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View Ontology Report


Nanoparticles (NP) are increasingly being in used in a wide range of applications, including biomedical and environmental. The potential hazard they may present is the focus of current nanotoxicology research. Among the nanoparticles with a broad spectrum of applications and known cellular responses are the carbon nanotubes, nano-titanium dioxide (TiO2) and nano-cerium oxide. TiO2 is a widely used pigment found in many consumer products that include cosmetics and sunscreens

Pathway Diagram:

Ariadne Genomics Inc. titanium dioxide nanoparticle --+> p53 signaling pathway titanium dioxide nanoparticle --+> FasL mediated signaling pathway 3N(O) ---- anatase 2P ---- anatase titanium dioxide nanoparticle ---> neutrophilia titanium dioxide nanoparticle ---> Lung Injury 3N(O) neutrophilia cytotoxicity genotoxicity Lung Injury brookite anatase rutile photocatalysis, under UV pigment titanium dioxide nanoparticle ---> cosmetics titanium dioxide nanoparticle ---> sunscreen titanium dioxide nanoparticle ---> prosthetic implants titanium dioxide nanoparticle ---> pigment cosmetics sunscreen prosthetic implants Bax Casp3 titanium dioxide nanoparticle ---> cytotoxicity mitochondrial function 2P anatase ---> photocatalysis, under UV titanium dioxide nanoparticle titanium dioxide nanoparticle --+> intrinsic apoptotic pathway Casp8 Fas Tp53 p53 signaling pathway Tlr4 titanium dioxide nanoparticle --+> Toll-like receptor signaling pathway intrinsic apoptotic pathway FasL mediated signaling pathway titanium dioxide nanoparticle ---| mitochondrial function titanium dioxide nanoparticle ---> genotoxicity Toll-like receptor signaling pathway

Genes in Pathway:

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titanium dioxide nanoparticle response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator ISO RGD PMID:22614867 PMID:22419868 RGD:7248687, RGD:7248688 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 ISO RGD PMID:22614867 PMID:22419868 RGD:7248687, RGD:7248688 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 ISO RGD PMID:22419868 RGD:7248688 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:22419868 RGD:7248688 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:23803652 RGD:7248686 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:22614867 RGD:7248687 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Pathway Gene Annotations

Disease Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway
Disease TermsGene Symbols
abdominal aortic aneurysmCasp3
abdominal obesity-metabolic syndrome 1Bax , Fas
Acanthamoeba KeratitisTlr4
Acne ConglobataTlr4
Acute Coronary SyndromeTlr4
Acute ErythroleukemiaTp53
Acute Experimental PancreatitisFas
acute kidney failureBax , Fas , Tlr4 , Tp53
Acute Liver FailureCasp3 , Casp8 , Fas , Tlr4
Acute Lung InjuryBax , Casp3 , Casp8 , Fas , Tlr4
acute lymphoblastic leukemiaBax , Casp8 , Fas , Tp53
acute megakaryocytic leukemiaTp53
acute myeloid leukemiaFas , Tp53
