TITANIUM DIOXIDE NANOPARTICLE RESPONSE PATHWAY (PW:0001437)

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Description

Nanoparticles (NP) are increasingly being in used in a wide range of applications, including biomedical and environmental. The potential hazard they may present is the focus of current nanotoxicology research. Among the nanoparticles with a broad spectrum of applications and known cellular responses are the carbon nanotubes, nano-titanium dioxide (TiO2) and nano-cerium oxide. TiO2 is a widely used pigment found in many consumer products that include cosmetics and sunscreens

Pathway Diagram:

Ariadne Genomics Inc. titanium dioxide nanoparticle --+> p53 signaling pathway titanium dioxide nanoparticle --+> FasL mediated signaling pathway 3N(O) ---- anatase 2P ---- anatase titanium dioxide nanoparticle ---> neutrophilia titanium dioxide nanoparticle ---> Lung Injury 3N(O) neutrophilia cytotoxicity genotoxicity Lung Injury brookite anatase rutile photocatalysis, under UV pigment titanium dioxide nanoparticle ---> cosmetics titanium dioxide nanoparticle ---> sunscreen titanium dioxide nanoparticle ---> prosthetic implants titanium dioxide nanoparticle ---> pigment cosmetics sunscreen prosthetic implants Bax Casp3 titanium dioxide nanoparticle ---> cytotoxicity mitochondrial function 2P anatase ---> photocatalysis, under UV titanium dioxide nanoparticle titanium dioxide nanoparticle --+> intrinsic apoptotic pathway Casp8 Fas Tp53 p53 signaling pathway Tlr4 titanium dioxide nanoparticle --+> Toll-like receptor signaling pathway intrinsic apoptotic pathway FasL mediated signaling pathway titanium dioxide nanoparticle ---| mitochondrial function titanium dioxide nanoparticle ---> genotoxicity Toll-like receptor signaling pathway
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Genes in Pathway:

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titanium dioxide nanoparticle response pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:7248687
RGD:7248688
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:7248687
RGD:7248688
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:7248688
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:7248688
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:7248686
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:7248687

Pathway Gene Annotations

Disease Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway
Disease TermsGene Symbols
Acanthamoeba KeratitisTlr4
acneTlr4
Acne ConglobataTlr4
Acute Coronary SyndromeTlr4
acute kidney failureBax , Fas , Tlr4 , Tp53
Acute Liver FailureCasp3 , Fas , Tlr4
Acute Lung InjuryBax , Casp3 , Casp8 , Fas , Tlr4
acute myeloid leukemiaFas , Tp53
acute myocardial infarctionCasp3
Acute Necrotizing PancreatitisCasp3 , Tlr4
acute T cell leukemiaBax
Acute Tubulointerstitial NephritisTlr4
Acute-On-Chronic Liver FailureTlr4
adenocarcinomaCasp8 , Tp53
adenoid cystic carcinomaTp53
adenomaTp53
adrenal carcinomaTp53
Adrenal Gland NeoplasmsTp53
Adrenal InsufficiencyBax
adrenocortical carcinomaTp53
adult T-cell leukemiaFas , Tp53
age related macular degeneration 10Tlr4
Alcohol-Related DisordersCasp8
allergic conjunctivitisTlr4
allergic contact dermatitisCasp8 , Tlr4
allergic rhinitisTlr4
Alzheimer's diseaseBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
