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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1increases activityISOCasp1 (Mus musculus)6480464CTDHydrogen Peroxide results in increased activity of CASP1 proteinPMID:11181820
Casp1increases expressionISOCASP1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of CASP1 mRNAPMID:33955754
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTDCannabidiol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP1 mRNA]PMID:33955754
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