acute myocardial infarctionBax , Casp3
acute necrotizing pancreatitisCasp3 , Tlr4
acute pancreatitisTlr4
Acute Tubulointerstitial NephritisTlr4
Acute-On-Chronic Liver FailureTlr4
adenocarcinomaCasp8 , Tp53
adenoid cystic carcinomaTp53
Adrenal Cortex NeoplasmsTp53
Adrenal Gland NeoplasmsTp53
Adrenal InsufficiencyBax
adrenocortical carcinomaTp53
adult T-cell leukemia/lymphomaFas , Tp53
Alcohol-Related DisordersCasp8
Alcoholic Fatty LiverTlr4
alcoholic hepatitisFas
Alcoholic Liver DiseasesFas
allergic conjunctivitisTlr4
allergic contact dermatitisCasp8 , Tlr4
allergic rhinitisTlr4
Alzheimer's diseaseBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
amyotrophic lateral sclerosisBax , Casp3 , Tp53
anaplastic astrocytomaTp53
Animal Disease ModelsFas , Tp53
ankylosing spondylitisTlr4
anogenital venereal wartTlr4
anterior uveitisTlr4
anti-basement membrane glomerulonephritisBax
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas
aplastic anemiaFas
Arsenic PoisoningTp53
asthmaFas , Tlr4
ataxia telangiectasiaBax
atherosclerosisCasp3 , Fas , Tlr4 , Tp53
atopic dermatitisCasp8 , Tlr4
atypical teratoid rhabdoid tumorTp53
autoimmune diseaseCasp8 , Fas
autoimmune hepatitisFas
autoimmune lymphoproliferative syndromeCasp8 , Fas
autoimmune lymphoproliferative syndrome type 2BCasp8
Autoimmune Lymphoproliferative Syndrome, Type IAFas
Autoimmune Lymphoproliferative Syndrome, Type VCasp8
autoimmune thrombocytopenic purpuraFas
Autosomal Recessive Dyskeratosis CongenitaTp53
autosomal recessive dyskeratosis congenita 3Tp53
B-Cell Chronic Lymphocytic LeukemiaFas , Tp53
B-lymphoblastic leukemia/lymphomaTp53
bacterial infectious diseaseCasp3 , Casp8
Bacterial KeratitisTlr4
bacterial pneumoniaTlr4
Balkan nephropathyTp53
Barrett's esophagusFas
basal cell carcinomaTp53
Behcet's diseaseFas , Tlr4
bone development diseaseTp53
Bone Marrow Failure Syndrome 5Tp53
Bone Marrow NeoplasmsTp53
bone osteosarcomaTp53
Brain ContusionCasp3 , Casp8
brain gliomaBax , Casp3 , Fas
Brain Hypoxia-IschemiaBax , Casp3 , Casp8 , Fas
Brain InjuriesBax , Casp3 , Casp8 , Fas , Tlr4
brain ischemiaCasp3 , Fas , Tlr4 , Tp53
Brain NeoplasmsTp53
breast adenocarcinomaTp53
breast cancerBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Breast Cancer, FamilialCasp8 , Tp53
breast carcinomaCasp3 , Fas , Tp53
Breast NeoplasmsBax , Casp8 , Tp53
Bronchial HyperreactivityTlr4
bronchiolo-alveolar adenocarcinomaTp53
bronchopulmonary dysplasiaBax , Casp3 , Casp8 , Tp53
BurnsBax , Casp3
Calcification of Aortic ValveTp53
calcinosisCasp3 , Tp53
carcinomaTlr4 , Tp53
cardiomyopathyFas , Tp53
CardiotoxicityFas , Tp53
Cardiovascular Pregnancy ComplicationsFas
carotid artery diseaseTlr4 , Tp53
carotid stenosisTlr4
cataractCasp3 , Fas , Tp53
Cecal NeoplasmsTp53
Central Nervous System NeoplasmsTp53
Cerebral HemorrhageBax , Casp3 , Casp8
cervical adenocarcinomaTp53
cervical cancerCasp3 , Tp53
cervical squamous cell carcinomaBax , Tp53
CHARGE syndromeTp53
Chemical and Drug Induced Liver InjuryBax , Casp8 , Fas , Tlr4
chemical colitisCasp3
