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Gene: Panx1 (Pannexin 1) Rattus norvegicus

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Symbol:

Panx1

Name:

Pannexin 1

RGD ID:

735204

Description:

Enables several functions, including protease binding activity; scaffold protein binding activity; and transmembrane transporter binding activity. Involved in cell-cell signaling. Located in plasma membrane. Part of protein-containing complex. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human PANX1 (pannexin 1); PARTICIPATES IN neuron-to-neuron signaling pathway via the electrical synapse; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; atrazine.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

pannexin-1; px1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PANX1 (pannexin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Panx1 (pannexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Panx1 (pannexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PANX1 (pannexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PANX1 (pannexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Panx1 (pannexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PANX1 (pannexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PANX1 (pannexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Panx1 (pannexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PANX1 (pannexin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Panx1 (pannexin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	panx1a (pannexin 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	panx1b (pannexin 1b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	panx1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	20,128,783 - 20,171,200 (-)	NCBI		GRCr8
mRatBN7.2	8	11,851,176 - 11,889,774 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	11,850,730 - 11,889,774 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	15,835,505 - 15,873,902 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	14,133,250 - 14,171,653 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	12,114,170 - 12,153,042 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	13,567,185 - 13,606,040 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,566,739 - 13,606,040 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	13,508,401 - 13,547,151 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	11,809,752 - 11,849,392 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	11,809,751 - 11,849,392 (-)	NCBI
Celera	8	13,320,676 - 13,358,794 (-)	NCBI		Celera
Cytogenetic Map	8	q12	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Panx1	Rat	autosomal recessive polycystic kidney disease		IEP		14995937		RGD
Panx1	Rat	depressive disorder		ISO	RGD:1347653	401854249	DNA:SNP:CDS:multiple (human)	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Panx1	Rat	intellectual disability		ISO	RGD:1347653	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar
Panx1	Rat	Oocyte/Zygote/Embryo Maturation Arrest 7		ISO	RGD:1347653	8554872	ClinVar Annotator: match by term: Oocyte maturation defect 7 \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:25741868\|PMID:28492532\|PMID:30918116

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Panx1	Rat	Acute Liver Failure		ISO	RGD:1347653	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:29246445
Panx1	Rat	Chemical and Drug Induced Liver Injury		ISO	RGD:1347653	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:29246445
Panx1	Rat	Massive Hepatic Necrosis		ISO	RGD:1347653	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:29246445

