INTERLEUKIN-1 SIGNALING PATHWAY (PW:0000883)

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Description

Interleukin 1 is a member of the interleukin-1 family of cytokines that plays important roles in innate and adaptive immunity and which has been associated with acute and chronic inflammation. Interleukin 1 (alpha and beta) signaling involves the same receptor but there are differences between the localization, processing and function of the two cytokines. Il1b is considered the more potent cytokine while 1a can be active in its precursor form, can be membrane-associated and active and can also

Pathway Diagram:

Ariadne Genomics Inc. NLRP1 inflammasome Myd88 Tollip AIM2 inflammasome NLRP3 inflammasome Map3k7-Tab(s) complex Pellino members Ube2n Il1rap Il1r1 Il-1beta processing cytTraf6 --+> cytMap3k7 cytTraf6 ---- Ube2v1 cytTraf6 ---- Ube2n Pellino members ---> diss-Irak1 diss-Irak1 ---> Pellino members diss-Traf6 ---- Map3k7-Tab(s) complex diss-Irak1 ---- diss-Traf6 diss-Irak1 ---- Map3k7-Tab(s) complex Il1r1 ---- negative regulators Il1rap ---- negative regulators Il1a ---- Il1r1 cytMap3k7 --+> c-Jun N-terminal kinases MAPK signaling pathway cytMap3k7 --+> p38 MAPK signaling pathway cytMap3k7 --+> nuclear factor kappa B signaling pathway Irak1 ---- Myd88 Irak4 ---- Myd88 Irak1 ---- Traf6 Il1r1 ---- Il1rap Il1rap ---- Myd88 Il1r1 ---- Myd88 Il1rap ---- Tollip Il1r1 ---- Tollip Irak4 ---> Irak1 K63-polyubiquitination Irak4 ---> Irak2 Irak4 Traf6 Irak2 Irak1 Ube2v1 Il1a Il1b Il1b ---- Il1r1 diss-Irak1 diss-Traf6 NLRP3 inflammasome ---> Il-1beta processing NLRP1 inflammasome ---> Il-1beta processing AIM2 inflammasome ---> Il-1beta processing p38 MAPK signaling pathway c-Jun N-terminal kinases MAPK signaling pathway nuclear factor kappa B signaling pathway Il-1beta secretion Il-1beta processing ---> Il-1beta secretion cytTraf6 negative regulators ---| Il1rap negative regulators ---| Il1r1 negative regulators cytTab(s) cytMap3k7
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Genes in Pathway:

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interleukin-1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aim2 absent in melanoma 2 JBrowse link 13 91,919,834 91,963,080 RGD:5490211
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:5490210
RGD:6484113
RGD:5490211
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 4 152,087,393 152,380,023 RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6484113
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:5490209
RGD:6484113
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:5490209
RGD:6484113
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:5490209
RGD:6484113
RGD:5130945
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:5490209
RGD:6484113
G Il1rap interleukin 1 receptor accessory protein JBrowse link 11 77,456,648 77,593,208 RGD:5490209
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:5490209
RGD:6484113
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:5490215
RGD:6484113
RGD:5490218
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:5490215
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:6484113
G Irak4 interleukin-1 receptor-associated kinase 4 JBrowse link 7 135,803,723 135,831,006 RGD:5490215
RGD:6484113
RGD:5490218
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5490215
RGD:6484113
RGD:5490218
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:5490215
RGD:6484113
RGD:5490218
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6484113
G Nlrp1a NLR family, pyrin domain containing 1A JBrowse link 10 57,692,474 57,747,608 RGD:5490211
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:5490210
RGD:5490211
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link 14 106,008,086 106,062,566 RGD:5490215
G Peli2 pellino E3 ubiquitin protein ligase family member 2 JBrowse link 15 24,942,218 25,086,350 RGD:5490215
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:5490215
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:6484113
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6484113
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:5490210
RGD:5490211
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6484113
