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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1increases expressionISOCasp1 (Mus musculus)6480464CTDDexamethasone results in increased expression of CASP1 mRNAPMID:21041162 PMID:22733784
Casp1multiple interactionsISOCasp1 (Mus musculus)6480464CTD[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]PMID:30102002 PMID:32687258 PMID:34998855
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTDDexamethasone inhibits the reaction [TNF protein results in increased expression of CASP1 mRNA]PMID:11397893
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