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Gene: CFLAR (CASP8 and FADD like apoptosis regulator) Homo sapiens
Symbol: CFLAR
Name: CASP8 and FADD like apoptosis regulator
Description: Exhibits enzyme activator activity and protease binding activity. Involved in apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; and regulation of programmed cell death. Localizes to death-inducing signaling complex and ripoptosome. Biomarker of acute myeloid leukemia; congestive heart failure; idiopathic pulmonary fibrosis; and myelodysplastic syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8 and FADD-like apoptosis regulator; CASP8AP1; caspase homolog; caspase-eight-related protein; caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; Casper; cellular FLICE-like inhibitory protein; cFLIP; CLARP; FADD-like anti-apoptotic molecule; FADD-like antiapoptotic molecule 1; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; inhibitor of FLICE; MACH-related inducer of toxicity; MRIT; testis secretory sperm-binding protein Li 233m; usurpin beta
Mus musculus (house mouse) : Cflar (CASP8 and FADD-like apoptosis regulator)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cflar (CASP8 and FADD-like apoptosis regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cflar (CASP8 and FADD like apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CFLAR (CASP8 and FADD like apoptosis regulator)
Canis lupus familiaris (dog) : CFLAR (CASP8 and FADD like apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cflar (CASP8 and FADD like apoptosis regulator)
Sus scrofa (pig) : CFLAR (CASP8 and FADD like apoptosis regulator)
Chlorocebus sabaeus (African green monkey) : CFLAR (CASP8 and FADD like apoptosis regulator)
Heterocephalus glaber (naked mole-rat) : Cflar (CASP8 and FADD like apoptosis regulator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2201,116,154 - 201,176,687 (+)EnsemblGRCh38hg38GRCh38
GRCh382201,116,104 - 201,176,687 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372201,980,877 - 202,037,411 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,689,135 - 201,737,260 (+)NCBINCBI36hg18NCBI36
Build 342201,806,395 - 201,854,507NCBI
Celera2195,735,441 - 195,783,644 (+)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2193,832,403 - 193,888,781 (+)NCBIHuRef
CHM1_12201,986,792 - 202,043,389 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CFLAR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report