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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1decreases expressionISOCASP1 (Homo sapiens)6480464CTDCannabidiol results in decreased expression of CASP1 mRNA; Cannabidiol results in decreased expression of CASP1 proteinPMID:27932991 PMID:34269108
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP1 protein]]; AM 251 inhibits the reaction [Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]]; Cannabidiol binds to and results in decreased activity of CASP1 protein; Cannabidiol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP1 mRNA]; Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP1 protein]; Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]; iodopravadoline inhibits the reaction [Cannabidiol results in decreased expression of CASP1 protein]; Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of CASP1 protein]PMID:27932991 PMID:33955754 PMID:34269108
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