CASP3 (caspase 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CASP3 (caspase 3) Homo sapiens
Analyze
Symbol: CASP3
Name: caspase 3
RGD ID: 731002
HGNC Page HGNC
Description: Enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway and cysteine-type endopeptidase activity involved in execution phase of apoptosis. Involved in several processes, including cellular response to staurosporine; erythrocyte differentiation; and positive regulation of amyloid-beta formation. Acts upstream of or within negative regulation of apoptotic process and neurotrophin TRK receptor signaling pathway. Located in cytosol and nucleus. Implicated in Parkinson's disease; colon cancer; and lung non-small cell carcinoma. Biomarker of several diseases, including breast cancer (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); neurodegenerative disease (multiple); and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apopain; CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; CPP-32; CPP32; CPP32B; cysteine protease CPP32; PARP cleavage protease; procaspase3; SCA-1; SREBP cleavage activity 1; Yama
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: CASP3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4184,627,696 - 184,649,509 (-)EnsemblGRCh38hg38GRCh38
GRCh384184,627,696 - 184,649,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374185,548,850 - 185,570,601 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364185,785,844 - 185,807,623 (-)NCBINCBI36hg18NCBI36
Build 344185,923,999 - 185,945,750NCBI
Celera4182,877,510 - 182,899,293 (-)NCBI
Cytogenetic Map4q35.1NCBI
HuRef4181,303,305 - 181,324,956 (-)NCBIHuRef
CHM1_14185,525,377 - 185,547,156 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model