amyotrophic lateral sclerosisBax , Casp3 , Tp53
Anaplastic Thyroid CarcinomaTp53
Angina, StableTlr4
angiosarcomaTp53
Animal Disease ModelsFas , Tp53
ankylosing spondylitisTlr4
anterior uveitisTlr4
anti-basement membrane glomerulonephritisBax
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas
aplastic anemiaFas
Arsenic PoisoningTp53
arteriosclerosisTlr4
arthritisTlr4
asthmaFas , Tlr4
astrocytomaTp53
atherosclerosisCasp3 , Fas , Tlr4
atopic dermatitisCasp8 , Tlr4
Autoimmune DiseasesCasp8 , Fas
autoimmune lymphoproliferative syndromeCasp8 , Fas
autoimmune lymphoproliferative syndrome type 2BCasp8
Autoimmune Lymphoproliferative Syndrome, Type IAFas
autoimmune thrombocytopenic purpuraFas
Autosomal Recessive Dyskeratosis CongenitaTp53
B-Cell Chronic Lymphocytic LeukemiaFas , Tp53
BacteremiaTlr4
bacterial infectious diseaseCasp3 , Casp8
Bacterial KeratitisTlr4
bacterial pneumoniaTlr4
Balkan nephropathyTp53
Barrett's esophagusFas
basal cell carcinomaTp53
Behcet's diseaseFas , Tlr4
bladder urothelial carcinomaTp53
bone development diseaseTp53
Bone Marrow NeoplasmsTp53
Brain ContusionCasp3 , Casp8
brain gliomaBax , Casp3 , Fas
Brain InjuriesBax , Casp3 , Casp8 , Fas , Tlr4
brain ischemiaCasp3 , Fas , Tlr4 , Tp53
Brain NeoplasmsTp53
breast adenocarcinomaTp53
breast cancerCasp8 , Tp53
Breast Cancer, FamilialTp53
Breast NeoplasmsBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Bronchial HyperreactivityTlr4
bronchiolo-alveolar adenocarcinomaTp53
Bronchopulmonary DysplasiaBax , Casp3 , Casp8 , Tp53
BurnsBax , Casp3
calcinosisCasp3
carcinomaTlr4 , Tp53
cardiomyopathyFas , Tp53
carotid artery diseaseTlr4 , Tp53
carotid stenosisTlr4
cataractCasp3 , Fas , Tp53
Cecal NeoplasmsTp53
Cell Transformation, NeoplasticTp53
Central Nervous System NeoplasmsTp53
Cerebral HemorrhageBax , Casp3 , Casp8
cervical cancerTp53
cervix carcinomaTp53
CHARGE syndromeTp53
Chemical and Drug Induced Liver InjuryBax , Casp8 , Fas
chemical colitisCasp3
Chemotherapy-Induced Febrile NeutropeniaTp53
Chest TraumaFas
cholangiocarcinomaTp53
cholesteatomaTlr4
cholesteatoma of middle earTlr4 , Tp53
chorioamnionitisFas
choroid plexus carcinomaTp53
choroid plexus papillomaTp53
Chromosome 17 DeletionTp53
chronic conjunctivitisFas
Chronic HepatitisCasp3
Chronic Intermittent HypoxiaBax
chronic lymphocytic leukemiaTp53
chronic myeloid leukemiaFas
chronic obstructive pulmonary diseaseCasp3 , Casp8 , Fas , Tlr4 , Tp53
Chronic PainTlr4
Chronic PeriodontitisTlr4
Chronic UveitisFas
clear cell adenocarcinomaTp53
clonorchiasisFas
colitisTlr4
colon cancerTp53
colon carcinomaBax , Tp53
Colonic NeoplasmsBax , Casp3 , Fas , Tp53
colorectal adenocarcinomaTp53
colorectal cancerTp53
Colorectal NeoplasmsBax , Casp8 , Tlr4 , Tp53
Combined Oxidative Phosphorylation Deficiency 11Tp53
congestive heart failureBax , Casp3 , Fas , Tp53
contact dermatitisCasp8 , Tlr4
Contrast-Induced NephropathyCasp3
Copper-Overload CirrhosisCasp3
corneal neovascularizationFas
coronary artery diseaseTlr4
coronary restenosisTp53
Craniofacial AbnormalitiesTp53
Crohn's diseaseTlr4
cryptorchidismCasp3
cutaneous leishmaniasisTlr4
Cutaneous Malignant Melanoma, Susceptibility To, 1Tp53
cutaneous T cell lymphomaBax , Fas , Tp53
cystic fibrosisFas , Tlr4
dementiaBax
Dementia, Multi-InfarctBax
demyelinating diseaseTp53
