RGD Reference Report - Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats.

Authors: Liu, Yuzhu  Qiu, Changwei  Li, Wenyu  Mu, Weiwei  Li, Chengye  Guo, Mengyao 
Citation: Liu Y, etal., Biol Trace Elem Res. 2016 Oct;173(2):345-53. doi: 10.1007/s12011-016-0659-6. Epub 2016 Feb 26.
RGD ID: 13782281
Pubmed: PMID:26920733   (View Abstract at PubMed)
DOI: DOI:10.1007/s12011-016-0659-6   (Journal Full-text)

The essential trace element selenium (Se) modulates the functions of many regulatory proteins in signal transduction, conferring benefits in inflammatory diseases. Endometritis is a reproductive obstacle disease both in humans and animals. Staphylococcus aureus is the major pathogen that causes endometritis. The present study analyzes the protection and mechanism of Se-methylselenocysteine (MSC) and methylseleninic acid (MSA) on S. aureus-induced endometritis. An atomic fluorescence spectrophotometry study showed that the uterine Se content increased with the addition of MSC and MSA. Histopathology observation and TUNEL detection showed that Se supplementation displayed a greater defense against uterine inflammatory damage. The quantitative PCR (qPCR) and ELISA analyses showed that the expressions of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) increased with S. aureus infection and decreased with the addition of MSC and MSA. The Toll-like receptor 2 (TLR2) expression showed the same status as the inflammatory cytokines. The Western blot results showed that the increased phosphorylation of IκBα and NF-κB p65 was also reduced by the addition of MSC and MSA. The qPCR and Western blot results also showed that the transcription expressions and the protein dissociation of caspase-9, caspase-3, caspase-7, caspase-6, and poly(ADP-ribose) polymerase (PARP), which were increased by S. aureus infection, were inhibited by Se supplementation. All of the results displayed that the protection conferred by MSC was stronger than MSA. The present study indicated the Se supplementation might be a potential prevention and control measure for S. aureus-induced endometritis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CASP3Humanendometritis treatmentISOCasp3 (Rattus norvegicus) RGD 
CASP6Humanendometritis treatmentISOCasp6 (Rattus norvegicus) RGD 
CASP7Humanendometritis treatmentISOCasp7 (Rattus norvegicus) RGD 
CASP9Humanendometritis treatmentISOCasp9 (Rattus norvegicus) RGD 
Casp3Ratendometritis treatmentIEP  RGD 
Casp3Mouseendometritis treatmentISOCasp3 (Rattus norvegicus) RGD 
Casp6Ratendometritis treatmentIEP  RGD 
Casp7Ratendometritis treatmentIEP  RGD 
Casp7Mouseendometritis treatmentISOCasp7 (Rattus norvegicus) RGD 
Casp9Ratendometritis treatmentIEP  RGD 
Casp9Mouseendometritis treatmentISOCasp9 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp3  (caspase 3)
Casp6  (caspase 6)
Casp7  (caspase 7)
Casp9  (caspase 9)

Genes (Mus musculus)
Casp3  (caspase 3)
Casp7  (caspase 7)
Casp9  (caspase 9)

Genes (Homo sapiens)
CASP3  (caspase 3)
CASP6  (caspase 6)
CASP7  (caspase 7)
CASP9  (caspase 9)


Additional Information