Pycard (PYD and CARD domain containing) - Rat Genome Database

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Gene: Pycard (PYD and CARD domain containing) Rattus norvegicus
Analyze
Symbol: Pycard
Name: PYD and CARD domain containing
RGD ID: 628637
Description: Enables protease binding activity and transmembrane transporter binding activity. Predicted to be involved in several processes, including positive regulation of cellular component organization; regulation of cytokine production; and regulation of signal transduction. Predicted to act upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of cytokine production; and regulation of autophagy. Located in neuronal cell body. Part of protein-containing complex. Orthologous to human PYCARD (PYD and CARD domain containing); PARTICIPATES IN interleukin-1 signaling pathway; influenza A pathway; NOD-like receptor signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apoptosis-associated speck-like protein containing a CARD; Asc
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,601,657 - 182,603,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,601,174 - 182,602,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,952,277 - 190,953,310 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,138,364 - 198,139,397 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,808,830 - 190,809,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,438,029 - 199,439,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,437,832 - 199,439,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,460,883 - 206,461,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,276,089 - 187,277,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,425,969 - 187,427,003 (-)NCBI
Celera1180,252,771 - 180,253,804 (-)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,5-hexanedione  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-mercaptopropanoic acid  (ISO)
3-methyladenine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
acetamide  (EXP)
acetate ester  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP,ISO)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
anthocyanin  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
ATP  (EXP,ISO)
baicalin  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-cyclodextrin  (ISO)
bisphenol A  (EXP,ISO)
Brevetoxin B  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chlorquinaldol  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corilagin  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dieldrin  (EXP)
diosmetin  (EXP)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ergosterol  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
fonofos  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP,ISO)
galangin  (EXP)
gallic acid  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyburide  (EXP)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydralazine  (ISO)
hydrogen chloride  (ISO)
hydroquinone  (ISO)
isobutanol  (ISO)
isoflurane  (EXP,ISO)
kaempferol  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium carbonate  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lonidamine  (ISO)
luteolin  (EXP)
LY294002  (EXP)
magnesium dihydroxide  (ISO)
melatonin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (EXP)
microcystin-LR  (ISO)
minocycline  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nicotine  (ISO)
nigericin  (EXP,ISO)
nitrofen  (EXP)
NMN zwitterion  (EXP)
ochratoxin A  (ISO)
oxycodone  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
Palbinone  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phosgene  (EXP)
pirinixic acid  (ISO)
procyanidin B2  (EXP)
pterostilbene  (ISO)
puerarin  (ISO)
pyrethrins  (ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (EXP,ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
ubiquinone-0  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to tumor necrosis factor  (ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
defense response to virus  (ISO)
inflammatory response  (ISO)
innate immune response  (IEA)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
macropinocytosis  (ISO)
myeloid dendritic cell activation  (ISO)
myeloid dendritic cell activation involved in immune response  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of interferon-beta production  (ISO)
NLRP3 inflammasome complex assembly  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of adaptive immune response  (ISO)
positive regulation of antigen processing and presentation of peptide antigen via MHC class II  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of defense response to virus by host  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of T cell activation  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (ISO)
protein homooligomerization  (ISO)
regulation of apoptotic process  (ISO)
regulation of autophagy  (ISO)
regulation of inflammatory response  (ISO)
regulation of intrinsic apoptotic signaling pathway  (ISO)
regulation of protein stability  (ISO)
regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
response to bacterium  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. de Rivero Vaccari JP, etal., J Cereb Blood Flow Metab. 2009 Jul;29(7):1251-61. Epub 2009 Apr 29.
2. A molecular platform in neurons regulates inflammation after spinal cord injury. de Rivero Vaccari JP, etal., J Neurosci. 2008 Mar 26;28(13):3404-14.
3. Immunological and inflammatory functions of the interleukin-1 family. Dinarello CA Annu Rev Immunol. 2009;27:519-50.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos. Masumoto J, etal., Exp Cell Res 2001 Jan 15;262(2):128-33.
6. Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development. Masumoto J, etal., J Biol Chem 2003 Feb 7;278(6):4268-76.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The inflammasomes. Schroder K and Tschopp J, Cell. 2010 Mar 19;140(6):821-32. doi: 10.1016/j.cell.2010.01.040.
12. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.
Additional References at PubMed
PMID:12191486   PMID:12486103   PMID:12646168   PMID:12656673   PMID:14730312   PMID:15030775   PMID:15190255   PMID:15817483   PMID:16585594   PMID:16964285   PMID:16982856   PMID:17008311  
PMID:19158675   PMID:19158676   PMID:19158679   PMID:19494289   PMID:21487011   PMID:21575908   PMID:21892172   PMID:22002608   PMID:22267217   PMID:22297845   PMID:22732093   PMID:23229815  
PMID:23302887   PMID:23997220   PMID:24287373   PMID:24407287   PMID:24531343   PMID:24581500   PMID:24630722   PMID:25006247   PMID:25416956   PMID:29884910   PMID:37549514  