dermatomyositisFas , Tlr4
diabetes mellitusTlr4
Diabetes Mellitus, Experimental Bax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
diabetic angiopathyCasp3 , Fas
Diabetic CardiomyopathiesCasp3 , Casp8
Diabetic FootTlr4
Diabetic NephropathiesCasp3 , Casp8 , Fas , Tlr4 , Tp53
diabetic neuropathyCasp3 , Tlr4
diabetic retinopathyCasp3 , Tlr4
Diamond-Blackfan anemiaTp53
diffuse large B-cell lymphomaFas , Tp53
dilated cardiomyopathyBax , Casp3 , Casp8 , Fas , Tp53
disease of cellular proliferationTp53
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
dry eye syndromeTlr4
ductal carcinoma in situTp53
dyskeratosis congenitaTp53
EdemaCasp3 , Casp8
EmphysemaTp53
end stage renal failureTlr4
endometrial cancerTp53
Endometrial NeoplasmsTp53
endometriosisBax
endometritisCasp3
endophthalmitisFas
EndotoxemiaBax , Casp3 , Fas , Tlr4
Endotoxin HyporesponsivenessTlr4
EntamoebiasisTlr4
EosinophiliaTlr4
esophageal cancerTp53
esophageal carcinomaTp53
Esophageal NeoplasmsBax , Casp8 , Fas , Tp53
esophagus adenocarcinomaFas , Tlr4 , Tp53
esophagus squamous cell carcinomaTp53
eumycotic mycetomaTlr4
exfoliation syndromeTlr4
Experimental Allergic AsthmaFas
Experimental ArthritisBax
Experimental Autoimmune EncephalomyelitisCasp3 , Casp8 , Tlr4
Experimental Autoimmune MyocarditisCasp3 , Casp8
Experimental Autoimmune NeuritisTlr4
Experimental Autoimmune UveitisFas , Tlr4
Experimental ColitisFas
Experimental Liver CirrhosisFas , Tlr4
Experimental Liver NeoplasmsTp53
Experimental NeoplasmsTp53
extrahepatic cholestasisTlr4
eye diseaseTlr4
familial Mediterranean feverTlr4
Familial Prostate CancerCasp8
fatty liver diseaseTlr4
Female InfertilityTp53
Fetal Growth RetardationBax , Casp3 , Fas
FibrosisTlr4
Fungal Eye InfectionsTlr4
Fungal KeratitisTlr4
gallbladder carcinomaTp53
Gallbladder NeoplasmsTp53
gastric adenocarcinomaTp53
gastric ulcerCasp3 , Fas
Gastrointestinal HemorrhageBax
Gaucher's diseaseTp53
Gaucher's disease type ITp53
genetic diseaseFas
glaucomaBax , Fas
glioblastoma multiformeTp53
glomerulonephritisFas , Tlr4
grade III astrocytomaTp53
Graft vs Host DiseaseFas , Tp53
Graves' diseaseFas , Tp53
Hashimoto DiseaseFas
Head and Neck NeoplasmsTp53
head and neck squamous cell carcinomaCasp8 , Tp53
Hearing LossTlr4
heart diseaseBax , Casp3 , Casp8
heart valve diseaseCasp3
hematopoietic system diseaseFas
hepatoblastomaTp53
hepatocellular carcinomaCasp3 , Casp8 , Tlr4 , Tp53
hepatorenal syndromeTlr4
Hereditary Adrenocortical CarcinomaTp53
hereditary breast ovarian cancer syndromeTp53
Hereditary Neoplastic SyndromesTp53
hereditary spastic paraplegia 11Tp53
heroin dependenceFas
Herpes Simplex EncephalitisTlr4
herpes simplex virus keratitisTlr4
human immunodeficiency virus infectious diseaseBax , Fas
Huntington's diseaseBax , Casp3 , Casp8 , Fas
HyperalgesiaTlr4
HypercholesterolemiaCasp3
hyperglycemiaCasp8
HyperoxiaFas
HyperplasiaBax
hypersplenismFas
hypertensionBax , Casp3 , Casp8 , Tlr4 , Tp53
hypertrophic cardiomyopathyCasp3 , Tp53
HypothermiaFas
HypoxiaCasp3
Hypoxia-Ischemia, BrainBax , Casp3 , Casp8 , Fas
idiopathic pulmonary fibrosisFas
IgA glomerulonephritisFas
ileitisTlr4
impotenceBax , Casp3
inclusion body myositisFas
infectious mononucleosisFas
InflammationTlr4
Insulin ResistanceCasp3 , Casp8 , Fas , Tlr4
intermittent claudicationBax , Casp3
intestinal diseaseBax , Casp3