Chemotherapy-Induced Febrile NeutropeniaTp53
Chest TraumaFas
cholesteatoma of middle earTlr4 , Tp53
choroid plexus carcinomaTp53
choroid plexus papillomaTp53
Chromosome 17 DeletionTp53
chronic conjunctivitisFas
Chronic HepatitisCasp3
Chronic Hepatitis BTlr4
Chronic Hepatitis CTlr4
Chronic Intermittent HypoxiaBax
chronic lymphocytic leukemiaTp53
chronic myeloid leukemiaFas
chronic obstructive pulmonary diseaseCasp3 , Casp8 , Fas , Tlr4 , Tp53
Chronic PainTlr4
Chronic PeriodontitisTlr4
Chronic UveitisFas
clear cell adenocarcinomaTp53
clear cell renal cell carcinomaBax , Tp53
Cognitive DysfunctionTp53
colon adenocarcinomaBax
colon cancerCasp3
colon carcinomaBax , Tp53
Colon DiverticulumTp53
Colonic NeoplasmsBax , Casp3 , Fas , Tp53
colorectal adenocarcinomaTp53
colorectal cancerBax , Tp53
colorectal carcinomaTp53
Colorectal NeoplasmsBax , Casp8 , Tlr4 , Tp53
common variable immunodeficiencyTp53
common variable immunodeficiency 1Casp8
congenital fibrosarcomaTp53
congenital myasthenic syndrome 2ATp53
congestive heart failureBax , Casp3 , Fas , Tp53
contact dermatitisCasp8 , Tlr4
Contrast-Induced NephropathyCasp3
Copper-Overload CirrhosisCasp3
corneal neovascularizationFas
coronary artery diseaseTlr4 , Tp53
coronary restenosisTp53
Craniofacial AbnormalitiesTp53
Crohn's diseaseTlr4
cryptorchidismCasp3 , Fas
cutaneous leishmaniasisTlr4
cystic echinococcosisTlr4
cystic fibrosisFas , Tlr4
demyelinating diseaseTp53
depressive disorderBax
dermatomyositisFas , Tlr4
diabetes mellitusCasp3 , Tlr4
diabetic angiopathyCasp3 , Fas
Diabetic CardiomyopathiesBax , Casp3 , Casp8
Diabetic FootTlr4
Diabetic NephropathiesCasp3 , Casp8 , Fas , Tlr4 , Tp53
diabetic neuropathyCasp3 , Tlr4
diabetic retinopathyCasp3 , Tlr4
Diamond-Blackfan anemiaTp53
diffuse large B-cell lymphomaFas , Tp53
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtypeTp53
DiGeorge syndromeTp53
dilated cardiomyopathyBax , Casp3 , Casp8 , Fas , Tp53
disease of cellular proliferationTp53
Disease ProgressionFas , Tp53
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
dry eye syndromeTlr4
Ductal CarcinomaTp53
ductal carcinoma in situTp53
dyskeratosis congenitaTp53
EdemaCasp3 , Casp8
end stage renal diseaseTlr4
endometrial adenocarcinomaTp53
endometrial cancerTp53
endometrial carcinomaTp53
Endometrial Intraepithelial NeoplasiaTp53
Endometrial NeoplasmsTp53
EndotoxemiaBax , Casp3 , Fas , Tlr4
Escherichia Coli MeningitisTlr4
esophageal cancerTp53
esophageal carcinomaTp53
Esophageal NeoplasmsBax , Casp8 , Fas , Tp53
esophagus adenocarcinomaCasp8 , Fas , Tlr4 , Tp53
esophagus squamous cell carcinomaCasp8 , Tp53
essential hypertensionTlr4
eumycotic mycetomaTlr4
exfoliation syndromeTlr4
Experimental Allergic AsthmaFas
Experimental ArthritisBax
Experimental Autoimmune EncephalomyelitisCasp3 , Casp8 , Tlr4
Experimental Autoimmune MyocarditisCasp3 , Casp8
Experimental Autoimmune NeuritisTlr4
Experimental Autoimmune UveitisFas , Tlr4
Experimental ColitisFas
Experimental Diabetes MellitusBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Experimental Liver CirrhosisFas , Tlr4
