GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | increases activity | EXP | | 6480464 | CTD | Decitabine results in increased activity of CASP3 protein | PMID:23385821 | Casp3 | increases expression | EXP | | 6480464 | CTD | Decitabine results in increased expression of CASP3 mRNA | PMID:31733319 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | Decitabine inhibits the reaction [Benzene results in increased expression of CASP3 mRNA]; Decitabine inhibits the reaction [Cadmium Chloride results in decreased cleavage of CASP3 protein]; Decitabine promotes the reaction [gibberellic acid results in increased expression of CASP3 mRNA]; gibberellic acid promotes the reaction [Decitabine results in increased expression of CASP3 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased activity of CASP3 protein] | PMID:21143203 PMID:22457795 PMID:23385821 PMID:31733319 | Casp3 | increases expression | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Decitabine results in increased expression of CASP3 protein modified form | PMID:27915011 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | [Decitabine affects the methylation of CASP3 gene] which affects the expression of CASP3 protein; [Decitabine co-treated with Busulfan] results in increased activity of CASP3 protein; [Decitabine co-treated with trichostatin A] results in increased activity of CASP3 protein; [Valproic Acid co-treated with Decitabine co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; Decitabine promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Decitabine promotes the reaction [IFNA2 protein results in increased cleavage of and results in increased activity of CASP3 protein]; Decitabine promotes the reaction [IFNB1 protein results in increased cleavage of and results in increased activity of CASP3 protein] | PMID:17019711 PMID:17283156 PMID:17653094 PMID:18649362 PMID:19732952 PMID:21771726 | | ||||||||||||||||||||||
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