G Sigirr single Ig and TIR domain containing JBrowse link 1 213,898,395 213,907,697 RGD:5490209
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:5490215
RGD:6484113
RGD:5490218
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:5490215
RGD:6484113
RGD:5490218
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5490218
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:6484113
G Tollip toll interacting protein JBrowse link 1 214,823,993 214,844,861 RGD:5490218
RGD:6484113
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:5490215
RGD:6484113
RGD:5130945
RGD:5490218
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:5490215
RGD:6484113
RGD:5490218
G Ube2v1 ubiquitin conjugating enzyme E2 V1 JBrowse link 3 164,343,833 164,366,684 RGD:5490215
RGD:6484113
RGD:5490218

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ComplexMap3k7-Tab(s) complexa pre-formed complex at the membrane consisting of Map3k7 and members of Tab family
Proteindiss-Irak1Irak1 dissociated from the receptor complex
ProteincytMap3k7Map3k7 translocated to the cytoplasm in the Traf6-Map3k7-Tab(s) complex
Pathwaynuclear factor kappa B signalingnf-kappaB signaling plays essential role in the proper functioning of the immune system
Pathwayp38 MAPK signaling pathwayone of the two stress activated MAPK cascades that responds to inflammatory cytokines and various stresses
Pathwayc-Jun N-terminal kinases MAPK signaling pathwayone of the two stress activated MAPK cascades that responds to inflammatory cytokines and various stresses
Functional Classnegative regulatorsspecific and broad negative regulators of interleukin-1 signaling
ProteincytTab(s)Tab(s) translocated to the cytoplasm in the Traf6-Map3k7-Tab(s) complex
ComplexAIM2 inflammasomethe AIM2 inflammasome that processes Il-1beta
Functional ClassPellino membersthe members of E3 ubiqutin ligase Pellino family
ComplexNLRP1 inflammasomethe NLRP1 inflammasome complex that processes Il-1beta
ComplexNLRP3 inflammasomethe NLRP3 inflammasome complex that processes Il-1beta
ProteincytTraf6Traf6 translocated to the the cytoplasm in the Traf6-Map3k7-Tab(s) complex
Proteindiss-traf6Traf6 dissociated from the receptor complex

Pathway Gene Annotations

Disease Annotations Associated with Genes in the interleukin-1 signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmMapk8
abdominal obesity-metabolic syndromePrkci
Abortion, SpontaneousIl1b
AbscessIl1rn
acute kidney failureCasp1 , Il1a , Il1b , Il1rn , Nfkb1
Acute Liver FailureIl1rn , Mapk8
Acute Lung InjuryIl1b , Il1rn
acute myeloid leukemiaIl1a
Acute Necrotizing PancreatitisIl1b , Il1rn , Rela
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaIl1b , Nfkb1 , Pik3ca , Pycard
adenoid cystic carcinomaPik3ca
adrenal carcinomaPik3ca
adrenocortical carcinomaPik3ca
adult respiratory distress syndromeIl1b , Il1rn
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
aggressive periodontitisIl1r2
agranulocytosisIl1b
AIDS Dementia ComplexIl1b
AlbuminuriaCasp1 , Il1b , Pycard
alcoholic liver cirrhosisRela
Alcoholic Liver DiseasesIl1b
allergic bronchopulmonary aspergillosisIl1a
allergic conjunctivitisIl1b , Il1rn
allergic contact dermatitisIl1a
allergic hypersensitivity diseaseCasp1 , Il1b , Il1r1 , Il1r2 , Map2k6
allergic rhinitisIl1b
alopecia areataIl1rn
Alport syndromeIl1b
Alzheimer's diseaseCasp1 , Ikbkb , Il1a , Il1b , Mapk8 , Pik3r1
amnestic disorderIl1a
amphetamine abuseRela
amyotrophic lateral sclerosisSqstm1
amyotrophic lateral sclerosis type 1Casp1
AnaphylaxisNlrp3
anemiaIl1b
angiosarcomaJun
Anhidrotic Ectodermal Dysplasia with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Animal Disease ModelsIl1b , Irak4 , Mapk8
Animal Mammary NeoplasmsMap2k6 , Pik3r1
ankylosing spondylitisIl1r2 , Irak1
AnorexiaIl1a , Il1b , Il1rn
anterior uveitisIl1rn
anthracosisIl1a , Il1b , Il1rn
anti-basement membrane glomerulonephritisIl1b , Il1rn , Mapk8
Arsenic PoisoningIl1a , Il1b , Il1rn , Peli1
arteriosclerosisIl1b , Rela
asbestosisNlrp3
AsphyxiaJun
aspiration pneumoniaIl1a
asthmaCasp1 , Chuk , Il1a , Il1b , Il1rn
Asthma-Related Traits, Susceptibility To, 5Irak3
astroblastomaPik3r1
atherosclerosisIl1b
atopic dermatitisIl1b , Mapk8
atrophic gastritisIl1b
AtrophyIl1rn
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