Experimental Liver NeoplasmsFas , Tp53
Experimental Mammary NeoplasmsBax , Casp3 , Casp8 , Fas , Tp53
Experimental NeoplasmsTp53
Experimental Radiation InjuriesCasp3 , Casp8 , Fas
extrahepatic cholestasisTlr4
eye diseaseTlr4
Eye NeoplasmsTp53
familial Mediterranean feverTlr4
familial melanomaTp53
Familial Prostate CancerCasp8
Familial Thoracic Aortic Aneurysm 6Fas
fatty liver diseaseTlr4
Female InfertilityTp53
Fetal Growth RetardationBax , Casp3 , Fas
Fungal Eye InfectionsTlr4
Fungal KeratitisTlr4
Funnel ChestTp53
gallbladder cancerTp53
gallbladder carcinomaTp53
Gallbladder NeoplasmsTp53
gastric adenocarcinomaTp53
gastric ulcerCasp3 , Fas
Gastrointestinal HemorrhageBax
genetic diseaseBax , Casp3 , Casp8 , Fas , Tlr4
glaucomaBax , Fas
glomerulonephritisFas , Tlr4
graft-versus-host diseaseFas , Tp53
Graves' diseaseFas , Tp53
Hashimoto DiseaseFas
head and neck cancerTp53
Head and Neck NeoplasmsTp53
head and neck squamous cell carcinomaCasp8 , Tp53
Hearing LossTlr4
heart diseaseBax , Casp3 , Casp8
heart valve diseaseCasp3
HELLP syndromeFas
hematologic cancerTp53
hematopoietic system diseaseFas
Hemorrhagic ShockCasp3 , Casp8 , Tlr4
hepatitis BFas
hepatoblastomaFas , Tp53
hepatocellular carcinomaBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
hepatorenal syndromeTlr4
Hereditary Adrenocortical CarcinomaTp53
hereditary breast ovarian cancer syndromeTp53
Hereditary Neoplastic SyndromesTp53
heroin dependenceFas
Herpes Simplex EncephalitisTlr4
herpes simplex virus keratitisTlr4
high grade gliomaFas , Tp53
human immunodeficiency virus infectious diseaseBax , Fas
Huntington's diseaseBax , Casp3 , Casp8 , Fas
hypertensionBax , Casp3 , Casp8 , Tlr4 , Tp53
hypertrophic cardiomyopathyCasp3 , Tp53
Hypogonadism and Testicular AtrophyTp53
idiopathic pulmonary fibrosisFas
IgA glomerulonephritisFas
impotenceBax , Casp3
inclusion body myositisFas
infectious mononucleosisFas
Insulin ResistanceCasp3 , Casp8 , Fas , Tlr4
intermittent claudicationBax , Casp3
intestinal diseaseBax , Casp3
Intestinal NeoplasmsBax
Intestinal Reperfusion InjuryCasp3
intrahepatic cholangiocarcinomaFas
invasive aspergillosisTlr4
ischemiaBax , Tp53
Kaposi's sarcomaTp53
Kashin-Beck DiseaseBax , Fas
Kawasaki diseaseTlr4
kidney diseaseCasp3 , Casp8
kidney failureTlr4
Kidney Reperfusion InjuryBax , Casp3 , Fas , Tlr4
Knee OsteoarthritisBax
learning disabilityTlr4
Leber hereditary optic neuropathyTp53
Li-Fraumeni syndromeTp53
Li-Fraumeni syndrome 1Tp53
Li-Fraumeni-Like SyndromeTp53
limited sclerodermaFas
Lip NeoplasmsTp53
liver cirrhosisCasp3 , Casp8 , Tlr4
liver diseaseFas
Liver InjuryFas , Tlr4
Liver NeoplasmsTp53
Liver Reperfusion InjuryBax , Casp3 , Casp8 , Fas , Tlr4
low tension glaucomaTlr4 , Tp53
lung adenocarcinomaFas , Tlr4 , Tp53
lung cancerCasp8
lung diseaseTlr4
Lung InjuryTlr4
Lung NeoplasmsCasp8 , Fas , Tlr4 , Tp53
lung non-small cell carcinomaBax , Casp3 , Casp8 , Tp53
lung oat cell carcinomaTp53
Lung Reperfusion InjuryBax , Casp3 , Tlr4
lung sarcomatoid carcinomaTp53
lung small cell carcinomaTp53
