CASP1 (caspase 1) - Rat Genome Database

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Gene: CASP1 (caspase 1) Pan paniscus
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Symbol: CASP1 (Ensembl: CARD16)
Name: caspase 1 (Ensembl:caspase recruitment domain family member 16)
RGD ID: 12008066
Description: ENCODES a protein that exhibits scaffold protein binding (ortholog); INVOLVED IN cellular response to organic substance (ortholog); defense response to bacterium (ortholog); defense response to Gram-negative bacterium (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; type II interferon signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); allergic disease (ortholog); FOUND IN AIM2 inflammasome complex (ortholog); canonical inflammasome complex (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CARD16; caspase 1, apoptosis-related cysteine peptidase; caspase recruitment domain family, member 16; caspase recruitment domain-containing protein 16; caspase-1; LOC100986637
RGD Orthologs
Human
Mouse
Rat
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29105,815,530 - 105,827,153 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111106,903,793 - 106,914,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01199,965,964 - 99,975,640 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111103,448,497 - 103,468,367 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11103,467,368 - 103,468,288 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl11103,448,497 - 103,458,149 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
AIM2 inflammasome complex assembly  (IEA)
apoptotic process  (IEA)
cellular response to lipopolysaccharide  (IEA)
cellular response to mechanical stimulus  (IEA)
cellular response to organic substance  (IEA,ISO)
cellular response to type II interferon  (IEA)
cytokine precursor processing  (IEA)
defense response  (IEA)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (ISO)
lung development  (ISO)
membrane hyperpolarization  (ISO)
memory  (ISO)
microglial cell activation  (ISO)
midgut development  (ISO)
mitochondrial depolarization  (ISO)
myoblast fusion  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-1 alpha production  (ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-18 production  (IEA)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
programmed necrotic cell death  (ISO)
protein autoprocessing  (IEA)
protein maturation  (IEA)
protein processing  (ISO)
proteolysis  (IEA)
pyroptosis  (IEA,ISO)
regulation of apoptotic process  (IEA)
regulation of autophagy  (ISO)
regulation of inflammatory response  (IEA,ISO)
response to ATP  (ISO)
response to bacterium  (IEA,ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
signaling receptor ligand precursor processing  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CASP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29105,815,530 - 105,827,153 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111106,903,793 - 106,914,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01199,965,964 - 99,975,640 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111103,448,497 - 103,468,367 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11103,467,368 - 103,468,288 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl11103,448,497 - 103,458,149 (-)Ensemblpanpan1.1panPan2
CASP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811105,025,443 - 105,036,686 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11105,025,397 - 105,035,250 (-)EnsemblGRCh38hg38GRCh38
GRCh3711104,896,170 - 104,905,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611104,401,445 - 104,411,067 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411104,401,448 - 104,411,067NCBI
Celera11102,060,400 - 102,070,022 (-)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11100,827,223 - 100,836,872 (-)NCBIHuRef
CHM1_111104,779,164 - 104,788,813 (-)NCBICHM1_1
T2T-CHM13v2.011105,029,522 - 105,040,777 (-)NCBIT2T-CHM13v2.0
Casp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3995,298,517 - 5,307,281 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl95,298,508 - 5,307,290 (+)EnsemblGRCm39 Ensembl
GRCm3895,298,517 - 5,307,281 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl95,298,508 - 5,307,290 (+)EnsemblGRCm38mm10GRCm38
MGSCv3795,298,517 - 5,307,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3695,298,517 - 5,307,281 (+)NCBIMGSCv36mm8
Celera3117,396,675 - 117,405,459 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Casp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8810,746,338 - 10,882,295 (+)NCBIGRCr8
mRatBN7.282,587,812 - 2,597,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl82,587,831 - 2,597,383 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx86,559,379 - 6,568,854 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.084,857,147 - 4,866,622 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.082,840,611 - 2,850,083 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.082,605,743 - 2,614,637 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl82,604,962 - 2,614,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.082,627,976 - 2,636,870 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.482,027,976 - 2,036,872 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.182,027,975 - 2,036,866 (+)NCBI
Celera82,455,483 - 2,464,376 (+)NCBICelera
Cytogenetic Map8q11NCBI
CASP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl935,186,420 - 35,200,328 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1935,188,066 - 35,199,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2939,210,251 - 39,221,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,389,697 - 96,400,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,389,657 - 96,400,849 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604329,497,194 - 29,506,147 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000036767   ⟹   ENSPPAP00000014091
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11103,448,497 - 103,458,149 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000036783   ⟹   ENSPPAP00000014107
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11103,449,245 - 103,458,103 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063498   ⟹   ENSPPAP00000040581
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11103,467,368 - 103,468,288 (-)Ensembl
RefSeq Acc Id: XM_008953761   ⟹   XP_008952009
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29105,815,530 - 105,827,149 (-)NCBI
NHGRI_mPanPan111106,903,798 - 106,914,716 (-)NCBI
Mhudiblu_PPA_v01199,965,964 - 99,975,640 (-)NCBI
PanPan1.111103,448,497 - 103,458,240 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014346986   ⟹   XP_014202472
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29105,815,530 - 105,827,153 (-)NCBI
NHGRI_mPanPan111106,903,793 - 106,914,716 (-)NCBI
Mhudiblu_PPA_v01199,965,964 - 99,975,640 (-)NCBI
PanPan1.111103,448,497 - 103,458,149 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034933611   ⟹   XP_034789502
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29105,815,530 - 105,826,010 (-)NCBI
NHGRI_mPanPan111106,903,798 - 106,914,409 (-)NCBI
Mhudiblu_PPA_v01199,965,964 - 99,975,288 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008952009 (Get FASTA)   NCBI Sequence Viewer  
  XP_014202472 (Get FASTA)   NCBI Sequence Viewer  
  XP_034789502 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000014091.1
  ENSPPAP00000014107.1
RefSeq Acc Id: XP_008952009   ⟸   XM_008953761
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_014202472   ⟸   XM_014346986
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034789502   ⟸   XM_034933611
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000014091   ⟸   ENSPPAT00000036767
RefSeq Acc Id: ENSPPAP00000014107   ⟸   ENSPPAT00000036783
RefSeq Acc Id: ENSPPAP00000040581   ⟸   ENSPPAT00000063498

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030163 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAG00000042935 Ensembl
Ensembl Transcript ENSPPAT00000036767.1 UniProtKB/TrEMBL
  ENSPPAT00000036783.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
NCBI Gene LOC100986637 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/TrEMBL
  CASPASE-1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PIRSF Caspase_ICE UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
SMART CARD UniProtKB/TrEMBL
  CASc UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A0A2R9AB18_PANPA UniProtKB/TrEMBL
  A0A2R9AFG4_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-21 CASP1  caspase 1  LOC100986637  caspase-1  Symbol and/or name change 5135510 APPROVED
2023-05-02 LOC100986637  caspase-1  CASP1  caspase 1  Symbol and/or name change 5135510 APPROVED
2018-05-08 CASP1  caspase 1  LOC100986637  caspase-1  Symbol and/or name change 5135510 APPROVED