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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620692
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xiap
Name: X-linked inhibitor of apoptosis
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xiapdecreases expressionISOXIAP (Homo sapiens)6480464CTDCannabidiol results in decreased expression of XIAP proteinPMID:31699976
Xiapincreases ubiquitinationISOXIAP (Homo sapiens)6480464CTDCannabidiol results in increased ubiquitination of XIAP proteinPMID:31699976
Xiapmultiple interactionsISOXIAP (Homo sapiens)6480464CTD[Cannabidiol co-treated with moringin] results in increased expression of XIAP mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cannabidiol promotes the reaction [DIABLO protein binds to XIAP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cannabidiol results in decreased expression of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cannabidiol results in increased ubiquitination of XIAP protein]; Cannabidiol promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of XIAP protein]; Cannabidiol promotes the reaction [DIABLO protein binds to XIAP protein]; Cannabidiol results in decreased expression of and results in decreased stability of XIAP protein; DIABLO protein affects the reaction [Cannabidiol results in decreased expression of XIAP protein]; NUPR1 protein affects the reaction [Cannabidiol results in decreased expression of XIAP protein]PMID:30096889 PMID:31699976
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