autistic disorderIl1rn
autoimmune thrombocytopenic purpuraIl1a , Il1rn
AUTOINFLAMMATION WITH ARTHRITIS AND DYSKERATOSISNlrp1a
autosomal dominant nonsyndromic deafness 34Nlrp3
autosomal dominant polycystic kidney diseaseIl1rn
autosomal recessive polycystic kidney diseasePik3ca
B-Cell Chronic Lymphocytic LeukemiaIl1a , Il1b , Il1rn , Myd88
Bacterial Infections and MycosesIrak4
Bacterial KeratitisIl1r1 , Myd88
bacterial pneumoniaChuk , Il1b , Il1rn
Bannayan-Riley-Ruvalcaba syndromePik3ca
Barrett's esophagusRela
basal cell carcinomaPik3ca
Behcet's diseaseIkbkg , Il1b , Il1rn
beta thalassemiaIl1a
bladder urothelial carcinomaPik3ca
Bloch-Sulzberger syndromeIkbkg
bone development diseaseChuk
Brain DeathMap2k6
brain infarctionIl1b
Brain InjuriesCasp1 , Il1a , Il1b , Il1r1 , Il1rn , Jun , Rela , Ticam2
brain ischemiaIl1a , Il1b , Il1rn , Irak1 , Irak4 , Jun , Mapk8 , Nfkb1 , Rela
Brain NeoplasmsPik3ca , Pik3r1 , Rela
branched-chain keto acid dehydrogenase kinase deficiencyPycard
breast adenocarcinomaPik3ca
breast cancerIl1b , Nfkb1 , Pik3ca
Breast Cancer, FamilialPik3ca
Breast NeoplasmsIkbkb , Il1b , Jun , Pik3ca , Pik3r1 , Prkci , Rela
Bronchial HyperreactivityIl1b , Il1rn
bronchiectasisIl1b
bronchiolitisIl1b , Il1rn
bronchiolitis obliteransIl1rn
Bronchopulmonary DysplasiaIl1b , Il1rn
bronchus carcinomaIl1rn
Brugada syndromeMyd88
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaPik3r1
BurnsIl1a , Il1b
Burns, ChemicalIl1a , Il1b , Il1r1
CachexiaIl1b , Il1rn
calcinosisIl1b , Pycard
Calcium Oxalate NephrolithiasisIl1rn
cancerPik3ca , Pik3r1
carcinomaPik3r1
CardiomegalyIl1b , Map2k6 , Mapk8 , Prkcz , Rela
cardiomyopathyIl1a , Il1b , Irak1
Carotid Artery InjuriesIl1rn
Cell Transformation, NeoplasticJun , Mapk8 , Myd88 , Nfkb1 , Rela
Cerebral HemorrhageIl1rn , Nfkb1 , Rela , Sqstm1
cervix uteri carcinoma in situRela
Chemical and Drug Induced Liver InjuryIl1a , Il1b , Il1r2 , Irak1
Childhood SchizophreniaRela
cholestasisIl1a , Rela
cholesteatomaIl1a , Il1b
cholesteatoma of middle earIl1a , Il1r1 , Rela
chorioamnionitisIl1a
Choroidal NeovascularizationIkbkb
chronic kidney diseaseIl1b , Il1rn
chronic lymphocytic leukemiaMyd88
chronic myeloid leukemiaIl1b , Il1rn
chronic obstructive pulmonary diseaseIl1b , Il1rn , Mapk8
chronic progressive external ophthalmoplegiaIl1a , Il1b
Chronic RhinosinusitisIl1rn
Chronic UveitisIl1rn
cicatricial pemphigoidIl1rn
CINCA syndromeNlrp3
cleft palateChuk
CLOVES syndromePik3ca
cochlear diseaseIl1b
cocoon syndromeChuk
cognitive disorderIrak1
Cognitive DysfunctionIl1b
colitisChuk , Ikbkb , Il1b , Rela
colon cancerPik3ca
colon carcinomaPik3ca
Colonic NeoplasmsIkbkb , Il1b , Il1rn , Jun , Map2k6 , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela
colorectal adenocarcinomaJun , Mapk8
colorectal adenomaJun , Mapk8
colorectal cancerPik3ca
Colorectal NeoplasmsPik3ca , Pik3r1 , Pycard
common coldIl1a , Il1b , Il1rn
common variable immunodeficiencyNfkb1
Common Variable Immunodeficiency 12Nfkb1
complex cortical dysplasia with other brain malformationsPik3ca
Congenital Heart Defects, Multiple Types, 2Tab2
Congenital Limb DeformitiesChuk
congestive heart failureCasp1 , Il1b
Contrast-Induced NephropathyIl1b , Mapk8
corneal edemaIl1a
Corneal Graft RejectionIl1rn
corneal neovascularizationIl1rn
coronary artery diseaseIl1b , Irak1 , Traf6
Coronary DiseaseIl1b
Cowden diseasePik3ca
Cowden Syndrome 5Pik3ca
Cowden-Like SyndromePik3ca
Craniocerebral TraumaIl1a
crescentic glomerulonephritisIl1b , Il1rn
Creutzfeldt-Jakob diseaseIl1a
Crohn's diseaseNlrp3
Cryopyrin-Associated Periodic SyndromesIl1rn , Nlrp3
cryptorchidismRela
Currarino TriadPik3ca
cutaneous leishmaniasisIl1b
cystic fibrosisIl1a , Il1b , Il1rn
cystitisIl1b , Rela
dacryocystitisIl1rn
Deficiency of Interleukin-1 Receptor AntagonistIl1rn
dermatitisIkbkb
dermatomyositisIl1a , Il1b
Diabetes Mellitus, Experimental Casp1 , Ikbkb , Il1a , Il1b , Il1rn , Map2k6 , Pik3r1 , Prkci , Rela
diabetic angiopathyRela
Diabetic NephropathiesIl1b , Il1rn , Rela
diabetic neuropathyIl1b
diabetic retinopathyIl1a , Il1b
diarrheaIl1a , Il1rn
diffuse large B-cell lymphomaMyd88 , Pik3ca
Dilatation, PathologicCasp1
disease of cellular proliferationIl1b , Pik3ca , Pik3r1
Disease ProgressionIl1a , Il1rap , Pik3ca
