Xiap (X-linked inhibitor of apoptosis) - Rat Genome Database

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Gene: Xiap (X-linked inhibitor of apoptosis) Rattus norvegicus
Analyze
Symbol: Xiap
Name: X-linked inhibitor of apoptosis
RGD ID: 620692
Description: Enables protease binding activity and scaffold protein binding activity. Involved in cellular response to hydrogen peroxide and negative regulation of neuron apoptotic process. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis); PARTICIPATES IN intrinsic apoptotic pathway; Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Api3; apoptosis inhibitor protein 3; baculoviral IAP repeat-containing 4; baculoviral IAP repeat-containing protein 4; Birc4; E3 ubiquitin-protein ligase XIAP; IAP homolog A; IAP-3; inhibitor of apoptosis protein 3; LOC103694512; RIAP-3; riap3; RING-type E3 ubiquitin transferase XIAP; uncharacterized LOC103694512; X-linked IAP; X-linked inhibitor of apoptosis protein; X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X120,890,537 - 120,938,413 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX120,897,907 - 120,934,700 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX123,009,934 - 123,046,397 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X126,531,344 - 126,567,796 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X124,125,427 - 124,161,835 (+)NCBIRnor_WKY
Rnor_6.0X128,409,425 - 128,455,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX128,409,472 - 128,453,000 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X3,011,520 - 3,047,798 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X3,013,139 - 3,049,418 (-)NCBI
CeleraX120,012,721 - 120,049,014 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-phenylethynesulfonamide  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetylsalicylic acid  (ISO)
aclacinomycin A  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aprepitant  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
baicalein  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
Brusatol  (ISO)
busulfan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
Calpeptin  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
casticin  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
clofarabine  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
donepezil hydrochloride  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echinocystic acid  (ISO)
ellipticine  (ISO)
embelin  (ISO)
emetine  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
estrone  (ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
fenvalerate  (EXP,ISO)
fluoxetine  (EXP)
flutamide  (EXP)
furan  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
gadodiamide hydrate  (ISO)
gallic acid  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
gusperimus  (ISO)
Hexamethonium  (ISO)
hydrazine  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hyperforin  (ISO)
idarubicin  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoflurane  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lipopolysaccharide  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
LY294002  (ISO)
Magnolol  (ISO)
mangiferin  (ISO)
melittin  (ISO)
mercury dichloride  (ISO)
methylparaben  (ISO)
metiram  (ISO)
minocycline  (EXP,ISO)
mitomycin C  (ISO)
Mitotane  (EXP)
mitoxantrone  (ISO)
Myrtucommulone A  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
Pentoxifylline  (ISO)
PHA-665752  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
propiconazole  (ISO)
puerarin  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
romidepsin  (ISO)
rottlerin  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
spermidine  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
testosterone undecanoate  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
venom  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)
zorubicin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Immunohistochemical detection of the X-linked inhibitor of apoptosis protein (XIAP) in cervical squamous intraepithelial neoplasia and squamous carcinoma. Burstein DE, etal., Ann Diagn Pathol. 2008 Apr;12(2):85-9. Epub 2007 Oct 18.
2. Micellar delivery of bicalutamide and embelin for treating prostate cancer. Danquah M, etal., Pharm Res. 2009 Sep;26(9):2081-92. Epub 2009 May 5.
3. Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer. Devetzi M, etal., Sci Rep. 2016 Nov 9;6:36532. doi: 10.1038/srep36532.
4. Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer. Foster FM, etal., Breast Cancer Res. 2009;11(3):R41. Epub 2009 Jun 29.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesothelioma. Gordon GJ, etal., J Pathol. 2007 Mar;211(4):447-54. doi: 10.1002/path.2121.
7. Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes. Holcik M, etal., BMC Genomics 2002;3(1):5.
8. X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model. Hwang C, etal., Cell Death Differ. 2008 May;15(5):831-40. Epub 2008 Feb 8.
9. Immunohistochemical detection of antiapoptotic protein X-linked inhibitor of apoptosis in mammary carcinoma. Jaffer S, etal., Hum Pathol. 2007 Jun;38(6):864-70. Epub 2007 Mar 12.
