CASP3 (caspase 3) - Rat Genome Database
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Gene: CASP3 (caspase 3) Sus scrofa
Analyze
Symbol: CASP3
Name: caspase 3
RGD ID: 14134172
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity involved in apoptotic signaling pathway (ortholog); cysteine-type peptidase activity (ortholog); death receptor binding (ortholog); INVOLVED IN anterior neural tube closure (ortholog); axonal fasciculation (ortholog); cellular response to organic cyclic compound (ortholog); PARTICIPATES IN apoptotic cell death pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cytoplasm; nucleus; death-inducing signaling complex (ortholog); INTERACTS WITH 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid; 3-methyladenine; 3-oxalomalic acid
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CASP-3; caspase-3
Orthologs:
Homo sapiens (human) : CASP3 (caspase 3)  HGNC  Alliance
Mus musculus (house mouse) : Casp3 (caspase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Casp3 (caspase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp3 (caspase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP3 (caspase 3)
Canis lupus familiaris (dog) : CASP3 (caspase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp3 (caspase 3)
Chlorocebus sabaeus (African green monkey) : CASP3 (caspase 3)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1545,742,749 - 45,763,773 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11545,744,320 - 45,753,252 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21552,291,074 - 52,299,625 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
Acute Necrotizing Pancreatitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (ISO)
bacterial infectious disease  (ISO)
Brain Contusion  (ISO)
brain glioma  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Burns  (ISO)
calcinosis  (ISO)
cataract  (ISO)
Cerebral Hemorrhage  (ISO)
cervical cancer  (ISO)
chemical colitis  (ISO)
Chronic Hepatitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
Copper-Overload Cirrhosis  (ISO)
cryptorchidism  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (ISO)
endometritis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypoxia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
impotence  (ISO)
Insulin Resistance  (ISO)
intermittent claudication  (ISO)
intestinal disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
Mammary Neoplasms, Experimental  (ISO)
middle cerebral artery infarction  (ISO)
Mycoplasma Infections  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
Parkinsonian Disorders  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Radiation Injuries, Experimental  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
retinal disease  (ISO)
salivary gland disease  (ISO)
sciatic neuropathy  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
spermatic cord torsion  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Testis Reperfusion Injury  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
Viral Myocarditis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior neural tube closure  (ISO)
apoptotic process  (IBA)
apoptotic signaling pathway  (IEA)
axonal fasciculation  (ISO)
B cell homeostasis  (IEA)
cell fate commitment  (IEA)
cellular response to DNA damage stimulus  (IEA)
cellular response to organic cyclic compound  (ISO)
cellular response to organic substance  (ISO)
cellular response to staurosporine  (IEA)
erythrocyte differentiation  (IBA,IEA)
execution phase of apoptosis  (IEA)
glial cell apoptotic process  (IEA)
heart development  (IEA)
hippocampus development  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to osmotic stress  (IEA)
keratinocyte differentiation  (IBA,IEA)
learning or memory  (ISO)
leukocyte apoptotic process  (ISO)
luteolysis  (ISO)
negative regulation of activated T cell proliferation  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of B cell proliferation  (IEA)
negative regulation of cell cycle  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA)
neuron apoptotic process  (IEA)
neuron differentiation  (IBA)
neurotrophin TRK receptor signaling pathway  (IEA)
positive regulation of amyloid-beta formation  (IEA,ISS)
positive regulation of apoptotic process  (IBA,IEA)
positive regulation of neuron apoptotic process  (ISO)
protein processing  (IEA)
proteolysis  (IEA,ISS)
regulation of protein stability  (IEA,ISS)
response to amino acid  (ISO)
response to antibiotic  (ISO)
response to auditory stimulus  (ISO)
response to cobalt ion  (ISO)
response to drug  (ISO)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to metal ion  (ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to UV  (IEA)
response to wounding  (IEA)
response to X-ray  (ISO)
sensory perception of sound  (IEA)
striated muscle cell differentiation  (ISO)
T cell homeostasis  (IEA)
viral process  (IEA)
wound healing  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:11440638   PMID:15609044   PMID:17268855   PMID:17437340   PMID:19283610   PMID:21151608   PMID:21732350   PMID:21887717   PMID:23313858   PMID:26436384  