drug allergyNlrp3
Drug Hypersensitivity SyndromeIl1b , Il1rn
Drug-Induced AgranulocytosisIl1b , Il1rn
Drug-Induced DyskinesiaRela
Drug-Induced Immune ThrombocytopeniaIl1a , Il1b
Drug-induced NeutropeniaIl1a
dry eye syndromeIl1b , Il1rn
ductal carcinoma in situRela
Eales DiseaseIl1b
EdemaIl1b , Map2k6
Embryo LossUbe2n
encephalitisIl1b , Il1rn , Rela
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsIkbkg , Irak1
end stage renal failureIl1a , Il1b , Il1rn , Nfkb1 , Rela
endometrial adenocarcinomaPik3r1
endometrial cancerPik3r1
endometrial carcinomaPik3ca , Pik3r1
Endometrial NeoplasmsJun , Pik3ca
endometriosisIl1r1
endometritisIl1a
endophthalmitisIl1b
EndotoxemiaCasp1 , Il1a , Il1b , Il1rn
Endotoxin-Induced UveitisIl1rn
EntamoebiasisIl1b
EnterocolitisIl1a , Il1b
EosinophiliaMyd88
epidermal nevusPik3ca
epididymitisIl1b
epilepsyIl1b , Rela
esophageal carcinomaPik3ca
Esophageal NeoplasmsMap3k3
esophagus adenocarcinomaPik3ca
exanthemIl1rn
Experimental ArthritisIkbkb , Ikbkg , Il1a , Il1b , Il1rn , Myd88
Experimental Autoimmune EncephalomyelitisIl1rn
Experimental Autoimmune MyocarditisIl1rn
Experimental Autoimmune NeuritisIl1b
Experimental Autoimmune UveitisIl1rn
Experimental ColitisIl1rn
Experimental LeukemiaIl1a
Experimental Liver CirrhosisCasp1 , Il1b , Pycard , Rela
Experimental MelanomaIkbkb , Il1a , Il1b
Experimental NeoplasmsRela
Experimental PancreatitisIkbkg
extrahepatic cholestasisIl1b , Jun , Map3k7 , Mapk8 , Myd88 , Rela
Extravasation of Diagnostic and Therapeutic MaterialsIl1rn
extrinsic allergic alveolitisIl1a , Il1b
Eye BurnsIl1b
Eye ManifestationsIl1rn
Fabry diseaseIl1a
Facial AsymmetryPik3ca
familial cold autoinflammatory syndromeNlrp3
familial cold autoinflammatory syndrome 1Nlrp3
familial Mediterranean feverIl1b
Familial Paget's Disease of BoneSqstm1
fatty liver diseaseIkbkg , Il1b , Mapk8 , Nfkb1 , Rela
favismIkbkg
Femoral FracturesIl1a
Fetal DiseasesChuk
Fetal Growth RetardationIl1a
FeverIl1a , Il1b , Il1rn , Nlrp3
fibromyalgiaIl1rn
FibrosisIl1b , Il1rn
focal segmental glomerulosclerosisIl1b
follicular lymphomaMyd88
food allergyNlrp3
Forney Robinson Pascoe SyndromeMap3k7
Frontometaphyseal DysplasiaMap3k7
Frontometaphyseal Dysplasia 2Map3k7
FTDALS1Sqstm1
FTDALS3Sqstm1
gallbladder carcinomaPik3ca
Gallbladder NeoplasmsIl1b
gastric adenocarcinomaPik3ca
gastric ulcerIl1b
Gastrointestinal NeoplasmsPik3ca
genetic diseaseIkbkg , Nlrp3 , Pik3ca , Pik3r1
Genetic Predisposition to DiseaseIl1b
glaucomaSqstm1
glioblastoma multiformeIl1b , Pik3ca , Pik3r1
glomerulonephritisIl1a , Il1b , Il1r1 , Il1rn
glomerulosclerosisIl1b
glucosephosphate dehydrogenase deficiencyIkbkg
goutIl1b , Il1rn
Graft vs Host DiseaseIl1a , Il1rn
Gram-Negative Bacterial InfectionsIl1b
Graves OphthalmopathyIl1a , Il1rn
Graves' diseaseIl1b
Growth DisordersPik3ca
hairy cell leukemiaIl1rn
Head and Neck NeoplasmsPik3ca
head and neck squamous cell carcinomaPik3ca
Heart InjuriesIl1b
heart valve diseaseIl1b , Pycard
Heat StrokeIl1a , Il1b , Jun , Nfkb1 , Rela
HemimegalencephalyPik3ca
hemolytic-uremic syndromeIl1a , Il1b , Il1rn
HemorrhageIl1a
Henoch-Schoenlein purpuraIl1rn
Hepatic InsufficiencyRela
hepatitis CIl1b
hepatocellular carcinomaIl1b , Jun , Pik3ca , Pycard
HepatomegalyRela
Hereditary Neoplastic SyndromesPik3ca , Ticam2
herpes simplex virus keratitisIl1b , Il1rn
Hirschsprung Disease 1Irak3
HIV Wasting SyndromeIl1a , Il1b
Hodgkin's lymphomaJun
Human InfluenzaCasp1 , Il1a , Il1b , Il1rn
Huntington's diseaseNfkb1
hydronephrosisIl1b
HyperalgesiaIl1a , Il1b , Il1r1 , Il1rn , Mapk8 , Prkcz
HypercholesterolemiaIl1b
HyperemiaIl1b
hyperglycemiaIl1a , Il1b , Il1rn , Prkcz
hyperhomocysteinemiaCasp1 , Il1b , Pycard
HyperoxaluriaNfkb1
HyperoxiaIrak4
HyperplasiaIkbkb , Pik3ca
hypertensionIkbkb , Il1b , Il1rn , Jun , Mapk8 , Myd88 , Pik3r1 , Rela , Sqstm1
Hypoglossal Nerve InjuriesIl1r1
hypoglycemiaIl1b , Pik3r1
hypohidrotic ectodermal dysplasiaIkbkg , Traf6
Hypohidrotic Ectodermal Dysplasia, with Immune DeficiencyIkbkg
hypolipoproteinemiaIl1b
hypomelanosis of ItoIkbkg
HypotensionIl1a , Il1b
Hypoxia-Ischemia, BrainCasp1 , Il1b , Irak1 , Irak4
idiopathic pulmonary fibrosisIl1rn
IgA glomerulonephritisIl1a , Il1b , Il1rn
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
in situ carcinomaCasp1