10. 2-phenylethynesulfonamide inhibits growth of oral squamous cell carcinoma cells by blocking the function of heat shock protein 70. Jiang L and Xiao J, Biosci Rep. 2020 Mar 27;40(3). pii: 222262. doi: 10.1042/BSR20200079.
11. Down-regulation of the expression of rat inhibitor-of-apoptosis protein-1 and -3 during transforming growth factor-beta1-mediated apoptosis in rat brain microglia. Jung B, etal., Neuroreport 2003 May 6;14(6):857-60.
12. Regulated expression of inhibitor of apoptosis protein 3 in the rat corpus luteum. Lareu RR, etal., Biol Reprod 2003 Jun;68(6):2232-40.
13. In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures. Li T, etal., Exp Neurol. 2006 Feb;197(2):301-8. Epub 2005 Dec 5.
14. XIAP gene downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and reverses the cisplatin resistance of ovarian carcinoma. Ma JJ, etal., Eur J Obstet Gynecol Reprod Biol. 2009 Oct;146(2):222-6. Epub 2009 Sep 15.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Overexpression of XIAP expression in renal cell carcinoma predicts a worse prognosis. Mizutani Y, etal., Int J Oncol. 2007 Apr;30(4):919-25.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo. Perrelet D, etal., Nat Cell Biol 2002 Feb;4(2):175-9.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Synergetic effects of caspase 3 and mu-calpain in XIAP-breakdown upon focal cerebral ischemia. Rami A, etal., Neurochem Res. 2007 Dec;32(12):2072-9. Epub 2007 May 19.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Nuclear translocation of X-linked inhibitor of apoptosis (XIAP) determines cell fate after hypoxia ischemia in neonatal brain. Russell JC, etal., J Neurochem. 2008 Aug;106(3):1357-70. Epub 2008 May 13.
27. Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence. Seligson DB, etal., Clin Cancer Res. 2007 Oct 15;13(20):6056-63.
28. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.
29. Role of inhibitor of apoptosis protein in gentamicin-induced cochlear hair cell damage. Tabuchi K, etal., Neuroscience. 2007 Oct 12;149(1):213-22. Epub 2007 Aug 2.
30. Hydrogen peroxide predisposes neonatal rat ventricular myocytes to Fas-mediated apoptosis. Yaniv G, etal., Biochem Biophys Res Commun. 2005 Oct 28;336(3):740-6. doi: 10.1016/j.bbrc.2005.08.167.
Additional References at PubMed
PMID:9230442   PMID:11583623   PMID:12011074   PMID:12153481   PMID:12533426   PMID:12967350   PMID:14526223   PMID:14623868   PMID:14732288   PMID:15093730   PMID:15567514   PMID:15665297  
PMID:15737931   PMID:15774698   PMID:16157589   PMID:16189514   PMID:17375200   PMID:18049476   PMID:18213456   PMID:18703998   PMID:19273858   PMID:19473982   PMID:19500649   PMID:20154138  
PMID:21404022   PMID:21931591   PMID:22041713   PMID:22173242   PMID:22304967   PMID:22535253   PMID:22554503   PMID:22792159   PMID:23928917   PMID:24305822   PMID:24357921   PMID:24631528  
PMID:24955869   PMID:25394481   PMID:26845572   PMID:27052476   PMID:27107012   PMID:28327595   PMID:31515488   PMID:32790238   PMID:33310074  


Genomics

Comparative Map Data
Xiap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X120,890,537 - 120,938,413 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX120,897,907 - 120,934,700 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX123,009,934 - 123,046,397 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X126,531,344 - 126,567,796 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X124,125,427 - 124,161,835 (+)NCBIRnor_WKY
Rnor_6.0X128,409,425 - 128,455,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX128,409,472 - 128,453,000 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X3,011,520 - 3,047,798 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X3,013,139 - 3,049,418 (-)NCBI
CeleraX120,012,721 - 120,049,014 (+)NCBICelera
Cytogenetic MapXq35NCBI
XIAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X123,859,708 - 123,913,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX123,859,712 - 123,913,972 (+)EnsemblGRCh38hg38GRCh38
GRCh37X122,993,558 - 123,047,822 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X122,821,729 - 122,875,503 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X122,719,582 - 122,773,357NCBI
CeleraX123,378,893 - 123,432,624 (+)NCBICelera
Cytogenetic MapXq25NCBI
HuRefX112,377,835 - 112,430,903 (+)NCBIHuRef
CHM1_1X122,904,824 - 122,959,188 (+)NCBICHM1_1
T2T-CHM13v2.0X122,170,108 - 122,224,373 (+)NCBIT2T-CHM13v2.0
