RGD Reference Report - Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. - Rat Genome Database

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Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease.

Authors: Chen, M  Ona, V O  Li, M  Ferrante, R J  Fink, K B  Zhu, S  Bian, J  Guo, L  Farrell, L A  Hersch, S M  Hobbs, W  Vonsattel, J P  Cha, J H  Friedlander, R M 
Citation: Chen M, etal., Nat Med. 2000 Jul;6(7):797-801.
RGD ID: 13432082
Pubmed: PMID:10888929   (View Abstract at PubMed)
DOI: DOI:10.1038/77528   (Journal Full-text)

Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline derivative with proven safety. After ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase upregulation, and reduces infarction. As caspase-1 and nitric oxide seem to play a role in Huntington disease, we evaluated the therapeutic efficacy of minocycline in the R6/2 mouse model of Huntington disease. We report that minocycline delays disease progression, inhibits caspase-1 and caspase-3 mRNA upregulation, and decreases inducible nitric oxide synthetase activity. In addition, effective pharmacotherapy in R6/2 mice requires caspase-1 and caspase-3 inhibition. This is the first demonstration of caspase-1 and caspase-3 transcriptional regulation in a Huntington disease model.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CASP3HumanHuntington's disease treatmentISOCasp3 (Mus musculus) RGD 
Casp3RatHuntington's disease treatmentISOCasp3 (Mus musculus) RGD 
Casp3MouseHuntington's disease treatmentIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp3  (caspase 3)

Genes (Mus musculus)
Casp3  (caspase 3)

Genes (Homo sapiens)
CASP3  (caspase 3)


Additional Information