InflammationCasp1 , Chuk , Il1a , Il1b , Il1rn , Myd88 , Nlrp3
inflammatory bowel diseaseIkbkb , Il1rn
Insulin ResistanceCasp1 , Ikbkb , Il1b , Pik3r1 , Prkcz , Rela
interstitial lung diseaseIl1a , Il1rn
Intestinal NeoplasmsMapk8
Intestinal PolypsJun
Invasive Pneumococcal Disease, Recurrent Isolated, 1Irak4
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Invasive Pulmonary AspergillosisIl1a , Il1b
IRAK4 DeficiencyIrak4
iridocyclitisIl1a
irritable bowel syndromeIkbkg
juvenile rheumatoid arthritisIl1a , Il1rn , Jun
Kawasaki diseaseIl1b
Kearns-Sayre syndromeIl1a , Il1b
Keratitis Fugax HereditariaNlrp3
keratoconusIl1a , Il1b , Il1rn
kidney diseaseCasp1 , Il1rn , Pycard
kidney failureIl1b
Kidney NeoplasmsJun
Kidney Reperfusion InjuryIkbkb , Il1b , Il1rn
Knee OsteoarthritisIl1a
Kuhnt-Junius degenerationMapk8
large cell carcinomaPycard
learning disabilityIkbkg , Il1b , Il1rn
Leber hereditary optic neuropathyIl1a , Il1b
Left Ventricular HypertrophyPrkcz , Rela
leptospirosisIl1b
LethargyIl1b
leukemiaPrkcz
LeukocytosisIl1b , Il1rn
Lichen Sclerosus et AtrophicusIl1rn
listeriosisIl1rn
liver benign neoplasmJun
liver cancerPik3ca
liver diseaseIl1r2 , Il1rap , Nfkb1
Liver Reperfusion InjuryIkbkg , Il1a , Il1b , Il1rn , Mapk8
lung adenocarcinomaPik3ca , Pik3r1
lung cancerPik3ca
lung diseaseCasp1 , Il1a , Il1b
Lung NeoplasmsIkbkg , Il1b , Il1r2 , Jun , Pik3ca , Pycard
Lung Reperfusion InjuryIl1b
lung small cell carcinomaPik3ca , Pik3r1
lung squamous cell carcinomaPik3ca
lupus nephritisIl1b , Il1rn
Lyme NeuroborreliosisIl1b
Lymphatic MetastasisPik3ca , Rela
lymphomaMyd88 , Rela
lymphopeniaIl1b
lymphoplasmacytic lymphomaMyd88
macular degenerationSqstm1
malignant gliomaPik3ca
malignant mesotheliomaIl1a , Pycard
Mammary Neoplasms, ExperimentalCasp1 , Il1rn , Pik3r1 , Rela
Manganese PoisoningIl1b
mastoiditisRela
medulloblastomaPik3ca
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
Meibomian Gland DysfunctionIl1rn
melanomaIl1rn , Nfkb1 , Nlrp3 , Pik3ca , Pik3r1
MELAS syndromeIl1a , Il1b
membranoproliferative glomerulonephritisIl1b
membranous glomerulonephritisIl1b
Memory DisordersIl1b
mental depressionIl1b , Il1rn , Jun
Mercury Poisoning, Nervous SystemJun
MERRF SyndromeIl1a , Il1b
mesenchymal chondrosarcomaIl1a
Microvascular Complications of Diabetes, Susceptibility to, 4Il1rn
middle cerebral artery infarctionIkbkb , Il1b , Il1rn
migraineTab2
mitochondrial myopathyIl1a , Il1b
Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal BonesMap3k7
morbid obesityIl1rn
Mouth NeoplasmsPik3ca
Muckle-Wells syndromeIl1rn , Nlrp3
mucositisIl1b , Il1rn
Multiple AbnormalitiesChuk
Multiple Hamartoma SyndromePik3ca
multiple myelomaIl1a , Il1b , Il1rn , Myd88 , Pik3ca
Multiple Organ FailureIl1b , Il1rn
multiple sclerosisCasp1 , Il1b , Il1rn , Nlrp3
muscular atrophyChuk , Ikbkb
muscular diseaseIl1b
MYD88 DeficiencyMyd88
myelodysplastic syndromeIl1b
myocardial infarctionCasp1 , Il1b , Il1rn
Myocardial IschemiaIl1a , Il1b
Myocardial Reperfusion InjuryCasp1 , Il1a , Il1b , Il1rn , Irak1 , Map2k6 , Mapk8 , Myd88 , Rela
myocarditisIrak1
myositisIl1rn
Nasal PolypsIl1a , Jun
Nasopharyngeal NeoplasmsPik3ca
NecrosisIl1b , Il1rn
Nematode InfectionsPik3r1
Neonatal HyperbilirubinemiaIkbkb
Neoplasm InvasivenessIl1b , Il1rn , Myd88 , Rela
Neoplasm MetastasisChuk , Nfkb1 , Pik3ca
nephrosisIl1b
nephrotic syndromeIl1b , Il1rn
neuroblastomaPik3ca
Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy, Childhood-OnsetSqstm1
neutropeniaIl1b
Neutropenic EnterocolitisIl1b
non-Hodgkin lymphomaMyd88 , Pik3ca
non-small cell lung carcinomaIl1a , Il1b , Il1rn , Nfkb1 , Pik3ca , Pycard , Rela
Nonaka MyopathySqstm1
nonalcoholic fatty liver diseaseIkbkg , Il1a , Mapk8
Nontuberculous Mycobacterium InfectionsIl1r1
obesityCasp1 , Ikbkb , Il1b , Il1rn , Pik3r1 , Prkci , Rela
obstructive sleep apneaIl1b , Rela
OligoanuriaIl1rn
Onchocerciasis, OcularIl1r1
Optic Nerve InjuriesJun
Oral Lichen PlanusIl1a
osteoarthritisIl1a , Il1b
osteopetrosisJun
osteoporosisIl1a , Il1b , Il1rn , Irak3
osteosarcomaJun
otitis mediaIl1a , Il1b , Rela
Otitis Media with EffusionIl1b
ovarian cancerPik3ca
ovarian cystNfkb1
Ovarian NeoplasmsMap2k6 , Pik3ca , Pik3r1 , Prkci , Rela
ovarian serous cystadenocarcinomaPik3ca
