Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3affects expressionEXP 6480464CTDNicotine affects the expression of CASP3 mRNAPMID:20426880
Casp3increases activityEXP 6480464CTDNicotine results in increased activity of CASP3 protein; Nicotine results in increased activity of CASP3 protein alternative formPMID:18203686 PMID:20447445
Casp3increases cleavageEXP 6480464CTDNicotine results in increased cleavage of CASP3 proteinPMID:30959089 PMID:31678612
Casp3increases expressionEXP 6480464CTDNicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 proteinPMID:12218695 PMID:19815060
Casp3multiple interactionsEXP 6480464CTD[Ethanol co-treated with Nicotine] results in increased expression of CASP3 protein; Nicotine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]PMID:12218695 PMID:16237857
Casp3decreases activityISOCASP3 (Homo sapiens)6480464CTDNicotine results in decreased activity of CASP3 proteinPMID:11701223
Casp3decreases expressionISOCasp3 (Mus musculus)6480464CTDNicotine results in decreased expression of CASP3 mRNA; Nicotine results in decreased expression of CASP3 proteinPMID:17135361
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDNicotine results in decreased expression of CASP3 proteinPMID:20061081
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDNicotine results in increased activity of CASP3 proteinPMID:15831280
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDNicotine results in increased activity of CASP3 proteinPMID:12115584
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDNicotine results in increased cleavage of CASP3 proteinPMID:31783125
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDNicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein modified formPMID:15831280 PMID:22687363 PMID:30896085
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDNicotine results in increased expression of CASP3; Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein; Nicotine results in increased expression of CASP3 protein modified formPMID:16949557 PMID:20383341 PMID:20457658 PMID:33010382
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]; royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]PMID:22687363 PMID:23933227 PMID:30896085
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDgeldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein]; MK-886 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]PMID:12115584 PMID:20061081 PMID:20106947 PMID:22743290 PMID:23907605
Go Back to source page   Continue to Ontology report