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Gene: Xiap (X-linked inhibitor of apoptosis) Rattus norvegicus
Symbol: Xiap
Name: X-linked inhibitor of apoptosis
Description: Exhibits protease binding activity and scaffold protein binding activity. Involved in negative regulation of neuron apoptotic process. Localizes to several cellular components, including cytosol; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis); PARTICIPATES IN intrinsic apoptotic pathway; Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Api3; apoptosis inhibitor protein 3; baculoviral IAP repeat-containing 4; baculoviral IAP repeat-containing protein 4; Birc4; E3 ubiquitin-protein ligase XIAP; IAP homolog A; IAP-3; inhibitor of apoptosis protein 3; RIAP-3; riap3; RING-type E3 ubiquitin transferase XIAP; X-linked IAP; X-linked inhibitor of apoptosis protein; X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Homo sapiens (human) : XIAP (X-linked inhibitor of apoptosis)  HGNC  Alliance
Mus musculus (house mouse) : Xiap (X-linked inhibitor of apoptosis)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xiap (X-linked inhibitor of apoptosis)
Pan paniscus (bonobo/pygmy chimpanzee) : XIAP (X-linked inhibitor of apoptosis)
Canis lupus familiaris (dog) : XIAP (X-linked inhibitor of apoptosis)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xiap (X-linked inhibitor of apoptosis)
Sus scrofa (pig) : XIAP (X-linked inhibitor of apoptosis)
Chlorocebus sabaeus (African green monkey) : XIAP (X-linked inhibitor of apoptosis)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X128,409,425 - 128,455,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX128,409,472 - 128,453,000 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X3,011,520 - 3,047,798 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X3,013,139 - 3,049,418 (-)NCBI
CeleraX120,012,721 - 120,049,014 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Protein Structures

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Xiap
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620692
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.