Intestinal NeoplasmsBax
Intestinal Reperfusion InjuryCasp3
invasive aspergillosisTlr4
ischemiaBax , Tp53
Kaposi's sarcomaTp53
Kashin-Beck DiseaseBax , Fas
Kawasaki diseaseTlr4
keratitisTlr4
keratosisTp53
kidney diseaseCasp3 , Casp8
kidney failureTlr4
Kidney Reperfusion InjuryBax , Casp3 , Fas , Tlr4
learning disabilityTlr4
Leber hereditary optic neuropathyTp53
leiomyomaBax
leptospirosisTlr4
leukemiaTp53
Li-Fraumeni syndromeTp53
Li-Fraumeni Syndrome 1Tp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
limited sclerodermaFas
Lip NeoplasmsTp53
Lipoyltransferase 1 DeficiencyTp53
liver cancerCasp8 , Tp53
liver cirrhosisCasp3 , Casp8
liver diseaseFas
liver neoplasmTp53
Liver Reperfusion InjuryBax , Casp8 , Fas , Tlr4
low tension glaucomaTlr4 , Tp53
lung adenocarcinomaTp53
lung cancerCasp8
lung diseaseTlr4
Lung InjuryTlr4
Lung NeoplasmsCasp8 , Fas , Tlr4 , Tp53
Lung Reperfusion InjuryBax , Casp3 , Tlr4
lung small cell carcinomaTp53
lung squamous cell carcinomaTp53
Lymphatic MetastasisFas , Tlr4 , Tp53
lymphomaTp53
Lymphoma, Extranodal NK-T-CellFas
lymphoproliferative syndromeFas
macular degenerationBax , Fas , Tlr4
male infertilityBax , Fas , Tp53
malignant gliomaFas , Tp53
malignant mesotheliomaTp53
Mammary Neoplasms, ExperimentalBax , Casp3 , Casp8 , Fas , Tp53
marginal zone B-cell lymphomaTp53
mastitisTlr4
mastoiditisTlr4
medulloblastomaTp53
Megakaryoblastic Leukemia of Down SyndromeTp53
megakaryocytic leukemiaTp53
melanomaCasp8 , Fas , Tlr4 , Tp53
membranoproliferative glomerulonephritisTlr4
Meningitis, Escherichia ColiTlr4
meningococcal meningitisTlr4
mental depressionBax
MesotheliomaTp53
Metabolic Brain DiseasesFas
metabolic syndrome XBax , Fas
Microsatellite InstabilityBax
middle cerebral artery infarctionBax , Casp3
mixed connective tissue diseaseFas
morphine dependenceBax
Mouth NeoplasmsTp53
Moyamoya diseaseFas
multiple myelomaTp53
multiple sclerosisFas , Tlr4
multiple system atrophyFas
Multisystemic Smooth Muscle Dysfunction SyndromeFas
myasthenia gravisFas
Mycoplasma InfectionsCasp3
myelodysplastic syndromeFas , Tp53
myelofibrosisTp53
myocardial infarctionBax , Casp3 , Tlr4 , Tp53
Myocardial IschemiaBax
Myocardial Reperfusion InjuryBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Nasal PolypsFas , Tlr4
Nasopharyngeal NeoplasmsTp53
nasopharynx carcinomaTp53
NecrosisFas
Neoplasm InvasivenessTlr4
Neoplasm MetastasisBax , Casp3 , Fas , Tlr4 , Tp53
nephritisCasp8 , Fas
nephroblastomaTp53
Nephrosis, Puromycin AminonucleosideFas
Nerve DegenerationBax , Casp3
Nerve Sheath NeoplasmsTp53
nervous system diseaseCasp3 , Tp53
NeuralgiaTlr4
neuroblastomaTp53
Neuropathy, PainfulTlr4
non-Hodgkin lymphomaTp53
non-small cell lung carcinomaCasp3 , Casp8 , Tp53
nonalcoholic fatty liver diseaseFas , Tlr4
Nose NeoplasmsTp53
obesityTlr4
ocular hypertensionFas
Odontogenic MyxomaTp53
Onchocerciasis, OcularTlr4
Optic Nerve InjuriesBax , Tlr4
Oral Lichen PlanusTlr4 , Tp53
oral mucosa leukoplakiaTp53
oral submucous fibrosisTp53
Oropharyngeal NeoplasmsTp53
osteoarthritisBax , Casp3
Osteoarthritis, ExperimentalCasp3 , Casp8
Osteoarthritis, KneeBax
Osteoarthritis, Temporomandibular JointFas
osteoporosisBax
osteosarcomaTp53
otitis mediaTlr4
Otitis Media with EffusionTlr4
ovarian cancerTp53
Ovarian NeoplasmsFas , Tlr4 , Tp53
ovarian serous cystadenocarcinomaTp53
