Xiap (X-linked inhibitor of apoptosis) - Rat Genome Database
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Gene: Xiap (X-linked inhibitor of apoptosis) Rattus norvegicus
Analyze
Symbol: Xiap
Name: X-linked inhibitor of apoptosis
RGD ID: 620692
Description: Exhibits protease binding activity and scaffold protein binding activity. Involved in negative regulation of neuron apoptotic process. Localizes to several cellular components, including cytosol; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis); PARTICIPATES IN intrinsic apoptotic pathway; Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Api3; apoptosis inhibitor protein 3; baculoviral IAP repeat-containing 4; baculoviral IAP repeat-containing protein 4; Birc4; E3 ubiquitin-protein ligase XIAP; IAP homolog A; IAP-3; inhibitor of apoptosis protein 3; RIAP-3; riap3; RING-type E3 ubiquitin transferase XIAP; X-linked IAP; X-linked inhibitor of apoptosis protein; X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X120,890,537 - 120,938,413 (+)NCBI
Rnor_6.0 EnsemblX128,409,472 - 128,453,000 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X128,409,425 - 128,455,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X3,011,520 - 3,047,798 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X3,013,139 - 3,049,418 (-)NCBI
CeleraX120,012,721 - 120,049,014 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
2-methoxy-17beta-estradiol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetylsalicylic acid  (ISO)
aclacinomycin A  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
Anacardic acid  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aprepitant  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
baicalein  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
busulfan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
Calpeptin  (ISO)
camptothecin  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
casticin  (ISO)
ceruletide  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
clofarabine  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
Deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
donepezil hydrochloride  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echinocystic acid  (ISO)
ellipticine  (ISO)
embelin  (ISO)
emetine  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
estrone  (ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
fenvalerate  (EXP,ISO)
fluoxetine  (EXP)
flutamide  (EXP)
furan  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
gadodiamide hydrate  (ISO)
gallic acid  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gingerol  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
gusperimus  (ISO)
Hexamethonium  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (EXP,ISO)
idarubicin  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoflurane  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lipopolysaccharide  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
LY294002  (ISO)
Magnolol  (ISO)
mangiferin  (ISO)
melittin  (ISO)
mercury dichloride  (ISO)
methylparaben  (ISO)
minocycline  (EXP,ISO)
mitomycin C  (ISO)
Mitotane  (EXP)
mitoxantrone  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
Pentoxifylline  (ISO)
PHA-665752  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
puerarin  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
romidepsin  (ISO)
rottlerin  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
spermidine  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
testosterone undecanoate  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
venom  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)
zorubicin  (ISO)

References

References - curated
1. Burstein DE, etal., Ann Diagn Pathol. 2008 Apr;12(2):85-9. Epub 2007 Oct 18.
2. Danquah M, etal., Pharm Res. 2009 Sep;26(9):2081-92. Epub 2009 May 5.
3. Foster FM, etal., Breast Cancer Res. 2009;11(3):R41. Epub 2009 Jun 29.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Holcik M, etal., BMC Genomics 2002;3(1):5.
6. Hwang C, etal., Cell Death Differ. 2008 May;15(5):831-40. Epub 2008 Feb 8.
7. Jaffer S, etal., Hum Pathol. 2007 Jun;38(6):864-70. Epub 2007 Mar 12.
8. Jung B, etal., Neuroreport 2003 May 6;14(6):857-60.
9. Lareu RR, etal., Biol Reprod 2003 Jun;68(6):2232-40.
10. Li T, etal., Exp Neurol. 2006 Feb;197(2):301-8. Epub 2005 Dec 5.
11. Ma JJ, etal., Eur J Obstet Gynecol Reprod Biol. 2009 Oct;146(2):222-6. Epub 2009 Sep 15.
12. MGD data from the GO Consortium
13. Mizutani Y, etal., Int J Oncol. 2007 Apr;30(4):919-25.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline
16. Perrelet D, etal., Nat Cell Biol 2002 Feb;4(2):175-9.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. Rami A, etal., Neurochem Res. 2007 Dec;32(12):2072-9. Epub 2007 May 19.
20. RGD automated data pipeline
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. Russell JC, etal., J Neurochem. 2008 Aug;106(3):1357-70. Epub 2008 May 13.
24. Seligson DB, etal., Clin Cancer Res. 2007 Oct 15;13(20):6056-63.
25. Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.
26. Tabuchi K, etal., Neuroscience. 2007 Oct 12;149(1):213-22. Epub 2007 Aug 2.
Additional References at PubMed
PMID:9230442   PMID:11583623   PMID:12011074   PMID:12153481   PMID:12533426   PMID:12967350   PMID:14526223   PMID:14623868   PMID:14732288   PMID:15093730   PMID:15567514   PMID:15665297  
PMID:15737931   PMID:15774698   PMID:16157589   PMID:16189514   PMID:17375200   PMID:18049476   PMID:18213456   PMID:18703998   PMID:19273858   PMID:19473982   PMID:19500649   PMID:20154138  
PMID:21404022   PMID:21931591   PMID:22041713   PMID:22173242   PMID:22304967   PMID:22535253   PMID:22554503   PMID:22792159   PMID:23928917   PMID:24305822   PMID:24357921   PMID:24631528  
PMID:24955869   PMID:25394481   PMID:26845572   PMID:27052476   PMID:27107012   PMID:28327595   PMID:31515488   PMID:33310074  