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Panx1	Rat	Oocyte/Zygote/Embryo Maturation Arrest 7		ISO	RGD:1347653	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Panx1	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1552235	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PANX1 mRNA	CTD	PMID:22206623
Panx1	Rat	17alpha-ethynylestradiol	increases expression	EXP		6480464	Ethinyl Estradiol results in increased expression of PANX1 mRNA	CTD	PMID:29097150
Panx1	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of PANX1 mRNA	CTD	PMID:33387578
Panx1	Rat	3'-O-(4-Benzoyl)benzoyl ATP	decreases activity	ISO	RGD:1552235	6480464	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	4,4'-diaminodiphenylmethane	increases expression	ISO	RGD:1552235	6480464	4,4'-diaminodiphenylmethane results in increased expression of PANX1 mRNA	CTD	PMID:18648102
Panx1	Rat	4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid	decreases activity	ISO	RGD:1552235	6480464	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	4-Acetamido-4'-isothiocyanostilbene-2,2'-disulphonic acid	decreases activity	ISO	RGD:1552235	6480464	4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	4-hydroxyphenyl retinamide	increases expression	ISO	RGD:1552235	6480464	Fenretinide results in increased expression of PANX1 mRNA	CTD	PMID:28973697
Panx1	Rat	5-Nitro-2-(3-phenylpropylamino)benzoic acid	decreases activity	ISO	RGD:1552235	6480464	5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	aflatoxin B1	affects expression	ISO	RGD:1347653	6480464	Aflatoxin B1 affects the expression of PANX1 protein	CTD	PMID:20106945
Panx1	Rat	aflatoxin B1	increases expression	ISO	RGD:1347653	6480464	Aflatoxin B1 results in increased expression of PANX1 mRNA	CTD	PMID:27153756
Panx1	Rat	aflatoxin B1	decreases methylation	ISO	RGD:1347653	6480464	Aflatoxin B1 results in decreased methylation of PANX1 gene	CTD	PMID:27153756
Panx1	Rat	arsane	multiple interactions	ISO	RGD:1347653	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Panx1	Rat	arsenic atom	multiple interactions	ISO	RGD:1347653	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Panx1	Rat	ATP	decreases activity	ISO	RGD:1347653	6480464	Adenosine Triphosphate results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	ATP	decreases activity	ISO	RGD:1552235	6480464	Adenosine Triphosphate results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	ATP	multiple interactions	ISO	RGD:1347653	6480464	Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]; Probenecid inhibits more ...	CTD	PMID:19213873
Panx1	Rat	ATP	increases export	ISO	RGD:1347653	6480464	PANX1 protein results in increased export of Adenosine Triphosphate	CTD	PMID:19213873
Panx1	Rat	atrazine	affects methylation	EXP		6480464	Atrazine affects the methylation of PANX1 gene	CTD	PMID:28931070
Panx1	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1347653	6480464	Benzo(a)pyrene results in increased expression of PANX1 mRNA	CTD	PMID:26238291\|PMID:32234424
Panx1	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1347653	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PANX1 mRNA	CTD	PMID:19150397\|PMID:20382639
Panx1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of PANX1 mRNA	CTD	PMID:25181051
Panx1	Rat	bisphenol A	decreases methylation	ISO	RGD:1347653	6480464	bisphenol A results in decreased methylation of PANX1 gene	CTD	PMID:31601247
Panx1	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of PANX1 mRNA	CTD	PMID:29097150
Panx1	Rat	cadmium atom	multiple interactions	ISO	RGD:1347653	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PANX1 more ...	CTD	PMID:35301059
Panx1	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1347653	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PANX1 more ...	CTD	PMID:35301059
Panx1	Rat	carbamazepine	affects expression	ISO	RGD:1347653	6480464	Carbamazepine affects the expression of PANX1 mRNA	CTD	PMID:25979313
Panx1	Rat	CARBENOXOLONE	decreases activity	ISO	RGD:1552235	6480464	Carbenoxolone results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	CARBENOXOLONE	multiple interactions	ISO	RGD:1347653	6480464	Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]	CTD	PMID:19213873
Panx1	Rat	carbon nanotube	increases expression	ISO	RGD:1552235	6480464	Nanotubes, Carbon results in increased expression of PANX1 mRNA; Nanotubes, Carbon results in increased expression more ...	CTD	PMID:25554681\|PMID:32413421
Panx1	Rat	CGP 52608	multiple interactions	ISO	RGD:1347653	6480464	CGP 52608 promotes the reaction [RORA protein binds to PANX1 gene]	CTD	PMID:28238834
Panx1	Rat	chlorpyrifos	decreases expression	ISO	RGD:1552235	6480464	Chlorpyrifos results in decreased expression of PANX1 mRNA	CTD	PMID:37019170
Panx1	Rat	choline	multiple interactions	ISO	RGD:1552235	6480464	[Dietary Fats co-treated with Choline deficiency] results in increased expression of PANX1 mRNA; [Methionine deficiency more ...	CTD	PMID:20938992\|PMID:29246445
Panx1	Rat	cisplatin	increases expression	ISO	RGD:1347653	6480464	Cisplatin results in increased expression of PANX1 mRNA	CTD	PMID:27392435
Panx1	Rat	copper(II) chloride	increases expression	ISO	RGD:1347653	6480464	cupric chloride results in increased expression of PANX1 mRNA	CTD	PMID:38568856
Panx1	Rat	copper(II) sulfate	increases expression	ISO	RGD:1347653	6480464	Copper Sulfate results in increased expression of PANX1 mRNA	CTD	PMID:19549813
Panx1	Rat	crocidolite asbestos	affects expression	ISO	RGD:1347653	6480464	Asbestos, Crocidolite affects the expression of PANX1 mRNA	CTD	PMID:24160326
Panx1	Rat	cyclosporin A	increases expression	ISO	RGD:1347653	6480464	Cyclosporine results in increased expression of PANX1 mRNA	CTD	PMID:20106945
Panx1	Rat	doxorubicin	decreases expression	ISO	RGD:1347653	6480464	Doxorubicin results in decreased expression of PANX1 mRNA	CTD	PMID:29803840
Panx1	Rat	ethanol	multiple interactions	ISO	RGD:1552235	6480464	[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of PANX1 mRNA	CTD	PMID:30517762
Panx1	Rat	ethyl methanesulfonate	increases expression	ISO	RGD:1347653	6480464	Ethyl Methanesulfonate results in increased expression of PANX1 mRNA	CTD	PMID:23649840
Panx1	Rat	flufenamic acid	decreases activity	ISO	RGD:1552235	6480464	Flufenamic Acid results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	folic acid	multiple interactions	ISO	RGD:1552235	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PANX1 mRNA; [Methionine deficiency co-treated more ...	CTD	PMID:20938992\|PMID:22206623
Panx1	Rat	folpet	decreases expression	ISO	RGD:1552235	6480464	folpet results in decreased expression of PANX1 mRNA	CTD	PMID:31558096
Panx1	Rat	formaldehyde	increases expression	ISO	RGD:1347653	6480464	Formaldehyde results in increased expression of PANX1 mRNA	CTD	PMID:23649840
Panx1	Rat	glutathione	decreases oxidation	ISO	RGD:1552235	6480464	PANX1 gene mutant form results in decreased oxidation of Glutathione	CTD	PMID:29246445
Panx1	Rat	GTP	decreases activity	ISO	RGD:1552235	6480464	Guanosine Triphosphate results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	hydrogen peroxide	affects expression	ISO	RGD:1347653	6480464	Hydrogen Peroxide affects the expression of PANX1 mRNA	CTD	PMID:20044591
Panx1	Rat	L-methionine	multiple interactions	ISO	RGD:1552235	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ...	CTD	PMID:20938992
Panx1	Rat	leflunomide	decreases expression	ISO	RGD:1347653	6480464	leflunomide results in decreased expression of PANX1 mRNA	CTD	PMID:28988120
Panx1	Rat	lipopolysaccharide	increases expression	ISO	RGD:1552235	6480464	Lipopolysaccharides results in increased expression of PANX1 mRNA	CTD	PMID:22147977
Panx1	Rat	manganese atom	multiple interactions	ISO	RGD:1347653	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Panx1	Rat	manganese(0)	multiple interactions	ISO	RGD:1347653	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Panx1	Rat	manganese(II) chloride	multiple interactions	ISO	RGD:1347653	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Panx1	Rat	menadione	increases expression	ISO	RGD:1552235	6480464	Vitamin K 3 results in increased expression of PANX1 mRNA	CTD	PMID:25270620
Panx1	Rat	methyl methanesulfonate	increases expression	ISO	RGD:1347653	6480464	Methyl Methanesulfonate results in increased expression of PANX1 mRNA	CTD	PMID:23649840
Panx1	Rat	N-nitrosodiethylamine	increases expression	ISO	RGD:1552235	6480464	Diethylnitrosamine results in increased expression of PANX1 mRNA	CTD	PMID:24535843
Panx1	Rat	nickel atom	increases expression	ISO	RGD:1347653	6480464	Nickel results in increased expression of PANX1 mRNA	CTD	PMID:24768652\|PMID:25583101
Panx1	Rat	Niflumic acid	decreases activity	ISO	RGD:1552235	6480464	Niflumic Acid results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	nitrates	multiple interactions	ISO	RGD:1552235	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of PANX1 more ...	CTD	PMID:35964746
Panx1	Rat	okadaic acid	increases expression	ISO	RGD:1347653	6480464	Okadaic Acid results in increased expression of PANX1 mRNA	CTD	PMID:38832940
Panx1	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of PANX1 mRNA	CTD	PMID:25729387
Panx1	Rat	paracetamol	affects expression	ISO	RGD:1552235	6480464	Acetaminophen affects the expression of PANX1 mRNA	CTD	PMID:17562736
Panx1	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of PANX1 mRNA	CTD	PMID:33387578
Panx1	Rat	paracetamol	increases expression	ISO	RGD:1552235	6480464	Acetaminophen results in increased expression of PANX1 mRNA	CTD	PMID:27826632\|PMID:29246445
Panx1	Rat	paracetamol	affects localization	ISO	RGD:1552235	6480464	Acetaminophen affects the localization of PANX1 protein	CTD	PMID:27826632
Panx1	Rat	paracetamol	multiple interactions	ISO	RGD:1552235	6480464	PANX1 gene mutant form inhibits the reaction [Acetaminophen results in decreased expression of AADAT mRNA]; more ...	CTD	PMID:27826632\|PMID:29246445
Panx1	Rat	paracetamol	affects response to substance	ISO	RGD:1552235	6480464	PANX1 gene mutant form affects the susceptibility to Acetaminophen	CTD	PMID:29246445
Panx1	Rat	paracetamol	decreases expression	ISO	RGD:1347653	6480464	Acetaminophen results in decreased expression of PANX1 mRNA	CTD	PMID:21420995
Panx1	Rat	perfluorooctanoic acid	increases expression	EXP		6480464	perfluorooctanoic acid results in increased expression of PANX1 mRNA	CTD	PMID:35163327
Panx1	Rat	phenobarbital	affects expression	ISO	RGD:1347653	6480464	Phenobarbital affects the expression of PANX1 mRNA	CTD	PMID:19159669
Panx1	Rat	probenecid	multiple interactions	ISO	RGD:1347653	6480464	Probenecid inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]	CTD	PMID:19213873
Panx1	Rat	probenecid	decreases activity	ISO	RGD:1552235	6480464	Probenecid results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	resveratrol	multiple interactions	ISO	RGD:1347653	6480464	[Plant Extracts co-treated with Resveratrol] results in increased expression of PANX1 mRNA	CTD	PMID:23557933
Panx1	Rat	serpentine asbestos	affects expression	ISO	RGD:1347653	6480464	Asbestos, Serpentine affects the expression of PANX1 mRNA	CTD	PMID:24160326
Panx1	Rat	sodium arsenite	affects methylation	ISO	RGD:1347653	6480464	sodium arsenite affects the methylation of PANX1 gene	CTD	PMID:28589171
Panx1	Rat	sodium arsenite	decreases expression	ISO	RGD:1552235	6480464	sodium arsenite results in decreased expression of PANX1 mRNA	CTD	PMID:37682722
Panx1	Rat	sodium arsenite	multiple interactions	ISO	RGD:1347653	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Panx1	Rat	sodium arsenite	increases expression	ISO	RGD:1347653	6480464	sodium arsenite results in increased expression of PANX1 mRNA	CTD	PMID:38568856
Panx1	Rat	tacrolimus hydrate	increases expression	ISO	RGD:1552235	6480464	Tacrolimus results in increased expression of PANX1 mRNA	CTD	PMID:29362864
Panx1	Rat	testosterone	increases expression	ISO	RGD:1552235	6480464	Testosterone results in increased expression of PANX1 mRNA	CTD	PMID:20403060
Panx1	Rat	tetrachloromethane	increases expression	ISO	RGD:1552235	6480464	Carbon Tetrachloride results in increased expression of PANX1 mRNA	CTD	PMID:29987408
Panx1	Rat	tetrachloromethane	multiple interactions	ISO	RGD:1552235	6480464	[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of PANX1 mRNA; [PANX1 protein co-treated more ...	CTD	PMID:29987408\|PMID:30517762
Panx1	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of PANX1 mRNA	CTD	PMID:25729387
Panx1	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of PANX1 mRNA	CTD	PMID:33387578
Panx1	Rat	triphenyl phosphate	affects expression	ISO	RGD:1347653	6480464	triphenyl phosphate affects the expression of PANX1 mRNA	CTD	PMID:37042841
Panx1	Rat	UTP	decreases activity	ISO	RGD:1552235	6480464	Uridine Triphosphate results in decreased activity of PANX1 protein	CTD	PMID:19023039
Panx1	Rat	valproic acid	affects expression	ISO	RGD:1347653	6480464	Valproic Acid affects the expression of PANX1 mRNA	CTD	PMID:25979313

