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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:3193
Term: brucine
Definition: A monoterpenoid indole alkaloid that has formula C23H26N2O4.
Chemical ID: MESH:C083806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISORGD:7310026480464CTD[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; brucine results in increased activity of CASP3 proteinPMID:16443926 PMID:17449162 PMID:21684292
Casp3increases expressionISORGD:102896480464CTDbrucine results in increased expression of CASP3 proteinPMID:21684292
Casp3multiple interactionsISORGD:7310026480464CTDbrucine results in increased expression of and results in increased activity of CASP3 protein; Cyclosporine inhibits the reaction [[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]PMID:16442763 PMID:16443926
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