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Gene: Casp1 (caspase 1) Rattus norvegicus
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Symbol: Casp1
Name: caspase 1
Description: Exhibits scaffold protein binding activity. Involved in several processes, including myoblast fusion; positive regulation of circadian sleep/wake cycle, non-REM sleep; and positive regulation of interleukin-1 beta secretion. Localizes to several cellular components, including the cytoplasm; neuron projection; and nucleus. Used to study acute kidney failure and visual epilepsy. Orthologous to human CASP1 (caspase 1); PARTICIPATES IN interleukin-1 signaling pathway; type II interferon signaling pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CASP-1; caspase 1 apoptosis-related cysteine protease (interleukin 1 beta convertase); caspase-1; Ice; IL-1 beta-converting enzyme; IL-1BC; Il1bc; interleukin 1 beta convertase; interleukin 1, beta, convertase; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45
Orthologs:
Homo sapiens (human) : CASP1 (caspase 1)  HGNC  Alliance
Mus musculus (house mouse) : Casp1 (caspase 1)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CASP1 (caspase 1)
Sus scrofa (pig) : CASP1 (caspase 1, apoptosis-related cysteine peptidase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.082,605,743 - 2,614,637 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.082,627,976 - 2,636,870 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.482,027,976 - 2,036,872 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.182,027,975 - 2,036,866 (+)NCBI
Celera82,455,483 - 2,464,376 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Casp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2274
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.