Genomics

Comparative Map Data
Xiap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X120,890,537 - 120,938,413 (+)NCBI
Rnor_6.0 EnsemblX128,409,472 - 128,453,000 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X128,409,425 - 128,455,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X3,011,520 - 3,047,798 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X3,013,139 - 3,049,418 (-)NCBI
CeleraX120,012,721 - 120,049,014 (+)NCBICelera
Cytogenetic MapXq35NCBI
XIAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX123,859,724 - 123,913,979 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX123,859,724 - 123,913,976 (+)EnsemblGRCh38hg38GRCh38
GRCh38X123,859,708 - 123,913,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X122,993,558 - 123,047,822 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X122,821,729 - 122,875,503 (+)NCBINCBI36hg18NCBI36
Build 34X122,719,582 - 122,773,357NCBI
CeleraX123,378,893 - 123,432,624 (+)NCBI
Cytogenetic MapXq25NCBI
HuRefX112,377,835 - 112,430,903 (+)NCBIHuRef
CHM1_1X122,904,824 - 122,959,188 (+)NCBICHM1_1
Xiap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X41,148,483 - 41,198,541 (+)NCBIGRCm39mm39
GRCm39 EnsemblX41,148,556 - 41,198,533 (+)Ensembl
GRCm38X42,059,613 - 42,109,664 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX42,059,679 - 42,109,656 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X39,421,013 - 39,462,841 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X38,338,355 - 38,350,128 (+)NCBImm8
CeleraX29,643,660 - 29,685,399 (+)NCBICelera
Cytogenetic MapXA4NCBI
Xiap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547310,827,435 - 10,840,604 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547310,823,795 - 10,878,256 (-)NCBIChiLan1.0ChiLan1.0
XIAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X123,232,643 - 123,284,912 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX123,232,643 - 123,278,606 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X113,052,164 - 113,105,160 (+)NCBIMhudiblu_PPA_v0panPan3
XIAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX95,331,827 - 95,351,582 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X95,300,234 - 95,356,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Xiap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364796,677,533 - 6,724,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XIAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX101,399,898 - 101,440,022 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X101,399,374 - 101,440,021 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X116,234,274 - 116,253,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103247375
(Chlorocebus sabaeus - African green monkey)
No map positions available.