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Panx1	Rat	ATP transport	involved_in	ISO	RGD:1347653	1624291	PMID:15304325	RGD	PMID:15304325
Panx1	Rat	ATP transport	involved_in	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	ATP transport	involved_in	ISS	UniProtKB:Q96RD7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Panx1	Rat	calcium ion transmembrane transport	involved_in	IEA	UniProtKB-KW:KW-0107	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Panx1	Rat	calcium ion transport	involved_in	ISS	UniProtKB:Q96RD7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Panx1	Rat	calcium ion transport	involved_in	IEA	UniProtKB-KW:KW-0109	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Panx1	Rat	calcium ion transport	involved_in	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	calcium ion transport	involved_in	ISO	RGD:1347653	1624291	PMID:16908669	RGD	PMID:16908669
Panx1	Rat	cell-cell signaling		IMP		1299639		RGD
Panx1	Rat	cell-cell signaling	involved_in	IBA	PANTHER:PTN000405776\|RGD:735137\|RGD:735191\|RGD:735204	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Panx1	Rat	monoatomic anion transmembrane transport	involved_in	ISO	RGD:1552235	1624291	PMID:22311122	RGD	PMID:22311122
Panx1	Rat	monoatomic anion transmembrane transport	involved_in	IEA	UniProtKB:Q9JIP4\|ensembl:ENSMUSP00000126405	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	monoatomic anion transmembrane transport	involved_in	ISS	UniProtKB:Q9JIP4	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Panx1	Rat	monoatomic cation transport	involved_in	IEA	InterPro:IPR039099	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Panx1	Rat	monoatomic cation transport	involved_in	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	monoatomic cation transport	involved_in	IBA	PANTHER:PTN000405776\|UniProtKB:Q96RD7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Panx1	Rat	monoatomic cation transport	involved_in	ISO	RGD:1347653	1624291	PMID:17036048	RGD	PMID:17036048
Panx1	Rat	monoatomic ion transmembrane transport	involved_in	IEA	UniProtKB-KW:KW-0407	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Panx1	Rat	monoatomic ion transport	involved_in	IEA	UniProtKB-KW:KW-0406	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Panx1	Rat	positive regulation of interleukin-1 alpha production	acts_upstream_of_or_within	ISO	RGD:1552235	1624291	PMID:18490713	RGD	PMID:18490713
Panx1	Rat	positive regulation of interleukin-1 alpha production	acts_upstream_of_or_within	IEA	UniProtKB:Q9JIP4\|ensembl:ENSMUSP00000126405	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	positive regulation of interleukin-1 beta production	involved_in	ISO	RGD:1347653	1624291	PMID:17036048	RGD	PMID:17036048
Panx1	Rat	positive regulation of interleukin-1 beta production	acts_upstream_of_or_within	ISO	RGD:1552235	1624291	PMID:18490713	RGD	PMID:18490713
Panx1	Rat	positive regulation of interleukin-1 beta production	involved_in	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	positive regulation of interleukin-1 beta production	acts_upstream_of_or_within	IEA	UniProtKB:Q9JIP4\|ensembl:ENSMUSP00000126405	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	positive regulation of interleukin-1 production	involved_in	IEA	InterPro:IPR039099	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Panx1	Rat	positive regulation of macrophage cytokine production	acts_upstream_of_or_within	IEA	UniProtKB:Q9JIP4\|ensembl:ENSMUSP00000126405	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	positive regulation of macrophage cytokine production	acts_upstream_of_or_within	ISO	RGD:1552235	1624291	PMID:18490713	RGD	PMID:18490713
Panx1	Rat	response to ATP	acts_upstream_of_or_within	IEA	UniProtKB:Q9JIP4\|ensembl:ENSMUSP00000126405	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	response to ATP	acts_upstream_of_or_within	ISO	RGD:1552235	1624291	PMID:18490713	RGD	PMID:18490713
Panx1	Rat	response to ischemia	acts_upstream_of_or_within	ISO	RGD:1552235	1624291	MGI:1890615 PMID:22147915	RGD	PMID:22147915
Panx1	Rat	response to ischemia	acts_upstream_of_or_within	IEA	UniProtKB:Q9JIP4\|ensembl:ENSMUSP00000126405	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	transmembrane transport	involved_in	IEA	GO:0015267	1600115	GO_REF:0000108	GOC	GO_REF:0000108

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Panx1	Rat	bleb	located_in	ISO	RGD:1347653	1624291	PMID:17036048	RGD	PMID:17036048
Panx1	Rat	bleb	located_in	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	endoplasmic reticulum	located_in	ISS	UniProtKB:Q96RD7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Panx1	Rat	endoplasmic reticulum	located_in	IEA	UniProtKB-KW:KW-0256	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Panx1	Rat	endoplasmic reticulum	located_in	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	endoplasmic reticulum	located_in	ISO	RGD:1347653	1624291	PMID:16908669	RGD	PMID:16908669
Panx1	Rat	endoplasmic reticulum membrane	located_in	IEA	UniProtKB-SubCell:SL-0097	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Panx1	Rat	gap junction	located_in	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	gap junction	located_in	ISS	UniProtKB:Q96RD7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Panx1	Rat	gap junction	located_in	ISO	RGD:1347653	1624291	PMID:16908669, PMID:17715132	RGD	PMID:16908669\|PMID:17715132
Panx1	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Panx1	Rat	plasma membrane	located_in	ISO	RGD:1347653\|UniProtKB:Q96RD7-1\|UniProtKB:Q96RD7-2	1624291		RGD	GO_REF:0000052
Panx1	Rat	plasma membrane	located_in	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Panx1	Rat	plasma membrane	located_in	ISO	RGD:1552235	1624291	PMID:20086016, PMID:22311122	RGD	PMID:20086016\|PMID:22311122
Panx1	Rat	plasma membrane	is_active_in	IBA	MGI:1860055\|MGI:1918881\|PANTHER:PTN000405776\|RGD:735204\|UniProtKB:Q96RD6\|UniProtKB:Q96RD7\|ZFIN:ZDB-GENE-040426-766\|ZFIN:ZDB-GENE-070705-192	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Panx1	Rat	plasma membrane	located_in	IDA		15090844	PMID:17715132	UniProt
Panx1	Rat	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Panx1	Rat	plasma membrane	located_in	ISO	RGD:1347653	1624291	PMID:17036048	RGD	PMID:17036048
Panx1	Rat	plasma membrane	located_in	IEA	UniProtKB:Q9JIP4\|ensembl:ENSMUSP00000126405	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	protein-containing complex		IDA		5491011		RGD
Panx1	Rat	protein-containing complex	part_of	IDA		15090844	PMID:17715132	UniProt