Xiap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X41,148,483 - 41,198,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX41,148,556 - 41,198,533 (+)EnsemblGRCm39 Ensembl
GRCm38X42,059,613 - 42,109,664 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX42,059,679 - 42,109,656 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X39,421,013 - 39,462,841 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X38,338,355 - 38,350,128 (+)NCBIMGSCv36mm8
CeleraX29,643,660 - 29,685,399 (+)NCBICelera
Cytogenetic MapXA4NCBI
Xiap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547310,827,435 - 10,840,604 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547310,823,795 - 10,878,256 (-)NCBIChiLan1.0ChiLan1.0
XIAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X123,232,643 - 123,284,912 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX123,232,643 - 123,278,606 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X113,052,164 - 113,105,160 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
XIAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X95,300,234 - 95,356,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX95,331,827 - 95,351,582 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX81,399,414 - 81,419,171 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X97,072,115 - 97,127,995 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX97,072,142 - 97,127,986 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X94,548,275 - 94,568,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X96,304,355 - 96,324,070 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X96,093,813 - 96,113,573 (+)NCBIUU_Cfam_GSD_1.0
Xiap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X94,265,438 - 94,309,960 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364796,677,526 - 6,722,116 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364796,677,533 - 6,724,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XIAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX101,399,812 - 101,440,013 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X101,399,374 - 101,440,021 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X116,234,274 - 116,253,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XIAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606536,593,463 - 36,643,836 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Xiap
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:127
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000009336
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat

Markers in Region
PMC166414P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X120,920,962 - 120,921,132 (+)MAPPERmRatBN7.2
Rnor_6.0X128,439,745 - 128,439,914NCBIRnor6.0
Rnor_5.0X128,530,472 - 128,530,641UniSTSRnor5.0
RGSC_v3.4X3,024,606 - 3,024,775UniSTSRGSC3.4
CeleraX120,035,753 - 120,035,922UniSTS
Cytogenetic MapXq11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 53 37 19 37 6 6 74 34 34 11 6
Low 7 4 4 4 2 5 1 7 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB033366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF183429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009336   ⟹   ENSRNOP00000009336
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX120,897,937 - 120,934,218 (+)Ensembl
Rnor_6.0 EnsemblX128,416,722 - 128,453,000 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078482   ⟹   ENSRNOP00000073156
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX120,898,803 - 120,934,700 (+)Ensembl
Rnor_6.0 EnsemblX128,409,472 - 128,452,770 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085110   ⟹   ENSRNOP00000071268
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX120,897,907 - 120,934,187 (+)Ensembl
Rnor_6.0 EnsemblX128,416,809 - 128,452,969 (+)Ensembl
RefSeq Acc Id: NM_022231   ⟹   NP_071567
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,897,937 - 120,934,218 (+)NCBI
Rnor_6.0X128,416,722 - 128,453,000 (+)NCBI
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBI
RGSC_v3.4X3,011,520 - 3,047,798 (-)RGD
CeleraX120,012,721 - 120,049,014 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257506   ⟹   XP_006257568
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,897,963 - 120,938,413 (+)NCBI
Rnor_6.0X128,416,768 - 128,455,786 (+)NCBI
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257508   ⟹   XP_006257570
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,898,694 - 120,938,413 (+)NCBI
Rnor_6.0X128,417,493 - 128,455,786 (+)NCBI
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257509   ⟹   XP_006257571
