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Nanoparticles (NP) are increasingly being in used in a wide range of applications, including biomedical and environmental. The potential hazard they may present is the focus of current nanotoxicology research. Among the nanoparticles with a broad spectrum of applications and known cellular responses are the carbon nanotubes, nano-titanium dioxide (TiO2) and nano-cerium oxide. TiO2 is a widely used pigment found in many consumer products that include cosmetics and sunscreens

Pathway Diagram:

Ariadne Genomics Inc. titanium dioxide nanoparticle --+> p53 signaling pathway titanium dioxide nanoparticle --+> FasL mediated signaling pathway 3N(O) ---- anatase 2P ---- anatase titanium dioxide nanoparticle ---> neutrophilia titanium dioxide nanoparticle ---> Lung Injury 3N(O) neutrophilia cytotoxicity genotoxicity Lung Injury brookite anatase rutile photocatalysis, under UV pigment titanium dioxide nanoparticle ---> cosmetics titanium dioxide nanoparticle ---> sunscreen titanium dioxide nanoparticle ---> prosthetic implants titanium dioxide nanoparticle ---> pigment cosmetics sunscreen prosthetic implants Bax Casp3 titanium dioxide nanoparticle ---> cytotoxicity mitochondrial function 2P anatase ---> photocatalysis, under UV titanium dioxide nanoparticle titanium dioxide nanoparticle --+> intrinsic apoptotic pathway Casp8 Fas Tp53 p53 signaling pathway Tlr4 titanium dioxide nanoparticle --+> Toll-like receptor signaling pathway intrinsic apoptotic pathway FasL mediated signaling pathway titanium dioxide nanoparticle ---| mitochondrial function titanium dioxide nanoparticle ---> genotoxicity Toll-like receptor signaling pathway

Genes in Pathway:

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titanium dioxide nanoparticle response pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:7248687
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:7248687
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:7248688
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:7248688
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:7248686
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:7248687

Pathway Gene Annotations

Disease Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway
Disease TermsGene Symbols
Colitis, UlcerativeTp53
Pathway Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway
Pathway TermsGene Symbols
allograft rejection pathwayFas
altered p53 signaling pathwayTp53
Alzheimer disease pathwayCasp3 , Casp8 , Fas
amyotrophic lateral sclerosis disease pathwayBax , Casp3 , Tp53
apoptotic cell death pathwayBax , Casp3 , Casp8 , Fas , Tp53
autoimmune thyroid disease pathwayFas
basal cell carcinoma pathwayTp53
bladder cancer pathwayTp53
cell cycle pathway, mitoticTp53
ceramide signaling pathwayBax , Casp8 , Tp53
chronic myeloid leukemia pathwayTp53
colorectal cancer pathwayBax , Casp3 , Tp53
cytokine mediated signaling pathwayFas
endometrial cancer pathwayTp53
Endoplasmic Reticulum-associated degradation pathwayBax
Entamoeba histolyca infection pathwayCasp3 , Tlr4
extrinsic apoptotic pathwayCasp3 , Casp8 , Fas
FasL mediated signaling pathwayCasp3 , Casp8 , Fas
glioma pathwayTp53
graft-versus-host disease pathwayFas
hepatitis C virus infection pathwayTp53
Huntington disease pathwayBax , Casp3 , Casp8 , Tp53
influenza A virus infection pathwayFas , Tlr4
intrinsic apoptotic pathwayBax , Casp3 , Fas
Leishmania infection pathwayTlr4
measles infection pathwayFas , Tlr4 , Tp53
melanoma pathwayTp53
mitogen activated protein kinase signaling pathwayCasp3 , Fas , Tp53
Mycobacterium tuberculosis infection pathwayBax , Casp3 , Casp8 , Tlr4
myocarditis pathwayCasp3 , Casp8
neurotrophic factor signaling pathwayBax , Tp53
NOD-like receptor signaling pathwayCasp8
non-small cell lung cancer pathwayTp53
p53 signaling pathwayBax , Casp3 , Casp8 , Fas , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayTp53
Parkinson disease pathwayCasp3
phagocytosis pathwayTlr4
Plasmodium infection pathwayTlr4
prion diseases pathwayBax
prostate cancer pathwayTp53
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8
rheumatoid arthritis disease pathwayTlr4
small cell lung cancer pathwayTp53
syndecan signaling pathwayBax , Casp3
thyroid cancer pathwayTp53
titanium dioxide nanoparticle response pathwayBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Toll-like receptor signaling pathwayCasp8 , Tlr4
Toxoplasma gondii infection pathwayCasp3 , Casp8 , Tlr4
Trail mediated signaling pathwayCasp3 , Casp8
Trypanosoma brucei infection pathwayFas
Trypanosoma cruzi infection pathwayCasp8 , Fas , Tlr4
tumor necrosis factor mediated signaling pathwayCasp8
type 1 diabetes mellitus pathwayFas
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayTp53
Phenotype Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway

References Associated with the titanium dioxide nanoparticle response pathway:

Ontology Path Diagram:

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