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Panx1	Rat	actin binding	enables	ISO	RGD:1552235	1624291	PR:P60710 PMID:20086016	RGD	PMID:20086016
Panx1	Rat	actin binding	enables	IEA	UniProtKB:Q9JIP4\|ensembl:ENSMUSP00000126405	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	actin filament binding	enables	ISO	RGD:1552235	1624291	PMID:20086016	RGD	PMID:20086016
Panx1	Rat	actin filament binding	enables	IEA	UniProtKB:Q9JIP4\|ensembl:ENSMUSP00000126405	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	ATP transmembrane transporter activity	enables	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	ATP transmembrane transporter activity	enables	ISO	RGD:1347653	1624291	PMID:15304325	RGD	PMID:15304325
Panx1	Rat	ATP transmembrane transporter activity	enables	ISS	UniProtKB:Q96RD7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Panx1	Rat	calcium channel activity	enables	ISS	UniProtKB:Q96RD7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Panx1	Rat	calcium channel activity	enables	IEA	UniProtKB-KW:KW-0107	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Panx1	Rat	calcium channel activity	enables	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	calcium channel activity	enables	ISO	RGD:1347653	1624291	PMID:16908669	RGD	PMID:16908669
Panx1	Rat	channel activity	enables	IEA	InterPro:IPR039099	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Panx1	Rat	gap junction channel activity		IMP		1299639		RGD
Panx1	Rat	gap junction hemi-channel activity	NOT\|enables	IDA		15090844	PMID:17715132	UniProt
Panx1	Rat	identical protein binding	enables	ISO	RGD:1347653,UniProtKB:Q96RD7-1	1624291	UniProtKB:Q96RD7-1 PMID:32231289, PMID:32494015	RGD	PMID:32231289\|PMID:32494015
Panx1	Rat	leak channel activity	enables	ISS	UniProtKB:Q96RD7	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Panx1	Rat	leak channel activity	enables	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	leak channel activity	enables	ISO	RGD:1347653	1624291	PMID:16908669	RGD	PMID:16908669
Panx1	Rat	monoatomic anion channel activity	enables	IEA	UniProtKB:Q9JIP4\|ensembl:ENSMUSP00000126405	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	monoatomic anion channel activity	enables	ISS	UniProtKB:Q9JIP4	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Panx1	Rat	monoatomic anion channel activity	enables	ISO	RGD:1552235	1624291	PMID:22311122	RGD	PMID:22311122
Panx1	Rat	protease binding		IPI	RGD:2274	5491011		RGD
Panx1	Rat	protease binding		IPI	RGD:621757	5491011		RGD
Panx1	Rat	protein binding		IPI	RGD:620692	5491011		RGD
Panx1	Rat	protein binding	enables	ISO	RGD:1552235	1624291	UniProtKB:P97382 PMID:19780818	RGD	PMID:19780818
Panx1	Rat	protein binding	enables	ISO	RGD:1347653	1624291	UniProtKB:O95183\|UniProtKB:P01375\|UniProtKB:P02652\|UniProtKB:P37268\|UniProtKB:P41181\|UniProtKB:Q14508\|UniProtKB:Q8NBD8\|UniProtKB:Q92843\|UniProtKB:Q96IV6\|UniProtKB:Q9BQE5\|UniProtKB:Q9BXR6\|UniProtKB:Q9NVC3 PMID:32296183	RGD	PMID:32296183
Panx1	Rat	protein binding		IPI	RGD:1310963	5491011		RGD
Panx1	Rat	protein-containing complex binding		IMP		1299639	heterodimerization	RGD
Panx1	Rat	scaffold protein binding		IPI	RGD:628637	5491011		RGD
Panx1	Rat	signaling receptor binding	enables	ISO	RGD:1347653	1624291	UniProtKB:Q64663 PMID:17036048	RGD	PMID:17036048
Panx1	Rat	signaling receptor binding	enables	IEA	UniProtKB:Q96RD7\|ensembl:ENSP00000227638	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Panx1	Rat	structural molecule activity	enables	IDA		15090844	PMID:17715132	UniProt
Panx1	Rat	transmembrane transporter binding		IPI	RGD:3241	5491011		RGD
Panx1	Rat	wide pore channel activity	enables	IBA	MGI:1918881\|PANTHER:PTN000405776\|RGD:735191\|RGD:735204\|ZFIN:ZDB-GENE-040426-766\|ZFIN:ZDB-GENE-070705-192	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Pathway Annotations Click to see Annotation Detail View

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Panx1	Rat	neuron-to-neuron signaling pathway via the electrical synapse		TAS		1299639		RGD

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

autosomal recessive polycystic kidney disease (IEP)

Chemical and Drug Induced Liver Injury (ISO)

depressive disorder (ISO)

intellectual disability (ISO)

Massive Hepatic Necrosis (ISO)

Oocyte/Zygote/Embryo Maturation Arrest 7 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3'-O-(4-Benzoyl)benzoyl ATP (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid (ISO)

4-Acetamido-4'-isothiocyanostilbene-2,2'-disulphonic acid (ISO)

4-hydroxyphenyl retinamide (ISO)

5-Nitro-2-(3-phenylpropylamino)benzoic acid (ISO)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

ATP (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

CARBENOXOLONE (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

flufenamic acid (ISO)

folic acid (ISO)

folpet (ISO)

formaldehyde (ISO)

glutathione (ISO)

GTP (ISO)

hydrogen peroxide (ISO)

L-methionine (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

menadione (ISO)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

Niflumic acid (ISO)

nitrates (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

probenecid (ISO)

resveratrol (ISO)

serpentine asbestos (ISO)

sodium arsenite (ISO)

tacrolimus hydrate (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

topotecan (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

UTP (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ATP transport (IEA,ISO,ISS)

calcium ion transmembrane transport (IEA)

calcium ion transport (IEA,ISO,ISS)

cell-cell signaling (IBA,IMP)

monoatomic anion transmembrane transport (IEA,ISO,ISS)

monoatomic cation transport (IBA,IEA,ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

positive regulation of interleukin-1 alpha production (IEA,ISO)

positive regulation of interleukin-1 beta production (IEA,ISO)

positive regulation of interleukin-1 production (IEA)

positive regulation of macrophage cytokine production (IEA,ISO)

response to ATP (IEA,ISO)

response to ischemia (IEA,ISO)

transmembrane transport (IEA)

Cellular Component

bleb (IEA,ISO)

endoplasmic reticulum (IEA,ISO,ISS)

endoplasmic reticulum membrane (IEA)

gap junction (IEA,ISO,ISS)

membrane (IEA)

plasma membrane (IBA,IDA,IEA,ISO)

protein-containing complex (IDA)

Molecular Function

actin binding (IEA,ISO)

actin filament binding (IEA,ISO)

