Niddm21 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Niddm21 (Non-insulin dependent diabetes mellitus QTL 21) Rattus norvegicus

Symbol: Niddm21
Name: Non-insulin dependent diabetes mellitus QTL 21
RGD ID: 71120
Previously known as: Nidd3/of
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: plasma glucose level   (CMO:0000042)    
LOD Score: 3.73
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.281 - 3,402,289RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.081 - 3,442,354RGD_MAPPER_PIPELINERnor6.0
Rnor_5.081 - 3,460,265RGDRnor5.0
RGSC_v3.483,039,822 - 61,462,321RGDRGSC3.4
RGSC_v3.183,039,894 - 61,481,375RGD
Cross Type: F2
Strains Crossed: F344/DuCrlCrlj OLETF/Got 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Identification of a major locus for islet inflammation and fibrosis in the Spontaneously Diabetic Torii rat. Fuse M, etal., Physiol Genomics. 2008 Jul 8;.
2. OLETF allele of hyperglycemic QTL Nidd3/of is dominant. Kose H, etal., Exp Anim. 2008 Apr;57(2):135-8.
3. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
4. Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. Wei S, etal., Mamm Genome 1999 Mar;10(3):249-58
5. Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat. Yamada T, etal., Exp Diabetes Res. 2012;2012:582546. doi: 10.1155/2012/582546. Epub 2012 Oct 15.
Related QTLs

Related QTL Description Reference
Gluco36 maps to same region RGD:2298688


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2316374Vom1r-ps110vomeronasal 1 receptor pseudogene 1108175811176673Rat
11474511Fpr2-ps5formyl peptide receptor 2, pseudogene 58185272186306Rat
7694323Vmn2r116l-ps31vomeronasal 2, receptor 116 like, pseudogene 318338475363739Rat
41255161LOC120094355uncharacterized LOC1200943558455121465763Rat
621655Gucy1a2guanylate cyclase 1 soluble subunit alpha 28500212900201Rat
1591024Nsa2-ps14NSA2 ribosome biogenesis factor, pseudogene 148532919533722Rat
7707295Qdpr-ps1quinoid dihydropteridine reductase, pseudogene 18817654821999Rat
9094733LOC103693002uncharacterized LOC1036930028925754955304Rat
41115508LOC120094561U6 spliceosomal RNA810587571058857Rat
41389138LOC120094543U4 spliceosomal RNA811802901180379Rat
1597429St13-ps8ST13, Hsp70 interacting protein, pseudogene 8811945941195784Rat
7611148Envl-ps5MLV-related proviral Env polyprotein-like, pseudogene 5813721301374272Rat
1311360Aasdhpptaminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase814532261463990Rat
1310895Kbtbd3kelch repeat and BTB domain containing 3814641621491144Rat
7610771Znf431l-ps4zinc finger protein 431 like, pseudogene 4815128171514975Rat
1565380Msantd4Myb/SANT DNA binding domain containing 4 with coiled-coils815169791527587Rat
61863Gria4glutamate ionotropic receptor AMPA type subunit 4815621182035035Rat
40994038LOC120094073uncharacterized LOC120094073817196471733600Rat
1598340Pgk1-ps4phosphoglycerate kinase 1, pseudogene 4820792732080541Rat
1598339Hspa8-ps35heat shock protein family A (Hsp70) member 8, pseudogene 35821885812190467Rat
41015010LOC120094463small nucleolar RNA SNORA42/SNORA80 family821945612194674Rat
41251909Snora16bsmall nucleolar RNA, H/ACA box 16B823688822369014Rat
41073306LOC120094074uncharacterized LOC120094074824454472451562Rat
2274Casp1caspase 1825878122597403Rat
621757Casp4caspase 4825990172635097Rat
7652611LOC102557277uncharacterized LOC102557277826357512642119Rat
621758Casp12caspase 12826422962669549Rat
6500966Hnrnpa1-ps14heterogeneous nuclear ribonucleoprotein A1, pseudogene 14829603142962385Rat
41083724LOC120094075uncharacterized LOC120094075830762883113959Rat
6500564Elob-ps16elongin B, pseudogene 16832289203229273Rat
11403914LOC108351834uncharacterized LOC108351834832293693234906Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
36039D8Rat58174834021153402289Ratregion
37290D8Rat77200820976402097838Ratregion
42843D8Rat227241825697482569991Ratregion
44364D8Got3258817985121798770Ratregion
5045480RH131202190815272751527465Ratregion
5075156RH1384311268899996900122Ratregion
5069604AU0463872148497648497863Ratregion
5070522RH1270872078819421819628Ratregion
5080938RH141870194825962342597352Ratregion
5085147AW531802151819211171921268Ratregion
5507705UniSTS:252200816457441645780Ratregion
5506338Stn3881053822808602281913Ratregion
Position Markers

Flank 1: (D8Mgh7)
Rat AssemblyChrPosition (strand)Source
RGSC_v3.4861,462,322 - 61,462,542UniSTS
RGSC_v3.4861,462,321 - 61,462,542RGD
RGSC_v3.1861,481,375 - 61,481,596RGD
Celera857,561,916 - 57,562,112UniSTS
RH 3.4 Map8667.1RGD
RH 2.0 Map8519.0RGD
Cytogenetic Map8q24UniSTS
Peak: (D8Mgh9)
Rat AssemblyChrPosition (strand)Source
RH 3.4 Map8262.0UniSTS
RH 3.4 Map8262.0RGD
RH 2.0 Map8186.7RGD
Cytogenetic Map8 RGD
Flank 2: (D8Rat58)
Rat AssemblyChrPosition (strand)Source
mRatBN7.283,402,115 - 3,402,289 (+)MAPPER
Rnor_6.083,442,181 - 3,442,354NCBI
Rnor_5.083,460,092 - 3,460,265UniSTS
RGSC_v3.483,039,649 - 3,039,822UniSTS
RGSC_v3.483,039,648 - 3,039,822RGD
RGSC_v3.183,039,399 - 3,039,894RGD
Celera84,981,140 - 4,981,313UniSTS
RH 2.0 Map80.0RGD
SHRSP x BN Map80.0RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)813402289Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Niddm21

RGD Curation Notes
Note Type Note Reference
qtl_general syntenic region in human has APOA1, APOA4 and KCNJ5 as candidate genes 7207431
qtl_general region confirmed by the development of F344.OLETF-(D8Rat58-D8Mgh17)/Tj congenic strain 7207431
qtl_general LOD reported to be 3.06 when glucose was measured at 30 min in males which was confirmed in another experiment using the same strains 61021