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GENE - TERM ANNOTATION REPORT

RGD ID: 14134172
Species: Sus scrofa
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: DOID:8947
Term: diabetic retinopathy
Definition: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Definition Source(s): MESH:D003930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3 ISOCasp3 (Mus musculus)9068941RGDassociated with Diabetes Mellitus, Non-Insulin-DependentPMID:19013511 REF_RGD_ID:2311448
CASP3 ISOCasp3 (Rattus norvegicus)9068941RGDassociated with Diabetes Mellitus, Experimental;protein:increased expresssion:retinaPMID:19187597 REF_RGD_ID:2311444
CASP3 ISOCASP3 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:20654064
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