ATP transmembrane transporter activity (IEA,ISO,ISS)

calcium channel activity (IEA,ISO,ISS)

channel activity (IEA)

gap junction channel activity (IMP)

gap junction hemi-channel activity (IDA)

identical protein binding (ISO)

leak channel activity (IEA,ISO,ISS)

monoatomic anion channel activity (IEA,ISO,ISS)

protease binding (IPI)

protein binding (IPI,ISO)

protein-containing complex binding (IMP)

scaffold protein binding (IPI)

signaling receptor binding (IEA,ISO)

structural molecule activity (IDA)

transmembrane transporter binding (IPI)

wide pore channel activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

neuron-to-neuron signaling pathway via the electrical synapse (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Knockout of P2rx7 purinergic receptor attenuates cyst growth in a rat model of ARPKD.	Arkhipov SN, etal., Am J Physiol Renal Physiol. 2019 Oct 21. doi: 10.1152/ajprenal.00395.2019.
2.	Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane.	Boassa D, etal., J Biol Chem. 2007 Oct 26;282(43):31733-43. doi: 10.1074/jbc.M702422200. Epub 2007 Aug 22.
3.	Pannexins, a family of gap junction proteins expressed in brain.	Bruzzone R, etal., Proc Natl Acad Sci U S A 2003 Nov 11;100(23):13644-9. Epub 2003 Nov 3.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing.	Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	The pannexin 1 channel activates the inflammasome in neurons and astrocytes.	Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.

Additional References at PubMed

PMID:8889548	PMID:16616526	PMID:16908669	PMID:17036048	PMID:18490713	PMID:18649184	PMID:19009624	PMID:19056988	PMID:19780818	PMID:19946888	PMID:20086016	PMID:20200324
PMID:20237259	PMID:20332104	PMID:20516070	PMID:21041301	PMID:21185900	PMID:21267638	PMID:21337450	PMID:21467198	PMID:21659516	PMID:21685263	PMID:21865551	PMID:21907716
PMID:22147915	PMID:22301733	PMID:22733659	PMID:22956847	PMID:22972801	PMID:24269631	PMID:24839011	PMID:25170954	PMID:25172944	PMID:25376229	PMID:25605289	PMID:25630792
PMID:25637780	PMID:25925949	PMID:26854804	PMID:29484398	PMID:29895988	PMID:30456914	PMID:30481075	PMID:31138827	PMID:31712070	PMID:32386453	PMID:33640607	PMID:33688389
PMID:34205953	PMID:34301850	PMID:34638792	PMID:34768835	PMID:34808525	PMID:35029007	PMID:38338895

Genomics

Comparative Map Data

Panx1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	20,128,783 - 20,171,200 (-)	NCBI		GRCr8
mRatBN7.2	8	11,851,176 - 11,889,774 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	11,850,730 - 11,889,774 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	15,835,505 - 15,873,902 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	14,133,250 - 14,171,653 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	12,114,170 - 12,153,042 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	13,567,185 - 13,606,040 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,566,739 - 13,606,040 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	13,508,401 - 13,547,151 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	11,809,752 - 11,849,392 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	11,809,751 - 11,849,392 (-)	NCBI
Celera	8	13,320,676 - 13,358,794 (-)	NCBI		Celera
Cytogenetic Map	8	q12	NCBI

PANX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	94,128,841 - 94,181,968 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	94,128,841 - 94,181,968 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	93,862,007 - 93,915,134 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	93,501,742 - 93,554,786 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	93,501,741 - 93,554,783	NCBI
Celera	11	91,149,894 - 91,202,958 (+)	NCBI		Celera
Cytogenetic Map	11	q21	NCBI
HuRef	11	89,937,250 - 89,990,295 (+)	NCBI		HuRef
CHM1_1	11	93,745,100 - 93,798,158 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	94,045,617 - 94,098,852 (+)	NCBI		T2T-CHM13v2.0

Panx1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	14,917,081 - 14,956,774 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	14,913,424 - 14,956,774 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	15,005,785 - 15,045,478 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	15,002,128 - 15,045,478 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	14,810,229 - 14,849,922 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	14,756,178 - 14,795,871 (-)	NCBI		MGSCv36	mm8
Celera	9	12,286,408 - 12,326,356 (-)	NCBI		Celera
Cytogenetic Map	9	A2	NCBI
cM Map	9	4.52	NCBI

Panx1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	401,188 - 448,470 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	405,483 - 448,470 (-)	NCBI	ChiLan1.0	ChiLan1.0

PANX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	94,981,323 - 95,136,371 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	96,074,806 - 96,126,726 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	89,142,686 - 89,295,972 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	92,628,760 - 92,685,118 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	92,628,760 - 92,685,109 (+)	Ensembl	panpan1.1		panPan2

PANX1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	6,665,730 - 6,715,272 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	6,668,269 - 6,715,858 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	6,675,643 - 6,724,808 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	6,846,046 - 6,895,302 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	6,846,046 - 6,895,402 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	6,626,593 - 6,676,016 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	6,695,903 - 6,745,264 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	6,746,177 - 6,795,582 (-)	NCBI		UU_Cfam_GSD_1.0

Panx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	79,118,039 - 79,154,514 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936674	736,905 - 773,412 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936674	736,911 - 773,406 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PANX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	26,443,815 - 26,491,002 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	26,443,425 - 26,491,010 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	30,047,789 - 30,182,476 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PANX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	85,356,507 - 85,413,146 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	85,356,610 - 85,409,275 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	40,394,937 - 40,454,501 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Panx1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	38,766,981 - 38,819,092 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	38,766,973 - 38,823,284 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Panx1
293 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	215
Count of miRNA genes:	149
Interacting mature miRNAs:	183
Transcripts:	ENSRNOT00000013577
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	8736635	53736635	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	2097640	47097640	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	4705810	49705810	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	7670578	52670578	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	4705810	49705810	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	9712220	53356647	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	2097640	47097640	Rat
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	24597739	Rat
1354595	Despr4	Despair related QTL 4	2.16	0.0036	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	8	7688955	52688955	Rat
1354627	Despr14	Despair related QTL 14		0.0056	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	7688955	52688955	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	2097640	47097640	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	8736635	53736635	Rat
2317882	Alcrsp24	Alcohol response QTL 24	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	8	1	25902202	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	4705810	49705810	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	2097640	47097640	Rat

Markers in Region

RH138823

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	11,851,224 - 11,851,367 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	13,567,234 - 13,567,376	NCBI	Rnor6.0
Rnor_5.0	8	13,508,450 - 13,508,592	UniSTS	Rnor5.0
RGSC_v3.4	8	11,810,247 - 11,810,389	UniSTS	RGSC3.4
Celera	8	13,320,725 - 13,320,867	UniSTS
RH 3.4 Map	8	108.7	UniSTS
Cytogenetic Map	8	q11	UniSTS

AI232305

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	11,854,491 - 11,854,698 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	13,570,501 - 13,570,707	NCBI	Rnor6.0
Rnor_5.0	8	13,511,717 - 13,511,923	UniSTS	Rnor5.0
RGSC_v3.4	8	11,813,514 - 11,813,720	UniSTS	RGSC3.4
Celera	8	13,323,992 - 13,324,198	UniSTS
RH 3.4 Map	8	108.0	UniSTS
Cytogenetic Map	8	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001270548	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001270549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_199397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ557015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BM385439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GQ499839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GQ499840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013577 ⟹ ENSRNOP00000013577

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	11,850,730 - 11,889,774 (-)	Ensembl
Rnor_6.0 Ensembl	8	13,566,739 - 13,606,040 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083395 ⟹ ENSRNOP00000075246