Genomics

Comparative Map Data
Pycard
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,601,657 - 182,603,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,601,174 - 182,602,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,952,277 - 190,953,310 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,138,364 - 198,139,397 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,808,830 - 190,809,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,438,029 - 199,439,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,437,832 - 199,439,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,460,883 - 206,461,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,276,089 - 187,277,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,425,969 - 187,427,003 (-)NCBI
Celera1180,252,771 - 180,253,804 (-)NCBICelera
Cytogenetic Map1q37NCBI
PYCARD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,201,486 - 31,202,760 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,201,486 - 31,203,450 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,212,807 - 31,214,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,120,308 - 31,121,752 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,083,777 - 29,085,221 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,774,423 - 28,775,713 (-)NCBIHuRef
CHM1_11632,530,520 - 32,531,810 (-)NCBICHM1_1
T2T-CHM13v2.01631,588,907 - 31,590,181 (-)NCBIT2T-CHM13v2.0
Pycard
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,590,545 - 127,593,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,588,880 - 127,593,039 (-)EnsemblGRCm39 Ensembl
GRCm387127,991,373 - 127,993,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,989,708 - 127,993,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,134,887 - 135,137,381 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,783,251 - 127,784,895 (-)NCBIMGSCv36mm8
Celera7127,826,342 - 127,828,839 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.88NCBI
LOC100991103
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11639,210,581 - 39,211,917 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,764,386 - 23,765,732 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,572,332 - 31,573,828 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,571,363 - 31,573,828 (-)Ensemblpanpan1.1panPan2
PYCARD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,049,352 - 17,051,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,049,705 - 17,051,240 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,624,878 - 18,626,631 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,180,447 - 17,182,202 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,180,546 - 17,182,254 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,980,664 - 16,982,415 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,899,792 - 16,901,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,211,709 - 17,213,472 (+)NCBIUU_Cfam_GSD_1.0
Pycard
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,452,827 - 125,454,078 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,550,679 - 13,552,805 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,550,702 - 13,552,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PYCARD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,306,099 - 17,307,786 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,305,921 - 17,307,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,564,758 - 17,566,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PYCARD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,892,332 - 27,894,386 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,889,230 - 27,893,697 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,569,924 - 1,571,817 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pycard
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,247,864 - 14,249,000 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,247,333 - 14,249,861 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pycard
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:30
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000026699
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat

Markers in Region
BI282953  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,601,782 - 182,601,936 (+)MAPPERmRatBN7.2
Rnor_6.01199,438,072 - 199,438,225NCBIRnor6.0
Rnor_5.01206,460,926 - 206,461,079UniSTSRnor5.0
RGSC_v3.41187,276,132 - 187,276,285UniSTSRGSC3.4
Celera1180,252,814 - 180,252,967UniSTS
RH 3.4 Map11417.41UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 19 10 19 10 1 12 11
Low 41 38 31 31 8 11 74 34 29 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000026699   ⟹   ENSRNOP00000026699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,601,174 - 182,602,955 (-)Ensembl
Rnor_6.0 Ensembl1199,437,832 - 199,439,210 (-)Ensembl
RefSeq Acc Id: NM_172322   ⟹   NP_758825
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,601,657 - 182,602,952 (-)NCBI
Rnor_6.01199,438,029 - 199,439,062 (-)NCBI
Rnor_5.01206,460,883 - 206,461,916 (-)NCBI
RGSC_v3.41187,276,089 - 187,277,122 (-)RGD
Celera1180,252,771 - 180,253,804 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102588   ⟹   XP_038958516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,601,657 - 182,603,013 (-)NCBI
Protein Sequences
Protein RefSeqs NP_758825 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958516 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC43754 (Get FASTA)   NCBI Sequence Viewer  
  EDM17200 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026699
  ENSRNOP00000026699.2
RefSeq Acc Id: NP_758825   ⟸   NM_172322
- UniProtKB: A6I9Y0 (UniProtKB/TrEMBL),   Q8CHK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026699   ⟸   ENSRNOT00000026699
RefSeq Acc Id: XP_038958516   ⟸   XM_039102588
- Peptide Label: isoform X1
- UniProtKB: A6I9Y0 (UniProtKB/TrEMBL),   Q8CHK8 (UniProtKB/TrEMBL)
Protein Domains
CARD   Pyrin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8L1-F1-model_v2 AlphaFold G3V8L1 1-193 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690449
Promoter ID:EPDNEW_R974
Type:initiation region
Name:Pycard_1
Description:PYD and CARD domain containing
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,439,241 - 199,439,301EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628637 AgrOrtholog
BioCyc Gene G2FUF-57325 BioCyc
Ensembl Genes ENSRNOG00000019675 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026699 ENTREZGENE
  ENSRNOT00000026699.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD8/ASC/NALP1_CARD UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Pyrin UniProtKB/TrEMBL
KEGG Report rno:282817 UniProtKB/TrEMBL
NCBI Gene 282817 ENTREZGENE
PANTHER APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  PAAD_DAPIN UniProtKB/TrEMBL
PhenoGen Pycard PhenoGen
PROSITE CARD UniProtKB/TrEMBL
  DAPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019675 RatGTEx
SMART PYRIN UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
UniProt A6I9Y0 ENTREZGENE, UniProtKB/TrEMBL
  G3V8L1_RAT UniProtKB/TrEMBL
  Q8CHK8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Pycard  PYD and CARD domain containing    apoptosis-associated speck-like protein containing a CARD  Name updated 1299863 APPROVED
2004-09-10 Pycard  apoptosis-associated speck-like protein containing a CARD  Asc    Symbol and Name updated 1299863 APPROVED
2003-02-27 Asc  apoptosis-associated speck-like protein containing a CARD      Symbol and Name status set to provisional 70820 PROVISIONAL