Oxygen-Induced RetinopathyMapk8
Paget's disease of boneSqstm1
PainCasp1 , Il1rn
PALMOPLANTAR CARCINOMA, MULTIPLE SELF-HEALINGNlrp1a
pancreatic adenocarcinomaPik3ca
pancreatic cancerIl1a , Il1b , Rela
Pancreatic CystIl1b
pancreatitisIkbkb , Il1b
Pancreatitis, Experimental, Chronic Il1b
papillary renal cell carcinomaPik3ca
Parkinson's diseaseIl1b
Parkinsonian DisordersIl1b , Rela
penile neoplasmPik3ca
peptic ulcer diseaseIl1b
Perennial Allergic RhinitisIl1a , Il1r1
perinatal necrotizing enterocolitisIkbkg , Il1b
periodontitisIl1a , Il1b , Il1rn
Peripheral Nerve InjuriesIl1b
peripheral nervous system diseaseJun
Pick's diseaseMap2k6
plagueIl1b
plasmacytomaMyd88 , Pik3ca
pleural diseaseIl1rn
pleural tuberculosisIl1b , Il1rn
pleurisyIl1b , Il1rn
Pneumococcal MeningitisRela
pneumoniaCasp1 , Ikbkb , Il1a , Il1b , Il1r1 , Il1r2 , Il1rn , Myd88
Pneumonia, StaphylococcalIl1b
PoisoningIl1a
polycystic ovary syndromeTab1
PolymyositisIl1a , Il1b
polyneuropathyIl1b
portal hypertensionIl1b , Pik3r1
Postmenopausal OsteoporosisIl1b
Postoperative Cognitive DysfunctionIl1b , Il1rn
pre-eclampsiaIl1rn
pre-malignant neoplasmMapk8
PresbycusisIl1r2
Presenile and Senile DementiaIl1b
primary biliary cirrhosisNfkb1 , Rela
ProctocolitisIl1rn
progressive supranuclear palsyMap2k6
prostate adenocarcinomaChuk , Ikbkb , Pik3ca , Rela
prostate cancerChuk , Ikbkb , Nfkb1 , Nlrp1a , Pik3ca , Pik3r1
prostate carcinoma in situMap2k6 , Rela
prostatic hypertrophyCasp1 , Rela
Prostatic NeoplasmsCasp1 , Chuk , Il1rn , Irak4 , Jun , Map2k6 , Map3k7 , Pik3ca , Pik3r1 , Prkcz , Rela
prostatitisIl1rn
proteinuriaIl1rn
Pseudomonas Aeruginosa KeratitisIl1b , Il1rn
Pseudomonas InfectionsIl1b , Il1rn
psoriasisIkbkb , Il1b , Irak1
psoriatic arthritisIrak1
PTEN hamartoma tumor syndromePik3ca
pulmonary edemaIl1b
pulmonary emphysemaJun
pulmonary eosinophiliaIl1rn
pulmonary fibrosisIl1a , Il1b , Il1rn
pulmonary hypertensionIl1b , Il1rn , Rela
pulmonary sarcoidosisIl1rn
pulmonary tuberculosisIl1a , Il1b , Il1rn , Jun
pulpitisIl1r1
pyelonephritisIl1rn
Radiation InjuriesIl1a
Radiation Injuries, ExperimentalIl1b
Radiation PneumonitisIl1a
rectal neoplasmMapk8 , Pik3ca
renal carcinomaPik3ca
renal cell carcinomaIl1rn , Jun , Pik3ca , Pik3r1 , Rela
renovascular hypertensionRela
Reperfusion InjuryCasp1 , Il1a , Il1b , Irak3 , Jun , Mapk8 , Myd88 , Pik3r1 , Rela
respiratory allergyIl1a , Il1b , Il1rn
restrictive cardiomyopathyMap2k6
Retina Reperfusion InjuryIl1a , Il1b
retinal vein occlusionIl1b
retinitisIl1b
retinopathy of prematurityIl1b
Rett syndromeIrak1
rheumatoid arthritisIl1a , Il1b , Il1rn , Irak1 , Traf6
rhinitisCasp1 , Il1b , Il1rn
RhinosinusitisIl1b
sarcomaPik3ca
schizophreniaIl1b
Schnitzler syndromeIl1a , Il1rn
sciatic neuropathyIl1b , Il1rn
SclerosisIl1a , Il1rn
seborrheic keratosisPik3ca
Seizures, FebrileIl1b , Il1rn
SepsisIl1b , Il1rn , Irak4 , Rela
Septic PeritonitisPik3r1
SerositisIl1rn
Shock, HemorrhagicIl1a , Il1b , Rela
SHORT SyndromePik3r1
silicosisIl1b , Il1rn
sinusitisIl1b
Sjogren's syndromeIl1rn
Skin AbnormalitiesChuk
skin cancerChuk
skin diseaseIl1a , Il1b , Il1r1 , Il1rn , Peli1
skin melanomaPik3ca
Skin NeoplasmsIl1a , Rela
sleep disorderIl1b
small cell carcinomaPycard
Small-For-Size SyndromeIl1b
Smith-Magenis syndromeMap2k6 , Map3k3
Spinal Cord InjuriesCasp1 , Il1b , Il1r1 , Il1rn , Jun , Rela
Sporadic Papillary Renal Cell CarcinomaPik3ca
squamous cell carcinomaIrak1 , Pik3ca , Pycard
status asthmaticusIl1b
status epilepticusCasp1 , Il1b , Il1rn , Jun , Rela
stomach cancerIl1b , Il1rn , Pik3ca
Stomach NeoplasmsIl1b , Il1rn , Jun , Mapk8 , Pik3ca , Pycard
StrokeIl1b , Il1rn , Mapk8 , Pik3ca
Subarachnoid HemorrhageIl1rn
Systemic Inflammatory Response SyndromeIl1b
systemic lupus erythematosusIl1b , Il1rn , Irak4
systemic sclerodermaIl1b , Il1r1 , Irak1
thalassemiaIl1b
thrombocytopeniaIl1b
thrombocytosisIl1b
Thyroid NeoplasmsIl1b , Pik3ca
Tibial FracturesCasp1
tick infestationIl1a
Tobacco Use DisorderIl1rn
toxic shock syndromeIl1rn
transient cerebral ischemiaIkbkb , Il1b , Il1rn , Nfkb1
transitional cell carcinomaPik3ca
Transplant RejectionIkbkb , Il1b , Il1rn
trigeminal neuralgiaIl1b , Mapk8
type 1 diabetes mellitusIl1a , Il1b , Il1r1 , Il1rn , Irak3
type 1 diabetes mellitus 5Tab2
