Casp3 (caspase 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Casp3 (caspase 3) Chinchilla lanigera
Analyze
Symbol: Casp3
Name: caspase 3
RGD ID: 9026791
Description: ENCODES a protein that exhibits aspartic-type endopeptidase activity (ortholog); cyclin-dependent protein serine/threonine kinase inhibitor activity (ortholog); cysteine-type endopeptidase activity (ortholog); INVOLVED IN response to auditory stimulus; anterior neural tube closure (ortholog); apoptotic process (ortholog); PARTICIPATES IN apoptotic cell death pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); death-inducing signaling complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caspase 3, apoptosis-related cysteine peptidase; caspase-3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540324,315,712 - 24,326,271 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
acute necrotizing pancreatitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (ISO)
bacterial infectious disease  (ISO)
Brain Contusion  (ISO)
brain glioma  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
bronchopulmonary dysplasia  (ISO)
Burns  (ISO)
calcinosis  (ISO)
cataract  (ISO)
Cerebral Hemorrhage  (ISO)
cervical cancer  (ISO)
chemical colitis  (ISO)
Chronic Hepatitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
Copper-Overload Cirrhosis  (ISO)
cryptorchidism  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (ISO)
endometritis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypoxia  (ISO)
impotence  (ISO)
Insulin Resistance  (ISO)
intermittent claudication  (ISO)
intestinal disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
middle cerebral artery infarction  (ISO)
Mycoplasma Infections  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
retinal disease  (ISO)
salivary gland disease  (ISO)
sciatic neuropathy  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
spermatic cord torsion  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Testis Reperfusion Injury  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
traumatic brain injury  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
Ventricular Remodeling  (ISO)
Viral Myocarditis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior neural tube closure  (ISO)
apoptotic process  (ISO)
axonal fasciculation  (ISO)
B cell homeostasis  (ISO)
cell fate commitment  (ISO)
cellular response to staurosporine  (ISO)
DNA damage response  (ISO)
epithelial cell apoptotic process  (ISO)
erythrocyte differentiation  (ISO)
execution phase of apoptosis  (ISO)
fibroblast apoptotic process  (ISO)
glial cell apoptotic process  (ISO)
heart development  (ISO)
hippocampus development  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to osmotic stress  (ISO)
keratinocyte differentiation  (ISO)
learning or memory  (ISO)
leukocyte apoptotic process  (ISO)
luteolysis  (ISO)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of cytokine production  (ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (ISO)
neurotrophin TRK receptor signaling pathway  (ISO)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of pyroptotic inflammatory response  (ISO)
protein catabolic process  (ISO)
protein maturation  (ISO)
protein processing  (ISO)
proteolysis  (ISO)
pyroptotic inflammatory response  (ISO)
regulation of protein stability  (ISO)
regulation of synaptic vesicle cycle  (ISO)
response to amino acid  (ISO)
response to anesthetic  (ISO)
response to auditory stimulus  (IDA)
response to cobalt ion  (ISO)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to metal ion  (ISO)
response to nicotine  (ISO)
response to UV  (ISO)
response to wounding  (ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (ISO)
striated muscle cell differentiation  (ISO)
T cell homeostasis  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. The caspase pathway in noise-induced apoptosis of the chinchilla cochlea. Nicotera TM, etal., J Assoc Res Otolaryngol. 2003 Dec;4(4):466-77. Epub 2003 Oct 13.
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Casp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540324,315,712 - 24,326,271 (+)NCBIChiLan1.0ChiLan1.0
CASP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384184,627,696 - 184,649,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4184,627,696 - 184,650,062 (-)EnsemblGRCh38hg38GRCh38
GRCh374185,548,850 - 185,570,601 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364185,785,844 - 185,807,623 (-)NCBINCBI36Build 36hg18NCBI36
Build 344185,923,999 - 185,945,750NCBI
Celera4182,877,510 - 182,899,293 (-)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4181,303,305 - 181,324,956 (-)NCBIHuRef
CHM1_14185,525,377 - 185,547,156 (-)NCBICHM1_1
T2T-CHM13v2.04187,971,378 - 187,993,131 (-)NCBIT2T-CHM13v2.0
Casp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39847,070,326 - 47,092,733 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl847,070,326 - 47,092,724 (+)EnsemblGRCm39 Ensembl
GRCm38846,617,291 - 46,639,698 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl846,617,291 - 46,639,689 (+)EnsemblGRCm38mm10GRCm38
MGSCv37847,702,803 - 47,724,071 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36848,116,266 - 48,137,534 (+)NCBIMGSCv36mm8
Celera849,300,031 - 49,321,270 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.39NCBI
Casp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,395,539 - 52,413,794 (-)NCBIGRCr8
mRatBN7.21645,662,910 - 45,681,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1645,662,910 - 45,684,648 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1651,061,544 - 51,079,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01654,429,112 - 54,447,305 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01649,700,916 - 49,719,114 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01648,845,011 - 48,863,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,845,012 - 48,863,204 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01648,560,090 - 48,578,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41648,944,226 - 48,962,420 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11648,944,301 - 48,962,495 (-)NCBI
Celera1643,665,975 - 43,684,168 (-)NCBICelera
Cytogenetic Map16q11NCBI
CASP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23182,351,669 - 182,373,528 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14182,713,461 - 182,735,319 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04176,793,190 - 176,815,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14189,018,422 - 189,040,217 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4189,018,422 - 189,040,185 (-)Ensemblpanpan1.1panPan2
CASP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11645,920,074 - 45,940,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1645,920,071 - 45,940,505 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1646,413,238 - 46,434,538 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01648,136,012 - 48,157,278 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1648,135,662 - 48,157,268 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11646,101,180 - 46,122,422 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01646,715,535 - 46,736,806 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01646,848,704 - 46,870,015 (+)NCBIUU_Cfam_GSD_1.0
Casp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494333,516,817 - 33,538,924 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365544,571,072 - 4,593,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1545,742,751 - 45,764,213 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11545,744,320 - 45,753,252 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21552,291,074 - 52,299,625 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17130,589,592 - 130,610,845 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7130,591,166 - 130,610,899 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037110,841,187 - 110,862,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_013513062   ⟹   XP_013368516
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540324,315,712 - 24,326,271 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013368516 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000004231.1
  ENSCLAP00000020798
  ENSCLAP00000020798.1
RefSeq Acc Id: XP_013368516   ⟸   XM_013513062
- UniProtKB: A0A8C2VUD7 (UniProtKB/TrEMBL),   A0A8C2UQ68 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Caspase family p10   Caspase family p20


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003016 UniProtKB/TrEMBL
  ENSCLAG00000014245 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004313.1 UniProtKB/TrEMBL
  ENSCLAT00000020996 ENTREZGENE
  ENSCLAT00000020996.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1460 UniProtKB/TrEMBL
  Caspase-like UniProtKB/TrEMBL
InterPro Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
NCBI Gene Casp3 ENTREZGENE
PANTHER CASPASE-3 UniProtKB/TrEMBL
  PTHR10454 UniProtKB/TrEMBL
Pfam Peptidase_C14 UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
Superfamily-SCOP SSF52129 UniProtKB/TrEMBL
UniProt A0A8C2UQ68 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VUD7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Casp3  caspase 3    caspase 3, apoptosis-related cysteine peptidase  Symbol and/or name change 5135510 APPROVED