GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp1 | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased activity of CASP1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein; galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased activity of CASP1 protein] | PMID:34510229 PMID:35384154 | Casp1 | decreases expression | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | Cadmium results in decreased expression of CASP1 mRNA | PMID:33559965 | Casp1 | multiple interactions | ISO | Casp1 (Mus musculus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP1 protein | PMID:33359024 | Casp1 | multiple interactions | ISO | CASP1 (Homo sapiens) | 6480464 | CTD | 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein]; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein] | PMID:34510229 PMID:37300869 | | ||||||||||||||||||||||
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