ovary epithelial cancerTp53
Oxygen-Induced RetinopathyFas
PainTlr4
pancreatic adenocarcinomaTp53
pancreatic cancerCasp8 , Tp53
pancreatic carcinomaTp53
pancreatitisCasp3 , Tlr4
papillary renal cell carcinomaTp53
Papillomavirus InfectionsCasp8
paranasal sinus neoplasmTp53
Parasitic Liver DiseasesTp53
Parkinson's diseaseCasp3 , Fas
Parkinsonian DisordersCasp3
Pediatric Adrenocortical CarcinomaTp53
penile neoplasmTp53
perinatal necrotizing enterocolitisTlr4
peripheral vascular diseaseFas
Phyllodes TumorTp53
Plaque, AtheroscleroticTlr4
plasmacytomaTp53
Plasmodium falciparum malariaFas
pleural tuberculosisTlr4
Pneumococcal MeningitisTlr4
pneumoniaTlr4
polycystic ovary syndromeBax
PolyploidyTp53
post-traumatic stress disorderBax
pre-eclampsiaFas , Tlr4
pre-malignant neoplasmBax , Casp3 , Casp8 , Fas , Tp53
precursor B lymphoblastic lymphoma/leukemiaTp53
precursor lymphoblastic lymphoma/leukemiaCasp8 , Fas , Tp53
precursor T-lymphoblastic lymphoma/leukemiaBax
Pregnancy Complications, CardiovascularFas
Premature AgingBax , Tp53
primary immunodeficiency diseaseCasp8
primary open angle glaucomaTlr4 , Tp53
prion diseaseBax
prostate adenocarcinomaTp53
prostate cancerTp53
Prostatic NeoplasmsBax , Casp3 , Fas , Tlr4 , Tp53
proteinuriaFas
Pseudomonas Aeruginosa KeratitisTlr4
psoriasisTlr4 , Tp53
pterygiumTp53
pulmonary edemaTlr4
pulmonary emphysemaTlr4
pulmonary fibrosisTlr4
pulmonary hypertensionTlr4 , Tp53
pulmonary tuberculosisTlr4
pulpitisTlr4
Radiation Injuries, ExperimentalCasp3 , Casp8 , Fas
relapsing-remitting multiple sclerosisFas
renal carcinomaTp53
renal cell carcinomaCasp3 , Fas , Tp53
renal fibrosisTlr4
Reperfusion InjuryBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
respiratory allergyTlr4
Respiratory SoundsTlr4
respiratory syncytial virus infectious diseaseTlr4
Retina Reperfusion InjuryBax , Tlr4
retinal degenerationBax
retinal detachmentCasp3 , Casp8 , Fas
retinal diseaseCasp3
retinoblastomaFas
rhabdomyosarcomaTp53
rheumatoid arthritisFas
RhinosinusitisTlr4
salivary gland diseaseCasp3
sarcomaTp53
SarcopeniaBax
schizophreniaTp53
sciatic neuropathyCasp3 , Casp8 , Fas , Tlr4
scrapieBax , Casp3
Seasonal Allergic RhinitisTlr4
seminomaFas
SepsisCasp3 , Casp8 , Fas , Tlr4
serous cystadenocarcinomaTp53
Sezary's diseaseTp53
Shock, HemorrhagicCasp3 , Casp8
sinusitisTlr4
Sjogren's syndromeFas
Skin NeoplasmsCasp8 , Tp53
small cell carcinomaTp53
spermatic cord torsionCasp3
Spinal Cord CompressionFas
Spinal Cord InjuriesCasp3 , Fas , Tp53
Spinal Cord Reperfusion InjuryTlr4
SplenomegalyFas
Sporadic Papillary Renal Cell CarcinomaTp53
sporotrichosisTlr4
squamous cell carcinomaFas , Tp53
status epilepticusBax , Casp3 , Casp8
Stomach NeoplasmsCasp8 , Tp53
StrokeCasp3 , Tlr4
Subarachnoid HemorrhageCasp3 , Tlr4
suppurative otitis mediaTlr4
systemic lupus erythematosusFas , Tlr4
T-Cell LymphomaTp53
Taste DisordersFas
temporal arteritisTlr4
teratomaBax
Testicular InjuryFas
Testis Reperfusion InjuryBax , Casp3
thoracic aortic aneurysmFas
thymomaTp53
Thymus NeoplasmsTp53
Thyroid NeoplasmsTp53
thyroiditisBax
Tongue NeoplasmsTp53
tongue squamous cell carcinomaTp53
toxic encephalopathyCasp3
toxoplasmosisBax
transient cerebral ischemiaBax , Casp3 , Casp8 , Fas
transitional cell carcinomaCasp3 , Fas , Tp53
Transplant RejectionTlr4