type 2 diabetes mellitusIkbkb , Il1b , Il1rn , Mapk8 , Nfkb1 , Pik3r1 , Prkci , Prkcz , Rela
ulcerative colitisIl1b , Il1r2 , Il1rn , Rela
ureteral obstructionIl1b , Il1rn , Rela
urinary bladder cancerIl1b , Il1rn , Rela
Urinary CalculiIl1rn
Urinary Tract InfectionsIl1a , Il1b
urticariaIl1b , Nlrp3
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsMap2k6 , Pik3ca , Rela
Uterine NeoplasmsPik3ca , Pik3r1
uveitisIl1a , Il1b , Rela
Uveitis, Chronic AnteriorIl1rn
varicoceleIl1a , Il1b
vascular dementiaIl1b
vascular diseaseIl1rn
Vascular MalformationsPik3ca
Venous ThrombosisIl1a , Il1b , Il1rn
Ventilator-Induced Lung InjuryIl1b , Il1r1 , Il1rn
Viral BronchiolitisCasp1 , Il1rn
visceral leishmaniasisIl1b
visual epilepsyCasp1 , Il1b , Pik3ca
vitiligoIl1a , Pik3r1
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1Nlrp1a
Vulvar VestibulitisIl1b
Waldenstroem's macroglobulinemiaMyd88
Weight GainPik3ca , Pycard
Wolff-Parkinson-White syndromeMap3k7
Wounds and InjuriesIl1a
X-linked adrenal hypoplasia congenitaTab3
Pathway Annotations Associated with Genes in the interleukin-1 signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
adenosine signaling pathwayChuk , Ikbkb , Jun , Map2k6 , Mapk8 , Nfkb1 , Pik3ca , Prkcz
aldosterone signaling pathwayPik3ca , Pik3r1
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
altered ubiquitin/proteasome degradation pathwayUbe2n
Alzheimer's disease pathwayIl1b , Ube2n
amyotrophic lateral sclerosis pathwayCasp1 , Map2k6
angiotensin II signaling pathwayPrkcz
apoptotic cell death pathwayChuk , Ikbkb , Ikbkg , Il1a , Il1b , Il1r1 , Il1rap , Irak1 , Irak2 , Irak3 , Irak4 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela
ataxia telangiectasia-mutated (ATM) signaling pathwayUbe2n
B cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Jun , Nfkb1 , Pik3ca , Pik3r1 , Rela
Bone morphogenetic proteins signaling pathwayMap3k7 , Tab1 , Tab2
c-Jun N-terminal kinases MAPK signaling pathwayMap3k3 , Map3k7 , Mapk8
ceramide signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Prkcz , Rela
Chagas disease pathwayChuk , Ikbkb , Ikbkg , Il1b , Irak1 , Irak4 , Jun , Mapk8 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
chemokine mediated signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Prkcz , Rela
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
colorectal cancer pathwayJun , Mapk8 , Pik3ca , Pik3r1
cytokine mediated signaling pathwayIl1a , Il1b , Il1r1 , Il1r2 , Il1rap
E-cadherin signaling pathwayPik3ca , Pik3r1
eicosanoid signaling pathwayPrkcz
endocytosis pathwayPrkci , Prkcz , Traf6
endometrial cancer pathwayPik3ca , Pik3r1
Endoplasmic Reticulum-associated degradation pathwayMapk8
endothelin signaling pathwayJun , Mapk8
Entamoebiasis pathwayIl1b , Il1r1 , Il1r2 , Nfkb1 , Pik3ca , Pik3r1 , Rela
ephrin - ephrin receptor bidirectional signaling axisMap3k7 , Mapk8 , Pik3ca , Pik3r1
epidermal growth factor/neuregulin signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1 , Prkcz
Erk5 MAPK signaling pathwayMap3k3
erythropoietin signaling pathwayMapk8 , Nfkb1 , Pik3r1
FasL mediated signaling pathwayChuk , Ikbkb , Ikbkg , Map2k6 , Mapk8 , Pik3ca , Pik3r1
Fc epsilon receptor mediated signaling pathwayMap2k6 , Mapk8 , Pik3ca , Pik3r1
Fc gamma receptor mediated signaling pathwayPik3ca , Pik3r1
fibroblast growth factor signaling pathwayJun , Pik3ca , Pik3r1
forkhead class A signaling pathwayJun
glioma pathwayPik3ca , Pik3r1
glypican signaling pathwayMapk8
gonadotropin-releasing hormone signaling pathwayJun , Map2k6 , Map3k3 , Mapk8
graft-versus-host disease pathwayIl1a , Il1b
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Pik3ca , Pik3r1
Hedgehog signaling pathwayPik3ca , Pik3r1
hepatitis C pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
hypoxia inducible factor pathwayJun
inflammatory response pathwayMapk8
influenza A pathwayCasp1 , Ikbkb , Il1a , Il1b , Irak4 , Jun , Map2k6 , Mapk8 , Myd88 , Nfkb1 , Nlrp3 , Pik3ca , Pik3r1 , Pycard , Rela
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkci , Prkcz
insulin signaling pathwayIkbkb , Mapk8 , Pik3ca , Pik3r1 , Prkci , Prkcz
insulin-like growth factor signaling pathwayPik3ca , Pik3r1 , Prkcz