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,890,537 - 120,938,413 (+)NCBI
Rnor_6.0X128,409,425 - 128,455,786 (+)NCBI
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100017   ⟹   XP_038955945
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,890,537 - 120,938,413 (+)NCBI
RefSeq Acc Id: XM_039100018   ⟹   XP_038955946
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,897,949 - 120,938,413 (+)NCBI
RefSeq Acc Id: XM_039100019   ⟹   XP_038955947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,891,596 - 120,938,413 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_071567   ⟸   NM_022231
- UniProtKB: Q9R0I6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257571   ⟸   XM_006257509
- Peptide Label: isoform X2
- UniProtKB: Q9R0I6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257568   ⟸   XM_006257506
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K019 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257570   ⟸   XM_006257508
- Peptide Label: isoform X2
- UniProtKB: Q9R0I6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071268   ⟸   ENSRNOT00000085110
RefSeq Acc Id: ENSRNOP00000073156   ⟸   ENSRNOT00000078482
RefSeq Acc Id: ENSRNOP00000009336   ⟸   ENSRNOT00000009336
RefSeq Acc Id: XP_038955945   ⟸   XM_039100017
- Peptide Label: isoform X2
- UniProtKB: Q9R0I6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038955947   ⟸   XM_039100019
- Peptide Label: isoform X2
- UniProtKB: Q9R0I6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038955946   ⟸   XM_039100018
- Peptide Label: isoform X2
- UniProtKB: Q9R0I6 (UniProtKB/Swiss-Prot)
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure Video
XIAP multiple pdb structure build Q9R0I6 1-496 view protein structure view video
AF-Q9R0I6-F1-model_v2 AlphaFold Q9R0I6 1-496 view protein structure  

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702004
Promoter ID:EPDNEW_R12526
Type:single initiation site
Name:Xiap_1
Description:X-linked inhibitor of apoptosis
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X128,416,725 - 128,416,785EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620692 AgrOrtholog
BioCyc Gene G2FUF-1232 BioCyc
Ensembl Genes ENSRNOG00000006967 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009336 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071268 ENTREZGENE
  ENSRNOP00000071268.2 UniProtKB/TrEMBL
  ENSRNOP00000073156 ENTREZGENE
  ENSRNOP00000073156.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009336 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000078482 ENTREZGENE
  ENSRNOT00000078482.2 UniProtKB/TrEMBL
  ENSRNOT00000085110 ENTREZGENE
  ENSRNOT00000085110.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BIR_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XIAP/BIRC8_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:63879 UniProtKB/Swiss-Prot
NCBI Gene 63879 ENTREZGENE
Pfam BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Xiap PhenoGen
PROSITE BIR_REPEAT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K019 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K4S8_RAT UniProtKB/TrEMBL
  Q9EQ04_RAT UniProtKB/TrEMBL
  Q9R0I6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Xiap  X-linked inhibitor of apoptosis  LOC103694512  uncharacterized LOC103694512  Data Merged 737654 PROVISIONAL
2015-12-16 Xiap  X-linked inhibitor of apoptosis  Xiap  X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-01 Xiap  X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase  Xiap  X-linked inhibitor of apoptosis  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694512  uncharacterized LOC103694512      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-05-15 Xiap  X-linked inhibitor of apoptosis  Birc4  baculoviral IAP repeat-containing 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Birc4  baculoviral IAP repeat-containing 4      Symbol and Name status set to approved 1299863 APPROVED
2003-03-04 Birc4  baculoviral IAP repeat-containing 4  Api3  apoptosis inhibitor protein 3  Symbol and Name updated to reflect Human and Mouse nomenclature 628472 PROVISIONAL
2002-08-07 Api3  apoptosis inhibitor protein 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 89.4 % (DNA) and 89.5 % (protein) homology to xiap and 93.8 % (DNA) and 93.1 % (protein) homology to murine miap-3 632436
gene_homology has high similarity to human and mouse homologs, 89.5% and 93.1% homology respectively 632436
gene_product 496 amino acid protein and 56.1 kDa 632436