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	11,851,176 - 11,889,774 (-)	Ensembl
Rnor_6.0 Ensembl	8	13,567,185 - 13,606,040 (-)	Ensembl

RefSeq Acc Id:

NM_001270548 ⟹ NP_001257477

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	20,132,611 - 20,171,200 (-)	NCBI
mRatBN7.2	8	11,851,176 - 11,889,774 (-)	NCBI
Rnor_6.0	8	13,567,185 - 13,606,040 (-)	NCBI
Rnor_5.0	8	13,508,401 - 13,547,151 (-)	NCBI
Celera	8	13,320,676 - 13,358,794 (-)	NCBI

Sequence:

show sequence

CCCGGTTTCCCCCGCGTAGGTTCCGGAAGAGCTCGGTTCCCGTAGCCGAGCGCGCAGTGCAGGC
GCGAGCAGCTGTAGCGGAGAGCTAGCTTTGTTCCCGGCACGTTGTTGTCCCTGCGCGCTCAAGG
CGGCCGGAGTCCTGGTGTCGCGCGCGCTGGGGACCCGCGGGAGCTGAGCACGGGGTGTGATCGC
TGCCGCCAAGACTTCGGGGCTCGTGCGCCCTGTGTTGCTTGGAGCGATCCCAGGCGGCTGCAGC
TCTCGTGCGGTCCCTGCGAGGTAGGCGCAGCGACTGCCAAGGCGGTGCAATGCTGGGCCGGCCC
GGAAGCCGCGCTCCGGGTCGTTGACGGCGCGGACTCGGCGCCTCTCCCCGGCTTCCCGCAGCAC
CCGCGCCTGCCTTCGACTGCCCGTCCCGCGGCACCCGGCGCGCCGTGACCATGGCCATCGCCCA
CCTGGCCACGGAGTACGTGTTCTCGGACTTCTTGCTGAAGGAGCCCACCGAGCCCAAGTTCAAG
GGGCTGCGACTGGAGCTGGCAGTGGACAAGATGGTCACGTGCATTGCCGTGGGTCTGCCTCTGC
TGCTCATCTCGCTGGCCTTCGCTCAGGAGATCTCCATCGGTACCCAGATAAGCTGCTTCTCCCC
AAGTTCCTTCTCCTGGCGCCAGGCCGCCTTCGTGGACTCTTACTGCTGGGCCGCTGTACAGCAG
AAAAACTCCCTGCAGAGTGAGTCTGGAAACCTCCCGCTGTGGCTGCACAAGGTAATAATGAGTC
TGTGGGAGATATCCGAAAGCCACTTCAAGTACCCGATCGTGGAGCAGTACTTGAAGACGAAGAA
GAACTCCAGTCACCTAATCATGAAATACATTAGCTGCCGGCTGGTGACCTTTGCGGTGGTACTG
CTGGCTTGCATCTACTTGAGCTACTACTTCAGCCTCTCCTCGCTCTCCGACGAGTTTCTGTGTA
GCATCAAGTCGGGCGTCCTGAGGAACGACAGCACCATCCCCGATAGCTTCCAGTGCAAGCTCAT
CGCGGTCGGCATCTTCCAGCTGCTCAGCCTCATTAACCTCCTAGTGTACGCCCTGCTGGTCCCC
GTGGTCATCTACACGCTCTTCGTCCCGTTCCGGCAGAAGACGGACGTCCTCAAGGTATACGAGA
TCCTGCCCACCTTCGATGTTCTACATTTCAAGTCTGAAGGCTACAACGACTTGAGCCTCTACAA
CCTTTTTCTGGAAGAGAACATAAGTGAGCTCAAATCGTACAAGTGTCTTAAGGTGCTGGAGAAC
ATTAAGAGCAATGGGCAGGGCATCGACCCCATGTTACTTCTGACAAACCTAGGCATGATTAAGA
TGGACGTCATTGATGGAAAAGTCCCCATGTCCCTACAGACCAAGGGAGAGGACCAGGGCAGCCA
GAGAATGGACTTCAAAGATTTGGACCTGAGCAGCGAGACGGCAGCGAACAATGGGGAGAAGAAC
TCTCGCCAGCGACTTCTGAATTCATCCTGCTAATGGTTTCATTCTTGAATTTCAAGCCTGTGAC
TCCTGTGGCTGACCCACCCCTGTTGGAACCGTAGCTAGTTTGCAGTATATGTTTTTGGTATCGA
TGTGGTGTGTGTCCTAAGACATAATGGCCCACAGCGTTATGGAAGAATAGCTAGGAACGTCCTT
CAAGACTAAATATGGAAACGAGTAAGTGCTTTGTCTAAAGCCCTCGTCGGAGGGCTATTAAGAG
AGAGCACAGAGCCTTCTAGAGCCCCAGAGAAGCACCGTTCTGGACTGGCAGTGCTGGGAGACCT
GGAGCTTCTAGAGAACAAGCACTTTGTTTTGTGAGATAATAATAAACCTGTCAGGATGTAATTT
AATAACCCCTTCTGTGTGCCCTTTCTGACTGTTGGACAAGAAGAGCATTCACTGGCCTACCAGG
GAAATCGACCTGTTCGAGTGCAGCTGTGCCCTAAATTGGGTGTGACCTGCCGTTTGACCTCAGC
ACGGACAGCAGCCTGAGGCAGTGCTGACTAAACCCCAGCTATGGAGCCAGAGTCATGCCATGGT
GACTCTCAGAAGGAAGGCTTGAGAAACCTTCCCAGTGGGAAACCTGAGTTTAGATACCTGAGGC
AGGAGAACGGGATTTTACTGACGCCCATGTGAGGCACACTTTGTCCAATGAGGGCAGAACACGG
AACTGACCTAGCAGTGGCCTTGGCCATTTGTTTAGATCAGATTGATTAAATTTAAGCCCAACTT
TTAAAA

hide sequence

RefSeq Acc Id:

NM_001270549 ⟹ NP_001257478

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	20,132,611 - 20,171,200 (-)	NCBI
mRatBN7.2	8	11,851,176 - 11,889,774 (-)	NCBI
Rnor_6.0	8	13,567,185 - 13,606,040 (-)	NCBI
Rnor_5.0	8	13,508,401 - 13,547,151 (-)	NCBI
Celera	8	13,320,676 - 13,358,794 (-)	NCBI

Sequence:

