21319953 PMID:24690739 PMID:31491480 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]; [Chelating Agents binds to Copper] which results in increased cleavage of CASP3 protein; [Chelating Agents binds to Copper] which results in increased expression of CASP3 mRNA; [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP3 protein; [Disulfiram binds to Copper] which results in increased activity of CASP3 protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein; [NSC 689534 binds to Copper] which results in increased activity of CASP3 protein; [pyrrolidine dithiocarbamic acid binds to Copper] which results in increased activity of CASP3 protein; [Thiosemicarbazones binds to Copper] which results in decreased activity of CASP3 protein; Chitosan metabolite inhibits the reaction [Copper results in increased activity of CASP3 protein]; Copper inhibits the reaction [IAPP protein results in increased cleavage of CASP3 protein]; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein] | PMID:17327230 PMID:18671963 PMID:20931265 PMID:20971185 PMID:22951949 PMID:23793354 PMID:24690739 PMID:25542178 PMID:29115570 PMID:30911355 | | ||||||||||||||||||||||
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