PYCARD (PYD and CARD domain containing) - Rat Genome Database

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Gene: PYCARD (PYD and CARD domain containing) Canis lupus familiaris
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Symbol: PYCARD
Name: PYD and CARD domain containing
RGD ID: 12142365
Description: ENCODES a protein that exhibits protease binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); defense response to Gram-positive bacterium (ortholog); inflammatory response (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Albuminuria (ortholog); branched-chain keto acid dehydrogenase kinase deficiency (ortholog); FOUND IN AIM2 inflammasome complex (ortholog); IkappaB kinase complex (ortholog); inflammasome complex (ortholog); INTERACTS WITH ochratoxin A
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apoptosis-associated speck-like protein containing a CARD
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,049,352 - 17,051,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,049,705 - 17,051,240 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,624,878 - 18,626,631 (+)NCBI
ROS_Cfam_1.0617,180,447 - 17,182,202 (+)NCBI
ROS_Cfam_1.0 Ensembl617,180,546 - 17,182,254 (+)Ensembl
UMICH_Zoey_3.1616,980,664 - 16,982,415 (+)NCBI
UNSW_CanFamBas_1.0616,899,792 - 16,901,536 (+)NCBI
UU_Cfam_GSD_1.0617,211,709 - 17,213,472 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
ochratoxin A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (IEA)
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
activation of innate immune response  (IEA)
apoptotic process  (IBA)
cellular response to interleukin-1  (IEA)
cellular response to lipopolysaccharide  (IEA)
cellular response to tumor necrosis factor  (IEA)
defense response to Gram-negative bacterium  (IEA)
defense response to Gram-positive bacterium  (IEA,ISO)
defense response to other organism  (IEA)
defense response to virus  (IEA)
inflammatory response  (IEA,ISO)
innate immune response  (IEA)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA)
macropinocytosis  (IEA)
myeloid dendritic cell activation  (IEA)
myeloid dendritic cell activation involved in immune response  (IEA)
negative regulation of cytokine production involved in inflammatory response  (IEA)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
negative regulation of interferon-beta production  (IEA)
negative regulation of NF-kappaB transcription factor activity  (IEA)
negative regulation of protein serine/threonine kinase activity  (IEA)
positive regulation of actin filament polymerization  (IEA)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of adaptive immune response  (IEA)
positive regulation of antigen processing and presentation of peptide antigen via MHC class II  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of chemokine production  (IEA)
positive regulation of cysteine-type endopeptidase activity  (IEA)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
positive regulation of defense response to virus by host  (IEA)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of release of cytochrome c from mitochondria  (IEA)
positive regulation of T cell activation  (IEA)
positive regulation of T cell migration  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type II interferon production  (IEA)
protein homooligomerization  (IEA)
proteolysis  (IEA)
regulation of apoptotic process  (IEA,ISO)
regulation of autophagy  (IEA,ISO)
regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
regulation of GTPase activity  (IEA)
regulation of inflammatory response  (IEA,ISO)
regulation of intrinsic apoptotic signaling pathway  (IEA)
regulation of protein stability  (IEA)
regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
response to bacterium  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
PYCARD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,049,352 - 17,051,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,049,705 - 17,051,240 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,624,878 - 18,626,631 (+)NCBI
ROS_Cfam_1.0617,180,447 - 17,182,202 (+)NCBI
ROS_Cfam_1.0 Ensembl617,180,546 - 17,182,254 (+)Ensembl
UMICH_Zoey_3.1616,980,664 - 16,982,415 (+)NCBI
UNSW_CanFamBas_1.0616,899,792 - 16,901,536 (+)NCBI
UU_Cfam_GSD_1.0617,211,709 - 17,213,472 (+)NCBI
PYCARD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,201,486 - 31,202,760 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1631,201,486 - 31,203,450 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,212,807 - 31,214,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,120,308 - 31,121,752 (-)NCBINCBI36hg18NCBI36
Celera1629,083,777 - 29,085,221 (+)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1628,774,423 - 28,775,713 (-)NCBIHuRef
CHM1_11632,530,520 - 32,531,810 (-)NCBICHM1_1
T2T-CHM13v2.01631,588,907 - 31,590,181 (-)NCBI
Pycard
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,590,545 - 127,593,039 (-)NCBIGRCm39mm39
GRCm39 Ensembl7127,588,880 - 127,593,039 (-)Ensembl
GRCm387127,991,373 - 127,993,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,989,708 - 127,993,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,134,887 - 135,137,381 (-)NCBIGRCm37mm9NCBIm37
MGSCv367127,783,251 - 127,784,895 (-)NCBImm8
Celera7127,826,342 - 127,828,839 (-)NCBICelera
Cytogenetic Map7F3NCBI
Pycard