Position Markers
PMC166414P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X128,439,745 - 128,439,914NCBIRnor6.0
Rnor_5.0X128,530,472 - 128,530,641UniSTSRnor5.0
RGSC_v3.4X3,024,606 - 3,024,775UniSTSRGSC3.4
CeleraX120,035,753 - 120,035,922UniSTS
Cytogenetic MapXq11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X101333032146333032Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX107886746152409805Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X110957467155957467Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X110957467155957467Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118715462159970021Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX120045041143145818Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X121442246134627946Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:127
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000009336
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 53 37 19 37 6 6 74 34 34 11 6
Low 7 4 4 4 2 5 1 7 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009336   ⟹   ENSRNOP00000009336
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX128,416,722 - 128,453,000 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078482   ⟹   ENSRNOP00000073156
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX128,409,472 - 128,452,770 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085110   ⟹   ENSRNOP00000071268
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX128,416,809 - 128,452,969 (+)Ensembl
RefSeq Acc Id: NM_022231   ⟹   NP_071567
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,897,937 - 120,934,218 (+)NCBI
Rnor_6.0X128,416,722 - 128,453,000 (+)NCBI
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBI
RGSC_v3.4X3,011,520 - 3,047,798 (-)RGD
CeleraX120,012,721 - 120,049,014 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257506   ⟹   XP_006257568
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,897,963 - 120,938,413 (+)NCBI
Rnor_6.0X128,416,768 - 128,455,786 (+)NCBI
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257508   ⟹   XP_006257570
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,898,694 - 120,938,413 (+)NCBI
Rnor_6.0X128,417,493 - 128,455,786 (+)NCBI
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257509   ⟹   XP_006257571
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,890,537 - 120,938,413 (+)NCBI
Rnor_6.0X128,409,425 - 128,455,786 (+)NCBI
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602148   ⟹   XP_017457637
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X128,417,072 - 128,455,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602149   ⟹   XP_017457638
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X128,414,931 - 128,455,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602150   ⟹   XP_017457639
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X128,415,545 - 128,455,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602151   ⟹   XP_017457640
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X128,415,566 - 128,455,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100017   ⟹   XP_038955945
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,890,537 - 120,938,413 (+)NCBI
RefSeq Acc Id: XM_039100018   ⟹   XP_038955946
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,897,949 - 120,938,413 (+)NCBI
RefSeq Acc Id: XM_039100019   ⟹   XP_038955947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X120,891,596 - 120,938,413 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_071567   ⟸   NM_022231
- UniProtKB: Q9R0I6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257571   ⟸   XM_006257509
- Peptide Label: isoform X2
- UniProtKB: Q9R0I6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257568   ⟸   XM_006257506
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006257570   ⟸   XM_006257508
- Peptide Label: isoform X2
- UniProtKB: Q9R0I6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457638   ⟸   XM_017602149
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017457639   ⟸   XM_017602150
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017457640   ⟸   XM_017602151
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017457637   ⟸   XM_017602148
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000071268   ⟸   ENSRNOT00000085110
RefSeq Acc Id: ENSRNOP00000073156   ⟸   ENSRNOT00000078482
RefSeq Acc Id: ENSRNOP00000009336   ⟸   ENSRNOT00000009336
RefSeq Acc Id: XP_038955945   ⟸   XM_039100017
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955947   ⟸   XM_039100019
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955946   ⟸   XM_039100018
- Peptide Label: isoform X2
Protein Domains
RING-type

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
XIAP multiple pdb structure build Q9R0I6 1-496 view protein structure view video

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702004
Promoter ID:EPDNEW_R12526
Type:single initiation site
Name:Xiap_1
Description:X-linked inhibitor of apoptosis
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X128,416,725 - 128,416,785EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620692 AgrOrtholog
Ensembl Genes ENSRNOG00000006967 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009336 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071268 UniProtKB/TrEMBL
  ENSRNOP00000073156 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009336 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000078482 UniProtKB/TrEMBL
  ENSRNOT00000085110 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BIR_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XIAP/BIRC8_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:63879 UniProtKB/Swiss-Prot
NCBI Gene 63879 ENTREZGENE
Pfam BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Xiap PhenoGen
PROSITE BIR_REPEAT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q9EQ04_RAT UniProtKB/TrEMBL
  Q9R0I6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Xiap  X-linked inhibitor of apoptosis  Xiap  X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-01 Xiap  X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase  Xiap  X-linked inhibitor of apoptosis  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Xiap  X-linked inhibitor of apoptosis  Birc4  baculoviral IAP repeat-containing 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Birc4  baculoviral IAP repeat-containing 4      Symbol and Name status set to approved 1299863 APPROVED
2003-03-04 Birc4  baculoviral IAP repeat-containing 4  Api3  apoptosis inhibitor protein 3  Symbol and Name updated to reflect Human and Mouse nomenclature 628472 PROVISIONAL
2002-08-07 Api3  apoptosis inhibitor protein 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 89.4 % (DNA) and 89.5 % (protein) homology to xiap and 93.8 % (DNA) and 93.1 % (protein) homology to murine miap-3 632436
gene_homology has high similarity to human and mouse homologs, 89.5% and 93.1% homology respectively 632436
gene_product 496 amino acid protein and 56.1 kDa 632436