interleukin-1 signaling pathwayAim2 , Casp1 , Chuk , Erc1 , Ikbkb , Ikbkg , Il1a , Il1b , Il1r1 , Il1r2 , Il1rap , Il1rn , Irak1 , Irak2 , Irak3 , Irak4 , Jun , Map2k6 , Map3k3 , Map3k7 , Mapk8 , Myd88 , Nfkb1 , Nlrp1a , Nlrp3 , Peli1 , Peli2 , Peli3 , Pik3ca , Pik3r1 , Prkci , Prkcz , Pycard , Rela , Sigirr , Sqstm1 , Tab1 , Tab2 , Tab3 , Ticam2 , Tollip , Traf6 , Ube2n , Ube2v1
interleukin-12 signaling pathwayIl1b , Il1r1 , Map2k6 , Nfkb1 , Rela
interleukin-2 signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayIl1b , Nfkb1 , Pik3ca , Pik3r1 , Rela
interleukin-27 signaling pathwayIl1b
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayPik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayJun , Map2k6 , Pik3ca , Pik3r1
Jak-Stat signaling pathwayPik3ca , Pik3r1
Leishmaniasis pathwayIl1a , Il1b , Irak1 , Irak4 , Jun , Map3k7 , Myd88 , Nfkb1 , Rela , Traf6
malaria pathwayIl1b , Myd88
measles pathwayChuk , Il1a , Il1b , Irak1 , Irak4 , Map3k7 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
melanoma pathwayPik3ca , Pik3r1
mitochondrial autophagy pathwaySqstm1
mitogen activated protein kinase signaling pathwayChuk , Ikbkb , Ikbkg , Il1a , Il1b , Il1r1 , Il1r2 , Jun , Map2k6 , Map3k3 , Map3k7 , Mapk8 , Nfkb1 , Rela , Traf6
mTOR signaling pathwayIkbkb , Pik3ca , Pik3r1
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
neurotrophic factor signaling pathwayIkbkb , Irak1 , Irak2 , Irak3 , Irak4 , Jun , Map3k3 , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
NOD-like receptor signaling pathwayCasp1 , Chuk , Ikbkb , Ikbkg , Il1b , Map3k7 , Mapk8 , Nfkb1 , Nlrp1a , Nlrp3 , Pycard , Rela , Traf6
non-small cell lung carcinoma pathwayPik3ca , Pik3r1
nuclear factor kappa B signaling pathwayChuk , Erc1 , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Traf6
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb , Sqstm1
p38 MAPK signaling pathwayMap2k6 , Map3k3 , Map3k7 , Tab1 , Tab2 , Traf6
p53 signaling pathwayMapk8
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Pik3ca , Pik3r1
phosphoinositide metabolic pathwayPik3ca , Pik3r1
platelet-derived growth factor signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1
primary immunodeficiency pathwayIkbkg
prion disease pathwayIl1a , Il1b
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
protein kinase C (PKC) signaling pathwayPrkci , Prkcz
Reelin signaling pathwayMapk8 , Pik3ca , Pik3r1
renal cell carcinoma pathwayJun , Pik3ca , Pik3r1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Map3k7 , Mapk8 , Nfkb1 , Rela , Traf6
rheumatoid arthritis pathwayIl1a , Il1b , Jun
Rho/Rac/Cdc42 mediated signaling pathwayJun , Mapk8
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
sleeping sickness pathwayIl1b , Myd88
small cell lung carcinoma pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
sphingosine 1-phosphate signaling pathwayJun , Mapk8
syndecan signaling pathwayMapk8
T cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Jun , Map3k7 , Nfkb1 , Pik3ca , Pik3r1 , Rela
Toll-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Il1b , Irak1 , Irak2 , Irak4 , Jun , Map2k6 , Map3k7 , Mapk8 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Ticam2 , Tollip , Traf6 , Ube2n , Ube2v1
toxoplasmosis pathwayChuk , Ikbkb , Ikbkg , Irak1 , Irak4 , Map2k6 , Map3k7 , Mapk8 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Pik3ca , Pik3r1
transforming growth factor-beta Smad dependent signaling pathwayMap3k7 , Tab1 , Tab2
tuberculosis pathwayIl1a , Il1b , Irak1 , Irak2 , Irak4 , Mapk8 , Myd88 , Nfkb1 , Rela , Traf6
tumor necrosis factor mediated signaling pathwayChuk , Ikbkb , Ikbkg , Map3k3 , Map3k7 , Nfkb1 , Prkci , Prkcz , Rela , Sqstm1 , Tab1 , Tab2 , Tab3
type 1 diabetes mellitus pathwayIl1a , Il1b
type 2 diabetes mellitus pathwayIkbkb , Mapk8 , Pik3ca , Pik3r1 , Prkcz
type II interferon signaling pathwayCasp1 , Il1b , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayTraf6 , Ube2n
vascular endothelial growth factor signaling pathwayMap2k6 , Pik3ca , Pik3r1 , Prkcz
Wnt signaling pathwayJun , Map3k7 , Mapk8
Wnt signaling, non-canonical pathwayMap3k7 , Mapk8 , Prkcz , Tab1 , Tab2
Phenotype Annotations Associated with Genes in the interleukin-1 signaling pathway

References Associated with the interleukin-1 signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: