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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:31429
Term: colforsin daropate hydrochloride
Definition: The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Chemical ID: MESH:D005576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDColforsin inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]PMID:16396944
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDColforsin results in increased activity of CASP3 proteinPMID:20131233 PMID:31278978
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDColforsin inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]PMID:21745194
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDKT 5720 inhibits the reaction [Colforsin results in increased activity of CASP3 protein]PMID:20131233
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