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,601,657 - 182,603,013 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1182,601,174 - 182,602,955 (-)Ensembl
Rnor_6.01199,438,029 - 199,439,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,437,832 - 199,439,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,460,883 - 206,461,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,276,089 - 187,277,122 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11187,425,969 - 187,427,003 (-)NCBI
Celera1180,252,771 - 180,253,804 (-)NCBICelera
Cytogenetic Map1q37NCBI
PYCARD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11631,572,332 - 31,573,828 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,571,363 - 31,573,828 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01623,764,386 - 23,765,732 (+)NCBIMhudiblu_PPA_v0panPan3
Pycard
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,452,827 - 125,454,078 (-)NCBI
SpeTri2.0NW_00493650113,550,702 - 13,552,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100522011
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,306,099 - 17,307,786 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,305,921 - 17,307,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,564,758 - 17,566,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PYCARD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,892,332 - 27,894,386 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl527,889,230 - 27,893,697 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660681,569,924 - 1,571,817 (+)NCBIVero_WHO_p1.0
Pycard
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,247,864 - 14,249,000 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462478214,247,333 - 14,249,861 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 6 6 5 2
Low 1 22 6 6 12 8 5 4
Below cutoff 4 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026697   ⟹   ENSCAFP00000024803
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl617,049,705 - 17,051,240 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845021210   ⟹   ENSCAFP00845016675
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl617,180,546 - 17,182,254 (+)Ensembl
RefSeq Acc Id: XM_014114361   ⟹   XP_013969836
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1617,049,431 - 17,051,240 (+)NCBI
Dog10K_Boxer_Tasha618,624,978 - 18,626,630 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014114362   ⟹   XP_013969837
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1617,049,352 - 17,051,348 (+)NCBI
Dog10K_Boxer_Tasha618,624,878 - 18,626,631 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038478488   ⟹   XP_038334416
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1616,980,764 - 16,982,414 (+)NCBI
RefSeq Acc Id: XM_038478489   ⟹   XP_038334417
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1616,980,664 - 16,982,415 (+)NCBI
RefSeq Acc Id: XM_038539742   ⟹   XP_038395670
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0617,211,808 - 17,213,471 (+)NCBI
RefSeq Acc Id: XM_038539743   ⟹   XP_038395671
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0617,211,709 - 17,213,472 (+)NCBI
RefSeq Acc Id: XM_038603827   ⟹   XP_038459755
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0616,899,893 - 16,901,535 (+)NCBI
RefSeq Acc Id: XM_038603828   ⟹   XP_038459756
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0616,899,792 - 16,901,536 (+)NCBI
RefSeq Acc Id: XM_038668546   ⟹   XP_038524474
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0617,180,547 - 17,182,201 (+)NCBI
RefSeq Acc Id: XM_038668547   ⟹   XP_038524475
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0617,180,447 - 17,182,202 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_013969837   ⟸   XM_014114362
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013969836   ⟸   XM_014114361
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000024803   ⟸   ENSCAFT00000026697
RefSeq Acc Id: XP_038334417   ⟸   XM_038478489
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038334416   ⟸   XM_038478488
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038459756   ⟸   XM_038603828
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038459755   ⟸   XM_038603827
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038524475   ⟸   XM_038668547
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038524474   ⟸   XM_038668546
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038395671   ⟸   XM_038539743
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038395670   ⟸   XM_038539742
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845016675   ⟸   ENSCAFT00845021210
Protein Domains
CARD   Pyrin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016865 Ensembl
  ENSCAFG00040011032 UniProtKB/TrEMBL
  ENSCAFG00845011935 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00040017647 UniProtKB/TrEMBL
  ENSCAFP00845016675 ENTREZGENE
  ENSCAFP00845016675.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00040020345 UniProtKB/TrEMBL
  ENSCAFT00845021210 ENTREZGENE
  ENSCAFT00845021210.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD8/ASC/NALP1_CARD UniProtKB/TrEMBL
  DAPIN UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
NCBI Gene PYCARD ENTREZGENE
PANTHER PTHR10454 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  DAPIN UniProtKB/TrEMBL
SMART PYRIN UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A8C0S8E3_CANLF UniProtKB/TrEMBL
  A0A8I3RYZ8_CANLF UniProtKB/TrEMBL