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Gene: P2rx7 (purinergic receptor P2X 7) Rattus norvegicus
Symbol: P2rx7
Name: purinergic receptor P2X 7
Description: Exhibits several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and metal ion binding activity. Involved in several processes, including bleb assembly; neuronal action potential; and regulation of secretion by cell. Localizes to several cellular components, including the bleb; integral component of nuclear inner membrane; and membrane raft. Orthologous to human P2RX7 (purinergic receptor P2X 7); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
Also known as: ATP receptor; P2X purinoceptor 7; P2X7 purinoceptor; P2Z receptor; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7
Homo sapiens (human) : P2RX7 (purinergic receptor P2X 7)  HGNC  Alliance
Mus musculus (house mouse) : P2rx7 (purinergic receptor P2X, ligand-gated ion channel, 7)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2rx7 (purinergic receptor P2X 7)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RX7 (purinergic receptor P2X 7)
Canis lupus familiaris (dog) : P2RX7 (purinergic receptor P2X 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2rx7 (purinergic receptor P2X 7)
Sus scrofa (pig) : P2RX7 (purinergic receptor P2X 7)
more info ...
Allele / Splice: P2rx7em8Mcwi   P2rx7em12Mcwi   P2rx7em10Mcwi   P2rx7em13Mcwi  
Genetic Models: SS-P2rx7em12Mcwi SS-P2rx7em13Mcwi PCK-P2rx7em8Mcwi SS-P2rx7em10Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01239,353,613 - 39,396,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01241,804,060 - 41,808,755 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01241,242,368 - 41,284,797 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,074,025 - 35,117,152 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11234,937,412 - 34,980,540 (-)NCBI
Celera1235,564,374 - 35,607,476 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on P2rx7
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3241
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.