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Gene: CASP3 (caspase 3) Canis lupus familiaris
Symbol: CASP3
Name: caspase 3
RGD ID: 12072547
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity involved in apoptotic signaling pathway (ortholog); cysteine-type peptidase activity (ortholog); death receptor binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway in response to osmotic stress; positive regulation of apoptotic process; anterior neural tube closure (ortholog); PARTICIPATES IN apoptotic cell death pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cytoplasm; death-inducing signaling complex (ortholog); membrane raft (ortholog); INTERACTS WITH all-trans-retinoic acid; calcium oxalate; carvedilol
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CASP-3; caspase-3
Homo sapiens (human) : CASP3 (caspase 3)  HGNC  Alliance
Mus musculus (house mouse) : Casp3 (caspase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Casp3 (caspase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp3 (caspase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP3 (caspase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp3 (caspase 3)
Sus scrofa (pig) : CASP3 (caspase 3)
Chlorocebus sabaeus (African green monkey) : CASP3 (caspase 3)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1 Ensembl1645,920,071 - 45,940,505 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11645,920,074 - 45,940,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - uncurated


Comparative Map Data


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on CASP3
Ensembl Gene
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 12072547
Created: 2017-01-24
Species: Canis lupus familiaris
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.