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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:34757
Term: fenitrothion
Definition: An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.
Chemical ID: MESH:D005278
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTDFenitrothion results in increased expression of CASP3 mRNA; Fenitrothion results in increased expression of CASP3 proteinPMID:31173782 PMID:32034696 PMID:32572764 PMID:33393722 PMID:33439051 PMID:34968465
Casp3multiple interactionsEXP 6480464CTD[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CASP3 mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]PMID:31173782 PMID:32034696 PMID:32572764 PMID:33393722 PMID:33439051 PMID:34968465
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