show sequence

CCCGGTTTCCCCCGCGTAGGTTCCGGAAGAGCTCGGTTCCCGTAGCCGAGCGCGCAGTGCAGGC
GCGAGCAGCTGTAGCGGAGAGCTAGCTTTGTTCCCGGCACGTTGTTGTCCCTGCGCGCTCAAGG
CGGCCGGAGTCCTGGTGTCGCGCGCGCTGGGGACCCGCGGGAGCTGAGCACGGGGTGTGATCGC
TGCCGCCAAGACTTCGGGGCTCGTGCGCCCTGTGTTGCTTGGAGCGATCCCAGGCGGCTGCAGC
TCTCGTGCGGTCCCTGCGAGGTAGGCGCAGCGACTGCCAAGGCGGTGCAATGCTGGGCCGGCCC
GGAAGCCGCGCTCCGGGTCGTTGACGGCGCGGACTCGGCGCCTCTCCCCGGCTTCCCGCAGCAC
CCGCGCCTGCCTTCGACTGCCCGTCCCGCGGCACCCGGCGCGCCGTGACCATGGCCATCGCCCA
CCTGGCCACGGAGTACGTGTTCTCGGACTTCTTGCTGAAGGAGCCCACCGAGCCCAAGTTCAAG
GGGCTGCGACTGGAGCTGGCAGTGGACAAGATGGTCACGTGCATTGCCGTGGGTCTGCCTCTGC
TGCTCATCTCGCTGGCCTTCGCTCAGGAGATCTCCATCGGTACCCAGATAAGCTGCTTCTCCCC
AAGTTCCTTCTCCTGGCGCCAGGCCGCCTTCGTGGACTCTTACTGCTGGGCCGCTGTACAGCAG
AAAAACTCCCTGCAGAGTGAGTCTGGAAACCTCCCGCTGTGGCTGCACAAGTTCTTCCCCTACA
TCCTGCTACTGTTTGCCATACTCCTGTACCTGCCCGCTCTGTTCTGGCGCTTTGCGGCGGCTCC
ACACCTCTGCTCCGACCTGAAGTTTATCATGGAGGAGCTTGACAAAGTCTATAACCGCGCCATC
AAGGCTGCCAAGAGTGCTCGTGATTTGGACCTGAGAGATGGACCTGGACCTCCAGGAGTGACTG
AGAATGTGGGGCAGAGTCTGTGGGAGATATCCGAAAGCCACTTCAAGTACCCGATCGTGGAGCA
GTACTTGAAGACGAAGAAGAACTCCAGTCACCTAATCATGAAATACATTAGCTGCCGGCTGGTG
ACCTTTGCGGTGGTACTGCTGGCTTGCATCTACTTGAGCTACTACTTCAGCCTCTCCTCGCTCT
CCGACGAGTTTCTGTGTAGCATCAAGTCGGGCGTCCTGAGGAACGACAGCACCATCCCCGATAG
CTTCCAGTGCAAGCTCATCGCGGTCGGCATCTTCCAGCTGCTCAGCCTCATTAACCTCCTAGTG
TACGCCCTGCTGGTCCCCGTGGTCATCTACACGCTCTTCGTCCCGTTCCGGCAGAAGACGGACG
TCCTCAAGATTTGGACCTGAGCAGCGAGACGGCAGCGAACAATGGGGAGAAGAACTCTCGCCAG
CGACTTCTGAATTCATCCTGCTAATGGTTTCATTCTTGAATTTCAAGCCTGTGACTCCTGTGGC
TGACCCACCCCTGTTGGAACCGTAGCTAGTTTGCAGTATATGTTTTTGGTATCGATGTGGTGTG
TGTCCTAAGACATAATGGCCCACAGCGTTATGGAAGAATAGCTAGGAACGTCCTTCAAGACTAA
ATATGGAAACGAGTAAGTGCTTTGTCTAAAGCCCTCGTCGGAGGGCTATTAAGAGAGAGCACAG
AGCCTTCTAGAGCCCCAGAGAAGCACCGTTCTGGACTGGCAGTGCTGGGAGACCTGGAGCTTCT
AGAGAACAAGCACTTTGTTTTGTGAGATAATAATAAACCTGTCAGGATGTAATTTAATAACCCC
TTCTGTGTGCCCTTTCTGACTGTTGGACAAGAAGAGCATTCACTGGCCTACCAGGGAAATCGAC
CTGTTCGAGTGCAGCTGTGCCCTAAATTGGGTGTGACCTGCCGTTTGACCTCAGCACGGACAGC
AGCCTGAGGCAGTGCTGACTAAACCCCAGCTATGGAGCCAGAGTCATGCCATGGTGACTCTCAG
AAGGAAGGCTTGAGAAACCTTCCCAGTGGGAAACCTGAGTTTAGATACCTGAGGCAGGAGAACG
GGATTTTACTGACGCCCATGTGAGGCACACTTTGTCCAATGAGGGCAGAACACGGAACTGACCT
AGCAGTGGCCTTGGCCATTTGTTTAGATCAGATTGATTAAATTTAAGCCCAACTTTTAAAA

hide sequence

RefSeq Acc Id:

NM_199397 ⟹ NP_955429

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	20,132,611 - 20,171,200 (-)	NCBI
mRatBN7.2	8	11,851,176 - 11,889,774 (-)	NCBI
Rnor_6.0	8	13,567,185 - 13,606,040 (-)	NCBI
Rnor_5.0	8	13,508,401 - 13,547,151 (-)	NCBI
RGSC_v3.4	8	11,809,752 - 11,849,392 (-)	RGD
Celera	8	13,320,676 - 13,358,794 (-)	NCBI

Sequence:

show sequence

CCCGGTTTCCCCCGCGTAGGTTCCGGAAGAGCTCGGTTCCCGTAGCCGAGCGCGCAGTGCAGGC
GCGAGCAGCTGTAGCGGAGAGCTAGCTTTGTTCCCGGCACGTTGTTGTCCCTGCGCGCTCAAGG
CGGCCGGAGTCCTGGTGTCGCGCGCGCTGGGGACCCGCGGGAGCTGAGCACGGGGTGTGATCGC
TGCCGCCAAGACTTCGGGGCTCGTGCGCCCTGTGTTGCTTGGAGCGATCCCAGGCGGCTGCAGC
TCTCGTGCGGTCCCTGCGAGGTAGGCGCAGCGACTGCCAAGGCGGTGCAATGCTGGGCCGGCCC
GGAAGCCGCGCTCCGGGTCGTTGACGGCGCGGACTCGGCGCCTCTCCCCGGCTTCCCGCAGCAC
CCGCGCCTGCCTTCGACTGCCCGTCCCGCGGCACCCGGCGCGCCGTGACCATGGCCATCGCCCA
CCTGGCCACGGAGTACGTGTTCTCGGACTTCTTGCTGAAGGAGCCCACCGAGCCCAAGTTCAAG
GGGCTGCGACTGGAGCTGGCAGTGGACAAGATGGTCACGTGCATTGCCGTGGGTCTGCCTCTGC
TGCTCATCTCGCTGGCCTTCGCTCAGGAGATCTCCATCGGTACCCAGATAAGCTGCTTCTCCCC
AAGTTCCTTCTCCTGGCGCCAGGCCGCCTTCGTGGACTCTTACTGCTGGGCCGCTGTACAGCAG
AAAAACTCCCTGCAGAGTGAGTCTGGAAACCTCCCGCTGTGGCTGCACAAGTTCTTCCCCTACA
TCCTGCTACTGTTTGCCATACTCCTGTACCTGCCCGCTCTGTTCTGGCGCTTTGCGGCGGCTCC
ACACCTCTGCTCCGACCTGAAGTTTATCATGGAGGAGCTTGACAAAGTCTATAACCGCGCCATC
AAGGCTGCCAAGAGTGCTCGTGATTTGGACCTGAGAGATGGACCTGGACCTCCAGGAGTGACTG
AGAATGTGGGGCAGAGTCTGTGGGAGATATCCGAAAGCCACTTCAAGTACCCGATCGTGGAGCA
GTACTTGAAGACGAAGAAGAACTCCAGTCACCTAATCATGAAATACATTAGCTGCCGGCTGGTG
ACCTTTGCGGTGGTACTGCTGGCTTGCATCTACTTGAGCTACTACTTCAGCCTCTCCTCGCTCT
CCGACGAGTTTCTGTGTAGCATCAAGTCGGGCGTCCTGAGGAACGACAGCACCATCCCCGATAG
CTTCCAGTGCAAGCTCATCGCGGTCGGCATCTTCCAGCTGCTCAGCCTCATTAACCTCCTAGTG
TACGCCCTGCTGGTCCCCGTGGTCATCTACACGCTCTTCGTCCCGTTCCGGCAGAAGACGGACG
TCCTCAAGGTATACGAGATCCTGCCCACCTTCGATGTTCTACATTTCAAGTCTGAAGGCTACAA
CGACTTGAGCCTCTACAACCTTTTTCTGGAAGAGAACATAAGTGAGCTCAAATCGTACAAGTGT
CTTAAGGTGCTGGAGAACATTAAGAGCAATGGGCAGGGCATCGACCCCATGTTACTTCTGACAA
ACCTAGGCATGATTAAGATGGACGTCATTGATGGAAAAGTCCCCATGTCCCTACAGACCAAGGG
AGAGGACCAGGGCAGCCAGAGAATGGACTTCAAAGATTTGGACCTGAGCAGCGAGACGGCAGCG
AACAATGGGGAGAAGAACTCTCGCCAGCGACTTCTGAATTCATCCTGCTAATGGTTTCATTCTT
GAATTTCAAGCCTGTGACTCCTGTGGCTGACCCACCCCTGTTGGAACCGTAGCTAGTTTGCAGT
ATATGTTTTTGGTATCGATGTGGTGTGTGTCCTAAGACATAATGGCCCACAGCGTTATGGAAGA
ATAGCTAGGAACGTCCTTCAAGACTAAATATGGAAACGAGTAAGTGCTTTGTCTAAAGCCCTCG
TCGGAGGGCTATTAAGAGAGAGCACAGAGCCTTCTAGAGCCCCAGAGAAGCACCGTTCTGGACT
GGCAGTGCTGGGAGACCTGGAGCTTCTAGAGAACAAGCACTTTGTTTTGTGAGATAATAATAAA
CCTGTCAGGATGTAATTTAATAACCCCTTCTGTGTGCCCTTTCTGACTGTTGGACAAGAAGAGC
ATTCACTGGCCTACCAGGGAAATCGACCTGTTCGAGTGCAGCTGTGCCCTAAATTGGGTGTGAC
CTGCCGTTTGACCTCAGCACGGACAGCAGCCTGAGGCAGTGCTGACTAAACCCCAGCTATGGAG
CCAGAGTCATGCCATGGTGACTCTCAGAAGGAAGGCTTGAGAAACCTTCCCAGTGGGAAACCTG
AGTTTAGATACCTGAGGCAGGAGAACGGGATTTTACTGACGCCCATGTGAGGCACACTTTGTCC
AATGAGGGCAGAACACGGAACTGACCTAGCAGTGGCCTTGGCCATTTGTTTAGATCAGATTGAT
TAAATTTAAGCCCAACTTTTAAAA

