GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | increases activity | EXP | | 6480464 | CTD | Cyclosporine results in increased activity of CASP3 protein | PMID:17166486 PMID:17385075 | Casp3 | increases cleavage | EXP | | 6480464 | CTD | Cyclosporine results in increased cleavage of CASP3 protein | PMID:32569592 | Casp3 | increases expression | EXP | | 6480464 | CTD | Cyclosporine results in increased expression of CASP3 mRNA; Cyclosporine results in increased expression of CASP3 protein | PMID:33710703 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Cyclosporine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; NGF protein inhibits the reaction [Cyclosporine results in increased activity of CASP3 protein]; nilotinib inhibits the reaction [Cyclosporine results in increased expression of CASP3 mRNA]; nilotinib inhibits the reaction [Cyclosporine results in increased expression of CASP3 protein] | PMID:14599462 PMID:15799720 PMID:17385075 PMID:19135049 PMID:25947082 PMID:27588890 PMID:32569592 PMID:33710703 | Casp3 | increases activity | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Cyclosporine results in increased activity of CASP3 protein | PMID:15207740 PMID:22416070 | Casp3 | increases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Cyclosporine results in increased activity of CASP3 protein | PMID:22700542 | Casp3 | increases cleavage | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Cyclosporine results in increased cleavage of CASP3 protein | PMID:35033536 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Cyclosporine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of CASP3 protein]; Cyclosporine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [arsenite results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; Cyclosporine inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein] | PMID:10205001 PMID:33689844 PMID:35964836 PMID:37308051 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | 4-phenylbutyric acid inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; cobaltous chloride inhibits the reaction [Cyclosporine results in increased cleavage of and results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [arsenite results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [FAS protein results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; Cyclosporine inhibits the reaction [Mustard Gas results in increased cleavage of and results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Parathion results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [triphenyl phosphite results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]; Cyclosporine results in increased cleavage of and results in increased activity of CASP3 protein; Palmitic Acid promotes the reaction [Cyclosporine results in increased activity of CASP3 protein]; ursodoxicoltaurine inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein] | PMID:11032765 PMID:12871656 PMID:15548389 PMID:16443926 PMID:16935404 PMID:22343435 PMID:22700542 PMID:26884717 PMID:27544635 PMID:32652169 PMID:35033536 PMID:35964836 | | ||||||||||||||||||||||
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