lung squamous cell carcinomaTp53
lupus nephritisFas
Lymphatic MetastasisFas , Tlr4 , Tp53
Lymphomatoid PapulosisFas
lymphoproliferative syndromeFas
macular degenerationBax , Fas , Tlr4
male infertilityBax , Fas , Tp53
malignant astrocytomaTp53
malignant mesotheliomaTp53
marginal zone lymphomaTp53
melanomaCasp8 , Fas , Tlr4 , Tp53
membranoproliferative glomerulonephritisTlr4
meninges sarcomaTp53
meningococcal meningitisTlr4
Metabolic Brain DiseasesFas
Metabolic SyndromeFas
Microsatellite InstabilityBax
middle cerebral artery infarctionBax , Casp3
mismatch repair cancer syndromeTp53
mitochondrial metabolism diseaseCasp8 , Tp53
mixed connective tissue diseaseFas
morphine dependenceBax
Mouth NeoplasmsTp53
Moyamoya diseaseFas
Multi-Infarct DementiaBax
multiple myelomaTp53
multiple sclerosisFas , Tlr4
multiple system atrophyFas
Multisystemic Smooth Muscle Dysfunction SyndromeFas
myasthenia gravisFas
Mycoplasma InfectionsCasp3
myelodysplastic syndromeFas , Tp53
myeloid leukemia associated with Down SyndromeTp53
myeloid neoplasmTp53
myocardial infarctionBax , Casp3 , Tlr4 , Tp53
Myocardial IschemiaBax
Myocardial Reperfusion InjuryBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
nasal cavity cancerTp53
Nasal PolypsFas , Tlr4
nasal type extranodal NK/T-cell lymphomaFas
Nasopharyngeal NeoplasmsTp53
nasopharynx carcinomaTp53
Neoplasm InvasivenessTlr4
Neoplasm MetastasisBax , Casp3 , Fas , Tlr4 , Tp53
Neoplastic Cell TransformationTp53
nephritisCasp8 , Fas
Nerve DegenerationBax , Casp3
Nerve Sheath NeoplasmsTp53
nervous system diseaseCasp3 , Tp53
Neurodevelopmental DisordersCasp8
non-alcoholic fatty liver diseaseFas , Tlr4
non-Hodgkin lymphomaTp53
ocular hypertensionFas
Ocular OnchocerciasisTlr4
Odontogenic MyxomaTp53
Optic Nerve InjuriesBax , Tlr4
Oral Lichen PlanusTlr4 , Tp53
oral mucosa leukoplakiaTp53
oral squamous cell carcinomaTp53
oral submucous fibrosisTp53
Oropharyngeal NeoplasmsTp53
osteoarthritisBax , Casp3
Osteoarthritis, ExperimentalCasp3 , Casp8
otitis mediaTlr4
Otitis Media with EffusionTlr4
ovarian cancerFas , Tp53
ovarian carcinomaTp53
Ovarian NeoplasmsTlr4 , Tp53
ovarian serous cystadenocarcinomaTp53
ovarian small cell carcinomaTp53
ovary serous adenocarcinomaTp53
Oxygen-Induced RetinopathyCasp3 , Fas
Painful NeuropathyTlr4
pancreatic adenocarcinomaTp53
pancreatic cancerCasp8 , Tp53
pancreatic carcinomaTp53
pancreatic ductal carcinomaTp53
pancreatic intraductal papillary-mucinous neoplasmTp53
pancreatitisCasp3 , Tlr4
papillary renal cell carcinomaTp53
papillomavirus infectious diseaseCasp8
paranasal sinus benign neoplasmTp53
Parasitic Liver DiseasesTp53
Parkinson's diseaseCasp3 , Fas
Pediatric Adrenocortical CarcinomaTp53
Penile NeoplasmsTp53
perinatal necrotizing enterocolitisTlr4
peripheral vascular diseaseFas
Phyllodes TumorTp53
Plaque, AtheroscleroticTlr4
plasma cell neoplasmTp53
Plasmodium falciparum malariaFas
pleomorphic xanthoastrocytomaTp53
pleural tuberculosisTlr4
Pneumococcal MeningitisTlr4
polycystic ovary syndromeBax
post-traumatic stress disorderBax