Trigeminal Nerve InjuriesTp53
tuberculosisTlr4
Tumor Predisposition SyndromeTp53
tympanosclerosisTlr4
type 1 diabetes mellitusCasp3 , Casp8 , Fas , Tlr4
type 2 diabetes mellitusBax , Casp3 , Casp8 , Fas , Tlr4
ulcerative colitisCasp3 , Fas
ureteral obstructionCasp3
urinary bladder cancerBax , Casp3 , Fas , Tlr4 , Tp53
Urinary Tract InfectionsTlr4
Urogenital NeoplasmsTp53
Urologic NeoplasmsTp53
uterine carcinosarcomaTp53
Uterine Cervical NeoplasmsBax , Casp3 , Casp8 , Tp53
Uterine NeoplasmsTp53
uveitisTlr4
varicoceleFas
vascular dementiaTp53
Ventricular Dysfunction, LeftFas , Tlr4
Viral BronchiolitisTlr4
viral meningitisTlr4
Viral MyocarditisCasp3 , Casp8
visual epilepsyFas
vitiligoTlr4
Vulvar Lichen SclerosusTp53
Vulvar NeoplasmsTp53
Wallerian DegenerationTlr4
xeroderma pigmentosumTp53
Pathway Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway
Pathway TermsGene Symbols
allograft rejection pathwayFas
altered p53 signaling pathwayTp53
Alzheimer's disease pathwayCasp3 , Casp8 , Fas
amyotrophic lateral sclerosis pathwayBax , Casp3 , Tp53
apoptotic cell death pathwayBax , Casp3 , Casp8 , Fas , Tp53
autoimmune thyroiditis pathwayFas
basal cell carcinoma pathwayTp53
cell cycle pathway, mitoticTp53
ceramide signaling pathwayBax , Casp8 , Tp53
Chagas disease pathwayCasp8 , Fas , Tlr4
chronic myeloid leukemia pathwayTp53
colorectal cancer pathwayBax , Casp3 , Tp53
cytokine mediated signaling pathwayFas
endometrial cancer pathwayTp53
Endoplasmic Reticulum-associated degradation pathwayBax
Entamoebiasis pathwayCasp3 , Tlr4
extrinsic apoptotic pathwayCasp3 , Casp8 , Fas
FasL mediated signaling pathwayCasp3 , Casp8 , Fas
glioma pathwayTp53
graft-versus-host disease pathwayFas
hepatitis C pathwayTp53
Huntington's disease pathwayBax , Casp3 , Casp8 , Tp53
influenza A pathwayFas , Tlr4
intrinsic apoptotic pathwayBax , Casp3 , Fas
Leishmaniasis pathwayTlr4
malaria pathwayTlr4
measles pathwayFas , Tlr4 , Tp53
melanoma pathwayTp53
mitogen activated protein kinase signaling pathwayCasp3 , Fas , Tp53
myocarditis pathwayCasp3 , Casp8
neurotrophic factor signaling pathwayBax , Tp53
NOD-like receptor signaling pathwayCasp8
non-small cell lung carcinoma pathwayTp53
p53 signaling pathwayBax , Casp3 , Casp8 , Fas , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayTp53
Parkinson's disease pathwayCasp3
phagocytosis pathwayTlr4
prion disease pathwayBax
prostate cancer pathwayTp53
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8
rheumatoid arthritis pathwayTlr4
sleeping sickness pathwayFas
small cell lung carcinoma pathwayTp53
syndecan signaling pathwayBax , Casp3
thyroid cancer pathwayTp53
titanium dioxide nanoparticle response pathwayBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Toll-like receptor signaling pathwayCasp8 , Tlr4
toxoplasmosis pathwayCasp3 , Casp8 , Tlr4
Trail mediated signaling pathwayCasp3 , Casp8
tuberculosis pathwayBax , Casp3 , Casp8 , Tlr4
tumor necrosis factor mediated signaling pathwayCasp8
type 1 diabetes mellitus pathwayFas
urinary bladder cancer pathwayTp53
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayTp53
Phenotype Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway

References Associated with the titanium dioxide nanoparticle response pathway:

Ontology Path Diagram:

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