PYCARD (PYD and CARD domain containing) - Rat Genome Database

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Gene: PYCARD (PYD and CARD domain containing) Canis lupus familiaris
Analyze
Symbol: PYCARD
Name: PYD and CARD domain containing
RGD ID: 12142365
Description: ENCODES a protein that exhibits protease binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN defense response to Gram-positive bacterium (ortholog); inflammatory response (ortholog); negative regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Albuminuria (ortholog); Brain Contusion (ortholog); FOUND IN cytoplasm (ortholog); IkappaB kinase complex (ortholog); neuronal cell body (ortholog); INTERACTS WITH ochratoxin A
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apoptosis-associated speck-like protein containing a CARD
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,049,352 - 17,051,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,049,705 - 17,051,240 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,624,878 - 18,626,631 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,180,447 - 17,182,202 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,180,546 - 17,182,254 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,980,664 - 16,982,415 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,899,792 - 16,901,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,211,709 - 17,213,472 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
ochratoxin A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IBA,IEA)
apoptotic signaling pathway  (IEA)
cellular response to interleukin-1  (IEA)
cellular response to lipopolysaccharide  (IEA)
cellular response to tumor necrosis factor  (IEA)
defense response to Gram-negative bacterium  (IEA)
defense response to Gram-positive bacterium  (IEA,ISO)
defense response to virus  (IEA)
inflammatory response  (IBA,IEA,ISO)
innate immune response  (IEA)
intrinsic apoptotic signaling pathway  (IBA)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA)
macropinocytosis  (IEA)
myeloid dendritic cell activation  (IEA)
myeloid dendritic cell activation involved in immune response  (IEA)
negative regulation of canonical NF-kappaB signal transduction  (IEA)
negative regulation of cytokine production involved in inflammatory response  (IEA)
negative regulation of interferon-beta production  (IEA)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
NLRP3 inflammasome complex assembly  (IEA)
obsolete activation of cysteine-type endopeptidase activity  (ISO)
obsolete positive regulation of cysteine-type endopeptidase activity  (ISO)
obsolete regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of actin filament polymerization  (IEA)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of adaptive immune response  (IEA)
positive regulation of antigen processing and presentation of peptide antigen via MHC class II  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of chemokine production  (IEA)
positive regulation of defense response to virus by host  (IEA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of release of cytochrome c from mitochondria  (IEA)
positive regulation of T cell activation  (IEA)
positive regulation of T cell migration  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type II interferon production  (IEA)
protein homooligomerization  (IEA)
regulation of apoptotic process  (IEA,ISO)
regulation of autophagy  (IEA,ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of intrinsic apoptotic signaling pathway  (IEA)
regulation of protein stability  (IEA)
regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
response to bacterium  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PYCARD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,049,352 - 17,051,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,049,705 - 17,051,240 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,624,878 - 18,626,631 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,180,447 - 17,182,202 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,180,546 - 17,182,254 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,980,664 - 16,982,415 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,899,792 - 16,901,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,211,709 - 17,213,472 (+)NCBIUU_Cfam_GSD_1.0
PYCARD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,201,486 - 31,202,760 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,201,486 - 31,203,450 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,212,807 - 31,214,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,120,308 - 31,121,752 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,083,777 - 29,085,221 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,774,423 - 28,775,713 (-)NCBIHuRef
CHM1_11632,530,520 - 32,531,810 (-)NCBICHM1_1
T2T-CHM13v2.01631,588,907 - 31,590,181 (-)NCBIT2T-CHM13v2.0
Pycard
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,590,545 - 127,593,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,588,880 - 127,593,039 (-)EnsemblGRCm39 Ensembl
GRCm387127,991,373 - 127,993,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,989,708 - 127,993,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,134,887 - 135,137,381 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,783,251 - 127,784,895 (-)NCBIMGSCv36mm8
Celera7127,826,342 - 127,828,839 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.88NCBI
Pycard
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,032,124 - 192,033,419 (-)NCBIGRCr8
mRatBN7.21182,601,657 - 182,603,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,601,174 - 182,602,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,952,277 - 190,953,310 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,138,364 - 198,139,397 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,808,830 - 190,809,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,438,029 - 199,439,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,437,832 - 199,439,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,460,883 - 206,461,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,276,089 - 187,277,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,425,969 - 187,427,003 (-)NCBI
Celera1180,252,771 - 180,253,804 (-)NCBICelera
Cytogenetic Map1q37NCBI
PYCARD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,409,182 - 34,410,910 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,210,581 - 39,211,917 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,764,386 - 23,765,732 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,572,332 - 31,573,828 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,571,363 - 31,573,828 (-)Ensemblpanpan1.1panPan2
Pycard
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,452,827 - 125,454,078 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,550,679 - 13,552,805 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,550,702 - 13,552,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PYCARD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,306,099 - 17,307,786 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,305,921 - 17,307,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,564,758 - 17,566,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PYCARD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,892,332 - 27,894,386 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,889,230 - 27,893,697 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,569,924 - 1,571,817 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pycard
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,247,864 - 14,249,000 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,247,333 - 14,249,861 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PYCARD
51 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000026697   ⟹   ENSCAFP00000024803
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl617,049,705 - 17,051,240 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845021210   ⟹   ENSCAFP00845016675
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl617,180,546 - 17,182,254 (+)Ensembl
RefSeq Acc Id: XM_014114361   ⟹   XP_013969836
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1617,049,431 - 17,051,240 (+)NCBI
Dog10K_Boxer_Tasha618,624,978 - 18,626,630 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014114362   ⟹   XP_013969837
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1617,049,352 - 17,051,348 (+)NCBI
Dog10K_Boxer_Tasha618,624,878 - 18,626,631 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038478488   ⟹   XP_038334416
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1616,980,764 - 16,982,414 (+)NCBI
RefSeq Acc Id: XM_038478489   ⟹   XP_038334417
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1616,980,664 - 16,982,415 (+)NCBI
RefSeq Acc Id: XM_038539742   ⟹   XP_038395670
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0617,211,808 - 17,213,471 (+)NCBI
RefSeq Acc Id: XM_038539743   ⟹   XP_038395671
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0617,211,709 - 17,213,472 (+)NCBI
RefSeq Acc Id: XM_038603827   ⟹   XP_038459755
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0616,899,893 - 16,901,535 (+)NCBI
RefSeq Acc Id: XM_038603828   ⟹   XP_038459756
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0616,899,792 - 16,901,536 (+)NCBI
RefSeq Acc Id: XM_038668546   ⟹   XP_038524474
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0617,180,547 - 17,182,201 (+)NCBI
RefSeq Acc Id: XM_038668547   ⟹   XP_038524475
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0617,180,447 - 17,182,202 (+)NCBI
RefSeq Acc Id: XP_013969837   ⟸   XM_014114362
- Peptide Label: isoform X2
- UniProtKB: A0A8C0M8V6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013969836   ⟸   XM_014114361
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KW69 (UniProtKB/TrEMBL),   A0A8C0S8E3 (UniProtKB/TrEMBL),   A0A8I3RYZ8 (UniProtKB/TrEMBL),   A0A8C0M8V6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000024803   ⟸   ENSCAFT00000026697
RefSeq Acc Id: XP_038334417   ⟸   XM_038478489
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038334416   ⟸   XM_038478488
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038459756   ⟸   XM_038603828
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038459755   ⟸   XM_038603827
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038524475   ⟸   XM_038668547
- Peptide Label: isoform X2
- UniProtKB: A0A8C0M8V6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038524474   ⟸   XM_038668546
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KW69 (UniProtKB/TrEMBL),   A0A8C0S8E3 (UniProtKB/TrEMBL),   A0A8I3RYZ8 (UniProtKB/TrEMBL),   A0A8C0M8V6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395671   ⟸   XM_038539743
- Peptide Label: isoform X2
- UniProtKB: A0A8C0M8V6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395670   ⟸   XM_038539742
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KW69 (UniProtKB/TrEMBL),   A0A8C0M8V6 (UniProtKB/TrEMBL),   A0A8C0S8E3 (UniProtKB/TrEMBL),   A0A8I3RYZ8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845016675   ⟸   ENSCAFT00845021210
Protein Domains
CARD   Pyrin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016865 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030003532 UniProtKB/TrEMBL
  ENSCAFG00040011032 UniProtKB/TrEMBL
  ENSCAFG00845011935 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026697.5 UniProtKB/TrEMBL
  ENSCAFT00030006593.1 UniProtKB/TrEMBL
  ENSCAFT00040020345.1 UniProtKB/TrEMBL
  ENSCAFT00845021210 ENTREZGENE
  ENSCAFT00845021210.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD8/ASC/NALP1_CARD UniProtKB/TrEMBL
  DAPIN UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  NLRP_Inflammasome UniProtKB/TrEMBL
KEGG Report cfa:100856347 UniProtKB/TrEMBL
NCBI Gene PYCARD ENTREZGENE
PANTHER APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  DAPIN UniProtKB/TrEMBL
SMART PYRIN UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A8C0KW69 ENTREZGENE
  A0A8C0M8V6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S8E3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RYZ8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:111676 ENTREZGENE