pre-eclampsiaFas , Tlr4
pre-malignant neoplasmBax , Casp3 , Casp8 , Fas , Tp53
Premature AgingBax , Tp53
primary biliary cholangitisFas
primary cutaneous T-cell non-Hodgkin lymphomaBax , Fas , Tp53
primary immunodeficiency diseaseCasp8 , Fas
primary open angle glaucomaTlr4 , Tp53
Primary Pulmonary Hypertension, 1Casp8
prion diseaseBax
prostate adenocarcinomaTp53
prostate cancerBax , Casp3 , Fas , Tp53
prostate carcinomaBax
Prostatic NeoplasmsBax , Casp3 , Fas , Tlr4 , Tp53
Pseudomonas Aeruginosa KeratitisTlr4
psoriasisTlr4 , Tp53
Pulmonary Arterial HypertensionCasp8
pulmonary edemaTlr4
pulmonary emphysemaTlr4
pulmonary fibrosisTlr4
pulmonary hypertensionTlr4 , Tp53
pulmonary tuberculosisTlr4
Puromycin Aminonucleoside NephrosisFas
relapsing-remitting multiple sclerosisFas
renal cell carcinomaCasp3 , Fas , Tp53
Renal Cell Carcinoma 1Tp53
renal fibrosisTlr4
Reperfusion InjuryBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
respiratory allergyTlr4
Respiratory SoundsTlr4
respiratory syncytial virus infectious diseaseTlr4
Retina Reperfusion InjuryBax , Tlr4
retinal degenerationBax
retinal detachmentCasp3 , Casp8 , Fas
retinal diseaseCasp3
rheumatic heart diseaseBax
rheumatoid arthritisFas
Right Ventricular HypertrophyBax
salivary gland diseaseCasp3
SAPHO syndromeTp53
sciatic neuropathyCasp3 , Casp8 , Fas , Tlr4
scrapieBax , Casp3
Seasonal Allergic RhinitisTlr4
SepsisCasp3 , Casp8 , Fas , Tlr4
serous cystadenocarcinomaTp53
severe acute respiratory syndromeCasp3
severe COVID-19Tlr4
Sezary's diseaseTp53
Sjogren's syndromeFas
skin melanomaTp53
Skin NeoplasmsCasp8 , Tp53
small cell carcinomaTp53
spermatic cord torsionCasp3
Spinal Cord CompressionFas
Spinal Cord InjuriesBax , Casp3 , Fas , Tlr4 , Tp53
Spinal Cord Reperfusion InjuryTlr4
Sporadic Papillary Renal Cell CarcinomaTp53
squamous cell carcinomaFas , Tlr4 , Tp53
Stable AnginaTlr4
status epilepticusBax , Casp3 , Casp8
stomach cancerBax , Casp3 , Tp53
Stomach NeoplasmsCasp8 , Tp53
StrokeCasp3 , Tlr4
Subarachnoid HemorrhageCasp3 , Tlr4
suppurative otitis mediaTlr4
systemic lupus erythematosusFas , Tlr4
T-cell acute lymphoblastic leukemiaBax
T-cell non-Hodgkin lymphomaTp53
Taste DisordersFas
temporal arteritisTlr4
Temporomandibular Joint OsteoarthritisFas
Testicular InjuryFas
Testis Reperfusion InjuryBax , Casp3
thoracic aortic aneurysmFas
Thymus NeoplasmsTp53
thyroid gland anaplastic carcinomaTp53
thyroid gland papillary carcinomaTp53
Thyroid NeoplasmsTp53
Tongue NeoplasmsTp53
tongue squamous cell carcinomaTp53
toxic encephalopathyCasp3
transient cerebral ischemiaBax , Casp3 , Casp8 , Fas
transitional cell carcinomaCasp3 , Fas , Tp53
Transplant RejectionTlr4
transthyretin amyloidosisTp53
traumatic brain injuryCasp3 , Tp53
Trigeminal Nerve InjuriesTp53
type 1 diabetes mellitusCasp3 , Casp8 , Fas , Tlr4
type 2 diabetes mellitusBax , Casp3 , Casp8 , Fas , Tlr4
ulcerative colitisCasp3 , Fas , Tp53
ureteral obstructionCasp3
urinary bladder cancerBax , Casp3 , Fas , Tlr4 , Tp53
Urinary Bladder NeoplasmTp53
urinary tract infectionTlr4