hide sequence

RefSeq Acc Id:

XM_039081351 ⟹ XP_038937279

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	20,128,783 - 20,150,170 (-)	NCBI
mRatBN7.2	8	11,851,858 - 11,868,740 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001257477	(Get FASTA)	NCBI Sequence Viewer
	NP_001257478	(Get FASTA)	NCBI Sequence Viewer
	NP_955429	(Get FASTA)	NCBI Sequence Viewer
	XP_038937279	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ADM92601	(Get FASTA)	NCBI Sequence Viewer
	ADM92602	(Get FASTA)	NCBI Sequence Viewer
	CAD89522	(Get FASTA)	NCBI Sequence Viewer
	EDL78455	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013577
	ENSRNOP00000013577.3
	ENSRNOP00000075246
GenBank Protein	P60570	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_955429 ⟸ NM_199397
- Peptide Label:	isoform a
- UniProtKB:	P60570 (UniProtKB/Swiss-Prot), A6JNB1 (UniProtKB/TrEMBL), E0X642 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQI SCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPALFWR FAAAPHLCSDLKFIMEELDKVYNRAIKAAKSARDLDLRDGPGPPGVTENVGQSLWEISESHFKY PIVEQYLKTKKNSSHLIMKYISCRLVTFAVVLLACIYLSYYFSLSSLSDEFLCSIKSGVLRNDS TIPDSFQCKLIAVGIFQLLSLINLLVYALLVPVVIYTLFVPFRQKTDVLKVYEILPTFDVLHFK SEGYNDLSLYNLFLEENISELKSYKCLKVLENIKSNGQGIDPMLLLTNLGMIKMDVIDGKVPMS LQTKGEDQGSQRMDFKDLDLSSETAANNGEKNSRQRLLNSSC hide sequence

RefSeq Acc Id:	NP_001257478 ⟸ NM_001270549
- Peptide Label:	isoform d
- UniProtKB:	E0X643 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQI SCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPALFWR FAAAPHLCSDLKFIMEELDKVYNRAIKAAKSARDLDLRDGPGPPGVTENVGQSLWEISESHFKY PIVEQYLKTKKNSSHLIMKYISCRLVTFAVVLLACIYLSYYFSLSSLSDEFLCSIKSGVLRNDS TIPDSFQCKLIAVGIFQLLSLINLLVYALLVPVVIYTLFVPFRQKTDVLKIWT hide sequence

RefSeq Acc Id:	NP_001257477 ⟸ NM_001270548
- Peptide Label:	isoform c
- UniProtKB:	A0A0G2KA39 (UniProtKB/TrEMBL), E0X642 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQI SCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKVIMSLWEISESHFKYPIVEQY LKTKKNSSHLIMKYISCRLVTFAVVLLACIYLSYYFSLSSLSDEFLCSIKSGVLRNDSTIPDSF QCKLIAVGIFQLLSLINLLVYALLVPVVIYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYND LSLYNLFLEENISELKSYKCLKVLENIKSNGQGIDPMLLLTNLGMIKMDVIDGKVPMSLQTKGE DQGSQRMDFKDLDLSSETAANNGEKNSRQRLLNSSC hide sequence

Ensembl Acc Id:

ENSRNOP00000075246 ⟸ ENSRNOT00000083395

Ensembl Acc Id:

ENSRNOP00000013577 ⟸ ENSRNOT00000013577

RefSeq Acc Id:	XP_038937279 ⟸ XM_039081351
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P60570-F1-model_v2	AlphaFold	P60570	1-426	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695750

Promoter ID:

EPDNEW_R6273

Type:

multiple initiation site

Name:

Panx1_1

Description:

Pannexin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	13,606,013 - 13,606,073	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735204	AgrOrtholog
BioCyc Gene	G2FUF-31676	BioCyc
Ensembl Genes	ENSRNOG00000010060	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000013577	ENTREZGENE
	ENSRNOT00000013577.6	UniProtKB/Swiss-Prot
	ENSRNOT00000083395	ENTREZGENE
InterPro	Innexin	UniProtKB/Swiss-Prot
	Pannexin	UniProtKB/Swiss-Prot
KEGG Report	rno:315435	UniProtKB/Swiss-Prot
NCBI Gene	315435	ENTREZGENE
PANTHER	PANNEXIN-1	UniProtKB/Swiss-Prot
	PTHR15759	UniProtKB/Swiss-Prot
Pfam	Innexin	UniProtKB/Swiss-Prot
PhenoGen	Panx1	PhenoGen
PROSITE	PANNEXIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000010060	RatGTEx
UniProt	A0A0G2KA39	ENTREZGENE, UniProtKB/TrEMBL
	A6JNB1	ENTREZGENE, UniProtKB/TrEMBL
	E0X642	ENTREZGENE, UniProtKB/TrEMBL
	E0X643	ENTREZGENE, UniProtKB/TrEMBL
	P60570	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Panx1	Pannexin 1	px1		Symbol updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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