Genomics

Comparative Map Data
CASP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1545,742,749 - 45,763,773 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11545,744,320 - 45,753,252 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21552,291,074 - 52,299,625 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4184,627,696 - 184,649,509 (-)EnsemblGRCh38hg38GRCh38
GRCh384184,627,696 - 184,649,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374185,548,850 - 185,570,629 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364185,785,844 - 185,807,623 (-)NCBINCBI36hg18NCBI36
Build 344185,923,999 - 185,945,750NCBI
Celera4182,877,510 - 182,899,293 (-)NCBI
Cytogenetic Map4q35.1NCBI
HuRef4181,303,305 - 181,324,956 (-)NCBIHuRef
CHM1_14185,525,377 - 185,547,156 (-)NCBICHM1_1
Casp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39847,070,326 - 47,092,733 (+)NCBI
GRCm38846,617,291 - 46,639,698 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl846,617,291 - 46,639,689 (+)EnsemblGRCm38mm10GRCm38
MGSCv37847,702,803 - 47,724,071 (+)NCBIGRCm37mm9NCBIm37
MGSCv36848,116,266 - 48,137,534 (+)NCBImm8
Celera849,300,031 - 49,321,270 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.39NCBI
Casp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01648,845,011 - 48,863,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,845,012 - 48,863,204 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01648,560,090 - 48,578,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41648,944,226 - 48,962,420 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11648,944,301 - 48,962,495 (-)NCBI
Celera1643,665,975 - 43,684,168 (-)NCBICelera
Cytogenetic Map16q11NCBI
Casp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540324,315,712 - 24,326,271 (+)NCBIChiLan1.0ChiLan1.0
CASP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14189,018,422 - 189,040,217 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4189,018,422 - 189,040,185 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04176,793,190 - 176,815,023 (-)NCBIMhudiblu_PPA_v0panPan3
CASP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1645,920,071 - 45,940,505 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11645,920,074 - 45,940,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Casp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365544,571,072 - 4,593,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl7130,591,166 - 130,610,899 (-)Ensembl
ChlSab1.17130,589,592 - 130,610,845 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 1 5 1 2 3 3
Low 2 2 2 22
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000042090   ⟹   ENSSSCP00000049424
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1545,742,749 - 45,751,203 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000064876   ⟹   ENSSSCP00000038262
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1545,742,752 - 45,763,750 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000091301   ⟹   ENSSSCP00000067227
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1545,742,761 - 45,763,773 (-)Ensembl
RefSeq Acc Id: NM_214131   ⟹   NP_999296
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11545,744,320 - 45,753,252 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999296 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB55544 (Get FASTA)   NCBI Sequence Viewer  
  JAG69675 (Get FASTA)   NCBI Sequence Viewer  
  Q95ND5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999296   ⟸   NM_214131
- UniProtKB: Q95ND5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000038262   ⟸   ENSSSCT00000064876
RefSeq Acc Id: ENSSSCP00000067227   ⟸   ENSSSCT00000091301
RefSeq Acc Id: ENSSSCP00000049424   ⟸   ENSSSCT00000042090
Protein Domains
CASPASE_P10   CASPASE_P20


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034012 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000038262 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000049424 UniProtKB/TrEMBL
  ENSSSCP00000067227 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000042090 UniProtKB/TrEMBL
  ENSSSCT00000064876 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000091301 UniProtKB/TrEMBL
InterPro Caspase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397244 UniProtKB/Swiss-Prot
NCBI Gene CASP3 ENTREZGENE
PANTHER PTHR10454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CASc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.15886 ENTREZGENE
UniProt A0A287A3E4_PIG UniProtKB/TrEMBL
  A0A287AZZ1_PIG UniProtKB/TrEMBL
  A0A5G2QQP0_PIG UniProtKB/TrEMBL
  CASP3_PIG UniProtKB/Swiss-Prot, ENTREZGENE