Urogenital NeoplasmsTp53
Urologic NeoplasmsTp53
uterine cancerTp53
uterine carcinosarcomaTp53
Uterine Cervical NeoplasmsCasp8 , Tp53
vascular dementiaTp53
Ventricular Dysfunction, LeftFas , Tlr4
Ventricular RemodelingBax , Casp3
very long chain acyl-CoA dehydrogenase deficiencyTp53
Viral BronchiolitisFas , Tlr4
viral meningitisTlr4
Viral MyocarditisCasp3 , Casp8
visual epilepsyFas
Vulvar Lichen SclerosusTp53
Vulvar NeoplasmsTp53
Wallerian DegenerationTlr4
Weight LossTlr4
xeroderma pigmentosumTp53
Pathway Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway
Pathway TermsGene Symbols
allograft rejection pathwayFas
altered p53 signaling pathwayTp53
Alzheimer's disease pathwayCasp3 , Casp8 , Fas
amyotrophic lateral sclerosis pathwayBax , Casp3 , Tp53
apoptotic cell death pathwayBax , Casp3 , Casp8 , Fas , Tp53
autoimmune thyroiditis pathwayFas
basal cell carcinoma pathwayTp53
cell cycle pathway, mitoticTp53
ceramide signaling pathwayBax , Casp8 , Tp53
Chagas disease pathwayCasp8 , Fas , Tlr4
chronic myeloid leukemia pathwayTp53
colorectal cancer pathwayBax , Casp3 , Tp53
cytokine mediated signaling pathwayFas
endometrial cancer pathwayTp53
Endoplasmic Reticulum-associated degradation pathwayBax
Entamoebiasis pathwayCasp3 , Tlr4
extrinsic apoptotic pathwayCasp3 , Casp8 , Fas
FasL mediated signaling pathwayCasp3 , Casp8 , Fas
glioma pathwayTp53
graft-versus-host disease pathwayFas
hepatitis C pathwayTp53
Huntington's disease pathwayBax , Casp3 , Casp8 , Tp53
influenza A pathwayFas , Tlr4
intrinsic apoptotic pathwayBax , Casp3 , Fas
Leishmaniasis pathwayTlr4
malaria pathwayTlr4
measles pathwayFas , Tlr4 , Tp53
melanoma pathwayTp53
mitogen activated protein kinase signaling pathwayCasp3 , Fas , Tp53
myocarditis pathwayCasp3 , Casp8
neurotrophic factor signaling pathwayBax , Tp53
NOD-like receptor signaling pathwayCasp8
non-small cell lung carcinoma pathwayTp53
p53 signaling pathwayBax , Casp3 , Casp8 , Fas , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayTp53
Parkinson's disease pathwayCasp3
phagocytosis pathwayTlr4
prion disease pathwayBax
prostate cancer pathwayTp53
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8
rheumatoid arthritis pathwayTlr4
sleeping sickness pathwayFas
small cell lung carcinoma pathwayTp53
syndecan signaling pathwayBax , Casp3
thyroid cancer pathwayTp53
titanium dioxide nanoparticle response pathwayBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Toll-like receptor signaling pathwayCasp8 , Tlr4
toxoplasmosis pathwayCasp3 , Casp8 , Tlr4
Trail mediated signaling pathwayCasp3 , Casp8
tuberculosis pathwayBax , Casp3 , Casp8 , Tlr4
tumor necrosis factor mediated signaling pathwayCasp8
type 1 diabetes mellitus pathwayFas
urinary bladder cancer pathwayTp53
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayTp53
Phenotype Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway

References Associated with the titanium dioxide nanoparticle response pathway:

Ontology Path Diagram:

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Import into Pathway Studio: